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    Tytuł:
    Characterization of a possible uptake mechanism of selective antibacterial peptides
    Autorzy:
    Polanco, Carlos
    Samaniego, José
    Castañón-González, Jorge
    Buhse, Thomas
    Sordo, Marili
    Powiązania:
    https://bibliotekanauki.pl/articles/1039457.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Polarity index method
    cell penetrating peptides
    selective antibacterial peptides
    Opis:
    Selective antibacterial peptides containing less than 30 amino acid residues, cationic, with amphipathic properties, have been the subject of several studies due to their active participation and beneficial effects in strengthening the immune system of all living organisms. This manuscript reports the results of a comparison between the group of selective antibacterial peptides and another group called "cell penetrating peptides". An important number of the selective antibacterial peptides are cell penetrating peptides, suggesting that their toxicity is related to their uptake mechanism. The verification of this observation also includes the adaptation of a method previously published, called Polarity index, which reproduces and confirms the action of this new set of peptides. The efficiency of this method was verified based on four different databases, yielding a high score. The verification was based exclusively on the peptides already reported in the databases which have been experimentally verified.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 4; 629-633
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peptydy penetrujące : rodzaje i mechanizmy przenikania przez błony komórkowe
    Cell-penetrating peptides : types and mechanisms of penetration
    Autorzy:
    Kawczyński, M. T.
    Kreczko-Kurzawa, J.
    Maćkiewicz, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/172725.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    peptydy penetrujące
    penetratyna
    endocytoza
    amfipatyczność
    CPP
    cell-penetrating peptides
    penetratin
    endocytosis
    amphipaticity
    Opis:
    Before discovery of the Tat peptide over twenty years ago, it was assumed that large peptides and proteins do not penetrate cell membranes. After discovery of Tat, Penetratin [1, 2] and several other peptides of natural origin, able to cross the cell membranes in an energy-independent manner, the structural determinants of their cell-penetrating potency were established, including polycationic character, amphipaticity and presence of proline-rich motifs [3, 4]. Currently known cell-penetrating peptides of natural or synthetic origin are composed of 5 to 40 amino acid residues and belong to one of the three families: oligocationic, amphipatic or proline-rich and penetrate the biological membranes by endocytosis or other ways of direct translocation. Most of these translocation mechanisms are not exclusive and may occur simultaneously, and their contribution may be different for each peptide depending on the conditions (e.g. CPP concentration, pH, etc.). Most CPPs demonstrate little or no mammalian cell toxicity what makes them promising vectors for drug delivery. Such vectors might be useful for efficient internalization of compounds otherways poorly penetrating biological membranes. Novel CPP-effector conjugates may become effective anticancer or antimicrobial agents of a great potential for chemotherapy [3, 5]. In this short review we present a glimpse at the current state of knowledge concerning sub‑families, types and mechanisms of action of most prominent members of CPP family.
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 1-2; 9-33
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Intranasal insulin and cell-penetrating peptides in the treatment of Alzheimer’s disease
    Autorzy:
    Marciniec, Michał
    Kulczyński, Marcin
    Nowak, Andrzej
    Kwak, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/1178799.pdf
    Data publikacji:
    2017
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Alzheimer's disease
    GLP-1 agonists
    anti-diabetic drugs
    cell-penetrating peptides
    cognitive function
    dementia
    intranasal insulin
    Opis:
    Alzheimer’s disease (AD) is the most common cause of dementia and is responsible for up to 75% of the nearly 47 million dementia cases worldwide. AD is the clinical manifestation of toxic β-amyloid and neurofibrillary tangles accumulation caused by altered proteostasis. Due to not fully understood molecular mechanisms of AD only symptomatic treatment is available. Considering that cognitive decline is associated with insulin resistance, metabolic alterations may be the primary causes of the AD and insulin therapy is proposed as a novel approach in AD treatment. Intranasal administration of insulin appears to be a profitable solution for drug delivery to the brain due to blood-brain barrier bypassing, higher bioavailability and the lack of systemic side effects. When applying this method, insulin is sprayed into the nasal cavity, enters the mucosa and is transported along the axon bundles to the brain. Clinical trials of AD treatment with intranasal insulin revealed improvement in cognition, verbal memory and functional status. Notably, enhancement in memory and cognition were observed both in healthy adults and in AD patients and were ApoE ε4-related. The use of cell-penetrating peptides (CPPs) improve cellular uptake of insulin, enhance bioavailability and increase the direct insulin transport into the deeper regions of the brain such as the olfactory bulb and hippocampus. Animal studies revealed beneficial effects on AD symptoms of other molecules applied in connection with CPPs and most of them approve CPPs formulations for use in clinical trials. This review article summarize clinical trials results of intranasal insulin administration in AD treatment and propose the use of CPPs as an additive to conventional and experimental therapies for AD.
    Źródło:
    World Scientific News; 2017, 90; 138-149
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Modulowanie właściwości peptydów penetrujących do komórek
    Modulating properties of the cell penetrating peptides
    Autorzy:
    Lipiński, W.
    Kolesińska, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/172238.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    peptydy penetrujące do komórek
    CPPs
    aktywowalne peptydy zdolne do przenikania przez błony komórkowe
    cargo
    transport związków chemicznych do komórek
    mechanizm przenikania
    diagnostyka nowotworów
    cell penetrating peptides
    activatable cell penetrating peptides
    ACPPs
    transport into the cells
    mechanism of penetration
    Opis:
    Cell penetrating peptides (CPPs) are short peptides able to efficiently cross cellular membrane. The group includes great diversity of sequences and besides capability to enter various types of cells, their characteristic feature is lack of toxicity. CPPs can be divided according to their origin (natural and synthetic) or according to their physicochemical properties responsible for the cellpenetrating ability (cationic, amphipathic and hydrophobic). Properties of CPPs are closely related to their mechanism of internalisation. Endocytic pathway is probably the dominating mechanism for majority of CPPs, but less common energyindependent internalisation (occurring via inverted micelle, carpet-like, barrel stave pore or toroidal pore model may also play a relevant part in the uptake across membranes. CPPs have been applied in transporting various compounds. They are very effective in delivering small molecules (fluorophores, drugs, peptides), macromolecules (proteins, nucleic acids) and even nanoparticles (metal nanoparticles, liposomes). Conjunction of CPP and cargo can be achieved either covalently (peptide bond, sulphide bridge etc.) or noncovalently (electrostatic or hydrophobic interaction, hydrogen bonding). Ability to unspecific enter almost any kind of cell and tissue becomes a great problem in the case of in vivo applications. Another disadvantage of CPPs is their low plasma stability. Many strategies have been suggested to overcome these issues. Selectivity can be improved by attaching targeting ligands (e.g. short peptides, antibodies, proteins, folic acid or hyaluronic acid) or by incorporating CPPs into macromolecular drug carriers, which exploit the so called enhanced permeability and retention (EPR) effect. The most recent and most sophisticated way of improving CPPs’ stability and selectivity is the synthesis of activatable cell penetrating peptides (ACPPs). The deactivating moiety may consist of anionic sequence, polymer chain or smaller protecting groups. The deactivating parts are connected to the delivery system via linker that can be cleaved under conditions characteristic for the site of action. ACPPs may be activated by enzymes, pH and oxidative potential change, temperature or radiation. CPPs may find application in tumour therapy, diagnostics and the combination of both – theranostics. Despite many successful studies in delivering drugs and tags in vivo and in vitro, CPPs have passed only few clinical trials (some are being run currently). It is sure that this research area will develop in next years
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 9-10; 695-726
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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