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Wyświetlanie 1-8 z 8
Tytuł:
A novel adaptive checkpointing method based on information obtained from workflow structure
Autorzy:
Kail, E.
Kacsuk, P.
Kozlovszky, M.
Powiązania:
https://bibliotekanauki.pl/articles/305730.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
scientific workflow
checkpoint
dynamic execution
Opis:
Scientific workflows are data- and compute-intensive; thus, they may run for days or even weeks on parallel and distributed infrastructures such as grids, supercomputers, and clouds. In these high-performance computing infrastruc- tures, the number of failures that can arise during scientific-workflow enact- ment can be high, so the use of fault-tolerance techniques is unavoidable. The most-frequently used fault-tolerance technique is taking checkpoints from time to time; when failure is detected, the last consistent state is restored. One of the most-critical factors that has great impact on the effectiveness of the checkpointing method is the checkpointing interval. In this work, we propose a Static (Wsb) and an Adaptive (AWsb) Workflow Structure Based checkpoint- ing algorithm. Our results showed that, compared to the optimal checkpointing strategy, the static algorithm may decrease the checkpointing overhead by as much as 33% without affecting the total processing time of workflow execution. The adaptive algorithm may further decrease this overhead while keeping the overall processing time at its necessary minimum.
Źródło:
Computer Science; 2016, 17 (3); 387-406
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of immune checkpoint inhibitors in prostate cancer
Autorzy:
Surdacki, G.
Szudy-Szczyrek, A.
Gorący, A.
Chyl-Surdacka, K.
Hus, M.
Powiązania:
https://bibliotekanauki.pl/articles/2082066.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
prostate cancer
checkpoint inhibitor
PD-1
PD-L1
CTLA-4
Opis:
Introduction. Prostate cancer (PC) is the most commonly diagnosed malignant tumour and the third cause of cancer deaths among men in Europe. The treatment of early-stage PC is very effective and in many cases allows achievement of a complete cure, whereas the treatment of metastatic prostate cancer (mPC) is still a huge challenge for clinicians. New therapeutic strategies for mPC are urgently needded. One of the most promising methods of treatment is anticancer immunotherapy including the monoclonal antibodies against immune checkpoint inhibitors. Objectives. To present the potential possibilities of using checkpoint inhibitors blockage in the treatment of mPC, and to overview the results of recent research on immune checkpoint inhibitors in patients with PC. State of knowledge. Recent studies suggest that monoclonal antibodies directed against immune checkpoint inhibitors in combination with traditional therapy may become a breakthrough in the treatment of mPC in the near future. Conclusions. The immunotherapy using monoclonal antibodies against immune checkpoint inhibitors seems to be a new opportunity for patients with advanced PC. The key to achieve the maximum anti-tumour response is to choose the best candidates for this therapy and determine the optimal sequence and combination of drugs. The introduction of immunotherapy as the standard treatment of patients with advanced PC requires further studies.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 120-124
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gamma-radiation-induced ATM-dependent signalling in human T-lymphocyte leukemic cells, MOLT-4
Autorzy:
Tichý, Aleš
Záškodová, Darina
Řezáčová, Martina
Vávrová, Jiřina
Vokurková, Doris
Pejchal, Jaroslav
Vilasová, Zdena
Cerman, Jaroslav
Österreicher, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1041075.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
checkpoint kinase-2
ionizing radiation
p53
ATM kinase
Mdm2
Opis:
ATM kinase (ATM) is essential for activation of cell cycle check points and DNA repair in response to ionizing radiation (IR). In this work we studied the molecular mechanisms regulating DNA repair and cell death in human T-lymphocyte leukemic cells, MOLT-4. Apoptosis was evaluated by flow-cytometric detection of annexin V. Early apoptotic cells were determined as sub-G1 cells and late apoptotic cells were determined as APO2.7-positive ones. Proteins involved in ATM signalling pathway were analysed by Western-blotting. We observed a rapid (0.5 h) phosphorylation of ATM declining after 6 h after irradiation by all the doses studied (1.5, 3.0, and 7.5 Gy). Checkpoint kinase-2 (Chk-2) was also phosphorylated after 0.5 h but its phosphorylated form persisted 4, 2, and 1 h after the doses of 1.5, 3.0, and 7.5 Gy, respectively. The amount of p53 protein and its form phosphorylated on Ser-392 increased 1 h after irradiation (1-10 Gy). The lethal dose of 7.5 Gy caused an immediate induction and phosphorylation of p53 after 0.5 h post-irradiation. At the time of phosphorylation of p53, we found simultaneous phosphorylation of the oncoprotein Mdm2 on Ser-166. Neither ATM nor its downstream targets showed a dose-dependent response after 1 h when irradiated by the doses of 1-10 Gy. MOLT-4 cells were very sensitive to the effect of IR. Even low doses, such as 1.5 Gy, induced apoptosis 16 h after irradiation (evaluated according to the cleavage of nuclear lamin B to a 48-kDa fragment). IR-induced molecular signalling after exposure to all the tested doses was triggered by rapid phosphorylation of ATM and Chk-2. Subsequent induction of p53 protein and its phosphorylation was accompanied by concomitant phosphorylation of its negative regulator, oncoprotein Mdm2, and followed by induction of apoptosis.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 281-287
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ukrainian - Russian border experiment iternational transport crossing point "Deakovo - Kujbyshevo - 2"
Ukrainsko - Rossijjskijj pogranichnyjj exksperiment mezhdunarodnogo avtomobil'nogo punkta propuska "D'jakovo - Kujjbyshevo - 2"
Autorzy:
Slobodyanyuk, M.
Lapaeva, E.
Powiązania:
https://bibliotekanauki.pl/articles/792420.pdf
Data publikacji:
2013
Wydawca:
Komisja Motoryzacji i Energetyki Rolnictwa
Tematy:
state border
transport system
checkpoint
border crossing
vehicle movement
Russian Federation
Ukraine
Źródło:
Teka Komisji Motoryzacji i Energetyki Rolnictwa; 2013, 13, 3
1641-7739
Pojawia się w:
Teka Komisji Motoryzacji i Energetyki Rolnictwa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Traveling salesman problem in the function of freight transport optimization
Autorzy:
Prokudin, G.
Chupaylenko, O.
Dudnik, O.
Dudnik, A.
Pylypenko, Y.
Powiązania:
https://bibliotekanauki.pl/articles/2140887.pdf
Data publikacji:
2018
Wydawca:
Fundacja Centrum Badań Socjologicznych
Tematy:
freight
logistics
information technology
traveling salesman problem
closed contour
optimization
route
checkpoint
Opis:
The use of modern information technology means in solving the traveling salesman problem to optimize the routing of freight transportation in international traffic is motivated in this article. The process of solving the traveling salesman problem is automated by modern information technology means, in particular the Delphi Software and the function "Search Solution" in the Microsoft Office Excel table processor. The existing requirements and restrictions on the specificity and dimension of the problem are considered as well.
Źródło:
Journal of Sustainable Development of Transport and Logistics; 2018, 3, 1; 29-36
2520-2979
Pojawia się w:
Journal of Sustainable Development of Transport and Logistics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiz processa vozdejjstvija ehlehktromagnitnykh impulsnykh signalov na biologicheshikh vreditelejj, nakhodjashhikhsja v pochve
Analysis of the effects of electromagnetic pulse signals on biological pests in the soil
Autorzy:
Kozak, A.
Gorbijjchuk, I.
Semenishina, I.
Vil'chinskaja, D.
Powiązania:
https://bibliotekanauki.pl/articles/77530.pdf
Data publikacji:
2015
Wydawca:
Komisja Motoryzacji i Energetyki Rolnictwa
Tematy:
electromagnetic pulse
plant protection
chemical method
alternative method
environmental safety
pest
electromagnetic radiation
checkpoint
Źródło:
Motrol. Motoryzacja i Energetyka Rolnictwa; 2015, 17, 1
1730-8658
Pojawia się w:
Motrol. Motoryzacja i Energetyka Rolnictwa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Advances in immunotherapy for osteosarcoma: a review of emerging treatment strategies
Autorzy:
Poboży, Kamil
Domański, Paweł
Domańska, Julia
Konarski, Wojciech
Poboży, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/22792557.pdf
Data publikacji:
2023-09-13
Wydawca:
Medical Education
Tematy:
osteosarcoma
immunotherapy
immune checkpoint inhibitors
cancer vaccines
autophagy
pyroptosis
chimeric antigen receptor T cells
Opis:
Advances in immunotherapy for osteosarcoma have shown promising results, with the use of monoclonal antibodies and immune checkpoint inhibitors. These strategies are aimed at targeting specific molecules and pathways involved in tumour immune evasion and promoting anti-tumour immune responses. Other emerging immunotherapeutic approaches include autophagy and pyroptosis induction, chimeric antigen receptor T-cell therapy, gadolinium-bisphosphonate nanoparticles and dendritic cell-based vaccines. Continued research into these emerging treatment strategies is essential for developing effective therapies for patients with high-grade osteosarcoma.
Źródło:
OncoReview; 2023, 13, 3; 75-84
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of ergonomic analysis methods as supprt in the assessment of occupational risk in the position of a seller in a small grocery store (Poland)
Autorzy:
Kielesińska, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1831307.pdf
Data publikacji:
2021
Wydawca:
Stowarzyszenie Menedżerów Jakości i Produkcji
Tematy:
occupational risk
musculoskeletal load
risk assessment methods
work safety
Ergonomic Checkpoint List
ryzyko zawodowe
obciążenie mięśniowo-szkieletowe
metody oceny ryzyka
bezpieczeństwo pracy
ergonomiczna lista punktów kontrolnych
Opis:
The profession of a seller (especially in small grocery stores) does not enjoy a social respect. The reasons for this are, above all, low requirements, low salary and difficult working conditions. In addition, too little attention is paid in the literature to this profession from the point of view of safety and hazards at work. However, the problem of working conditions in the position of a salesman is an important issue concerning a very large number of people. The paper deals with this difficult topic by describing selected methods of ergonomic analysis and using them to assess occupational risk at the seller's workplace. In the paper, the results of the Ergonomic Checkpoint List, as well as the results of questionnaire surveys are presented. All the results are related to the possibility of proper identification and the probability of hazards occurrence in the position of a seller.
Źródło:
System Safety : Human - Technical Facility - Environment; 2021, 3, 1; 214-227
2657-5450
Pojawia się w:
System Safety : Human - Technical Facility - Environment
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-8 z 8

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