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    Wyświetlanie 1-6 z 6
    Tytuł:
    Microbial canthaxanthin: an orange-red keto carotenoid with potential pharmaceutical applications
    Autorzy:
    Gaur, Vinita
    Bera, Surojit
    Powiązania:
    https://bibliotekanauki.pl/articles/16708506.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    canthaxanthin
    antioxidant
    feed supplement
    neuroprotection
    immunomodulation
    Opis:
    Canthaxanthin is an orange-red keto-carotenoid that occurs naturally and is also manufactured by synthetic methods for regular applications. In nature, canthaxanthin mainly exists in microbes such as different bacterial species, fungi, and algae, as well as in animals such as crustaceans, certain fishes, and birds. However, the amount of canthaxanthin produced in these organisms varies significantly. Additionally, the compound can be generated from genetically modified organisms using genetic engineering techniques Canthaxanthin finds extensive application as an additive in animal feed, in the pharmaceutical industry, as a coloring agent for various food products, and in cosmetics. It has powerful antioxidant properties and plays a role in lipid metabolism, neuroprotection, and immunomodulation. This article gives an extensive insight into the structure and methods of synthesis of canthaxanthin along with its various newly discovered sources identified so far. The significant applications of canthaxanthin, particularly its role in pharmaceuticals, are critically evaluated. Furthermore, the article discusses future aspects and challenges associated with canthaxanthin production and regulation.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 3; 315-328
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis of highly 13C enriched carotenoids: access to carotenoids enriched with 13C at any position and combination of positions
    Autorzy:
    Lugtenburg, Johan
    Dawadi, Prativa
    Powiązania:
    https://bibliotekanauki.pl/articles/1039761.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    astaxanthin
    β-carotene
    zeaxanthin
    canthaxanthin
    spheroidene
    Opis:
    Carotenoids and their metabolites are essential factors for the maintenance of important life processes such as photosynthesis. Animals cannot synthesize carotenoids de novo, they must obtain them via their food. In order to make intensive animal husbandry possible and maintain human and animal health synthetic nature identical carotenoids are presently commercially available at the multi-tonnes scale per year. Synthetically accessible 13C enriched carotenoids are essential to apply isotope sensitive techniques to obtain information at the atomic level without perturbation about the role of carotenoids in photosynthesis, nutrition, vision, animal development, etc. Simple highly 13C enriched C1, C2 and C3 building blocks are commercially available via 99% 13CO. The synthetic routes for the preparation of the 13C enriched building blocks starting from the commercially available systems are discussed first. Then, how these building blocks are used for the synthesis of the various 13C enriched carotenoids and apocarotenoids are reviewed next. The synthetic Schemes that resulted in 13C enriched β-carotene, spheroidene, β-cryptoxanthin, canthaxanthin, astaxanthin, (3R,3'R)-zeaxanthin and (3R,3'R,6'R)-lutein are described. The Schemes that are reviewed can also be used to synthetically access any carotenoid and apocarotenoid in any 13C isotopically enriched form up to the unitarily enriched form.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 1; 11-16
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Exceptional molecular organization of canthaxanthin in lipid membranes
    Autorzy:
    Sujak, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1039765.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    molecular interactions
    retinopathy
    lipid membranes
    canthaxanthin
    Opis:
    Canthaxanthin (β,β-carotene 4,4' dione) used widely as a drug or as a food and cosmetic colorant may have some undesirable effects on human health, caused mainly by the formation of crystals in the macula lutea membranes of the retina of an eye. Experiments show the exceptional molecular organization of canthaxanthin and a strong effect of this pigment on the physical properties of lipid membranes. The most striking difference between canthaxanthin and other macular pigments is that the effects of canthaxanthin at a molecular level are observed at much lower concentration of this pigment with respect to lipid (as low as 0.05 mol%). An analysis of the molecular interactions of canthaxanthin showed molecular mechanisms such as: strong van der Waals interactions between the canthaxanthin molecule and the acyl chains of lipids, restrictions to the segmental molecular motion of lipid molecules, modifications of the surface of the lipid membranes, effect on the membrane thermotropic properties and finally interactions based on the formation of the hydrogen bonds. Such interactions can lead to a destabilization of the membrane and loss of membrane compactness. In the case of the retinal vasculature, it can lead to an increase in the permeability of the retinal capillary walls and the development of retinopathy.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 1; 31-33
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Carotenoid accumulation in Dietzia maris NITD protects from macromolecular damage
    Autorzy:
    Bera, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2097097.pdf
    Data publikacji:
    2020
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    canthaxanthin
    ROS
    protein oxidation
    nutraceutical
    linoleic acid
    Opis:
    Over the past decades, nutraceuticals have attracted considerable interest because of their potential nutritional, safety and therapeutic effects. Carotenoid molecules are potent nutraceuticals with an attractive colour and have been shown to play crucial roles in the immune system and susceptibility of organisms to certain diseases. Reactive oxygen species (ROS) are considered to be a major threat to cellular components and lead to protein oxidation, lipid peroxidation and DNA damage. In the present study, canthaxanthin (CX), an orange-red keto-carotenoid, was extracted from Dietzia maris NITD. Carbonyl content measurement showed that the presence of CX can prevent protein oxidation in D. maris NITD. The inhibition of protein oxidation in vitro revealed a high correlation coefficient of the extracted CX with positive controls. Both the linoleic acid model (IC50 = 932.48 μg/ml) and the goat liver model experiments showed that CX can also inhibit lipid peroxidation in vitro. CX from D. maris NITD was also proved to be effective in maintaining the observable intactness of a model DNA (pBR322). The present study indicated that bacterial CX can be a useful bioactive compound to prevent oxidative damage incurred by cellular macromolecules in terms of pharmaceutical and nutraceutical aspects.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2020, 101, 3; 171-178
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Canthaxanthin in recent sediments as an indicator of heterocystous cyanobacteria in coastal waters
    Autorzy:
    Krajewska, M.
    Szymczak-Zyla, M.
    Kobos, J.
    Witak, M.
    Kowalewska, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/47440.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Instytut Oceanologii PAN
    Tematy:
    Cyanoprokaryota
    chlorophyll a
    coastal water
    carotenoid
    chloropigment
    canthaxanthin
    Gdansk Gulf
    Baltic Sea
    recent sediment
    Źródło:
    Oceanologia; 2019, 61, 1
    0078-3234
    Pojawia się w:
    Oceanologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Astaxanthin, canthaxanthin and astaxanthin esters in the copepod Acartia bifilosa (Copepoda, Calanoida) during ontogenetic development
    Autorzy:
    Lotocka, M.
    Styczynska-Jurewicz, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/48096.pdf
    Data publikacji:
    2001
    Wydawca:
    Polska Akademia Nauk. Instytut Oceanologii PAN
    Tematy:
    canthaxanthin
    Pomeranian Bay
    ontogenetic development
    astaxanthin
    Baltic Sea
    Calanoida
    Acartia bifilosa
    astaxanthin ester
    Gdansk Gulf
    Copepoda
    copepod
    Opis:
    The contents of astaxanthin, canthaxanthin and astaxanthin esters were studied in natural populations of the copepod Acartia bifilosa from the Pomeranian Bay and Gulf of Gdańsk in the southern Baltic Sea. Samples dominated by any one of three developmental groups: (1) nauplii, (2) copepodids I–III and (3) copepodids IV–V and adults of Acartia bifilosa were analysed by means of high performance liquid chromatography (HPLC). As ontogenetic development progressed, significant changes occurred in the proportion of particular pigments in the total pigment pool of the various developmental groups. Astaxanthin and canthaxanthin occurred in all the groups, the former being clearly dominant. However, an increasing percentage of astaxanthin esters was recorded in the copepodids I–III, and even more in the copepodids IV–V and adults group. Most probably, astaxanthin is the main pigment active in copepod lipid metabolism. Carotenoid pigments in copepods very likely act as efficient free-electron quenchers and may be involved as antioxidants in rapid lipid metabolism. The exogenously feeding stages (late nauplii and copepodids) transform plant carotenoids taken from food and are evidently capable of metabolising astaxanthin by esterification and further degradation. It is emphasised that, according to literature data, astaxanthin esters may have an even higher quenching ability. It is suggested that crustacean carotenoid pigments, with their electron donor-acceptor abilities, may replace oxygen in peroxidation processes connected with lipid metabolism. The consequences of such a physiological role of astaxanthin for present-day estimations of energy balances in zooplankton communities are mentioned.
    Źródło:
    Oceanologia; 2001, 43, 4
    0078-3234
    Pojawia się w:
    Oceanologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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