Skocz do pozycji: 1.

Tytuł:

CD4- and CD8-expressing cells found in the bovine and porcine anterior chamber of the eye

Autorzy:

Ziółkowski, H.
Maślanka, T.
Socha, P.
Ziółkowska, N.
Dąbrowski, M.
Małaczewska, J.

Powiązania:

https://bibliotekanauki.pl/articles/2087714.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

anterior chamber
CD4+ cells
CD8+ cells
DP cells
cattle
pig

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 2; 293-298
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 2.

Tytuł:

Micro- and nanopatterned surfaces for guided adhesion, growth and phenotypic maturation of cells

Autorzy:

Bacakova, L.
Filova, E.
Grausova, L.
Vandrovcova, M.
Parizek, M.
Novotna, K.
Svorcik, V.
Vacik, J.
Rypacek, F.
Kromka, A.
Heitz, J.
Shard, A.

Powiązania:

https://bibliotekanauki.pl/articles/284586.pdf

Data publikacji:

2009

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

surface patterning
microstructure
nanostructure
biofunctionalization
endothelial cells
vascular smooth muscle cells
bone cells

Opis:

Micropatterned surfaces were created by UV light-irradiation of polytetrafluoroethylene through a metallic mask, by successive plasma polymerization of acrylic acid and 1,7-octadiene, or by creation of prominences and grooves by deposition of fullerenes C60 through a metallic mask. All these surface types were capable of inducing regionally-selective adhesion, proliferation and phenotypic maturation of vascular endothelial cells, vascular smooth muscle cells or human bone-derived MG 63 cells. Nanopatterned surfaces created by tethering GRGDSG oligopeptides through polyethylene oxide chains on a polymeric surface promoted spreading, formation of focal adhesion plaques and DNA synthesis in vascular smooth muscle cells. Surfaces nanopatterned with nanocrystalline diamond gave good support for the adhesion, growth and metabolic activity of osteoblast-like MG 63 cells.

Źródło:

Engineering of Biomaterials; 2009, 12, no. 89-91; 18-21
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 3.

Tytuł:

Stem cells: applications, perspectives, misunderstandings

Autorzy:

Dulak, Józef

Powiązania:

https://bibliotekanauki.pl/articles/704245.pdf

Data publikacji:

2020

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

stem cells
cellular therapies
gene therapy
embryonic stem cells
induced pluripotent stem cells

Opis:

Stem cells exist and can do a lot. For several decades, bone marrow and umbilical cord blood transplants containing haematopoietic stem cells have been used in the treatment of blood diseases. Genetic modifications (gene therapy) of such cells help to cure complex immunodeficiencies and severe anaemias. The limbal stem cells taken from the eye and properly multiplied can regenerate the damaged cornea, and the epidermal stem cells help in the treatment of severe burns and some hereditary, severe skin diseases. Promising experimental research is under way on other uses of stem cells. However, these cells are appropriately selected, having real ability to differentiate into specialized cells whose malfunction is the cause of the disease. Therapeutic applications of stem cells are apparently limited to date. Meanwhile, the Internet is full of advertisements for supposedly miraculous treatments for almost any disease. Stem cells have become a modern synonym of the Holy Grail. A wonderful dish, transforming every drink into elixir of health, youth and long life. Stem cells from a single source, e.g., umbilical cord blood, or so-called cells, although without proven properties of stem cells, are offered in commercial private clinics as a panacea for autism, cerebral palsy, spina bifida, eye diseases, amyotrophic lateral sclerosis and dozens other disorders. Without justification for their action in these diseases, without convincing evidence of safety, but for a high fee. This article discusses stem cells and misunderstandings about including any cells among them. It draws attention to the real possibilities and confirmed uses of stem cells and presents the problems, doubts and dangers for patients associated with commercial offers of treatments using “stem” cells. The author cites the positions of scientific institutions and societies warning against premature commercialization of unjustified and potentially dangerous therapies

Źródło:

Nauka; 2020, 1
1231-8515

Pojawia się w:

Nauka

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 4.

Tytuł:

Comparison of the CRLC models describing the Helmholtz type cells for the nondestructive photoacoustic spectroscopy

Autorzy:

Chrobak, Ł. B.
Maliński, M. A.

Powiązania:

https://bibliotekanauki.pl/articles/221397.pdf

Data publikacji:

2014

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

nondestructive testing
photoacoustic spectroscopy
photoacoustic cells
Helmholtz cells

Opis:

The photoacoustic cell is the heart of the nondestructive photoacoustic method. This article presents a new simple lumped-components CRLC model of the Helmholtz type photoacoustic cell. This model has been compared with the well known literature models describing the Helmholtz type cells for photoacoustic spectroscopy. Experimental amplitude and phase frequency data obtained for the two photoacoustic cells have been presented and interpreted in a series of models. Results of the fitting of theoretical curves, obtained in these models, to the experimental data have been shown and discussed.

Źródło:

Metrology and Measurement Systems; 2014, 21, 3; 545-552
0860-8229

Pojawia się w:

Metrology and Measurement Systems

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 5.

Tytuł:

Preliminary studies of phthalocyanine sensitizers incorporated into human leukemia cells from two cell-lines.

Autorzy:

Wiktorowicz, Krzysztof
Cofta, Justyna
Dudkowiak, Alina
Waszkowiak, Aneta
Frąckowiak, Danuta

Powiązania:

https://bibliotekanauki.pl/articles/1041548.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

MOLT 4 cells
fluorescence
photodynamic therapy
phthalocyanine
CCRF cells

Opis:

Three phthalocyanine dyes-sensitizers were incorporated into two types of human T leukemia cells from two cell-lines: CCRF and MOLT 4. The efficiency of the dye incorporation into cells and photochemical properties of stained cells were investigated using fluorescence spectroscopy. The dyes exhibited different properties in each of the two cell-lines. Small differences in cell membrane properties have a strong influence on the efficiency of dye incorporation and on the course of photodynamic reaction. It is suggested that, for a given patient, an optimal dye-sensitizer should be established before photodynamic treatment.

Źródło:

Acta Biochimica Polonica; 2004, 51, 3; 703-710
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 6.

Tytuł:

Evaluation of cytocompatibility of PLGA and PGLA-based nanocomposite biomaterials in osteoblast cultures

Autorzy:

Ścisłowska-Czarnecka, A.
Stodolak-Zych, E.
Prawdzik, E.
Boguń, M.
Menaszek, E.

Powiązania:

https://bibliotekanauki.pl/articles/285320.pdf

Data publikacji:

2012

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

kompozyty
nanokompozyty
cells materials interaction
cells factors
composites
nanocomposites

Opis:

The aim of this study was to evaluate biocompatibility of multilevel composites based on bioresorbable poly(lactide-co-glycolide) (PGLA). Polymer matrix was modified with multidimensional (MD) short biopolymer fibers of calcium alginate (CA) containing bioactive ceramic nanoparticles (nanohydroxyapatite - HA or nanosilica - SiO2). The nanocomposite fibres present in the polymer samples influenced cells morphology, viability and secretory activity which was estimated using human osteoblasts cells (NHOst). The results indicate that biodegradable nanocomposite CA-HA/PGLA improves biological properties of the basic biomaterial (PGLA) suggesting its potential application for bone tissue engineering.

Źródło:

Engineering of Biomaterials; 2012, 15, 112; 2-5
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 7.

Tytuł:

Endothelial cell proteome changed by contact with surfaces of biomaterials

Autorzy:

Komorowski, P.
Jerczyńska, H.
Pawłowska, Z.
Walkowiak, M.
Walkowiak, B.

Powiązania:

https://bibliotekanauki.pl/articles/285099.pdf

Data publikacji:

2009

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

biomaterials
implants
cells

Opis:

Biomaterials used for medical implants or instruments production can cause numerous undesirable effects in human organism. They may affect cells being in a direct contact with them and can cause changes in genes expression, and as a consequence, also in protein profile of these cells. The aim of the present work was to examine an effect of medical steel 316L, poly-paraxylylene (Parylene) and nanocrystalline diamond (NCD) surfaces on protein expression in human endothelial cell line EA.hy 926.Cells were grown in Dulbecco’s MEM (DMEM) supplemented with antibiotics (penicillin and streptomycin), glucose, 10% heat inactivated fetal bovine serum and HAT-supplement. After 48h of incubation cells were washed with PBS and treated with lysis buffer (7M urea, 2M thiourea, 4% CHAPS, 2 % IPG buffer pH 4-7, 1% DTT). Proteins were purified from cell lysates with 2-D CleanUp Kit, and concentration was assessed with 2D Quant Kit. After overnight rehydration of IEF strips (pH 4-7, 11cm), in the presence of purified proteins, isoelectric focusing procedure was performed until 40kVh. Then, stripes were equilibrated, and focused proteins were separated in 12,5% polyacrylamide gels (SDS PAGE). Silver stained gels were recorded with ImageScanner and analyzed with ImageMaster 2D Platinium 6.0 (GE Healthcare) software. Numerous changes in protein expression were detected in endothelial cells exposed to artificial surfaces of tested materials (see TABLE I).

Źródło:

Engineering of Biomaterials; 2009, 12, no. 89-91; 30
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 8.

Tytuł:

The influence of the surface topography on the cell-differentiation effect

Autorzy:

Lackner, J. M.
Major, R.

Powiązania:

https://bibliotekanauki.pl/articles/284478.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

plasticity
cells
therapy

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 22
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 9.

Tytuł:

Stem cells are the hope of modern stomatology

Autorzy:

Gabiec, K.
Wyrzykowska, K.
Dąbrowska, Z.
Antoniak, M.
Dąbrowska, E.

Powiązania:

https://bibliotekanauki.pl/articles/1918468.pdf

Data publikacji:

2017

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

Stem cells
stomatology

Opis:

Introduction: Stem cells are often hailed as the medicine of the 21st century. They provide us with potential tools to effectively counteract not only diseases, but even aging. For stomatology, stem cells are the technology of the future in the regeneration of the periodontium and pulp, and dental replantation and transplantation. Materials and methods: On the basis of a literature review, the previous achievements and potential capabilities of stem cell therapy were discussed, focusing on dental applications. Conclusions: The paper discusses the modulation of stem cells and their therapeutic potential and capabilities. The presence and properties of stem cells in the pulp of human deciduous and permanent teeth, the periodontal membrane and the dental sac are also discussed. The results of the studies conducted by the cited researchers are promising and give hope for the development of regenerative and restorative processes of the dental and periodontal tissues. Summary: In the future, stem cells obtained from primary and permanent teeth deposited in special dental banks will be able to prevent the degradation of periodontal tissue, or even heal the teeth.

Źródło:

Progress in Health Sciences; 2017, 7(1); 175-181
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 10.

Tytuł:

The adhesion and growth of human osteoblast-like MG 63 cells in cultures on titanium modified with gold microparticles and polyethylene imine)

Autorzy:

Parizek, M.
Base, T.
Hruby, M.
Lisa, V.
Bacakova, L.

Powiązania:

https://bibliotekanauki.pl/articles/284730.pdf

Data publikacji:

2012

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

osteoblasts
cells
titanium

Opis:

Metallic materials are indispensable for construction of surgical implants, particularly those designed for load-bearing application, such as the bone-anchoring parts of big joint replacements. For good osteointegration, long-term function, durability and also mechanical and chemical resistance of the implant, the physical and chemical properties of the material surface are of a great importance. These properties can be favorably influenced by coating the bone-anchoring parts of the implants with appropriate biocompatible and bioactive films. Therefore, in this study, we have investigated the adhesion and growth of human osteoblast-like MG 63 cells in cultures on titanium substrates coated with films made of gold microparticles and/or poly(ethylene imine) (PEI). Gold microparticles were chosen for good biocompatibility of gold and absence of its cytotoxicity, which has been proved by numerous studies performed in vitro and in vivo [1,2]. When deposited on the material surface, these microparticles provide this surface with microstructure, which has been reported to enhance the osteogenic differentiation of bone-derived cells. On the other hand, the material surface microroughness has dual effect on the cell adhesion, spreading and proliferation - some studies reported the enhancement, other the reduction of these events (for a review, see [3,4]). This suggests that not only the size of the microscale irregularities, but also their shape should be taken into account. Therefore, in our study, gold microparticles were used in the form of plates or polyhedral crystals [5]. These microparticles were deposited on square samples of Ti (1x1 cm, thickness 1 mm) and annealed with a hydrogen flame. As for PEI, this polymer has been used as precursor base layer for further functionalization of metallic substrates, particularly with polyelectrolyte multilayer films [6] or biomolecules such as gelatin, hyaluronan or chitosan [7,8]. Other reason for the PEI deposition was creation of an intermediate layer which would compensate the differences in mechanical properties (e.g., hardness, toughness, specific weight) between a metallic implant and bone tissue. PEI was deposited either on pure or on gold microparticle-coated Ti samples. The materials were sterilized with 70% ethanol (1 hour), inserted into 24-well polystyrene plates (well diameter 1.5 cm; TPP, Switzerland) and seeded with human osteoblast-like MG 63 cells (30 000 cells/well, i.e. 17 000 cells/cm2). Each well contained 1.5 ml of a medium DMEM with 10% of fetal bovine serum and 40 /jg/ml of gentamicin. On days 1, 3 and 7 after seeding, the cell number and morphology were evaluated. For evaluating the cell number, the cells were trypsinized and counted in Bürker hemocytometer. For evaluating the cell morphology, i.e. the cell shape and the size of cell spreading area, the cells were fixed with 70% ethanol (-20°C, 10 min) and stained with a combination of fluorescence dyes Texas Red C2-maleimide, which stains the cell membrane and cytoplasm, and Hoechst #33342, which stains the cell nuclei. The microphotographs of cells were taken using an Olympus IX 51 microscope equipped with a DP 70 digital camera, and the cell spreading area was measured on these pictures using a software Atlas (Tescan, Brno, Czech Rep.) One day after seeding, the highest number of initially adhered cells was found on the surface modified by gold polyhedral crystals. This trend was the same on days 3 and 7 after seeding (FIG.1,2). However, the cell number on Ti modified with gold plates was significantly lower than on Ti with polyhedral crystals. Nevertheless, the numbers of cells on Ti samples coated with gold microparticles without PEI were significantly higher than on PEI-coated samples. Also the cell spreading areas were significantly larger on the samples without PEI. The cells on the samples without PEI were mostly polygonal, while the cells on PEI-coated samples were of star-like appearance, i.e. with multiple long protrusions (FIG.2). This is in accordance with findings published by other authors, documenting cytotoxic effects of PEI, particularly that of a high molecular weight [6], which was also used in our study (m.w. 750 kDa). Nevertheless, this cytotoxicity was considerably reduced by further functionalization of PEI with biomolecules, such as gelatin, hyaluronan or chitosan [7,8]. Thus, it can be concluded that the modification of titanium plates by gold microparticles supported the adhesion and growth of MG 63 cells. In this context, the polyhedral crystals were more advantageous than plates. The effects of PEI coatings on cell behavior need further investigation.

Źródło:

Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 149-150
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 11.

Tytuł:

Mental imagery and spatio-temporal continuity: Evidence from the function of the hippocampal formation

Autorzy:

Kocsis, Anna

Powiązania:

https://bibliotekanauki.pl/articles/2199957.pdf

Data publikacji:

2019

Wydawca:

Projekt Avant

Tematy:

hippocampus
grid cells
mental imagery
place cells
spatio-temporal continuity

Opis:

The aim of this paper is to suggest a novel account of mental imagery according to which mental images are not a-temporal picture-like representations, but processes characterized by their spatio-temporal continuity. Evidence based in particular on recent advances in understating the functional role of the hippocampal formation in cognition and spatial coding is provided. Under this account, mental images are a pervasive form of cognition that is supported by the complex interaction of the hippocampus and the entorhinal cortex, encompassing cognitive functions such as navigation, episodic memory, as well as mental rotation and scanning. The functional role of the hippocampus is twofold: it forms elements of spatio-temporal continuity and re-combines them in novel ways in the process of scene reconstruction that underpins various forms of spatial cognition.

Źródło:

Avant; 2019, 10, 2
2082-6710

Pojawia się w:

Avant

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 12.

Tytuł:

Prospects for the use of the achievements of regenerative medicine in otorhinolaryngology

Autorzy:

Ciechanowicz, Andrzej K

Powiązania:

https://bibliotekanauki.pl/articles/1400044.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

regenerative medicine
pluripotent stem cells
embryonic stem cells
very small embryonic-like stem cells
tissue engineering

Opis:

Regenerative medicine is focusing on searching for stem cells, which can be efficiently and safely used for regeneration of damaged tissues and organs. Pluripotent stem cells would be ideal for this purpose. It is because they have the ability to differentiate into cells of all three germ layers (ecto-, meso- and endoderm). One of the sources of their isolation are embryos. For many years, they are made unsuccessful attempts to use of very controversial embryonic stem cells that are isolated from embryos. So strong ethical controversy forced scientists to look for other, undoubted ethically, sources of pluripotent stem cells. Induced pluripotent stem cells are proposed, as a more promising alternative to cells isolated from embryos. Unfortunately, both embryonic stem cells and induced pluripotent stem cells tend to genetic instability leading to the formation of teratomas. In parallel studies scientists try to use of stem cells isolated from adult tissues (e.g. bone marrow cells or adipose tissue) in the regeneration of parenchymal organs. Unfortunately, there is no convincing evidence for most of these cells that can regenerate damaged parenchymal organs. Regenerative medicine more frequently is employed in the otorhinolaryngological therapies. More and more researchers’ efforts are put into the development of an effective method of stimulation (in vitro) of pluripotent stem cells isolated from adult tissue for differentiation of the renewable progenitor stem cells which can keep their potential after transplantation into the recipient (e.g. in the treatment of imbalances or hearing loss). Moreover, there are promising methods for employing of the stem cells potential in tissue engineering as they are more effectively introduced as a clinical therapies.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 1-7
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 13.

Tytuł:

Immunomodelling Characteristics of Mature Dendritic Cells Stimulated by Colon Cancer Cells Lysates

Autorzy:

Radej, Sebastian
Roliński, Jacek
Rawicz-Pruszyński, Karol
Bury, Paweł
Borowski, Grzegorz
Furmaga, Jacek
Chrościcki, Andrzej
Wallner, Grzegorz
Maciejewski, Ryszard

Powiązania:

https://bibliotekanauki.pl/articles/1395534.pdf

Data publikacji:

2015-02-01

Wydawca:

Index Copernicus International

Tematy:

dendritic cells
colon cancer
cancer cells lysates
Th1
Th2

Opis:

Application of cells with high TAA (tumor associated antigen) presentation potential seems to be crucial in neoplasia immunotherapy. Such feature is distributed in dendritic cells, which present peptides from processed TAA - MHC molecules complex to the T cells of a host. The aim of the study was to assess the influence of colon neoplasia tissue lysate on functioning of generated autologous DC’s in the field of autologous CD4+ lymphocytes immunological response towards Th1/Th2 under in vitro environment together with comparison and assessment of DCs’ immunosuppressive properties acquired from patients with colon cancer. Material and methods. The population of this study consisted of 16 healthy- controls, 36colon cancer patients. Blood samples were collected 24h before planned surgery and preventive antibiotic therapy. Neoplastic tissue sample, was digested for cell lysates preparation. DC’s generation from PBMC was carried out in standard conditionsand medium enriched with rhGM-CSF and rhIL-4. Mature DC`s and cocultured autologous CD4 lymphocytes immunophenotype assessment was analyzed with flow cytometer. Intracellular and culture medium cytokines concentration was analyzed with ELISA and FACS method. Results. DC`s generated from colon cancer patients stimulated with lysates presented greater maturity, lower expression of CD206 antigen, significantly higher expression of HLA-DR, CD208 and CD209 and high intracellular expression of IL-12, compared to non-stimulated cells. Conclusions. The neoplastic tissue in vivo produces a number of substances having an unfavorable effect on immune system, our results suggests using lysates as good dendritic cells stimulators that possibly could have application in colon cancer immunotherapy

Źródło:

Polish Journal of Surgery; 2015, 87, 2; 71-82
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 14.

Tytuł:

Stem cell biology - a never ending quest for understanding.

Autorzy:

Majka, Marcin
Kucia, Magdalena
Ratajczak, Mariusz

Powiązania:

https://bibliotekanauki.pl/articles/1041413.pdf

Data publikacji:

2005

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

stem cells
TCSC
plasticity

Opis:

Stem cells (SC) research is an important part of biotechnology that could lead to the development of new therapeutic strategies. A lot of effort has been put to understand biology of the stem cells and to find genes and subsequently proteins that are responsible for their proliferation, self-renewal and differentiation. Different cytokines and growth factors has been used to expand stem cells, but no combination of these factors was identified that could effectively expand the most primitive stem cells. Recently, however, genes and receptors responsible for SC proliferation and differentiation have been described. Ligands for these receptors or these genes themselves are being already used for ex vivo expansion of stem cells and the first data are very promising. New markers, such as CXCR4 and CD133, have been discovered and shown to be present on surface of hematopoietic stem cells. The same markers were recently also found to be expressed on neuronal-, hepatic- or skeletal muscle-stem cells. By employing these markers several laboratories are trying to isolate stem cells for potential clinical use. New characteristics of stem cells such as transdifferentiation and cell fusion have been described. Our team has identified a population of tissue committed stem cells (TCSC). These cells are present in a bone marrow and in other tissues and they can differentiate into several cell types including cardiac, neural and liver cells.

Źródło:

Acta Biochimica Polonica; 2005, 52, 2; 353-358
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 15.

Tytuł:

The impact of unmodified graphene - based substrates on basic properties of human umbilical cord-derived mesenchymal stem cells in vitro

Autorzy:

Noga, S.
Moździerz, A.
Sekuła, M.
Karnas, E.
Jagiełło, J.
Madeja, Z.
Lipińska, L.
Zuba-Surma, E.

Powiązania:

https://bibliotekanauki.pl/articles/285808.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

stem cells
graphene
substrates

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 83
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 16.

Tytuł:

Adhesion and growth of vascular cells on porous polyethylene terephthalate scaffolds

Autorzy:

Havlikova, J.
Turek, K.
Dajko, G.
Bacakova, L.

Powiązania:

https://bibliotekanauki.pl/articles/283781.pdf

Data publikacji:

2010

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

polymers
scaffolds
vascular cells

Opis:

Polymers such as polyethylene terephthalate (PET) have been used for large-caliber vascular prostheses with a relative success but their application is limited in small-caliber grafts. Blood vessel grafts with an internal diameter smaller than 6 mm are prone to fail mainly due to their thrombogenicity and poor haemodynamics. One of the possible solutions of these problems may be reconstruction of the tunica intima and media on the synthetic grafts. For this purpose, special PET foils were prepared. Six-μm thick foils were irradiated by copper ions or fission fragments from a radionuclide etalon source 252Cf and etched by 1M sodium hydroxide to obtain holes of a defined diameter (from 80 to100 nm in foils irradiated by copper ions and from 1.0 to 1.5 μm in foils irradiated by fission fragments) and density (1x106 cm-2 - fission fragments to 5x108 cm-2 – copper ions) (FIG.1). Afterward these materials were seeded with vascular smooth muscle cells (VSMC) derived from the rat aorta, or endothelial cells of the line CPAE. Adhesion, proliferation and viability of the cells were monitored after one, three and seven days. The cell proliferation was evaluated by changes in the cell number in several time intervals and construction of growth curves. Determination of cell viability was based on staining of live cells with calcein emitting green fluorescence, and the dead cells with ethidium bromide emitting red fluorescence. Experiments with the growth of vascular smooth muscle cells and endothelial cells on the PET scaffolds with different pore size showed that endothelial cells prefer pores around 1 μm while VSMC have no preferences concerning the pore size of the polymer scaffolds tested. Although the highest cell population densities were found on the glass coverslips used as control material, the number of cells growing on pristine PET did not differ from the densities on PET foils irradiated by Cu-ions or fission fragments of Cf. The obtained data showed applicability of our improved polymer foils as supporting scaffolds for vascular cells. In the further step, these porous PET membranes could serve as synthetic analogues of internal elastic lamina separating vascular smooth muscle cells and endothelial cells in a newly constructed bioartificial vascular wall.

Źródło:

Engineering of Biomaterials; 2010, 13, no. 99-101; 108-109
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 17.

Tytuł:

Optimization of in vitro cell culture conditions for human mesenchymal stem cells of different origin for applications in tissue engineering

Autorzy:

Kmiotek-Wasylewska, K.
Karnas, E.
Sekuła, M.
Łabędź-Masłowska, A.
Noga, S.
Szkaradek, A.
Dźwigońska, M.
Boruczkowski, D.
Madeja, Z.
Zuba-Surma, E. K.

Powiązania:

https://bibliotekanauki.pl/articles/284408.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

cells
tissue engineering
regeneration

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 25
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 18.

Tytuł:

The influence of environmental factors on metabolic activity of cancer cells

Autorzy:

KOZIOROWSKA, ANNA
STATS, KATARZYNA
ROMEROWICZ-MISIELAK, MARIA

Powiązania:

https://bibliotekanauki.pl/articles/457987.pdf

Data publikacji:

2016

Wydawca:

Uniwersytet Rzeszowski

Tematy:

cells viability
Electromagnetic field

Opis:

The paper presents the results of viability of breast cancer cells under the influence of electromagnetic field. MCF-7 cell line was subjected to an electromagnetic field with a frequency of 5 Hz, 60 Hz and 120 Hz and an MTT assay was performed immediately after the influence of the field and after 24 hours. No statistical difference was demonstrated in cell viability immediately after exposure to EMF, and there are demonstrated differences in the case of field frequencies of 5 Hz and 120 Hz within 24 hours after exposure.

Źródło:

Edukacja-Technika-Informatyka; 2016, 7, 2; 306-315
2080-9069

Pojawia się w:

Edukacja-Technika-Informatyka

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

Impact of Flotation Machine Characteristics on the Performance of Fine Coal Beneficiation (-0.5mm & -0.25mm) – a Case Study of Tatasteel
Wpływ doboru maszyny flotacyjnej na wyniki wzbogacalności drobnego węgla (-0,5 mm i -0,25 mm) – studium przypadku Tatasteel

Autorzy:

Dhavala, Bhargav
Koparthi, Prasad
Singh, Jitender
Sit, Suman Krishna
Chakraborty, D. P.

Powiązania:

https://bibliotekanauki.pl/articles/318961.pdf

Data publikacji:

2019

Wydawca:

Polskie Towarzystwo Przeróbki Kopalin

Tematy:

maszyny flotacyjne mechaniczne
maszyny flotacyjne kolumnowe
maszyny flotacyjne Jamesona
uzysk
mechanical cells
column cells
jameson cells
unit yield

Opis:

Tatasteel coal washeries at West Bokaro are designed to treat (+) 0.5mm in dense media cyclones & (-) 0.5mm in mechanical type flotation cells. Typically, ~20% of the raw coal feed reports to the flotation circuit. Through several plant audits carried out for the fines circuit, it was established that there is a scope for yield improvement in the fines circuit by ~3–4% on raw coal basis w.r.t the maximum theoretical flotability of the coal. Flotation is a complex process controlled by factors which can be divided into three facets: coal characteristics, chemistry and machine characteristics. Factors within the coal and chemistry areas are dynamic and hence, need to be dealt with by personnel on an ongoing basis in normal plant operations. One of the most important characteristics of any flotation technology is air bubble generation and the size of air bubbles produced as this controls flotation kinetics and also, it dictates the carrying capacity of the machine. Another crucial component is how the machine effects collision and contact between air bubbles and particles. Apart from mechanical type flotation cells, the most popular flotation technologies elsewhere are Jameson & Column flotation. Jameson cells hold an edge over Column & mechanical flotation cells in terms of providing better kinetics, low footprint, lower operating & maintenance costs. In the present study, authors have tested West Bokaro coal in conventional mechanical & Column flotation cells at Tatasteel R&D whereas testwork in Jameson flotation cells was carried out at University of Queensland (Australia) for (-)0.5mm & (-)0.25mm size fractions .Results for (-)0.5mm size fraction show that Jameson cell gives 78.5% yield , Column cells give ~71% compared to 65% in mechanical cells on unit basis. Results for (-)0.25mm size fraction show that Jameson cell gives 87% yield , Column cells give ~83% compared to 80% in mechanical cells on unit basis. It is evident from the testwork carried out that Jameson cells are capable of giving higher yields at the same product ash and based on the same ,a pilot scale installation of Jameson cells has been proposed to validate the lab findings.
Zakłady wzbogacania Tatasteel w West Bokaro są przeznaczone do przeróbki klasy ziarnowej +0,5 mm w cyklonach z cieczą ciężką i klasy ziarnowej -0,5 mm w mechanicznych maszynach flotacyjnych. Zazwyczaj ~20% surowego węgla podaje się do flotacji. W wyniku szeregu badań układu wzbogacania miału węglowego ustalono, że istnieje możliwość poprawy wydajności wzbogacania miału o ~3–4% w przeliczeniu na surowy węgiel. Flotacja jest złożonym procesem który zależy od szeregu czynników , które można podzielić na trzy grupy: charakterystykę węgla, zjawiska fizykochemiczne i charakterystykę maszyny. Czynniki w obszarze są dynamiczne i dlatego obsługa procesu musi na bieżąco je kontrolować podczas normalnej pracy zakładu. Jedną z najważniejszych cech technologii flotacji jest generowanie pęcherzyków powietrza i wielkość wytwarzanych pęcherzyków powietrza, ponieważ wpływa to na kinetykę flotacji, a także decyduje o wydajności maszyny. Kolejnym istotnym elementem jest wpływ kontaktu pęcherzyków powietrza z cząsteczkami w maszynie flotacyjnej. Oprócz mechanicznych komór flotacyjnych, najpopularniejszymi technologiami flotacji są maszyny flotacyjne Jamesona i kolumnowe. Maszyny flotacyjne Jamesona mają przewagę nad kolumnowymi i mechanicznymi komorami flotacyjnymi pod względem lepszej kinetyki flotacji, małych gabarytów, niższych kosztów eksploatacji i konserwacji. W niniejszym artykule autorzy pokazali wyniki flotacji węgla West Bokaro w konwencjonalnych mechanicznych i kolumnowych maszynach flotacyjnych w Tatasteel R&D. Badania w komorach flotacyjnych Jamesona przeprowadzono na University of Queensland (Australia) dla węgla o uziarnieniu - 0,5 mm i - 0,25 mm. Wyniki dla klasy ziarnowej o wielkości -0,5 mm pokazują, że w komorze Jamesona uzysk wynosi 78,5%, w maszynie kolumnowej ~71% w porównaniu do 65% w maszynie mechanicznej. Wyniki dla klasy ziarnowej - 0,25 mm pokazują, że w komorach Jamesona otrzymuje się uzysk 87%, w maszynie kolumnowej ~83% w porównaniu do 80% w maszynie mechanicznej. Z przeprowadzonych testów wynika, że maszyny Jamesona są w stanie dawać wyższe wydajności przy tej samej zawartości popiołu w produkcie. Na tej samej podstawie zaproponowano instalację maszyn flotacyjnych Jamesona w skali pilotażowej w celu potwierdzenia wyników badań laboratoryjnych.

Źródło:

Inżynieria Mineralna; 2019, 21, 1/2; 113-116
1640-4920

Pojawia się w:

Inżynieria Mineralna

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Adult stem cells: hopes and hypes of regenerative medicine

Autorzy:

Dulak, Józef
Szade, Krzysztof
Szade, Agata
Nowak, Witold
Józkowicz, Alicja

Powiązania:

https://bibliotekanauki.pl/articles/1038957.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

embryonic stem cells
induced pluripotent stem cells
myocardial infarction
very small embryonic-like stem cells
heme oxygenase-1

Opis:

Stem cells are self-renewing cells that can differentiate into specialized cell type(s). Pluripotent stem cells, i.e. embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) differentiate into cells of all three embryonic lineages. Multipotent stem cells, like hematopoietic stem cells (HSC), can develop into multiple specialized cells in a specific tissue. Unipotent cells differentiate only into one cell type, like e.g. satellite cells of skeletal muscle. There are many examples of successful clinical applications of stem cells. Over million patients worldwide have benefited from bone marrow transplantations performed for treatment of leukemias, anemias or immunodeficiencies. Skin stem cells are used to heal severe burns, while limbal stem cells can regenerate the damaged cornea. Pluripotent stem cells, especially the patient-specific iPSC, have a tremendous therapeutic potential, but their clinical application will require overcoming numerous drawbacks. Therefore, the use of adult stem cells, which are multipotent or unipotent, can be at present a more achievable strategy. Noteworthy, some studies ascribed particular adult stem cells as pluripotent. However, despite efforts, the postulated pluripotency of such events like "spore-like cells", "very small embryonic-like stem cells" or "multipotent adult progenitor cells" have not been confirmed in stringent independent studies. Also plasticity of the bone marrow-derived cells which were suggested to differentiate e.g. into cardiomyocytes, has not been positively verified, and their therapeutic effect, if observed, results rather from the paracrine activity. Here we discuss the examples of recent studies on adult stem cells in the light of current understanding of stem cell biology.

Źródło:

Acta Biochimica Polonica; 2015, 62, 3; 329-337
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 21.

Tytuł:

Effect of tigecycline on the production of selected cytokines and counts of murine CD4+ and CD8+ T cells - an in vitro study

Autorzy:

Jasiecka-Mikołajczyk, A.
Jaroszewski, J.J.
Maślanka, T.

Powiązania:

https://bibliotekanauki.pl/articles/2087626.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

tigecycline
CD4+ T cells
CD8+ T cells
cytokines
mouse

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 4; 819-822
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 22.

Tytuł:

DNAzyme as an efficient tool to modulate invasiveness of human carcinoma cells

Autorzy:

Wiktorska, Magdalena
Papiewska-Pająk, Izabela
Okruszek, Andrzej
Sacewicz-Hofman, Izabela
Niewiarowska, Jolanta

Powiązania:

https://bibliotekanauki.pl/articles/1040367.pdf

Data publikacji:

2010

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cancer cells
DNAzyme
integrin

Opis:

In this study we evaluated efficiency of DNAzymes to modulate motility of cancer cells, an important factor in the progression and metastasis of cancers. For this purpose we targeted β1 integrins that are predominant adhesive receptors in various carcinoma cell lines (CX1.1, HT29, LOVO, LS180, PC-3). To evaluate invasiveness of cancer cells, we used a transwell migration assay that allowed analyzing chemotactic migration of colon carcinoma cell lines across an ECM-coated membrane. Their adhesive properties were also characterized by the analysis of adhesion to fibronectin, laminin and collagen. In addition, the expression of major integrin subunits, selected intact β1 integrins, and other adhesive receptors (ICAM, E-selectin, uPAR) was analyzed by flow cytometry. Inhibition of β1 integrin expression by DNAzyme to β1 mRNA almost abolished the invasiveness of the CX1.1, HT29, LS180, LOVO and PC-3 cells in vitro. These data show that DNAzymes to β1 integrin subunit can be used to inhibit invasiveness of carcinoma cells.

Źródło:

Acta Biochimica Polonica; 2010, 57, 3; 269-275
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 23.

Tytuł:

Osteoblast behaviour on novel whey protein isolate hydrogels

Autorzy:

Stählke, S.
Mazur, K.
Krężel, A.
Żydek, J.
Pietryga, K.
Pamuła, E.
Keppler, J. K.
Nebe, J. B.
Douglas, T. E. L.

Powiązania:

https://bibliotekanauki.pl/articles/285936.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

hydrogels
biomaterials
osteogenic cells

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 105
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 24.

Tytuł:

Nanofibrous membrane with fibrin and collagen structures as carriers for skin cells

Autorzy:

Bacakova, M.
Riedel, T.
Stranska, D.
Brynda, E.
Bacakova, L.

Powiązania:

https://bibliotekanauki.pl/articles/283803.pdf

Data publikacji:

2014

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

cells
nanofibrous
collagen structure

Źródło:

Engineering of Biomaterials; 2014, 17, no. 128-129; 2-4
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 25.

Tytuł:

Stem cells and their derivatives – current perspectives in tissue engineering and regeneration

Autorzy:

Zuba-Surma, E.

Powiązania:

https://bibliotekanauki.pl/articles/283888.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

cells
tissue engineering
regeneration

Opis:

Several current approaches in tissue and organ regeneration focus on applications of recent achievements of cell-based therapies and biomaterial sciences. Such combined approaches relying on both components such as stem cells (SCs) with high regenerative potential and new biocompatible scaffolds opens new opportunities in tissue engineering and injured organ treatment. Several types of SCs with multi- and pluripotent characteristics such as mesenchymal stem cells (MSCs) of various origin and induced pluripotent SCs (iPSCs) have been indicated as potential source of cells for therapy. When combined with optimized biocompatible carriers and scaffolds, such SC fractions become leading targets for cell-based regenerative applications in several tissue injuries. Although such SC populations have been employed in experimental therapies of several organs injuries as well as in clinical studies, there is still discussion which subpopulation/s would be the most efficient and safe for therapies in humans. The selection of the optimal cell population for tissue regeneration would include predominantly safety aspects as well as major mechanisms of action critical for a specific tissue repair that are provided by specific SC population. Such mechanisms of SC activity includes extracellular vesicles (EVs) release. Such stem cell derivatives may modulate endogenous cell functions in place of transplantation by transferring several bioactive SC- derived molecules including proteins and transcripts. Thus, the newest trends in tissue regeneration would focus not only on combined applications of biocompatible materials with selected and optimized SC fractions, but also with their bioactive derivatives such as EVs. However, successful applications of SCs and their derivatives in regenerative medicine requires safety, ethical acceptance and therapeutic efficacy, which still need further investigations and optimization.

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 39
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 26.

Tytuł:

GMP compliant isolation and culture of human adipose tissue- derived mesenchymal stem cells for applications in tissue engineering

Autorzy:

Labedz-Maslowska, A.
Szkaradek, A.
Zuba-Surma, E.

Powiązania:

https://bibliotekanauki.pl/articles/284325.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

tissue engineering
cells
scaffolds

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 71
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 27.

Tytuł:

Simvastatin modulates β-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells

Autorzy:

Cruz, P.
Reyes, F.
Torres, C.G.

Powiązania:

https://bibliotekanauki.pl/articles/2087784.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

β-catenin
MDR1
simvastatin
canine mammary carcinoma cells
cancer stem cells

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 1; 95-99
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 28.

Tytuł:

Participation of phospholipase A2 isoforms in the control of calcium influx into electrically non-excitable cells

Autorzy:

Zabłocki, Krzysztof
Waśniewska, Magdalena
Duszyński, Jerzy

Powiązania:

https://bibliotekanauki.pl/articles/1044292.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

MDCK cells
Jurkat cells
calcium influx
store-operated channels
phospholipase A2

Opis:

The participation of phospholipase A2 isoforms in capacitative store-operated Ca2+ influx into Jurkat leukemic T and MDCK cells was investigated. Preincubation of Jurkat cells with either bromophenacyl bromide (an inhibitor of secreted phospholipase A2, sPLA2) or Helss (an inhibitor of calcium independent phospholipase A2 - iPLA2) resulted in a significant inhibition of the calcium influx. The extent of this inhibition depended on the pH of the extracellular millieu; it increased with alkalisation. The rate of Ca2+ influx into MDCK cells was reduced by bromophenacyl bromide. Preincubation of these cells with Helss resulted in the stimulation of the influx. These observations suggest the participation of different PLA2 isoforms in the regulation of Ca2+ influx. They also show that the extent that PLA2 isoforms control the influx depends on the pH of the medium. Finally, these data indicate that various phospholipase A2 isoforms may play a role in the control of Ca2+ influx in different cell lines.

Źródło:

Acta Biochimica Polonica; 2000, 47, 3; 591-599
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 29.

Tytuł:

Komórki macierzyste – możliwość ich wykorzystania do regeneracji tkanek
Stem cells and tissue regeneration

Autorzy:

Nowicka, Grażyna

Powiązania:

https://bibliotekanauki.pl/articles/1817715.pdf

Data publikacji:

2005-12-31

Wydawca:

Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie

Tematy:

komórki macierzyste
zarodkowe komórki macierzyste
regeneracja
stem cells
embryo stem cells
regeneration

Opis:

Rozwój nauk biologicznych przyczynia się do lepszego poznania procesów związanych z rozwojem i działaniem różnych organizmów, w tym organizmu człowieka, a jednym z efektów postępu naukowego w tym zakresie jest opracowywanie coraz doskonalszych metod diagnozowania i leczenia chorób. Ostatnio szczególne zainteresowanie wśród naukowców i lekarzy wzbudzają komórki macierzyste. Celem badań komórek macierzystych jest poznanie mechanizmów kierujących procesami tworzenia i rozwoju komórek, tkanek i narządów, a także opracowanie metod ich wykorzystania do regeneracji uszkodzonych tkanek i narządów np. do regeneracji mięśnia sercowego uszkodzonego w czasie zawału lub komórek trzustki, które utraciły zdolność produkcji insuliny (co leży u podstaw rozwoju cukrzycy typu I), komórek nerwowych, które utraciły zdolność syntezy dopaminy (co wiąże się z rozwojem choroby Parkinsona)
Stem cells there are undifferentiated, primitive cells with ability to differentiate into specific kinds of cells. Stem cell research has a history of more than 20 years and has made an outstanding contribution to our understanding of haematopoiesis and embryology. Stem cells hold the promise of allowing researchers to grow specialized cells or tissue, which could be used for treatment of injured tissues. Development of this area depends on the results of ethical debate over stem cel research, which is controversial, because the most powerful human stem cells there are embryonic stem cells. Adult bone marrow has been found as an important source of adult stem cells. Adult stem cells have been used in animal and human studies for tissue regeneration. The utility of stem cell transplantation for the treatment of acute myocardial infarction to repair of injured myocardium has been shown.

Źródło:

Studia Ecologiae et Bioethicae; 2005, 3, 1; 109-115
1733-1218

Pojawia się w:

Studia Ecologiae et Bioethicae

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 30.

Tytuł:

Application of micronucleus assay in plants to monitor environmental pollution in situ

Autorzy:

Kośmider, Beata
Osiecka, Regina
Siciński, Jan T

Powiązania:

https://bibliotekanauki.pl/articles/764964.pdf

Data publikacji:

2008

Wydawca:

Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego

Tematy:

monitoring in situ
environmental pollution
micronuclei
pollen mother cells
root tip cells

Opis:

Samples of 5 vascular plant species: Achillea millefolium L., Artemisia vulgaris L., Festuca gigantea (L.) VILL., Ranunculus acris L. s. str. and Vicia angustifolia L. were collected near Fuel Storage Station, Chemical Fibre Factory “Wistom” in Tomaszów Mazowiecki and Sewage Treatment Plant in Sulejów. Genotoxicity of environmental pollution was analysed using micronucleus assays in pollen mother and root tip cells in comparison with plant material collected in the Tatra and Babia G óra National Parks. Abnorm alities in morphology of plants growing in polluted areas were also found. The cytogenetical analyses revealed positive correlation between the percentage of micronuclei and the presence of heavy metals in soil. Pollen mother cells (germ line) were found more susceptible to DNA damage as compared with root tip cells (somatic line).

Źródło:

Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2008, 4
1730-2366
2083-8484

Pojawia się w:

Acta Universitatis Lodziensis. Folia Biologica et Oecologica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 31.

Tytuł:

Building a cognitive map using an SOM2

Autorzy:

Tokunaga, K.
Furukawa, T.

Powiązania:

https://bibliotekanauki.pl/articles/384201.pdf

Data publikacji:

2010

Wydawca:

Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów

Tematy:

self-organizing map
map building
place cells
head direction cells
autonomous robot

Opis:

In this paper, we propose a new method for building an environmental map in a self-organizing manner using visual information from a mobile robot. This method is based on a Higher Rank of Self-Organizing Map (SOM ), in which Kohonen’s SOM is extended to create a map of data distributions (set of manifolds). It is expected that the “SOM” is capable of creating an environmental map in a self-organizing manner from visual information, since the set of visual information obtained from each position in the environment forms a manifold at every position. We also show the effectiveness of the proposed method.

Źródło:

Journal of Automation Mobile Robotics and Intelligent Systems; 2010, 4, 2; 39-47
1897-8649
2080-2145

Pojawia się w:

Journal of Automation Mobile Robotics and Intelligent Systems

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 32.

Tytuł:

Interaction of membrane skeletal proteins with membrane lipid domain.

Autorzy:

Sikorski, Aleksander
Hanus-Lorenz, Beata
Jezierski, Adam
Dluzewski, Anton

Powiązania:

https://bibliotekanauki.pl/articles/1044290.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

non-erythroid cells
membrane skeleton
membrane lipid domains
cytoskeleton
red blood cells

Opis:

The object of this paper is to review briefly the studies on the interaction of red blood cell membrane skeletal proteins and their non-erythroid analogues with lipids in model systems as well as in natural membranes. An important question to be addressed is the physiological significance and possible regulatory molecular mechanisms in which these interactions are engaged.

Źródło:

Acta Biochimica Polonica; 2000, 47, 3; 565-578
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 33.

Tytuł:

Krótki przegląd na temat komórek macierzystych
A short overview of stem cells

Autorzy:

Kmiecik, B.
Skotny-Krakowian, A.
Rybak, Z.

Powiązania:

https://bibliotekanauki.pl/articles/261099.pdf

Data publikacji:

2015

Wydawca:

Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej

Tematy:

embrionalne komórki macierzyste
indukowane pluripotencjalne komórki macierzyste
mezenchymalne komórki macierzyste
embryonic stem cells
induced pluripotent stem cells
mesenchymal stem cells

Opis:

Wykorzystanie komórek macierzystych może mieć duży potencjał w medycynie. Stale jednak toczą się debaty, jakie rodzaje komórek macierzystych powinny być w przyszłości wykorzystywane w celach regeneracyjnych. W poniższej pracy dokonano porównania embrionalnych, indukowanych pluripotencjalnych i somatycznych komórek macierzystych. Jednak, by bezpiecznie wykorzystywać komórki macierzyste do regeneracji ciała ludzkiego, należy jeszcze dokładniej poznać mechanizmy ich działania. Z tego powodu Amerykańska Agencja ds. Żywności i Leków (FDA) już w 2006 roku zdecydowała się na opracowanie procedur, które mają zapewnić bezpieczeństwo pacjentom korzystającym z terapii opartych na komórkach macierzystych.
Applications of stem cells has a huge medical potential. However, among scientists there is an ongoing debate, concerning which stem cells should be used in the future for regeneration purposes. This paper presents a comparison of embryonic, induced pluripotent, and somatic stem cells. Gaining a better understanding of the molecular functioning of stem cells will probably lead to more efficient treatment methods for many incurable diseases. For this reason, American agency for Food and Drug Administration (FDA) established some general procedures, which, to some degree, should ensure the safety of experimental stem cell therapies.

Źródło:

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2015, 21, 1; 40-45
1234-5563

Pojawia się w:

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 34.

Tytuł:

Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting

Autorzy:

Styczynski, Jan
Drewa, Tomasz

Powiązania:

https://bibliotekanauki.pl/articles/1040856.pdf

Data publikacji:

2007

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

stem cell markers
metabolic pathways
drug resistance
leukemic stem cells
cancer stem cells

Opis:

Cancer stem cells are a small subset of cancer cells constituting a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. These cells are identified by specific stem cell markers: antigens, molecules and signaling pathways. Transcription factors and molecules associated with oncogenesis, such as NF-κB, Bmi-1, Notch, WNT beta-catenin, Sonic hedgehog and their biochemical pathways, active only in a small minority of cancer cells might play key roles in determining the biology and the overall long-term behavior of a tumor. The molecules and pathways specific for cancer stem cells, which contribute to their drug resistance, are potential targets for new therapeutic strategies.

Źródło:

Acta Biochimica Polonica; 2007, 54, 4; 717-726
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Use of cell therapy as a means of targeting chemotherapy to inoperable pancreatic cancer

Autorzy:

Günzburg, Walter
Salmons, Brian

Powiązania:

https://bibliotekanauki.pl/articles/1041363.pdf

Data publikacji:

2005

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cytochrome P450
chemotherapy
genetically modified cells
cell therapy
encapsulated cells
pancreatic cancer

Opis:

Although approved for the treatment of pancreatic cancer, the chemotherapeutic agent ifosfamide is not an effective therapy for this type of tumour. Ifosfamide must be activated by cytochrome P450 (P450) enzymes in the liver, initially to a short lived intermediate and then to toxic metabolites that are subsequently distributed by the circulatory system. Particularly for pancreatic cancer, this liver-mediated conversion results in relatively high systemic toxicities and poor therapeutic concentrations at the liver-distant site of the tumour. Activation of ifosfamide at the site of the tumour may allow lower doses to be used, while increasing the therapeutic index due to the resultant active concentrations generated locally. A cell-based therapy has been conceived where encapsulated, 293-derived cells genetically modified to overexpress a cytochrome P450 enzyme, are implanted near solid tumours. The cells are encapsulated in polymers of cellulose sulphate in order to provide a means of immunoprotection in vivo as well as to physically constrain them to the vicinity of the tumour. A major advantage of this strategy is that it allows one standard cell line to be applied to all patients and this approach can be extended to the treatment of other tumour types. After proof of principle studies in animal models, a phase I/II clinical trial was initiated in patients with stage III/IV nonresectable pancreatic cancer. Encapsulated cells were angiographically placed into the tumour vasculature of 14 patients and followed by systemic low dose ifosfamide treatment. Angiographic delivery of encapsulated cells proved feasible in all but one patient, and was well tolerated with no capsule or ifosfamide treatment-related adverse events. Four of the treated patients showed tumour regressions after capsule delivery and ifosfamide treatment in computer-tomography scans. The other 10 patients showed no further tumour growth (i.e. stable disease) during 20 weeks observation period. The median life expectancy of the patient collective was extended two fold as compared to age and status matched historical controls, with a 3-fold improvement in one year survival being attained. Evidence for a clinical benefit of the treatment was also obtained on the basis of standard parameters for quality of life. This approach has been evaluated by the European Medicines Evaluation Agency (EMEA) and orphan drug status has been granted. A pivotal clinical trial is now being planned with the help of the EMEA. Taken together, the data from this clinical trial suggest that encapsulated cytochrome P450-expressing cells combined with chemotherapy may be useful for the local treatment of a number of solid tumours and support the performance of further clinical studies of this new treatment.

Źródło:

Acta Biochimica Polonica; 2005, 52, 3; 601-607
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 36.

Tytuł:

Cell therapy for regenerative medicine: facts and controversy
Fakty i kontrowersje związane z terapią komórkową w medycynie regeneracyjnej

Autorzy:

Sarnowska, Anna
Machaliński, Bogusław
Radoszkiewicz, Klaudia
Bużańska, Leonora

Powiązania:

https://bibliotekanauki.pl/articles/2121315.pdf

Data publikacji:

2022

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

cell therapy
regenerative medicine
human mesenchymal stem cells
human induced pluripotent stem cells

Opis:

Cellular therapy, as a part of regenerative medicine, implies to the treatment of human disorders with cells as a medical product, so called – “living drugs”. Usually such therapy is applied when other alternative efficient pharmacological therapies are not available. Stem cells of different origin: 1) tissue specific e.g. hematopethic, epithelial, neuronal, limbal; 2) mesenchymal stem cells (MSC) harvested from variety of tissues; 3) pluripotent stem cells: embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) – serve as a source of cells for regenerative medicine application, depending upon disease and application re- quirements. Currently MSC are the type of stem cells that are most frequently used in registered regenerative medicine clinical trials. In this paper we provide the information on the application of cell therapy in orthopedics, hematology, ophthalmology, dermatology, gastrology and neurology. The influence of origin of MSCs and iPSCs on their mode of action as therapeutic, regenerative agents are discussed. Advantages and disadvantages of application of different cell types for cell therapy are underlined. Last, but not least current low regulations in Poland and requirements of European regulatory bodies for cell therapy are pointed out and discussed.

Źródło:

Nauka; 2021, 4; 67-92
1231-8515

Pojawia się w:

Nauka

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 37.

Tytuł:

Interstitial Cajal-Like Cells and Bile Lithogenicity in the Pathogenesis of Gall-Stone Disease

Autorzy:

Pasternak, Artur
Matyja, Andrzej
Gil, Krzysztof
Gajda, Mariusz
Tomaszewski, Krzysztof A.
Matyja, Maciej
Walocha, Jerzy A.
Kulig, Jan

Powiązania:

https://bibliotekanauki.pl/articles/1396274.pdf

Data publikacji:

2013-06-01

Wydawca:

Index Copernicus International

Tematy:

bile lithogenecity
interstitial Cajal-like cells
gall-stone disease
c-Kit
mast cells

Opis:

Gall-stone disease constitutes a serious clinical problem and is the most frequent cause of elective cholecystectomies. There are many etiopatogenic factors however; lithogenic bile and its stasis due to gall-bladder hypomotility seem to be the most important. In recent years discovery of pacemaker function of Interstitial Cells of Cajal changed our understanding of smooth muscle physiology and helped to disclose many gastrointestinal motility disorders. The aim of the study was identification and quantification of interstitial Cajal-like cells (ICLCs) in gall-bladder muscle wall from patients with cholelithiasis and in gall-stone-free controls, as well as determination of the relationship between the number of ICLCs and Cholesterol Saturation Index (CSI) of bile in both analyzed groups. Material and methods. 20 patients operated for symptomatic cholelithiasis were enrolled into the study group. The control group consisted of 20 patients operated for pancreatic head tumors, with no pre- and intraoperative signs of gall-stones. Identification of ICLCs in the gall-bladder was performed by means of double immunofluorescence technique with anti c-Kit and anti-mast cell tryptase antibodies. Quantitative analysis was carried out under fluorescence microscopy conjoined with image analysis software. Bile samples were used for calculation of CSI. Results. ICLCs were detected within gall-bladder muscle wall. Number of ICLCs was statistically significantly lower in patients from the study group as compared to control. The study also revealed statistically significantly higher CSI in the study group. Conclusions. The quantity of ICLCs is diminished in the gall-bladder from patients with cholelithiasis and there is negative correlation between the number of ICLCs and CSI of bile. Regarding the role of ICCs in regulation of GI tract motility, it appears that reduction in their number may be important etiopatogenic factor of cholelithiasis.

Źródło:

Polish Journal of Surgery; 2013, 85, 6; 311-316
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 38.

Tytuł:

Domestic hydrogen installation in Poland – technical and economic analysis

Autorzy:

Cholewiński, M.
Tomków, Ł.

Powiązania:

https://bibliotekanauki.pl/articles/141725.pdf

Data publikacji:

2015

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

hydrogen
fuel cells
energy storage

Opis:

The application of renewable energy sources poses the problems connected with output volatility. In order to decrease this effect the energy storage technologies can be applied, particularly fuel cells connected with hydrogen storage. In this paper the application of SOFC system for a household in Poland is proposed. Economic and technical analysis is performed. It was found that the proposed installation is profitable after 25 years of operation when compared with conventional solution - heat pumps and gas-fired boilers.

Źródło:

Archives of Electrical Engineering; 2015, 64, 2; 189-196
1427-4221
2300-2506

Pojawia się w:

Archives of Electrical Engineering

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells.

Autorzy:

Misiewicz, Irena
Skupińska, Katarzyna
Kowalska, Elżbieta
Lubiński, Jan
Kasprzycka-Guttman, Teresa

Powiązania:

https://bibliotekanauki.pl/articles/1041549.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cancer chemoprevention
sulforaphane
lymphoblastoid cells

Opis:

The effect of sulforaphane on human lymphoblastoid cells originating from a patient of a high cancer risk was studied. Sulforaphane (SFN) is a naturally occurring substance of chemopreventive activity. In our study, changes in cell growth, induction of apoptosis and phase 2 enzymes as well as glutathione level were examined. Apoptosis was tested by confocal microscopy at three stages: change in mitochondrial membrane potential, caspase activation and phosphatidylserine externalization. We show that SFN increases the activity of the detoxification system: it increases quinone reductase activity at low concentration (0.5-1 μM) and raises glutathione level in a dose-dependent manner. At higher doses (2.5-10 μM) sulforaphane is a cell growth modulator, as it caused cell growth cessation (IC50 = 3.875 μM), and apoptosis inducer. The results obtained suggest that sulforaphane acts as a chemopreventive agent in human lymphoblastoid cells.

Źródło:

Acta Biochimica Polonica; 2004, 51, 3; 711-721
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 40.

Tytuł:

Tumors and the danger model.

Autorzy:

Kowalczyk, Dariusz

Powiązania:

https://bibliotekanauki.pl/articles/1043752.pdf

Data publikacji:

2002

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cancer
danger signal
dendritic cells

Opis:

This article reviews the evidence for the danger model in the context of immune response to tumors and the insufficiency of the immune system to eliminate tumor growth. Despite their potential immunogenicity tumors do not induce significant immune responses which could destroy malignant cells. According to the danger model, the immune surveillance system fails to detect tumor antigens because transformed cells do not send any danger signals which could activate dendritic cells and initiate an immune response. Instead, tumor cells or antigen presenting cells turn off the responding T cells and induce tolerance. The studies reviewed herein based on model tumor antigens, recombinant viral vectors and detection of tumor specific T cells by MHC/peptide tetramers underscore the critical role of tumor antigen presentation and the context in which it occurs. They indicate that antigen presentation only by activated but not by cancer or resting dendritic cells is necessary for the induction of immune responses to tumor antigens. It becomes apparent that the inability of dendritic cells to become activated provides a biological niche for tumor escape from immune destruction and seems to be a principal mechanism for the failure of tumor immune surveillance.

Źródło:

Acta Biochimica Polonica; 2002, 49, 2; 295-302
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 41.

Tytuł:

Influence of microstructure and chemistry of carbon nanomaterials coatings on nerve cells

Autorzy:

Frączek-Szczypta, A.
Wedel-Grzenda, A.
Jantas, D.

Powiązania:

https://bibliotekanauki.pl/articles/285693.pdf

Data publikacji:

2016

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

carbon nanomaterials
nerve cells
microstructure

Źródło:

Engineering of Biomaterials; 2016, 19, 138; 119
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 42.

Tytuł:

Improved adhesion and growth of vascular smooth muscle cells on polycaprolactone nanofibrous membranes modified by amine-rich plasma

Autorzy:

Parizek, M.
Blahova, L.
Michlicek, M.
Medalova, J.
Cernochova, P.
Bacakova, L.
Zajickova, L.

Powiązania:

https://bibliotekanauki.pl/articles/970894.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

muscle cells
nanofibrous membranes
polymers

Źródło:

Engineering of Biomaterials; 2018, 21, 148; 117
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

Effects of short moderate exercise on hematological parameters and stem cells in healthy humans

Autorzy:

Sochoń, K.
Sienkiewicz, D.
Okurowska-Zawada, B.
Paszko-Patej, G.
Wojtkowski, J.
Dmitruk, E.
Żak, J
Kułak, W.

Powiązania:

https://bibliotekanauki.pl/articles/1918279.pdf

Data publikacji:

2016

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

Exercise
healthy subjects
stem cells

Opis:

Introduction: Exercise at various durations and intensities impact on blood and stem cells. This pilot study examined the effects of 30 minutes of treadmill walking on hematological indices and progenitor stem cells CD34+ in healthy subjects. Materials and methods: A total of 17 non-smoking, healthy students, aged 20 to 22 years participated. Hemoglobin, hematocrit, white blood cells, platelets, and stem cell CD34+ numbers were assessed before and after moderate exercise. Statistical analyses examined the relationships between CD34+ cells versus hematological indices, age, and body mass index. Results: Following exercise, significant increases were observed in leukocytes, neutrophils, eosinophils, and CD34+ cells numbers. For CD34+ cells, a fourfold increase was seen. Significant correlations between CD34+ cells, white blood cells, and neutrophils were found. Conclusion: Our results suggest that moderate exercise has a physiological impact on hematologic parameters and stem cells CD34+ in healthy subjects. Furthermore, our findings suggest that brief treadmill exercise may enhance tissue repair mechanisms so important in physiotherapy.

Źródło:

Progress in Health Sciences; 2016, 6(2); 184-187
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 44.

Tytuł:

Gastrointestinal neuroendocrine cells in various types of hypertension – a review

Autorzy:

Niezgoda, M.
Kasacka, I.

Powiązania:

https://bibliotekanauki.pl/articles/1918578.pdf

Data publikacji:

2017

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

Neuroendocrine cells
gastrointestinal tract
hypertension

Opis:

Recent years have witnessed a progressive increase in the number of people suffering from hypertension, which is one of the most serious health problems in the world. Hypertension results in changes leading to function disorders, not only of the organs and tissues, but also changes leading to the activation of many defense mechanisms in the cells in order to prevent damage. One of them is the expression of neuroendocrine (NE) hormones and biologically active substances, which has been the focus of extensive research for a number of years. Active involvement of NE cells and the biological and therapeutic properties of various substances synthesized by them have been confirmed in clinical trials and in various experimental models. Results obtained in many research studies indicate intense activity of enteroendocrine cells in the gastrointestinal tract in various pathological conditions, including hypertension. In the present review, we discuss the morphological and functional changes of gastrointestinal neuroendocrine cells under conditions of different types of hypertension.

Źródło:

Progress in Health Sciences; 2017, 7(2); 117-125
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 45.

Tytuł:

Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer

Autorzy:

Grudzińska, M.
Jakubowska, K.
Kańczuga-Koda, L.
Kisielewski, W.
Famulski, W.
Smereczański, N.M.
Lomperta, K.
Płoński, M.A.
Rogoz-Jezierska, N.
Koda, M.

Powiązania:

https://bibliotekanauki.pl/articles/1918914.pdf

Data publikacji:

2020-06-10

Wydawca:

Uniwersytet Medyczny w Białymstoku

Tematy:

Colorectal cancer
inflammatory cells
fibrosis

Opis:

Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer

Źródło:

Progress in Health Sciences; 2020, 10(1); 69-76
2083-1617

Pojawia się w:

Progress in Health Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 46.

Tytuł:

Use of the chemical permeabilization process in yeast cells: production of high-activity whole cell biocatalysts

Autorzy:

Trawczynska, I.

Powiązania:

https://bibliotekanauki.pl/articles/2097138.pdf

Data publikacji:

2020

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

permeabilization
biocatalyst
yeast cells
microorganisms

Opis:

Yeast cells are popular microorganisms for use in various bioprocesses because of their ability to produce various enzymes. They are also known for their low price. However, the activity of these biocatalysts is limited by cell membrane diffusion. One of the possible solutions to this problem is permeabilization, which makes cell walls and membranes of microorganisms more permeable to allow for easier reagent diffusion, while also maintaining properties of the cells, such as their structure and enzymatic activity. The reusability of permeabilized baker’s yeast cells is a major asset that allows them to be successfully used in biotransformation processes. Because of extensive research on this process, numerous procedures have been developed regarding the production of highly active biocatalysts in the form of permeabilized cells. The most commonly used technique is chemical permeabilization. Its effectiveness is based on the activity of various intracellular enzymes: one enzyme or several enzymes simultaneously. Multiple chemical substances, mostly organic solvents and detergents, were analyzed to determine their effectiveness as permeabilizing agents. This review provides a state-of-the-science analysis of substances used as permeabilizing agents for yeast permeabilization

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 3; 239-252
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 47.

Tytuł:

Thermographic Research of Photovoltaic System Operating in Shaded Conditions

Autorzy:

Bożek, E.
Basista, G.

Powiązania:

https://bibliotekanauki.pl/articles/114460.pdf

Data publikacji:

2015

Wydawca:

Stowarzyszenie Inżynierów i Techników Mechaników Polskich

Tematy:

photovoltaic systems
polycrystalline cells
shaded photovoltaics
overheating of PV cells
thermovision in photovoltaics

Opis:

Results of infrared research conducted on a photovoltaic system which works in an on-grid mode for over a year are presented in the article. The installation described is regularly shadowed by a cooling system. Thermograms of photovoltaic modules in strong and light shadow were conducted. These images show that even in very weak shadow the PV cells are overheated. This has led to small point damages in the amorphous panels and in the future it may also lead to the destruction of polycrystalline modules.

Źródło:

Measurement Automation Monitoring; 2015, 61, 6; 253-256
2450-2855

Pojawia się w:

Measurement Automation Monitoring

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 48.

Tytuł:

Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Whartons jelly of the umbilical cord

Autorzy:

Zajdel, Alicja
Kałucka, Magdalena
Kokoszka-Mikołaj, Edyta
Wilczok, Adam

Powiązania:

https://bibliotekanauki.pl/articles/1038664.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

adipose derived mesenchymal stem cells
Wharton's jelly derived mesenchymal stem cells
osteogenic differentiation

Opis:

Induced osteogenesis of mesenchymal stem cells (MSCs) may provide an important tool for bone injuries treatment. Human umbilical cord and adipose tissue are routinely discarded as clinical waste and may be used as noncontroversial MSCs sources. It still remains to be verified which source of MSCs is the most suitable for bone regeneration. The aim of this research was to investigate the osteogenic potential of human MSCs derived from adipose tissue (AT-MSCs) and Wharton's jelly of the human umbilical cord (WJ-MSCs) differentiated under the same conditions. Osteogenic differentiation of MSCs was detected and quantified by alizarin red S (ARS) staining for calcium deposition and alkaline phosphatase (ALP) activity, osteoprotegerin (OPG), and osteocalcin (OC) secretion measurements. Under osteogenic conditions, after 21 days of differentiation, the measured ALP activity and calcium deposition were significantly higher in the AT-MSCs than in the WJ-MSCs, while the OPG and OC secretion were higher in the WJ-MSCs vs. AT-MSCs. Low concentrations of OPG and high levels of OC in AT-MSCs and WJ-MSCs, prove that these cells reached an advanced stage of the osteogenic differentiation. The levels of OC secreted by AT-MSCs were lower than by WJ-MSCs. Both cell types, AT-MSCs and WJ-MSCs possess a potential to differentiate towards the osteogenic lineage. The observed differences in the levels of osteogenic markers suggest that after 21-days of osteogenic differentiation, the AT-MSCs might have reached a more advanced stage of differentiation than WJ-MSCs.

Źródło:

Acta Biochimica Polonica; 2017, 64, 2; 365-369
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 49.

Tytuł:

Nonviral transfection of human umbilical cord blood dendritic cells is feasible, but the yield of dendritic cells with transgene expression limits the application of this method in cancer immunotherapy

Autorzy:

Markowicz, Sergiusz
Niedzielska, Joanna
Kruszewski, Marcin
Ołdak, Tomasz
Gajkowska, Agnieszka
Machaj, Eugeniusz
Skurzak, Henryk
Pojda, Zygmunt

Powiązania:

https://bibliotekanauki.pl/articles/1041291.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

CD34+ cells
umbilical cord blood
green fluorescent protein
electroporation
gene transfer
dendritic cells

Opis:

Dendritic cells (DC) generated from human umbilical cord blood might replace patients' DC in attempts to elicit tumor-specific immune response in cancer patients. We studied the efficiency of transfection of human cord blood DC with plasmid DNA carrying the enhanced version of green fluorescent protein (EGFP) as a reporter gene, to test if nonviral gene transfer would be a method to load DC with protein antigens for immunotherapy purposes. Cord blood mononuclear cells were cultured in serum-free medium in the presence of granulocyte-monocyte colony stimulating factor (GM-CSF), stem cell factor (SCF) and Flt-3 ligand (FL), to generate DC from their precursors, and thereafter transfected by electroporation. Maturation of DC was induced by stimulation with GM-CSF, SCF, FL and phorbol myristate acetate (PMA). Transfected DC strongly expressed EGFP, but transfection efficiency of DC, defined as HLA-DR+ cells lacking lineage-specific markers, did not exceed 2.5%. Expression of the reporter gene was also demonstrated in the DC generated from transfected, purified CD34+ cord blood cells, by stimulation with GM-CSF, SCF, FL, and tumor necrosis factor α (TNF-α). Transfection of CD34+ cells was very efficient, but proliferation of the transfected cells was much reduced as compared to the untransfected cells. Therefore, the yield of transgene-expressing DC was relatively low. In conclusion, nonviral transfection of cord blood DC proved feasible, but considering the requirements for immunotherapy in cancer patients, transfection of differentiated DC or generation of DC from transfected hematopoietic stem cells provide only a limited number of DC expressing the transgene.

Źródło:

Acta Biochimica Polonica; 2006, 53, 1; 203-212
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 50.

Tytuł:

Biosorption of Cu(II) by live and dead cells of Yarrowia lipolytica
Biosorpcja Cu(II) przez żywe i martwe komórki Yarrowia lipolytica

Autorzy:

Wierzba, S.

Powiązania:

https://bibliotekanauki.pl/articles/127390.pdf

Data publikacji:

2014

Wydawca:

Towarzystwo Chemii i Inżynierii Ekologicznej

Tematy:

biosorption
copper
Yarrowia lipolytica
live cells
dead cells
biosorpcja
miedź
żywe i martwe komórki

Opis:

The biosorption characteristic of Cu(II) using live and dead cells of Yarrowia lipolytica as biosorbents have been investigated in the present research. Biosorption of Cu(II) was enhanced with an increase in pH, temperature, agitation, contact time and initial concentration of the metal ion. It was observed that dead and live biomass efficiently removed copper at 30 min at an initial pH of 5.0. Temperature of 35ºC was optimum at agitation speed of 150 or 200 rpm. For initial copper concentrations of 1-200 mg · dm–3, the adsorption data provide an excellent fit to the Langmuir isotherm. Experimental maximum biosorption capacity turned out to be 12.56 mg · g–1 for living material and 14.31 mg · g–1 for dead sorbents, respectively.
Przedstawiono charakterystykę biosorpcji Cu(II) przy użyciu żywych i martwych komórek Yarrowia lipolytica jako biosorbentu. Biosorpcja Cu(II) zwiększała się wraz ze wzrostem pH, temperatury, szybkości mieszania, czasu kontaktu i początkowego stężenia jonu metalu. W pracy zaobserwowano, że żywa i martwa biomasa skutecznie usuwa miedź w ciągu 30 minut przy początkowym pH 5,0. Temperatura 35ºC była optymalna przy szybkości mieszania wynoszącej 150-200 rpm. Dla początkowego stężenia miedzi z zakresu 1-200 mg · dm–3 uzyskane dane biosorpcji były doskonale dopasowane do modelu Langmuira. Uzyskane w trakcie doświadczeń maksimum biosorpcji dla żywego i martwego sorbentu wynosiło odpowiednio 12,56 i 14,31 mg · g–1.

Źródło:

Proceedings of ECOpole; 2014, 8, 1; 103-108
1898-617X
2084-4557

Pojawia się w:

Proceedings of ECOpole

Dostawca treści:

Biblioteka Nauki

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