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    Tytuł:
    Neuropsychological consequences of COVID-19: current approach and clinical recommendations
    Autorzy:
    Treder-Rochna, Natalia
    Witkowska, Marta A.
    Powiązania:
    https://bibliotekanauki.pl/articles/29519204.pdf
    Data publikacji:
    2024-03-22
    Wydawca:
    Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
    Tematy:
    elderly
    chronic pulmonary diseases
    cognitive dysfunction
    neurodegenerative diseases
    mental health
    emotional functioning
    brain fog
    global pandemic
    psychosocial factors
    neuropsychological diagnosis
    neuropsychological rehabilitation
    hypoxia
    infection of SARS-CoV-2
    NeuroCOVID 19
    long COVID
    Opis:
    Nearly two years into the pandemic, a large body of data has emerged on how COVID-19-positive patients function with the viral infection. It is now known that the virus targets the central nervous system(CNS). As a result, in addition to the expected common health complaints, patients display cognitive and emotional problems. Cognitive deficits should be expected particularly in patients who have arrived at an intensive care unit as a result of respiratory failure, in patients suffering from comorbid neurodegenerative diseases and respiratory conditions, as well as in the elderly. However, these may also occur in patients with moderate to mild symptoms as well as in those of a younger age. The cognitive impairment has an unknown profile. Given the hypothesised hippocampal vulnerability to the SARS-CoV-2 virus, one might expect particular difficulties with memory, attention, information processing, and executive functions. With varying neuropsychological and emotional problems, convalescents in trying to return to their social, family and professional life require professional psychological assistance. The role of neuropsychologists is here crucial. Indeed, many patients will require a detailed, multifaceted neuropsychological diagnosis that will form the basis for subsequent neuropsychological rehabilitation. An early detection of neuropsychological manifestations could modify the risk of subsequent irreversible impairment and further neurocognitive decline.
    Źródło:
    Acta Neuropsychologica; 2024, 22(1); 107-128
    1730-7503
    2084-4298
    Pojawia się w:
    Acta Neuropsychologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Exhaled nitric oxide in smokers and former smokers with chronic obstructive pulmonary disease
    Autorzy:
    Galiniak, S.
    Aebisher, D.
    Rachel, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087917.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Opolski. Instytut Nauk o Zdrowiu
    Tematy:
    nitric oxide
    smoking
    respiratory diseases
    chronic obstructive pulmonary disease
    Opis:
    Background: Measurement of fractional exhaled nitric oxide (FeNO) is a useful technique for detection of eosinophilic airway inflammation and assessment of efficiency of corticosteroid treatment in patents with respiratory disease. Generally studies agree that measurement of FeNO is a useful non-invasive biomarker in patients with chronic obstructive pulmonary disease (COPD), however, there are reports that do not confirm such a relationship between FeNO and COPD. Aim of the study: The main objective of this study was to investigate FeNO levels in Polish patients with COPD compared to healthy controls. As a secondary objective, we assessed the influence of smoking on FeNO levels in healthy patients, and patients with COPD. Material and methods: FeNO concentration was measured using an electrochemical analyzer in healthy nonsmokers (n=21), healthy smokers (n=25), and former smokers with COPD (n=30) and smokers with COPD (n=38). General characteristics, hematological variables and serum biochemical parameters were also obtained and analyzed using the Kruskal-Wallis test. Results: FeNO measurement revealed significantly reduced NO levels in healthy smokers compared to healthy non-smokers, former smokers with COPD and smokers with COPD (median [range]: 14 [6–17] vs. 21 [15–29], 25 [15–53], and 19 [11–32] ppb, respectively, p<0.001). Moreover, we found increased FeNO levels in ex-smokers with COPD compared with smokers with COPD (p<0.05). No associations between FeNO and other analyzed parameters were found. Conclusions: Levels of FeNO, measured by with an electrochemical analyzer, were elevated among patients with COPD compared to healthy non-smoking controls. Moreover, our study confirms that smoking results in a reduction in FeNO concentration in both healthy patients and patients with COPD.
    Źródło:
    Medical Science Pulse; 2020, 14, 2; 36-43
    2544-1558
    2544-1620
    Pojawia się w:
    Medical Science Pulse
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanomedicine - a boon for respiratory disease management
    Autorzy:
    Balasubramanian, D.
    Lavanya, S.J.
    Girigoswami, A.
    Girigoswami, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/24200620.pdf
    Data publikacji:
    2023
    Wydawca:
    Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
    Tematy:
    nanomedicine
    asthma
    chronic obstructive pulmonary disease
    cystic fibrosis
    respiratory diseases
    nanomedycyna
    astma
    przewlekła obturacyjna choroba płuc
    mukowiscydoza
    choroby układu oddechowego
    Opis:
    Purpose: Respiratory diseases affect the lungs and other parts of the respiratory system. The respiratory disease affects hundreds of millions of humans, and premature death is observed in nearly four million people yearly. The major cause of the increase in this disease is the increased level of air pollution and higher tobacco usage in public places. Design/methodology/approach: We have used the search engines PubMed and Google Scholar for the keywords Respiratory diseases, Nanomaterials, diagnosis, Nanomedicine, and Target drug delivery; recent and relevant articles are selected for reviewing this paper. Findings: Nanomedicine is a recent field of research that deals with monitoring, repairing, theragnosis, and development of human biological systems at the sub-atomic level, where we utilize engineered nanodevices and nanostructures. The conventional therapeutic strategies designed for respiratory diseases have limited solubility and bioavailability. Moreover, the robust effect of the drugs led to adverse side effects due to their high dose requirement. The local delivery of therapeutic Nanoparticles (NPs) or drug-loaded nano vehicles to the lung is a safe technique for managing various respiratory tract-related diseases like chronic obstructive pulmonary diseases, cystic fibrosis, lung cancer, tuberculosis, asthma, and infection. To overcome the difficulties of conventional treatment with antibiotics and anti-inflammatory drugs, nano-enabled drug delivery, nanoformulations of drugs as well as drug nanoencapsulation have been used recently. In this mini-review, we will discuss the importance and application of nanomedicine for diagnosis, treatment and clinical research involved in the different types of respiratory diseases. Practical implications: Nanomedicine provides an alternative delivery of drugs with the help of various nanocarriers, which enhances controlled drug delivery at the pulmonary region and can be used for treating and diagnosing respiratory diseases in vivo and in vitro studies. Further experiments followed by clinical examination are warranted to prove the potential application of nanomedicine in treating respiratory disease. Originality/value: This mini-review will help the readers and budding scientists apply new methods for developing highly efficient drugs with low side effects and improved targeted sites of action.
    Źródło:
    Archives of Materials Science and Engineering; 2023, 119, 2; 71--85
    1897-2764
    Pojawia się w:
    Archives of Materials Science and Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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