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    Wyświetlanie 1-3 z 3
    Tytuł:
    Metal responsive transcription factor 1 (MTF-1) regulates zinc dependent cellular processes at the molecular level
    Autorzy:
    Grzywacz, Agata
    Gdula-Argasińska, Joanna
    Muszyńska, Bożena
    Tyszka-Czochara, Małgorzata
    Librowski, Tadeusz
    Opoka, Włodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038990.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    metal responsive-transcription factor 1
    cell signaling
    inflammation
    NF-κB
    Opis:
    Metal responsive transcription factor 1 (MTF-1) is a zinc dependent transcription factor which is involved in the regulation of intracellular signaling pathways. MTF-1 regulates the expression of two streams of genes functioning in metal homeostasis and anti-oxidative response. MTF-1 acts in the process of binding of toxic metal ions in the cell, due to the activation of the expression of metallothioneins (MTs). Additionally, MTF-1 regulates transcription of genes involved in the sequestration of zinc and its intracellular transport. Disruption of zinc and MT homeostasis has an indispensable influence on the development of several pathological states. Moreover, by increasing MT activity, MTF-1 can effectively protect cells from oxidative and hypoxic stresses. The mechanism of MTF-1 action in cells includes the regulation of the proper immune response through activation/repression of anti- and pro-inflammatory cytokines. MTF-1 function in immune response is related to nuclear factor-κB (NF-κB) activity. Synthesis of insulin is also related to the activity of this transcription factor and zinc balance. Insulin transport also depends on zinc. In pancreatic β-cells, several types of the zinc transporters are found. Zinc transporters coordinated action is crucial for the synthesis and secretion of insulin. Disturbances in the regulation of signaling pathways connected with MTF-1 function can entail further alterations in zinc intracellular status and this growing imbalance can promote the pathophysiology of degenerative disorders.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 491-498
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Planning identification experiments for cell signaling pathways: An NFκB case study
    Autorzy:
    Fujarewicz, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/908137.pdf
    Data publikacji:
    2010
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    komórka
    ścieżka sygnalizacyjna
    projektowanie eksperymentu
    estymacja parametrów
    cell signaling pathways
    experiment design
    parameter estimation
    Opis:
    Mathematical modeling of cell signaling pathways has become a very important and challenging problem in recent years. The importance comes from possible applications of obtained models. It may help us to understand phenomena appearing in single cells and cell populations on a molecular level. Furthermore, it may help us with the discovery of new drug therapies. Mathematical models of cell signaling pathways take different forms. The most popular way of mathematical modeling is to use a set of nonlinear ordinary differential equations (ODEs). It is very difficult to obtain a proper model. There are many hypotheses about the structure of the model (sets of variables and phenomena) that should be verified. The next step, fitting the parameters of the model, is also very complicated because of the nature of measurements. The blotting technique usually gives only semi-quantitative observations, which are very noisy and collected only at a limited number of time moments. The accuracy of parameter estimation may be significantly improved by a proper experiment design. Recently, we have proposed a gradient-based algorithm for the optimization of a sampling schedule. In this paper we use the algorithm in order to optimize a sampling schedule for the identification of the mathematical model of the NF[...]B regulatory module, known from the literature. We propose a two-stage optimization approach: a gradient-based procedure to find all stationary points and then pair-wise replacement for finding optimal numbers of replicates of measurements. Convergence properties of the presented algorithm are examined.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2010, 20, 4; 773-780
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lipid peroxidation and cell cycle signaling : 4-hydroxynonenal, a key molecule in stress mediated signaling.
    Autorzy:
    Yang, Yusong
    Sharma, Rajendra
    Sharma, Abha
    Awasthi, Sanjay
    Awasthi, Yogesh
    Powiązania:
    https://bibliotekanauki.pl/articles/1043608.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    glutathione S-transferase
    RLIP76
    4-hydroxynonenal
    RalBP1
    cell cycle signaling
    apoptosis
    Opis:
    Role of lipid peroxidation products, particularly 4-hydroxynonenal (4-HNE) in cell cycle signaling is becoming increasingly clear. In this article, recent studies suggesting an important role of 4-HNE in stress mediated signaling for apoptosis are critically evaluated. Evidence demonstrating the modulation of UV, oxidative stress, and chemical stress mediated apoptosis by blocking lipid peroxidation by the α-class glutathione S-transferases (GSTs) is presented which suggest an important role of these enzymes in protection against oxidative stress and a role of lipid peroxidation products in stress mediated signaling. Overexpression of 4-HNE metabolizing GSTs (mGSTA4-4, hGSTA4-4, or hGST5.8) protects cells against 4-HNE, oxidative stress (H2O2 or xanthine/xanthine oxidase), and UV-A mediated apoptosis by blocking JNK and caspase activation suggesting a role of 4-HNE in the mechanisms of apoptosis caused by these stress factors. The intracellular concentration of 4-HNE appears to be crucial for the nature of cell cycle signaling and may be a determinant for the signaling for differentiation, proliferation, transformation, or apoptosis. The intracellular concentrations of 4-HNE are regulated through a coordinated action of GSTs (GSTA4-4 and hGST5.8) which conjugate 4-HNE to GSH to form the conjugate (GS-HNE) and the transporter 76 kDa Ral-binding GTPase activating protein (RLIP76), which catalyze ATP-dependent transport of GS-HNE. A mild stress caused by heat, UV-A, or H2O2 with no apparent effect on the cells in culture causes a rapid, transient induction of hGST5.8 and RLIP76. These stress preconditioned cells acquire ability to metabolize and exclude 4-HNE at an accelerated pace and acquire relative resistance to apoptosis by UV and oxidative stress as compared to unconditioned control cells. This resistance of stress preconditioned cells can be abrogated by coating the cells with anti-RLIP76 antibodies which block the transport of GS-HNE. These studies and previous reports discussed in this article strongly suggest a key role of 4-HNE in stress mediated signaling.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 319-336
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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