Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "cell" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 1166
Tytuł:
Outcomes of surgery for giant cell tumors of the tendon sheath within the hand
Autorzy:
Żyluk, Andrzej
Owczarska, Ada
Powiązania:
https://bibliotekanauki.pl/articles/1391812.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
giant cell tumor of the tendon sheath
hand tumor
soft tissue tumor
tendon sheath
Opis:
Introduction: Giant cell tumor of the tendon sheath is the most common benign proliferative lesion involving the upper limb, characterized by relatively high recurrence rate after surgery. Aim: The objective of the study was a retrospective analysis of outcomes of the operative treatment of these tumors, in a longterm (a mean of 4,2 year) follow-up. Material and methods: Preoperative examination was performed in 58 patients, 36 females (62%) and 22 males (38%), in a mean age of 41 years, and treatment outcomes were assessed in 47 persons (81% of the operated patients), at a mean of 4.2-year follow-up. The final assessment was performed in a form of phone interview. Results: The most common site of the tumors was the fingers – 42 cases (72%). In 31 patients (53%) the lesion had a well-defined capsule, and in 11 (19%) a satellite nodule was found around the main tumor. A total of 9 relapses (21%) occurred, all within the first 2 years following surgery. Two patients had a next episode of recurrence after the second operation. In 8 out of the 9 patients with a recurrence, the primary lesion did not have a well-defined capsule. In 38 patients who had no relapse, 31 were completely symptom-free, whereas 7 complained of mild pain of the scar and/or numbness of a part of the involved finger. Conclusions: The main factor that impacted the high rate of recurrence was incomplete tumor excision, which resulted from inadequately accurate surgery and the tumor morphology (having no well-defend capsule). The role of operating with the use of magnifying devices and keeping a greater surgical margin at resection of the non-capsulated lesions was emphasized, as it could translate into reducing the recurrence rate.
Źródło:
Polish Journal of Surgery; 2020, 92, 6; 16-21
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rodzaje ogniw paliwowych i ich potencjalne kierunki wykorzystania
Types of fuel cells and their potential directions of use
Autorzy:
Żyjewska, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/2143658.pdf
Data publikacji:
2021
Wydawca:
Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Tematy:
ogniwo paliwowe
wodór
alternatywne źródła energii
fuel cell
hydrogen
alternative energy sources
Opis:
Ogniwa paliwowe nie są technologią nową, ale zyskują na popularności i są intensywnie rozwijane. W artykule przedstawiono i scharakteryzowano różne rodzaje ogniw paliwowych będących obecnie w kręgu zainteresowania ośrodków naukowo-badawczych zajmujących się problematyką ochrony środowiska naturalnego. Są to ogniwa paliwowe typu: alkaliczne (AFC, ang. alkaline fuel cell), z kwasem fosforowym (PAFC, ang. phosphoric acid fuel cell), stałotlenkowe (SOFC, ang. solid oxide fuel cell), ze stopionym węglanem (MCFC, ang. molten carbonate fuel cell), z membraną do wymiany protonów (PEMFC, ang. proton exchange membrane fuel cell), w tym ogniwo zasilane bezpośrednio metanolem (DMFC, ang. direct methanol fuel cell). Porównano parametry pracy wymienionych ogniw paliwowych oraz opisano zasadę ich działania. Rosnące zainteresowanie urządzeniami wykorzystującymi wodór jako paliwo wynika również z rozwoju technologii power-to-gas (P2G). Ponadto w artykule przedstawione zostały potencjalne kierunki rozwoju i możliwości wykorzystania ogniw paliwowych w różnych dziedzinach i sektorach gospodarki. Ogniwa paliwowe mogą znaleźć zastosowanie np. w transporcie. Przedstawiono charakterystykę pojazdów samochodowych używanych w Unii Europejskiej, a także specyfikację techniczną samochodów osobowych komercyjnie dostępnych wykorzystujących ogniwa paliwowe z membraną do wymiany protonów. Omówiono możliwość użycia ogniw paliwowych w transporcie zbiorowym (autobusy, pociągi). Przedstawiono możliwości pracy ogniw paliwowych w układach skojarzonych (wytwarzających energię elektryczną i ciepło na cele grzewcze i/lub chłodnicze). Rozważono wykorzystanie technologii ogniw paliowych w dużych jednostkach kogeneracyjnych oraz w układach mikro. Jednym z przedstawionych układów kogeneracyjnych jest połączenie ogniw paliwowych z turbiną gazową. Innym sposobem wykorzystania ogniw paliwowych jest magazynowanie energii w systemach EES. Interesującym rozwiązaniem mogą być również systemy power-to-power, które także zostały krótko scharakteryzowane.
Fuel cells are not a new technology, but they are gaining in popularity and are being intensively developed. The article presents and characterizes various types of fuel cells that are currently of interest to research and development centers dealing with environmental protection issues. These include: alkaline fuel cell (AFC), phosphoric acid fuel cell (PAFC), solid oxide fuel cell (SOFC), molten carbonate fuel cell (MCFC), proton exchange membrane fuel cell (PEMFC), including direct methanol fuel cell (DMFC). The operating param- eters of the previously mentioned fuel cells were compared. The principle of operation of a fuel cell was described. The growing interest in devices using hydrogen as a fuel also results from the development of Power to Gas technology (P2G). Furthermore, the article presents the potential directions of development and use of fuel cells in various fields and sectors of the economy. Fuel cells can be used in transport. The characteristic of motor vehicles fleet by fuel type in usage in the European Union was presented. The technical specification of commercially available passenger cars using fuel cells with proton exchange membrane was presented. The possibility of using fuel cells in public transport (buses, trains) was discussed. The possibilities of operation of fuel cells in combined heat and power systems (CHP) were presented. Usage of fuel cell technology in large cogeneration units and micro systems was considered. One of the presented cogeneration systems is a combination of fuel cells with a gas turbine. Another possibility of using fuel cells is energy storage systems (EES). Interesting way of using fuel cells can also be Power to Power systems, which were briefly characterized.
Źródło:
Nafta-Gaz; 2021, 77, 5; 332-339
0867-8871
Pojawia się w:
Nafta-Gaz
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Renal Carcinoma Metachronous Metastases to the Gall-Bladder and Pancreas - Case Report
Autorzy:
Zygulska, Aneta
Wójcik, Adrian
Richter, Piotr
Krzesiwo, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1396695.pdf
Data publikacji:
2012-06-01
Wydawca:
Index Copernicus International
Tematy:
clear cell renal carcinoma
metastasis to the gall-bladder and pancreas
Opis:
Renal carcinoma metastases to the gastrointestinal tract are seldom reported in medical literature. The study presented a case of a 76-year old female patient who underwent nephrectomy, due to T2N0M0 clear cell renal carcinoma and was additionally diagnosed with two metachronous metastases to the gall-bladder and pancreas. Abdominal ultrasound performed 32 months after nephrectomy demonstrated the presence of cholelithiasis and gall-bladder polyp. Laparoscopic cholecystectomy was performed. Clear cell renal carcinoma metastasis restricted to the gall-bladder mucosa was diagnosed on the basis of the histopathological examination. After surgery the patient remained under follow-up. In December, 2009 (47 months after nephrectomy) abdominal computer tomography (CT) revealed the presence of a tumor located in the tail of the pancreas. Distal pancreatic resection and splenectomy was performed. The histopathological examination confirmed the presence of clear cell renal carcinoma metastasis. The patient is in good general condition, under follow-up at the Oncological Outpatient Clinic.
Źródło:
Polish Journal of Surgery; 2012, 84, 6; 313-316
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On continuous time version of two-phase cell cycle model of Tyrcha
Autorzy:
Zwoleński, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/748777.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
cell cycle
transport equations
invariant density
Markov operators
Opis:
We consider a model of two-phase cell cycle in a maturity-structured cellular population, which consists of a system of first order linear partial differential equations (transport equations). The model is based on similar biological assumptions as models of Lasota-Mackey, Tyson-Hannsgen and Tyrcha. We examine behavior of the solutions of the system along characteristics, give conditions for existence of invariant density, and compare results with outcomes of generational model.
Źródło:
Mathematica Applicanda; 2013, 41, 1
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Difficulties in clinical staging of external ear canal carcinoma– a case report
Autorzy:
Żurek, Michał
Rzepakowska, Anna
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399738.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
squamous cell carcinoma
external auditory canal
lateral petrosectomy
facial nerve
Opis:
Carcinoma of the external auditory canal (EAC) is known to be very rare with a rate of 1-6 per million people. It affects mostly people over the age of 50 regardless of gender. The most common type of carcinoma of EAC is squamous cell carcinoma (SCC). The aim of this paper is to present the case of a 56-year-old woman with carcinoma of EAC. She was admitted to otolaryngology clinic due to ear buzzing lasting for five months, periodic otorrhea and hearing deterioration in her right ear. In otoscopic examination a tumor in the right ear meatus was identified. It filled almost the entire canal. Biopsy confirmed the presence of squamous-cell cancer. Tumor advancement was diagnosed using computer tomography of the temporal bones, magnetic resonance imaging of the head and ultrasonography of the neck. Imaging examinations indicated T3 N0 stage. Doctors decided to perform lateral petrosectomy with elective neck dissection. During the operation, the results of histopathological examination of frozen specimens from marginal tissues revealed an invasion of the anterior wall of the ear canal, capsule of temporomandibular joint and parotid gland. The resection eventually included also parotid gland and temporo-mandibular joint with the caput of the mandible. After recuperation, the patient had complementary radiotherapy. The presented case shows that precise imaging is necessary before surgical treatment, but unfortunately the invasion of cancer may not be estimated properly. Based on literature, the best prognosis concerns wide resection with complementary radiotherapy, although the schedule of treatment is not determined.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2018, 7, 1; 45-50
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Drought on the Performance of Threeturf Grass Species
Autorzy:
Żurek, Grzegorz
Prokopiuk, Kamil
Rachwalska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2199706.pdf
Data publikacji:
2018-12-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
drought,
grasses,
turf,
cell membrane stability,
Lolium perenne,
Festuca rubra,
Poa pratensis.
Opis:
Drought is the main environmental factor hampering world agriculture production. In the face of warmingclimate and reduced fresh water resources it become obvious that search for any factors decreasing water useis strongly recommended. Turf grasses able to withstand drought period longer could be recommended for turfareas as parks, lawns, home gardens etc. and relatively lower amounts of water should ensure satisfactory turfquality. Therefore, twelve turf varieties from three major cool-season turf grass species: perennial ryegrass(Lolium perenne L.), Kentucky bluegrass (Poa pratensis L.) and red fescue (Festuca rubra L.) were tested inglasshouse pot experiment and in the laboratory for determination of their relative ability to withstand greenlonger in the face of water deficit.The different response of the examined forms to drought was noted. Conditions that favor fast water depletionwere the most suitable for the expression of water deficit-related traits. Therefore, sandy mixture of 16%volumetric moisture content at field water capacity was mostly suitable for observation of the variation oftested forms. Turf condition of Kentucky bluegrass, as contrary to red fescue, was strongly connected with thesoil moisture. Different manifestation of drought resistance was observed in tested species. Kentucky bluegrass,as rather no resistant to drought, exposed low level of drought avoidance. Red fescue was able to survivedrought mainly due to leaf blades resistant to desiccation. In perennial ryegrass some other mechanismsevolved to survive drought. Early leaf wilting and senescence contributes to nutrient remobilization duringdrought and avoids large water loses during the transpiration. Therefore, perennial ryegrass turf was able toregenerate better after drought, as compared to the other tested grass species.Search for new turf forms should focus on searching for ability to maintain acceptable conditions longer ina presence of increasing water deficit. It will then reduce the duration of period of poor turf conditions andfurther, turf water demands.
Źródło:
Plant Breeding and Seed Science; 2018, 78; 3-22
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The analysis of drivers’ reaction time using cell phone in the case of vehicle stabilization task
Autorzy:
Žuraulis, Vidas
Nagurnas, Saulius
Pečeliūnas, Robertas
Pumputis, Vidmantas
Skačkauskas, Paulius
Powiązania:
https://bibliotekanauki.pl/articles/2162015.pdf
Data publikacji:
2018-10-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
driver
cell phone
reaction time
statistical analysis
psychophysiology
vehicle stabilization
Opis:
Objectives The article analyzes the driver’s psychophysiological qualities such as complex reaction and individual ability to control the vehicle that has suddenly lost its stability. The comparative analysis of the duration of reaction time was performed to assess the negative influence of speaking on a phone and driving with one hand. Material and Methods The experimental research was carried out on special training grounds with the road surface having low adhesion coefficient, where sudden lateral vehicle destabilization was caused by the moving plate mounted on the road surface. The vehicle onboard equipment was used for identifying the difference between the destabilization moment and the responsive driver’s steering wheel movement which in this research was assumed as the reaction time. Results Statistical methods of research applied for the analysis of results showed high probability that the driver’s actions would be significantly late in controlling a vehicle. When stabilizing a vehicle movement, the complex reaction time of a vehicle driver speaking on a mobile phone is increased by 18.1% as compared with the conventional driving by a driver not speaking on a phone. Conclusions The risk of using the phone depends on the driver characteristics, traits and attitudes that affect the level of their experienced dangers, and the intensity of using mobile phones and driving. Speaking on a phone while driving increases the driver’s reaction time and mental workload, and changes his or her visual overview ability as well as understanding of the situation. Int J Occup Med Environ Health 2018;31(5):633–648
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 5; 633-648
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Significance of the PIK3CA mutations in the differential diagnosis of ovarian epithelial carcinoma
Autorzy:
Żuk, Monika
Koczkowska, Magdalena
Gorczyński, Adam
Sejda, Aleksandra
Biernat, Wojciech
Wasąg, Bartosz
Powiązania:
https://bibliotekanauki.pl/articles/895801.pdf
Data publikacji:
2019-02-05
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
PIK3CA
PI3K inhibitor
clear cell ovarian carcinoma
serous ovarian carcinoma
Opis:
Background: Ovarian carcinoma, one of the most common gynecological malignancies in Central and Eastern Europe, is characterized by a clinical and genetic heterogeneity with a distinct molecular signature for each histologic subtype. Material and methods: Here, we established the frequency of the PIK3CA mutations and amplifications in 100 FFPE tissues with the initial diagnosis of serous ovarian carcinoma. Accordingly, the diagnostic value of combining morphology with genetic and immunohistochemical testing was estimated in this cohort. Results: The PIK3CA mutations and amplifications were found in 4.1% (4/97) and 7.2% (7/97) of samples, respectively with a higher prevalence in low-grade tumors (p=0.0121). All identified variants were classified as pathogenic missense mutations, located within the PIK3CA mutational hotspots. In the light of the molecular and immunohistochemical results, two tumors with the somatic PIK3CA mutations and strongly positive expression for PI3K and hNF1β were eventually re-classified from serous to clear cell carcinomas after pathological re-evaluation. Conclusions: These findings demonstrate that the PIK3CA mutational screening facilitated establishing an accurate diagnosis of ovarian carcinomas and, more importantly, might allow for personalized treatment optimization. As the PIK3CA mutations result in the PI3K/AKT pathway deregulation, the individuals with the somatic PIK3CA variants may be eligible for personalized targeted therapies with PI3K inhibitors.
Źródło:
European Journal of Translational and Clinical Medicine; 2018, 1, 2; 23-30
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell binding and penetration of quaternized chitosan derivatives
Autorzy:
Zubareva, Anastasia A.
Shagdarova, Balzhima Ts.
Varlamov, Valery P.
Svirshchevskaya, Elena V.
Powiązania:
https://bibliotekanauki.pl/articles/1034738.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride
cell uptake
chitosan
cytotoxicity
quaternized chitosan
trypan blue
Opis:
Chitosan (Ch) is an attractive biopolymer with multiple reactive groups. However it is poorly soluble at neutral pH. Quaternization improves its solubility and permits the development of various positively charged drug delivery systems. The aim of this work was to study the solubility, toxicity, cell binding, and penetration of 20 kDa chitosan with 9, 40, 58 and 98% of quaternary ammonium group substitution (ChQ1 to ChQ4 accordingly). We showed that ChQ with substitution degree >40% was soluble in a wide pH range. Unexpectedly ChQ2 and ChQ3 were more toxic to cells than Ch, ChQ1 and ChQ4. Higher toxicity of ChQ was found against macrophage like cell line RAW264.7 than against epithelial cells MiaPaCa-2. All ChQ, in contrast to unmodified Ch, easily bound and penetrated the cells with the highest uptake by ChQ4. Thus, quaternized chitosan derivatives can be used for biomedical applications.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 217-223
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sexual cells in the reproductive system of female Ascaris suum
Autorzy:
Zoltowska, K.
Lopienska, E.
Gielwanowska, I.
Demianowicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/838103.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
oogenesis
sexual cell
reproductive system
Ascaris suum
female
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The first line therapy for intermediate/ high risk patients with advanced renal cell carcinoma according to therapeutic program B.10
Autorzy:
Żołnierek, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/22792533.pdf
Data publikacji:
2023-08-19
Wydawca:
Medical Education
Tematy:
renal cell carcinoma
intermediate risk group
unfavourable risk group
tyrosine kinases inhibitor
immune check-point inhibitor
Opis:
The purpose of this article is to discuss the use of therapeutic options for the first-line systemic treatment of patients with advanced renal cell carcinoma under the B.10 drug program effective in Poland as of May 2022 - with a focus on intermediate and high-risk patient populations according to the IMDC. The specific situation created by reimbursement conditions with the exclusion of regimens combined with a tyrosine kinase inhibitor and immune checkpoint inhibitors along with the marginalisation of the use of an mTOr inhibitor necessitates a choice between two-drug immunotherapy or an antian giogenic drug in monotherapy. In this context, choosing the right treatment in the context of specific clinical situations is a challenge.
Źródło:
OncoReview; 2023, 13, 2; 48-57
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Brachyterapia o wysokiej mocy dawki u chorych na raka szyjki macicy
High dose rate brachytherapy in cervical cancer: an update
Autorzy:
Żółciak-Siwińska, Agnieszka
Jońska-Gmyrek, Joanna
Staniaszek, Jagna
Kawczyńska, Maryla
Kulik, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1031065.pdf
Data publikacji:
2011
Wydawca:
Medical Communications
Tematy:
3D planning
HDR brachytherapy
allogeneic hematopoietic stem cell transplantation
brachyterapia HDR
cervical cancer
computed tomographye treatment
extracorporeal photopheresis
mesenchymal stem cells
planowanie trójwymiarowe (3D)
principles of treatment
rak szyjki macicy
tomografia komputerowa
zasady leczenia
Opis:
Selection of optimal treatment modality in a patient with cervical cancer depends on FIGO clinical stage. At stages IB2-IVA, the cornerstone of treatment is radiochemotherapy. As first step, patients undergo irradiation from external fields combined with chemotherapy (cisplatin, 40 mg/m2, QW). Brachytherapy is used as second-line treatment – an essential component thereof – enabling delivery of high dose of radiation to both genital organs and tumor. Quality of this treatment directly correlates with local control of the disease, long-term overall survival and quality of life of patients after completion of therapy. The paper presents current principles of high dose rate (HDR) brachytherapy in cervical cancer patients. Discussed are principles of two-dimensional (2D) planning, used to date in about 50% of brachytherapy centers worldwide, as well as three-dimensional (3D) magnetic resonance (MR)-based planning. As availability of MR in ours and many other oncology centers is limited, a computed tomography-based modification of gynecologic recommendations GIN GEC ESTRO has been suggested. Therapeutic areas are defined: high-risk clinical target volume (HR CTV) and intermediate risk clinical target volume (IR CTV) which may be safely contoured based on clinical exam and CT study, when no MRI is available. Acceptable doses for critical organs are listed. Based on own experience, indications and limitations for use of intraparenchymal (interstitial) and intracavitary applications were developed.
Wybór metody leczenia chorych na raka szyjki macicy jest uzależniony od stopnia zaawansowania, ocenionego według klasyfikacji FIGO (International Federation of Gynecology and Obstetrics). Zasadniczą metodą leczenia chorych na raka szyjki macicy w stopniach zaawansowania IB2-IVA jest radiochemioterapia. W pierwszym etapie przeprowadzane jest napromienianie z pól zewnętrznych wraz z chemioterapią z zastosowaniem cisplatyny w dawce 40 mg/m2, raz w tygodniu. W kolejnym etapie leczenia stosuje się brachyterapię. Brachyterapia jest istotną częścią leczenia, umożliwiającą podanie wysokiej dawki na narząd rodny wraz z guzem, a jakość tego leczenia ma wpływ na kontrolę miejscową nowotworu (LC), przeżycia odległe (OS), jak również na jakość życia chorych po zakończeniu terapii. W pracy przedstawiono zasady obowiązujące współcześnie podczas leczenia brachyterapią o wysokiej mocy dawki (high dose rate brachytherapy, HDR) u chorych na raka szyjki macicy. Opisano zasady planowania w systemie dwuwymiarowym (2D), stosowanym do dzisiaj mniej więcej w połowie ośrodków brachyterapii na świecie, oraz planowania w systemie trójwymiarowym (3D) na podstawie rezonansu magnetycznego (MR). Ponieważ dostępność MR w naszym i wielu ośrodkach onkologicznych jest utrudniona, zaproponowano modyfikację rekomendacji GIN (Gynaecological) GEC ESTRO dla potrzeb planowania, opierając się na tomografii komputerowej. Zdefiniowano obszary terapeutyczne: HR CTV (high-risk clinical target volume), IR CTV (intermediate risk clinical target volume), jakie można bezpiecznie konturować, opierając się na badaniu klinicznym i TK, przy braku MR. Opisano dopuszczalne dawki dla narządów krytycznych. Na podstawie własnych doświadczeń opracowano wskazania i ograniczenia w zastosowaniu aplikacji śródtkankowych i śródjamowych.
Źródło:
Current Gynecologic Oncology; 2011, 9, 4; 264-271
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
‘Lab-on-a-chip’ for cell engineering: towards cellular models mimicking in vivo
Autorzy:
Ziółkowska, K.
Chudy, M.
Dybko, A.
Brzózka, Z.
Powiązania:
https://bibliotekanauki.pl/articles/115885.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
Lab-on-a-chip
microfluidic tools
cancer
cell culture
Multicellular Tumor Spheroid (MCTS)
Opis:
One of the main scopes of modern cell engineering is development of cellular models that can replace animals in drug screening and toxicological tests, so called alternative methods. Construction of the alternative model is a very challenging task due to a richness of factors creating the in vivo environment. The monolayer cell culture — cultivation of adhesive cells on artificial surfaces such as glass or polymer — lack most of the in vivo-like interactions, but still is the only tool for the majority of applications. One of the most prospective approaches on mimicking in vivo environment is “Lab-on-a-chip” technology. Microfluidic devices offer lots of advantages over traditional in vitro culture, e.g. much higher cell volume-to-extracellular fluid volume ratio or possibility of regulation of hydrodynamic stress. This presentation aims to introduce latest advances of our team in microfluidic cell culture devices. Our novel approach is to cultivate three dimensional multicellular aggregates (spheroids) in microenvironments arranged in a microfluidic system. The geometry and materials of the system allow for cultivation, observation and analysis of multicellular spheroids. The results presented concern multicellular tumor spheroids (MCTS) rising from human cancer cells, which are considered to represent most of the conditionings of cancer tumor in vivo. The fully developed MCTS microdevice will be a reliable tool for anticancer drug screening, as the results most likely will be in a close accordance with the results obtained in vivo.
Źródło:
Challenges of Modern Technology; 2011, 2, 1; 79-82
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel designs and technologies for cell engineering
Autorzy:
Ziółkowska, K.
Chudy, M.
Dybko, A.
Brzózka, Z.
Powiązania:
https://bibliotekanauki.pl/articles/115526.pdf
Data publikacji:
2011
Wydawca:
Fundacja na Rzecz Młodych Naukowców
Tematy:
lab-on-a-chip
multicellular tumor spheroid
cancer
in vitro cell culture
cell engineering
Opis:
Microfluidic devices, such as lab-on-a-chip systems, are highly advantageous for cell engineering and cell based assays. It is a particularly useful approach for development of the in vitro cellular systems mimicking the in vivo environment. In this paper, a novel lab-on-a-chip device for three-dimensional human cell culture and anticancer drug testing is presented. Cells were cultured as Multicellular Tumor Spheroids (MCTS) — the best cancer tumor model developed so far. Diff erent designs were tested and novel technique of microfabrication in poly(dimethylsiloxane) was developed. MCTS were cultured in a system of polymeric microwells, with the network of microfluidic channels for culture medium flow. Design included optimal shear stress and proper nutrients supply for cultured cells. Final design provided MCTS culture for four weeks with the homeostasis-like state achievement, which is characteristic for the in vivo situation.
Źródło:
Challenges of Modern Technology; 2011, 2, 4; 54-60
2082-2863
2353-4419
Pojawia się w:
Challenges of Modern Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Three-dimensional modelling of thermal stresses in a planar solid oxide fuel cell of a novel design
Modelowanie 3D termicznych naprężeń w płaskim stałotlenkowym ogniwie paliwowym o nowatorskiej konstrukcji
Autorzy:
Zinko, T.
Pianko-Oprych, P.
Jaworski, Z.
Powiązania:
https://bibliotekanauki.pl/articles/408754.pdf
Data publikacji:
2016
Wydawca:
Politechnika Lubelska. Wydawnictwo Politechniki Lubelskiej
Tematy:
planar Solid Oxide Fuel Cell
thermal stresses
residual stresses
finite element method
computational fluid dynamics (CFD)
płaskie stałotlenkowe ogniwo paliwowe
naprężenie termiczne
naprężenie szczątkowe
Metoda Elementu Skończonego
Numeryczna Mechanika Płynów
Opis:
The presented modelling investigation was carried out to analyze thermal stresses and expansion in an anode supported planar Solid Oxide Fuel Cell (pSOFC). The temperature distribution was based on previously developed thermo-electrochemical model predicting fuel cell operation. The design of a single pSOFC consisted of three ceramic layers of membrane electrode assembly: anode, electrolyte, cathode and two cross-flow bipolar plates with 26 ribs. The gases flowed diagonally from one cell corner to the opposite one. The fuel and air flows were cross-wise opposed on each bipolar plate side. The study allowed to indicate the most vulnerable to thermal damage area of the fuel cell in the operating conditions. The results will be useful in further design modification and performance optimization of the SOFC.
Przeprowadzone symulacje numeryczne miały na celu analizę termicznych naprężeń i ocenę stopnia wydłużenia płaskiego stałotlenkowego ogniwa paliwowego typu pSOFC (ang. planar Solid Oxide Fuel Cell). Rozkład temperatury w ogniwie wyznaczono w oparciu o wcześniej opracowany model termiczno-elektrochemiczny [11]. Nowatorskie rozwiązanie ogniwa typu pSOFC objęło ceramiczną konstrukcję, w skład której weszły porowate elektrody – anoda i katoda, elektrolit oraz dwie płytki bipolarne z 26-cioma żebrami. Przepływ paliwa i powietrza odbywał się krzyżowo i przeciwprądowo, po przekątnej ogniwa. Wyniki symulacji pozwoliły na określenie obszarów ogniwa narażonych na uszkodzenie w wyniku wysokich wartości naprężeń termicznych. Uzyskane rezultaty FEM umożliwią dalszą modyfikację konstrukcji płaskiego ogniwa w celu optymalizacji wydajności pSOFC.
Źródło:
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska; 2016, 1; 69-72
2083-0157
2391-6761
Pojawia się w:
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 1166

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies