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Wyświetlanie 1-15 z 66
Tytuł:
Novel potential anticancer agents
Autorzy:
Jęśkowiak, Izabela
Ryng, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1178224.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
anticancer agents
carcinoma cell lines
drug design
Opis:
Cancer is a widespread and lethal disease. It is considered as the first leading cause of deaths in economically developed countries. Nonetheless, the search for an effective treatment of cancer is still a major challenge. In this review, we analyzed the core structure of compounds and their impact on antitumor activity. Diversity of heterocyclic ring in the innovatory anticancer substances showed the potential in the design and development of new anticancer drugs.
Źródło:
World Scientific News; 2018, 93; 40-49
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Skin of sailor: cutis rhomboidalis nuchae, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Case report
Autorzy:
Abdulaziz, Ahmad
Brzeziński, Piotr
Chiriac, Anca
Powiązania:
https://bibliotekanauki.pl/articles/1065852.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
actinic keratosis
basal cell carcinoma
sailor
squamous cell carcinoma
ultraviolet
Opis:
Chronic exposure to environmental ultraviolet radiation (UVR) plays a key role both in photocarcinogenesis and induction of accelerated skin ageing. Sailors commonly experience a significant number of cutaneous problems, related to the exposure to environmental factors due to their working conditions. Among these factors, sun exposure is able to determine both acute and chronic skin damage, mostly linked to the effects of the ultraviolet (UV) radiation on epidermal and dermal structures. We report a case of sailor with cutis rhomboidalis nuchae, solar elastosis, actinic keratosis (AK), numerous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) of the head and trunk.
Źródło:
OncoReview; 2014, 4, 1; A37-41
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A suspicious non-healing wound of the pinna
Podejrzana, niegojąca się rana małżowiny usznej
Autorzy:
Nasir, Mohd Shaiful Nizam Mamat
Yusof, Suhaimi
Bakar, Muhammad Nasri Abu
Mohamad, Irfan
Powiązania:
https://bibliotekanauki.pl/articles/1034786.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
pinna
squamous cell carcinoma
wound
Opis:
Squamous cell carcinoma of the pinna occurs primarily in older males who are exposed to sunlight for a prolonged period. Most squamous cell carcinomas of the pinna are well differentiated and present as a painless mass or a sessile nodule. We describe an interesting case of an adult woman with a non-healing wound located on the right pinna which was treated conservatively, and was later diagnosed as squamous cell carcinoma.
Rak kolczystokomórkowy skóry zlokalizowany w obrębie małżowiny usznej występuje głównie u mężczyzn w starszym wieku, którzy są narażeni na długotrwałe działanie promieni słonecznych. W większości przypadków nowotwór ten jest dobrze zróżnicowany i ma postać niebolesnej masy lub nieuszypułowanego guzka. W pracy opisujemy ciekawy przypadek dorosłej kobiety z niegojącą się raną prawej małżowiny usznej – pacjentkę leczono zachowawczo, zanim ustalono rozpoznanie raka kolczystokomórkowego.
Źródło:
Pediatria i Medycyna Rodzinna; 2018, 14, 4; 425-427
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypothyroidism caused by cabozantinib therapy of clear cell renal cell carcinoma – case report, own experience
Autorzy:
Buraczewska, Agnieszka
Kardas, Joanna
Młot, Beata
Solarek, Wojciech
Waśko-Grabowska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1062936.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
cabozantinib
hypothyroidism
renal cell carcinoma
Opis:
Cabozantinib, the latest available in Poland medication for the treatment of renal cell carcinoma, registered in this indication by the European Medicines Agency (EMA) in September 2016, has been available in several cancer centers in Poland since November 2016 as part of the expanded access program. Primary hypothyroidism is a common complication during thyrosine kinase inhibitors (TKI) treatment, although there are few reports of its occurrence during treatment with cabozantinib, which belongs to this medication group. We present a case of rapid development of clinically apparent hypothyroidism after cabozantinib treatment and report data on this complication in the group of our patients.
Źródło:
OncoReview; 2017, 7, 3; 121-125
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Retrospective assessment of everolimus treatment in patients suffering from advanced renal cell carcinoma
Autorzy:
Hernik, Paweł
Kruczała, Maksymilian
Ziobro, Marek
Powiązania:
https://bibliotekanauki.pl/articles/773514.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
everolimus
renal cell carcinoma
targeted therapy
Opis:
Objective: Results of second-line everolimus treatment in clear cell renal carcinoma. Material and methods: Clinical data of 32 patients of the Clinic of Systemic and Metastatic Malignancies, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute (Krakow Branch) treated with second-line everolimus between 2011 and 2016 were analysed. Results: Median progression-free survival was 7 months. Stable disease was observed in 24 cases. Adverse events occurred in 59% of all patients, and the majority were mild and moderate (G1 and G2) according to CTCAE. The most frequent adverse events included anaemia, stomatitis, rash and fatigue. Conclusion: Molecularly targeted drugs offer the only effective and available therapy in Poland, which can be administered in patients with advanced renal cell carcinoma. Second-line everolimus is a valuable therapeutic option in the above mentioned group (following progression on first-line TKI therapy), especially when it is necessary to avoid the accumulation of similar adverse events after TKI treatment (different toxicity profiles).
Źródło:
OncoReview; 2017, 7, 2; 88-91
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Merkel cell carcinoma
Autorzy:
Markiewicz, Jarosław
Dziewirski, Wirginiusz
Powiązania:
https://bibliotekanauki.pl/articles/1065725.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
Merkel cell carcinoma
cutaneous neuroendocrine carcinoma
therapy
Opis:
Merkel cell carcinoma (MCC) is a rare cutaneous malignancy, with aggressive behaviour. The discovery of MCC polyomavirus (MCPyV) provided a major insight into pathogenesis of MCC, as MCPyV is present in most MCC tumours. The primary treatment of locoregional MCC is surgery, and sentinel lymph node biopsy should be performed in all cases at clinical stage I-II. Adjuvant radiotherapy decreases disease recurrences in stage I-III of the disease. Chemotherapy is primarily used for palliation and provides overall response rates of approximately 70%; however, the disease often recurs within a few months. All cases of MCC should be managed in an experienced multidisciplinary setting.
Źródło:
OncoReview; 2014, 4, 3; A121-125
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Basal cell carcinoma of the facial skin penetrating to the orbit – case report
Autorzy:
Czesak, Małgorzata
Chęciński, Piotr
Osuch-Wójcikiewicz, Ewa
Bruzgielewicz, Antoni
Sokołowski, Jacek
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1400278.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
skin cancer
basal cell carcinoma
orbit
Opis:
Basal cell carcinoma (BCC) is the most frequent malignant neoplasm of the skin. In this report we present a case of a 59-year-old patient, who had noticed for five years gradually growing tumor of the facial skin. MR scans revealed pathological lesion in the left orbit. The patient required partial resection of the nose, orbital exenteration with anterolateral thigh free flap reconstruction. The authors present diagnostic problems and methods of treatment BCC.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2017, 6, 2; 64-69
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular and environmental aspects of skin cancers
Autorzy:
Zebracka, A.
Matysiak, M.
Dudra-Jastrzebska, M.
Kapka-Skrzypczak, L.
Powiązania:
https://bibliotekanauki.pl/articles/3509.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
molecular aspect
environmental aspect
skin
cancer
malignant melanoma
basal cell carcinoma
squamous cell carcinoma
ultraviolet radiation
carcinogenesis
Opis:
Skin cancers are one of the most common cancers in the Caucasian population. A constantly increasing number of nonmelanoma skin cancers and malignant melanomas is observed. The incidence of skin cancers is associated mainly with exposure to sunlight. Therefore, agricultural workers who work in open spaces are a particularly vulnerable group. Currently, studies on the pathogenesis of skin cancer focus on the molecular basis associated with ultraviolet radiation. This study is an attempt to summarize the current state of knowledge on this issue. There have been demonstrated mutations in different classes of genes associated with carcinogenesis, including protooncogenes, tumour suppressor genes, genes that control apoptosis, genes encoding transcription factors and DNA repair genes in patients with skin cancers. Mutations in the latter result in reducing the effectiveness of DNA repair and fixation of mutations. All changes at the gene level lead to structural changes, quantitative and dysfunction of proteins encoded by these genes. All these factors contribute to the process of carcinogenesis. Due to increasing number of skin cancers, it seems important to increase knowledge of the molecular basis of skin cancers. This knowledge could be crucial for predicting the course of the disease, and for the development of new therapeutic strategies.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hyalinising clear cell carcinoma of salivary gland: a case report
Autorzy:
Osuchowski, Michał
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/2037686.pdf
Data publikacji:
2020-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cancer
hyalinising clear cell carcinoma salivary gland
Opis:
Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 2; 127-130
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Papillary renal cell carcinoma – case report of a patient with disseminated disease treated with pazopanib with several years of survival against reviewing current literature
Autorzy:
Buraczewska, Agnieszka
Kardas, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1064903.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
molecular targeted therapies
papillary renal cell carcinoma
Opis:
Papillary renal cell carcinoma is the second most common histological type of renal cell carcinoma with distinct cytogenetics, histology and prognosis. It exhibits significantly poorer response to molecular targeted therapies, which are about the progress in clear cell carcinoma. We present an overview of the treatment trials and report a casuistic case of metastatic disease controlled for several years with pazopanib.
Źródło:
OncoReview; 2016, 6, 2; A62-65
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis
Autorzy:
Bargotya, Mona
Mehta, Ankita
Das, Payel
Sachan, Ashish
Powiązania:
https://bibliotekanauki.pl/articles/454981.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adenocarcinoma
cholecystectomy
gall bladder
pure squamous cell carcinoma
Opis:
Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas.It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 59-63
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Patient with metastatic renal cell carcinoma treated successfully with pazopanib for four years.
Autorzy:
Słowik, Agnieszka
Streb, Joanna
Chrzan, Robert
Krzemieniecki, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1065279.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
metastatic renal cell carcinoma
pazopanib
tyrosine kinase inhibitors
Opis:
We present a case of a patient with metastatic renal cell carcinoma who was treated with pazopanib in the first-line treatment. Although nephrectomy was not performed, there was a positive reaction to the therapy with multi-targeted tyrosine kinase inhibitor. After 18 months of the palliative treatment, the cancerous kidney was surgically removed and pazopanib was restarted with the effect of further disease remission. The development of hypertension, complete hair discoloration and isolated hyperbilirubinemia occurred, and there was occasionally hypokalaemia in laboratory findings within 48 months of therapy. No serious adverse events were reported.
Źródło:
OncoReview; 2015, 5, 3; A109-116
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Everolimus-induced interstitial lung disease in patient with metastatic renal cell carcinoma – case report and literature review
Autorzy:
Buraczewska, Agnieszka
Kardas, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1065282.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
everolimus
interstitial lung disease
metastatic renal cell carcinoma
Opis:
We present a case of a 70-year-old man with metastatic renal cell carcinoma treated with second-line everolimus after rapid progression on first-line tyrosine kinase inhibitor, in whom a side effect of the therapy occurred in the form of a drug-induced interstitial lung disease. We also provide a review of the literature concerning opinions on incidence, clinical picture, consequences and management of the complication discussed.
Źródło:
OncoReview; 2015, 5, 3; A117-121
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clear Cell Carcinoma of the abdominal wall
Autorzy:
Kostrzeba, Ewa
Barczyk, M
Wichtowski, M
Garstecki, R
Murawa, D
Powiązania:
https://bibliotekanauki.pl/articles/1393149.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
Clear cell carcinoma
cesarean delivery
malignant transformation scar
Opis:
Background: Clear cell carcinoma in scars after cesarean section is extremely rare, with only 22 cases reported in the literature. Management of this condition needs to be further explored. Here, we report of a patient with clear cell carcinoma of the abdominal wall that developed 35 years after cesarean section. Case Report: The material of the study was a group of 61 patients divided into two groups. Group I – 35 deaf or with profound sensorineural hearing loss children (the pupils of the deaf and hard of hearing school), aged 5–17 years (average 9,2 years), 14 males, 21 females, II – control group comprised 26 normal hearing patients, aged 5–16 years (average 10,4 years), 14 males, 12 females (patients of Department of Pediatric Otolaryngology, Audiology and Phoniatrics, Medical University of Lodz). In both groups, exon 2 sequencing of GJB2 gene was performed. Results. A 58-year-old woman was admitted to our department due to abdominal pain and a progressively growing mass in the abdominal wall. Based on biopsy, a preliminary diagnosis of clear cell carcinoma was made. A wide surgical excision of the tumor with clear margins, hysterectomy with bilateral salpingo-oophorectomy, and abdominal wall reconstruction using synthetic mesh were performed. The patient was discharged in good condition after fifteen days of hospitalization. The patient remained recurrence-free 6 months after the treatment. Conclusions: T Lack of standardized management of rare malignant transformations hinders patient care. Due to a growing number of cesarean deliveries, we can expect clear cell carcinoma prevalence of the abdominal wall to increase. Therefore, patients and clinicians should attend to any pain, itching, or change in the size of abdominal wall scars.
Źródło:
Polish Journal of Surgery; 2017, 89, 6; 40-43
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treatment of multiple superficial basal cell carcinomas with topical imiquimod
Autorzy:
Brzeziński, Piotr
Chiriac, Anca
Powiązania:
https://bibliotekanauki.pl/articles/1065071.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
basal cell carcinoma (BCC)
cryotherapy
imiquimod 5% cream
Opis:
Basal cell carcinoma is the most common malignancy of man. The use of the topical imiquimod 5% cream offers a noninvasive, nonsurgical, and an effective option for the treatment of primary types superficial basal cell carcinoma (sBCC). We present a case series of patients who used imiquimod 5% cream with good therapeutic effect. The medication had a good tolerability profile and there were no ocular adverse events. Imiquimod 5% cream could be considered the first choice treatment for BCCs in older patients who are poor candidates to surgery.
Źródło:
OncoReview; 2015, 5, 1; A42-A45
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 66

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