- Tytuł:
-
Glikozydy nasercowe : nowe trendy w chemii medycznej saponin i sapogenin
Cardiac glycosides : new trends in medicinal chemistry of saponins and their genins - Autorzy:
-
Grynkiewicz, G.
Szeja, W. - Powiązania:
- https://bibliotekanauki.pl/articles/171696.pdf
- Data publikacji:
- 2015
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
glikozydy nasercowe
digitoksyna
synteza digitoksozy
cardiac glycosides
digitoxin
digitoxose synthesis - Opis:
- Plant secondary metabolites – ubiquitous low molecular weight chemicals which are not essentials for the host existence and reproduction but serve many auxiliary functions, are frequently occurring as glycosides, for which particularly abundant examples exist in antibiotic, saponins and flavonoid categories. Cardiac glycosides (CG), originally isolated from Digitalis plants, also known as cardiotonic steroids, have particularly extensive record of ethnopharmacological and medicinal use. Although their application in treatment of dropsy is documented since 1875, long time has elapsed before their chemical structure were determined and mechanisms of their toxicity and cardiotonic action were recognized as inhibition of Na+ / K+ ATP-ase pump. Contemporary molecular pharmacology has revealed that cardiac glycosides are endogenous compounds in variety of animals, where they function as toxins or hormones. Besides, numerous recent studies confirmed anticancer activity of CGs at very low concentrations. These findings have been possible due to advances in ultrasensitive analytical techniques and also due to progress in organic synthesis, particularly total enantioselective syntheses of carbohydrates, which secured availability of individual CG and their analogs for medicinal chemistry studies.
- Źródło:
-
Wiadomości Chemiczne; 2015, 69, 11-12; 1047-1065
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł