Temat: cis-peptide bond - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A novel cis-peptide bond motif inducing β-turn type VI. The synthesis of enkephalin analogues modified with 4-aminopyroglutamic acid.
Autorzy:: Kaczmarek, Krzysztof
Kaleta, Maciej
Chung, Nga
Schiller, Peter
Zabrocki, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1044069.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: constrained enkephalin analogues
4-aminopyroglutamic acid
cis-peptide bond
β-turn mimetic
Opis:: A new pathway leading to a mixture of four isomers of 4-aminopyroglutamic acid is described. Michael type addition of Z-ΔAla-OMe to enolates prepared from acylaminomalonates, followed by hydrolysis and decarboxylation give protected 4-aminopyroglutamic acid with the 4-aminopyroglutamic acid with the cis:trans ratio approximately 3:2. This mixture was incorporated into Leu-enkephalin (position 2-3). After separation of peptides it appeared that all analogues were essentially inactive in guinea pig ileum and mouse vas deferens bioassays.
Źródło:: Acta Biochimica Polonica; 2001, 48, 4; 1159-1163
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

Skocz do pozycji: 2.

Tytuł:: Stereochemistry of insect kinin tetrazole analogues and their diuretic activity in crickets.
Autorzy:: Nachman, Ronald
Coast, Geoffrey
Kaczmarek, Krzysztof
Williams, Howard
Zabrocki, Janusz
Powiązania:: https://bibliotekanauki.pl/articles/1043327.pdf
Data publikacji:: 2004
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: constrained insect kinin analogue
tetrazole
diuresis
cis-peptide bond
β-turn mimetic
Opis:: Insect kinin analogues of the sequence Phe-Phe-ψ[CN4]-Ala-Trp-Gly-NH2 containing (L-Phe2,L-Ala3) and (L-Phe2,D-Ala3) stereochemical variants of the tetrazole moiety, a mimic of the type VI β-turn, demonstrate significant agonist and partial antagonist activity, respectively, in a cricket diuretic bioassay. A comparison of the solution conformations of these two stereochemical variants indicates a structural basis for their divergent bioactivities. The (D-Phe2,D-Ala3) stereochemical variant was synthesized and found to demonstrate significant agonist activity. The results further define stereochemical requirements for the diuretic activity of insect kinins in crickets and provide valuable information for the design of biostable analogues capable of disrupting digestive and diuretic processes in pest insects.
Źródło:: Acta Biochimica Polonica; 2004, 51, 1; 121-127
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

Artykuł

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