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    Wyświetlanie 1-7 z 7
    Tytuł:
    Chronic suppurative otitis media with cholesteatoma and chronic otitis media with granulation investigated by scanning electron microscope based on an analysis of 140 patients
    Autorzy:
    Wiatr, Agnieszka
    Job, Katarzyna
    Składzień, Jacek
    Wiatr, Maciej
    Powiązania:
    https://bibliotekanauki.pl/articles/1397266.pdf
    Data publikacji:
    2021
    Wydawca:
    Index Copernicus International
    Tematy:
    bone defects
    chronic otitis media
    inflammatory granulation
    scanning electron microscope
    structure of cholesteatoma
    Opis:
    Introduction: Chronic purulent cholesteatoma of the middle ear, as well as to a lesser extent chronic granulomatous otitis media, lead to destruction of bone structures within the middle ear space. The above process is controlled by the OPG/RANKL/RANK system. Aim: The aim of the study is a comparative analysis of surgical material obtained from patients with diagnosed chronić cholesteatoma and chronic otitis media with inflammatory granulation in the assessment of the Scanning Electron Microscope (SEM). Material and methods: An analysis of 140 patients operated on due to chronic otitis media was performed. Forty patients who had been diagnosed with chronic cholesteatoma of the middle ear and chronic granulomatous otitis media were selected for a detailed analysis in the SEM. The final study under SEM included 20 patients. Results: The regular structure of cholesteatoma depicted in the SEM concerned 5 patients. In the remaining 7 patients, the system was irregular and even chaotic. The lack of regularity can also be observed in the case of granulation tissue, which in the SEM image presented itself as an irregular tissue mass without detectable regularities. Conclusions: (1) The regular pattern of the cholesteatoma matrix cells observed in some patients with chronic cholesteatoma of the middle ear reduces the molecular permeability of inflammatory cytokines, concurrently limiting the destructive activity on bone structures; (2) the presence of inflammatory granulation tissue in the middle ear is accompanied by an influx of leukocytes: neutrophils and lymphocytes, which are the source of pro-inflammatory cytokines, the growth of which activates the processes leading to the damage of bone tissue and the development of inflammation; (3) no specimen of acquired cholesteatoma revealed the presence of commensal organisms from Demodex species on the surface of the exfoliated human epithelium.
    Źródło:
    Polish Journal of Otolaryngology; 2021, 75, 3; 21-27
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Congenital Cholesteatoma of Petrous Apex – case report and review of literature
    Autorzy:
    Makuszewska, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1400049.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    congenital petrosal cholesteatoma
    facial nerve palsy
    facial nerve reconstruction
    middle fossa approach
    Opis:
    Objective: Congenital cholesteatomas of the petrous apex are rare lesions that develop insidiously, which delays diagnosis and requires a high index of suspicion. A case report of supralabyrinthine congenital petrous bone cholesteatoma and review of recent literature are presented. Methods: A 27-year-old woman presented with progressive facial palsy. Otomicroscopy did not reveal any abnormalities, and hearing was normal. Although there were no complaints of vertigo or instability, vestibular examinations indicated a non-compensated peripheral vestibular lesion. Radiological examinations revealed a lesion in the petrous apex and epitympanum that had features of a cholesteatoma. Results: To preserve normal hearing, the middle fossa approach was chosen for surgery. A damaged part of the facial nerve was reconstructed with cable graft. Conclusion: Advances in radiological imaging facilitate surgical planning, and improvements in the techniques of lateral skull base surgery enable safe and radical removal of petrous bone cholesteatomas with minimal morbidity.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 62-67
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Congenital cholesteatomas
    Autorzy:
    Narożny, Waldemar
    Kuczkowski, Jerzy
    Stankiewicz, Czesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1401793.pdf
    Data publikacji:
    2015
    Wydawca:
    Index Copernicus International
    Tematy:
    congenital cholesteatoma
    middle ear
    etiology
    treatment
    overview
    Opis:
    Congenital cholesteatoma is a rare ear disorder. The most common presentation is a pearly and white mass, visible with an intact tympanic membrane in individuals with no previous history of ear discharge, ear surgery or perforation of tympanic membrane. Based on a careful overview of literature, authors of this article present: the most probable theories of the cause of development of congenital cholesteatoma, diagnostic criteria of congenital cholesteatoma, its most common clinical symptoms, preoperative studies, methods of surgical treatments and goals of postoperative proceedings. Furthermore, authors present a comparison of histological, molecular and clinical features of congenital and acquired cholesteatomas.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2015, 4, 2; 78-83
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnostic imaging in chronic otitis media: does CT and MRI fusion aid therapeutic decision making? – a pilot study
    Autorzy:
    Kusak, Artur
    Rosiak, Oskar
    Durko, Marcin
    Grzelak, Piotr
    Pietruszewska, Wioletta
    Powiązania:
    https://bibliotekanauki.pl/articles/1397788.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    magnetic resonance
    computed tomography
    cholesteatoma
    canal wall-up surgery
    Opis:
    Introduction: Despite the recent advances in otosurgery diagnosis of cholesteatoma and qualification for surgery remains an issue in contemporary laryngology. In cases of cholesteatoma recidivism, it is of utmost importance to properly locate the pathology in the middle ear to plan surgical approach. Magnetic Resonance imaging in diffusion-weighted non-echoplanar sequences (non-EPI DWI) enables cholesteatoma detection as small as 2 mm and could potentially prevent unnecessary second-look surgery. Computed Tomography of the temporal bone allows precise visualization of bony structures and topographical landmarks of the middle ear. A fusion of both imaging modalities combines the advantages of these techniques. Material and methods: Five patients treated in the Department of Otolaryngology, the Medical University of Lodz for probable cholesteatoma recidivism were included in this study. A high-resolution CT scan of the temporal bone and an MRI scan including non-EPI sequences was obtained in all patients. A fusion of CT and MRI studies was conducted using OsirixMD software. Fist, CT studies were fused with MRI BFFE sequences, then non-EPI sequences were added. Finally, if the patient qualified for surgical treatment histopathological diagnosis was compared with MRI results. Results: CT scans were analyzed to establish the extent of previous surgical interventions and anatomical landmarks preservation. In all cases, MRI results were suspicious of cholesteatoma recidivism. Four cases were confirmed in postoperative histopathological evaluation, there was one false positive case when intraoperatively scar tissue was identified, which was later confirmed as connective tissue upon histopathological evaluation. Conclusions: CT and MRI fusion provides a helpful diagnostic tool in preparation for surgery in patients with suspected cholesteatoma recidivism.
    Źródło:
    Polish Journal of Otolaryngology; 2019, 73, 1; 7-12
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pathogenesis of middle ear acquired cholesteatoma in the light of the research using high throughput, “omics”, technologies of molecular biology
    Autorzy:
    Makuszewska, Maria
    Bartoszewicz, Robert
    Niemczyk, Kazimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1399639.pdf
    Data publikacji:
    2019
    Wydawca:
    Index Copernicus International
    Tematy:
    aquired cholesteatoma
    gene expression
    microarray
    molecular biology
    pathogenesis
    proteomic analysis
    Opis:
    Cholesteatoma is described as cystic lesion consisting of keratinizing squamous cell epithelium, filed with keratin debris, surrounded by inflammatory fibrous tissue, gradually expanding in the middle ear and causing destruction of neighboring bones. This paper presents brief review of existing hypotheses explaining its etiology in the light of the researches using high throughput, “omics”, technologies of molecular biology. Classic theories of pathogenesis of acquired cholesteatoma as: immigration, squamous metaplasia, basal cell hyperplasia or invagination theory have not been able to explain fully all pathological processes observed in cholesteatoma tissue. This also concerns the newer concepts that cholesteatoma is a result of mucosal traction generated by interaction of migrating opposing surfaces, a natural attempt by the body to cure the underlying inflammation in the cavity or chronic wound healing process triggered by micro defects in the basement membrane of the epithelium in the retraction pocket. Introduction of high-throughput, “omics”, technologies of molecular biology to the studies under cholesteatoma pathogenesis allowed identification of cholesteatoma-related gene expression signatures using full-genome microarrays as well as proteomic analysis of cholesteatoma. Those studies confirmed known pathological processes observed in cholesteatoma tissue such as: high proliferative activity, decreased signal transduction, active immunological response, alterations in the extracellular matrix, increased expression of proinflammatory cytokines, neovascularization and may others. This technique allows precise and complete insight into molecular mechanisms in those processes. However, it is still unknown what is the cause that trigger epithelial hyperplasia, inhibited migration and inflammatory response in the preexisting retraction pocket.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2019, 8, 3; 14-19
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of N-acetyl-β-d-hexosaminidase in cholesteatoma tissue
    Autorzy:
    Olszewska, Ewa
    Olszewski, Slawomir
    Borzym-Kluczyk, Malgorzata
    Zwierz, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/1041088.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    hexosaminidase
    cholesteatoma
    HEX activity
    normal retroauricular skin
    Opis:
    Cholesteatoma is a destructive disease characterized by the progressive expansion of keratinizing squamous epithelium in the middle ear and mastoid, and chronic inflammatory reaction of the subepithelial connective tissue. N-Acetyl-β-d-hexosaminidase (HEX) catalyzes the release of terminal non-reducing N-acetyl-d-hexosamine residues acting on glucosides and galactosides in glycoproteins, GM2-gangliosides and glycosaminoglycans (GAGs). In this study the activities of HEX were measured in cholesteatoma tissue and in normal skin to demonstrate a possible role of HEX in bone resorption in the area adjacent to cholesteatoma. Cholesteatomas (n = 21) and normal adult retroauricular skin (controls, n = 21), were collected from patients during surgery due to chronic otitis media. In 20 of 21 specimens a significantly higher activity of HEX was observed in cholesteatoma tissue compared with that in normal skin. Mean release of HEX from the activated cells was 68.55 ± 30.77 nkat/g wet tissue in cholesteatoma and 31.79 ± 10.02 nkat/g wet tissue in skin specimens. It may explain the process of bone resorption in the area adjacent to cholesteatoma, i.e. ossicles or temporal bone. This study suggests that drugs inhibiting HEX activity, such as iminocyclitols, may be useful in cholesteatoma treatment.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 365-370
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of petrosectomy in cochlear implant surgery
    Autorzy:
    Amernik, Katarzyna
    Niemczyk, Kazimierz
    Twardowska, Renata
    Jaworowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1399062.pdf
    Data publikacji:
    2020
    Wydawca:
    Index Copernicus International
    Tematy:
    cholesteatoma
    chronic otitis
    cochlear implant
    hearing loss
    petrosectomy
    Opis:
    Introduction: The treatment and rehabilitation of hypoacusis with the use of cochlear implants is a safe and reliable method suitable for both children and adults. In people affected by chronic otitis media cholesteatomatosa or such who have previously undergone open repair of the ear, we use a special surgical technique known as lateral/subtotal petrosectomy. Material and methods: The study group consisted of patients with profound bilateral sensorineural hearing loss, in which otitis media with and without cholesteatoma has been diagnosed or after open repair of the middle ear. A retrospective analysis of patient data, as well as radiological and audiological results, was conducted. Results: In the Clinic of Otolaryngology and Laryngological Oncology of the Pomeranian Medical University in the years 2008–2018 we performed 90 cochlear implant surgeries, including a petrosectomy in 1 child with cholesteatoma (5 years) and in 2 adults after open repair (62 and 73 years). In all cases the procedure was done in a single stage. Healing proceeded correctly in all patients undergoing petrosectomy. The observation period ranges from 26 to 32 months, computed tomography examinations revealed no indirect characteristics of recurrent cholesteatoma. The patients remain under constant ENT supervision. The child has risk factors for autism and mental retardation, he displays good auditory responses and speech understanding; he has not developed active speech. As regarding free field pure tone audiometry, in adults hearing in the cochlear implant remains at 35 and 40 dB, and speech understanding at 80%. Discussion: Patients with chronic otitis media can be treated efficiently and safely with a cochlear implant using lateral petrosectomy. Lateral/subtotal petrosectomy is the access of choice when deep sensorimotor hearing loss coexists with chronic inflammation in the middle ear.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2020, 9, 2; 1-6
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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