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Tytuł:
Advances in immunotherapy for osteosarcoma: a review of emerging treatment strategies
Autorzy:
Poboży, Kamil
Domański, Paweł
Domańska, Julia
Konarski, Wojciech
Poboży, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/22792557.pdf
Data publikacji:
2023-09-13
Wydawca:
Medical Education
Tematy:
osteosarcoma
immunotherapy
immune checkpoint inhibitors
cancer vaccines
autophagy
pyroptosis
chimeric antigen receptor T cells
Opis:
Advances in immunotherapy for osteosarcoma have shown promising results, with the use of monoclonal antibodies and immune checkpoint inhibitors. These strategies are aimed at targeting specific molecules and pathways involved in tumour immune evasion and promoting anti-tumour immune responses. Other emerging immunotherapeutic approaches include autophagy and pyroptosis induction, chimeric antigen receptor T-cell therapy, gadolinium-bisphosphonate nanoparticles and dendritic cell-based vaccines. Continued research into these emerging treatment strategies is essential for developing effective therapies for patients with high-grade osteosarcoma.
Źródło:
OncoReview; 2023, 13, 3; 75-84
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The expression of CD44, CD90 and CD133 in response to cisplatin in hepatocellular cancer cells
Autorzy:
Donmez Cakıl, Yaprak
Gunes Ozunal, Zeynep
Gokceoglu Kayalı, Damla
Gulhan Aktas, Ranan
Powiązania:
https://bibliotekanauki.pl/articles/2040155.pdf
Data publikacji:
2021-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cancer
cisplatin
hepatocellular
stem cells
Opis:
Introduction. Cancer is a leading cause of mortality. Hepatocellular cancer is one of the malignancies associated with poor outcome and resistance to pharmacotherapy. Cancer stem cells (CSCs) contribute to resistance to therapy and hence lead to the treatment failure of tumors. Aim. This study aims to explore the expression of CSCs in response to cisplatin treatment in HepG2 hepatocellular cancer cell line. Material and methods. Cell proliferation test, CCK-8, was used to evaluate the cell proliferation following cisplatin treatment for 72 hours. The expressions of CSC markers CD44, CD90, and CD133 were assessed by flow cytometric analysis. Results. The results showed a dose-dependent decrease in cell proliferation and increased expression of CSC markers CD44 and CD90 in response to cisplatin. Conclusion. Understanding the roles of CSC markers may point to new targets and therapeutic strategies to predict and overcome cisplatin resistance.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 1; 18-22
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
BERBERINE INDUCES AUTOPHAGY, APOPTOSIS AND MODULATES MIR-155 IN HEAD AND NECK SQUAMOUS CARCINOMA CELLS.
Autorzy:
Xue, Kai
Zhang, Binbin
He, Jingchuan
Powiązania:
https://bibliotekanauki.pl/articles/895286.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
apoptosis
miR-155
Autophagy
berberine
Head and Neck cancer cells
Opis:
Berberine (BBR) an active natural plant alkaloid extracted from Coptidis rhizoma, displays potent anticancer activity over a variety of cancer cell lines. The cytotoxic activity of BBR in cancer cells is attributed to persuade, programmed cell death characterized by the release of cytochrome c, accompanied by activation of caspase-3 and caspase-9. In the present study, we evaluated BBR significantly reduces the cell viability and clonogenic property of head and neck squamous carcinoma (HNSC) cells. Our results revealed that BBR simultaneously induces apoptosis and autophagy in HNSC cells. Mechanistically, BBR induces autophagy in HNSC cells which were confirmed by acridine orange (AO) staining by visualization of prominent orange red color acidic autophagosomes in the cytoplasm. However, immunoblotting shows the steady conversion of MAP-LC-3I to LC-3II with concomitant degradation of autophagy substrate protein SQSTM1/p62. Annexin V FITC staining analysis by flow cytometry revealed a significant induction of apoptosis at higher doses of BBR. Furthermore, the immunoblotting analysis revealed a prominent cleavage of proapoptotic proteins procaspase-3 and PARP1 at higher doses of BBR. Additionally, we found significant upregulation and downregulation of tumor suppressor microRNA-155 (miR-155) and oncogenic miR-21 respectively, when HNSC cells were exposed to higher doses of BBR. In conclusion, these results demonstrate that BBR exhibits a significant anti-proliferative effect with the simultaneous induction of autophagy and apoptosis and modulates miRNA expression in HNSC cells.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 485-494
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation of clinico-pathologic data with inflammatory cells infiltration in colorectal cancer
Autorzy:
Grudzińska, M.
Jakubowska, K.
Kańczuga-Koda, L.
Kisielewski, W.
Famulski, W.
Smereczański, N.M.
Lomperta, K.
Płoński, M.A.
Rogoz-Jezierska, N.
Koda, M.
Powiązania:
https://bibliotekanauki.pl/articles/1918914.pdf
Data publikacji:
2020-06-10
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Colorectal cancer
inflammatory cells
fibrosis
Opis:
Introduction: Colorectal cancer (CRC) is the third most common cancer worldwide. At every phase of cancer development, the inflammatory process has an important impact. Accurate assessment inflammatory cells in the tumour environment in conjunction with clinico-pathologic features can be a relevant prognostic or predictive parameter. Purpose: To analyse inflammatory cell infiltration in CRC tumour mass and correlate with chosen clinico-pathologic parameters. Materials and methods: The study group consisted of 160 patients (64 women, 96 men) diagnosed with colorectal cancer who underwent surgery. Tissue material obtained from routine histopathological diagnosis was stained with H&E and used to assess the type of inflammatory cells in the invasive front and centre of the tumour. Results were subjected to statistical analysis with the age and gender of patients, tumour localization, tumour growth and size, TNM stage, adenocarcinoma type, fibrosis, necrosis, metastasis and tumour invasion (by the Spearman’s correlation coefficient test). Results: The presence of neutrophils in the invasive front of tumour mass was associated with fibrosis and inflammatory cell infiltration in the invasive front of tumour. Macrophages in the invasive front of tumour were found to correlate with tumour growth (expanding and infiltrate). Macrophages and eosinophils were associated with inflammatory cell infiltration in the invasive front and in the centre of tumour. Conclusions: The type of inflammatory cells in the invasive front or centre of the tumour may be useful to prognoses clinical features of colorectal cancer
Źródło:
Progress in Health Sciences; 2020, 10(1); 69-76
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High expression of CD133 – stem cell marker for prediction of clinically agressive type of colorectal cancer
Autorzy:
Kostovski, Ognen
Antovic, Svetozar
Trajkovski, Gjorgji
Kostovska, Irena
Jovanovic, Rubens
Jankulovski, Nikola
Powiązania:
https://bibliotekanauki.pl/articles/1391698.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
CD133
colorectal cancer
immunohistochemistry
stem cells
Opis:
Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. The cancer stem cell (CSC) markers are associated with aggressive cancer types and poor prognosis. The objective of the study was to evaluate the CD133 expression and to correlate it with clinicopathological features in patients with CRC. Material and Methods: Our study included ninety patients with CRC who underwent curative surgical resection from 2012 to 2017 at the University Clinic for Digestive Surgery, Skopje, North Macedonia. Tumor samples were first analyzed with standard histopathological methods and then the CD133 expression was investigated immunohistochemically. The level of expression of CD133 was classified semiquantitatively. Low positivity was defined as positive immunoreactivity in <50% of tumor glands, and high positivity was defined as positive immunoreactivity in ≥50% of tumor glands. Furthermore, clinicopathological features of patients were retrospectively reviewed. Results: High expression of CD133 was found in 47.8% of patients’ CRC samples. In 69.6% of patients with metastatic lesions in visceral organs we found high expression of CD133. We found statistically significant differences in the expression of CD133 between patients with and without visceral metastatic lesions (P = 0.0153), between patients with a different T category (P = 0.0119), N status (P = 0.0066) and grade (G) (P = 0.0115). Our results showed that the stage of disease has the greatest impact on expression of CD133 (P < 0.00001). Conclusion: High expression of CD133 is a useful marker for prediction of the clinically aggressive type of CRC and can be routinely implemented in standard pathohistological diagnostics.
Źródło:
Polish Journal of Surgery; 2020, 92, 3; 9-14
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of Doxorubicin Cytotoxicity by Isoliquiritin and Cynarin Combination on Different Cancer Cell Lines
Autorzy:
Al-AdamI, Salat G.
Al-Khateeb, EKBAL H.
NUMAN, NAWFAL A.
ABBAS, Mannal M.
Tawfiq, FATIMA A.
Shakya, Ashok K.
Powiązania:
https://bibliotekanauki.pl/articles/895633.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
doxorubicin
cancer cells
Modulation
Cynarin
Isoliquiritin
Opis:
Natural polyphenolic compounds produced by plant exhibit many pharmacological effects including antioxidant, chemopreventive as well as anticancer properties. This study was conducted to investigate the effect of cynarin ( from Artichoke, Cynara scolymus) and isoliquiritin (from Licorice, Glycyrrhiza uralensis) on doxorubicin (positive control) cytotoxicity in different cell lines including normal (Fibroblasts MCR-5 and Myoblasts H9c2) and cancer (colorectal HCT-116 and hepatocellular HEP-G2) cell lines. The cytotoxic effect of doxorubicin, isoliquiritin and cynarin alone or in different combination was studied on cancer cell lines as well as normal cell lines. The results obtained indicated that both cynarin and isoliquiritin enhance the cytotoxicity of doxorubicin. Both cynarin and isoliquiritin also reduce the cardiotoxicity of doxorubicin on normal cardiac cell lines. The combination of the three compounds (cynarin, isoliquiritin and doxorubicin) result in decrease the cytotoxicity of doxorubicin, which may indicate the presence of interaction and/or antagonism effect between cynarin and isoliquiritin. Cynarin was found to enhance the growth of (HCT-116 and HEP-G2) this might suggest avoiding use of Artichoke in subjects’ susceptibility for these cancers. All results were evaluated using statistical path and showed significant findings. The mechanism of enhanced doxorubicin’s cytotoxicity by cynarin or isoliquiritin also require further investigation to explain the increasing and/or the decreasing effect of these polyphenolic compounds on cytotoxicity of doxorubicin. The current finding can help to start with safe minimum dose of two or three combination of compounds in the context of clinical trials and practice.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 475-484
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface-modified SPION systems for cancer therapy
Autorzy:
Karewicz, Anna
Karnas, Karolina
Dulińska-Litewka, Joanna
Kapusta, Czesław
Lekka, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1844916.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
SPION systems
cancer therapy
tumor cells
system SPION
terapia
komórki rakowe
Źródło:
Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 13
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Trastuzumab Efficacy Quantified by Fluorine-19 Magnetic Resonance Imaging
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Czmil, Mrs Anna
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/895489.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
trastuzumab
magnetic resonance imaging
breast cancer cells
three-dimensional cell culture
Trastuzumab conjugates
Opis:
The purpose of this study was to conjugate Trastuzumab with fluorine-bearing PAMAM dendrimer to compare activities in three-dimensional (3D) cultured breast cancer cells with parent Trastuzumab. An in vitro study was performed to determine cellular responses to fluorinated Trastuzumab conjugates by Magnetic Resonance Imaging (MRI). Breast cancer cells were cultured in 3D geometry. Proton (1H) MRI and Fluorine-19 (19F) MRI were used for visualization of cellular locations within a Hollow Fiber Bioreactor (HFBR) device and to monitor the cellular response to treatment. The results of this study confirm that cell growth is significantly decreased following treatment with Trastuzumab conjugates. The use of fluorinated Trastuzumab conjugates decreases breast cancer cell growth in 3D cultures and allows for tracking of drug delivery to cancer cells via 19F.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 495-503
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of circulating tumour cells in the breast cancer using CytoTrack system
Autorzy:
Bogacz, A.
Wolek, M.
Górska, A.
Leporowska, E.
Procyk, D.
Kolenda, P.
Litwiniuk, M.
Uzar, I.
Gryszczyńska, A.
Łowicki, Z.
Czerny, B.
Powiązania:
https://bibliotekanauki.pl/articles/2048955.pdf
Data publikacji:
2019
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
circulating tumour cells
breast cancer
CytoTrack CT11
liquid biopsy
wolnokrążące komórki nowotworowe
rak piersi
CytroTrack CT11
płynna biopsja
Opis:
Introduction: Plants are a rich source of healing substances. Cancer is a leading cause of death worldwide while breast cancer is the most common cancer among women. Circulating tumour cells (CTCs) are potential founder cells for metastasis. Therefore, their assessment may be used for monitoring of treatment as well as detecting cancer metastatis. Hence, it is suggested that the number of CTCs may be a valuable tumour biomarker during therapy. Objective: The purpose of this study was to detect CTCs in breast cancer and to validate the method of assessment of CTC count using CytoTrack CT11 technology. Methods: MCF-7 cells were sorted by a FACSARIA flow cytometer from blood samples derived from patients who have not been diagnosed with cancer. Identification and quantitative assessment of MCF-7 cells in blood samples were determined by flow sorting. Then, blood samples containing MCF-7 cells or without MCF-7 were scanned with the use of an automated fluorescence scanning microscope. Results: In in vitro model analysing the glass CytoDisc™ with stained MCF-7 cells, we noted the correlation between the amount of observed tumour cells and expected number of tumour cells. Moreover, coefficient of variation in case of the recovery rate of the assumed number of MCF-7 cells was 30%, 17%, 18% and 15%, respectively. Conclusion: Our study suggest that CTCs could be predictive factor in patients with metastatic cancer especially in breast cancer.
Źródło:
Herba Polonica; 2019, 65, 4; 31-36
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of acupuncture TENS currents on the proliferation of cancer cells tested in vitro
Wpływ prądu TENS akupunkturowego na proliferację komórek nowotworowych w badaniach in vitro
Autorzy:
Pełczyńska, Marzena
Milczarek, Magdalena
Maciejewska, Magdalena
Wietrzyk, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1790857.pdf
Data publikacji:
2019-12-02
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
proliferation of cancer cells
in vitro assay
electrotherapy
physiotherapy
cancer
rehabilitation
proliferacja komórek nowotworowych
badania in vivo
elektroterapia
fizjoterapia
rehabilitacja
Opis:
Introduction: Transcutaneous Electrical Nerve Stimulation (TENS) is a very popular, non-pharmacological antianalgetic method. Nonetheless, knowledge on using this method is very limited in the treatment of patients with cancer anamnesis. Unfortunately, there are not many results of research referring to the application of this method. It is much more difficult to exclude the possibility of proneoplastic activity regarding these methods than to confirm this action. Aim: The aim of the study was to evaluate the influence of TENS currents on the proliferation of cancer cells tested in vitro. Materials and methods: The following human cell lines were used - A549, ES-2, HT29, MCF-7. The cells were plated 24 h before treatment. Then, the cells were exposed to AL-TENS currents (0.1 mA, 1.0 mA and 10 mA), t imp. 200μs; f 2 Hz, constant; duration: 20 min. The in vitro cytotoxic effects were examined after 96 h in SRB assay. In the other experiment, there were three expositions – 24, 48 and 72 hours from the beginning of the experiment. Results: In this assay, the acceleration of cancer cell proliferation after single or triple-dose expositions to AL-TENS currents was not observed. Conclusions: The AL-TENS current after repeated doses did not accelerate proliferation of cancer cells in in vitro conditions.
Wstęp: Przezskórna elektrostymulacja nerwów (TENS) jest szeroko stosowaną niefarmakologiczną metodą leczenia przeciwbólowego. Jednak wiedza na temat wpływu tej metody na proces nowotworowy jest fragmentaryczna. Dlatego też zastosowanie jej w leczeniu pacjentów po przebytej chorobie nowotworowej jest bardzo ograniczone. Niestety, w literaturze nie ma wielu wyników badań odnoszących się bezpośrednio do takich metod. Tym bardziej, że znacznie trudniej jest wykluczyć pronowotworową aktywność tych metod, niż ją potwierdzić. Cel pracy: Celem badań było sprawdzenie hipotezy o pobudzającym wpływie prądu TENS na proliferację komórek nowotworowych w warunkach in vitro. Materiał i metody: Badania przeprowadzono w oparciu o 96 godzinny test SRB proliferacji in vitro dla komórek linii nowotworowych: A549 (rak płuc); ES-2 (rak jajnika); HT29 (rak jelita grubego); MCF-7 (rak piersi). Komórki zostały poddane działaniu prądu TENS akupunkturowego o parametrach: 0,1 mA, 1 mA i 10 mA na dołek, czas impulsu 200μs, symetryczny, częstotliwość 2 Hz, stała, czas ekspozycji 20 min, w pojedynczej dawce po 24 godzinach lub w serii trzech ekspozycji po 24, 48 i 72 godzinach od początku eksperymentu. Wyniki: W wyniku przeprowadzonych badań uzyskano niewielkie zmiany proliferacji w badanych komórkach. Żadna ze zmian nie była statystycznie istotna, w szczególności nie obserwowano istotnego statystycznie przyspieszenia proliferacji. Wnioski: Ani pojedyncza ekspozycja na prąd TENS akupunkturowy, ani seria trzykrotnej ekspozycji nie powoduje istotnego przyspieszenia proliferacji komórek nowotworowych.
Źródło:
Medical Rehabilitation; 2019, 23(4); 42-46
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of Viburnum opulus polyphenolic compounds on metabolic activity and migration of HeLa and MCF cells
Autorzy:
Zakłos-Szyda, Małgorzata
Pawlik, Nina
Powiązania:
https://bibliotekanauki.pl/articles/105848.pdf
Data publikacji:
2019
Wydawca:
Centrum Badań i Innowacji Pro-Akademia
Tematy:
Viburnum opulus
polyphenols
cancer cells migration
mitochondrial potential
antioxidant effect
polifenole
migracja komórek rakowych
potencjał mitochondrialny
działanie przeciwutleniające
Opis:
In recent years, research of antitumor activity of natural compounds isolated from plant material has increased. Polyphenols have gained significant attention due to their proapoptotic abilities and their involvement in migration and inhibition of metastasis processes. The anticancer effects of polyphenolic extracts of Viburnum opulus fruit against human breast (MCF-7) and cervical (HeLa) cancer cell lines have been confirmed in this study. It was demonstrated that the tested preparations (methanol – M and acetone – A from pomace, juice – J and juice after extraction to the solid phase SPE – PF) show cytotoxic activity and regulate the migration process of cancer cells. The degree of inhibition of cell migration was measured at two times - 24 h and 48 h after addition of the tested preparations. The highest toxicity towards both cell lines was demonstrated by the polyphenol fraction obtained after juice purification SPE (IC50 values at concentration of 63,541 and 19,380 μg/mL for HeLa and MCF cell lines, respectively). At the same time, the same preparation inhibited cell migration the most (nearly 70% compared to controls at both times at the concertation of 15 and 30 μg/mL). All preparations showed the antioxidant ability, but the Viburnum opulus juice (200 and 350 μg/mL) and the preparation after its purification (15 and 30 μg/mL) have larger ability to inhibit the intracellular oxidative stress (30-40%) than preparation obtained from pomace (nearly by 20% at concentration of 20 and 50 μg/mL of M and A). Despite the antioxidative capacity of the preparations, they simultaneously decreased cellular mitochondrial potential. The results obtained indicate the high potential of components of Viburnum opulus polyphenolic compounds can be used in the production of innovative dietary supplements or pharmacological preparations for people with an increased risk or inclination towards developing breast or cervical cancer.
Źródło:
Acta Innovations; 2019, 31; 33-42
2300-5599
Pojawia się w:
Acta Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic and apoptosis inducing effect of some pyrano [3, 2-c] pyridine derivatives against MCF-7 breast cancer cells
Autorzy:
Rahnamay, Mohammad
Mahdavi, Majid
Shekarchi, Ali
Zare, Payman
Hosseinpour Feizi, Mohammad
Powiązania:
https://bibliotekanauki.pl/articles/1038367.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
apoptosis
pyrano-pyridine
breast cancer
MCF-7 cells
Opis:
Anti-cancer activities of some pyrano-pyridines have been previously reported. Herein, we investigated anti-proliferative and apoptotic effects of the novel pyrano [3, 2-c] pyridine (P.P, TPM.P, 4-CP.P and 3-NP.P) compounds against MCF-7 breast cancer cells. The MCF-7 cells were cultured in the presence of various concentrations (20-200 μM) of the tested compounds for 3 days and the cell viability was determined by MTT assay. Induction of apoptosis was qualitatively assayed by acridine orange/ethidium bromide (AO/EtBr) staining, DNA fragmentation assay, as well as quantitatively by Annexin V/PI double staining and cell cycle analysis. These compounds inhibited growth and proliferation of the MCF-7 cells in a dose- and time-dependent manner. The IC50 values of P.P, TPM.P, 4-CP.P and 3-NP.P after 24 h of exposure were calculated to be 100±5.0, 180±6.0, 60±4.0 and 140±5.0 μM, respectively. 4-CP.P was determined as the most potent compound and was chosen for further studies. The result of flow cytometric cell cycle analysis indicated an increase in sub-G1 population after 72 h treatment of the cells. Furthermore, this was accompanied by exposure of phosphatidylserine (PS) in the outer cell membrane after time course of treatment with the 4-CP.P. Based on these observations, the pyrano [3, 2-c] pyridines can be regarded as a valuable candidate for further pharmaceutical evaluations.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 397-402
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simvastatin modulates β-catenin/MDR1 expression on spheres derived from CF41.Mg canine mammary carcinoma cells
Autorzy:
Cruz, P.
Reyes, F.
Torres, C.G.
Powiązania:
https://bibliotekanauki.pl/articles/2087784.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
β-catenin
MDR1
simvastatin
canine mammary carcinoma cells
cancer stem cells
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 1; 95-99
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reactive oxygen species in BCR-ABL1-expressing cells - relevance to chronic myeloid leukemia
Autorzy:
Antoszewska-Smith, Joanna
Pawlowska, Elzbieta
Blasiak, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1038675.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
chronic myeloid leukemia
reactive oxygen species
DNA damage
DNA repair
cancer stem cells
imatinib resistance
Opis:
Chronic myeloid leukemia (CML) results from the t(9;22) reciprocal chromosomal translocation producing the BCR-ABL1 gene, conferring growth and proliferation advantages in the CML cells. CML progresses from chronic, often syndrome-free, to blast phase, fatal if not treated. Although the involvement of BCR-ABL1 in some signaling pathways is considered as the cause of CML, the mechanisms resulting in its progression are not completely known. However, BCR-ABL1 stimulates the production of reactive oxygen species (ROS), which levels increase with CML progression and induce BCR-ABL1 self-mutagenesis. Introducing imatinib and other tyrosine kinase inhibitors (TKIs) to CML therapy radically improved its outcome, but TKIs-resistance became an emerging problem. TKI resistance can be associated with even higher ROS production than in TKI-sensitive cells. Therefore, ROS-induced self-mutagenesis of BCR-ABL1 can be crucial for CML progression and TKI resistance and in this way should be taken into account in therapeutic strategies. As a continuous production of ROS by BCR-ABL1 would lead to its self-destruction and death of CML cells, there must be mechanisms controlling this phenomenon. These can be dependent on DNA repair, which is modulated by BCR-ABL1 and can be different in CML stem and progenitor cells. Altogether, the mechanisms of the involvement of BCR-ABL1 in ROS signaling can be engaged in CML progression and TKI-resistance and warrant further study.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 1-10
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Strategie odżywcze komórek nowotworowych – przegląd wybranych typów nowotworów z uwzględnieniem zmian w poziomie i wzorze ekspresji transporterów glukozy
Nutritional strategies of tumor cells – review of selected cancer types involving changes of expression level and pattern of glucose
Autorzy:
Gajek, K.
Wiatrak, B.
Ślęzak, A.
Ussowicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/261959.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Wydział Podstawowych Problemów Techniki. Katedra Inżynierii Biomedycznej
Tematy:
GLUT1
SGLT1
hipoksja
komórki nowotworowe
transport glukozy
hypoxia
cancer cells
glucose transport
Opis:
Zaburzona równowaga pomiędzy proliferacją a dojrzewaniem i różnicowaniem komórek nowotworowych powoduje szybki wzrost guza, prowadząc do zwiększenia zapotrzebowania na składniki odżywcze, m.in. glukozę i tlen. Pierwszą odpowiedzią komórek nowotworowych na niewystarczającą ilość składników odżywczych jest zmiana metabolizmu na beztlenowy (efekt Warburga). Glukoza niezbędna do przeprowadzenia tego procesu dostarczana jest za pomocą transporterów – najczęściej białek GLUT1 i SGLT1. Zmiana poziomu i wzoru ekspresji transporterów glukozy w komórkach nowotworowych w porównaniu z komórkami odpowiednich tkanek prawidłowych świadczy o adaptacji, do której doszło w obrębie guza. Dotychczasowe badania pozwoliły ustalić, w których rodzajach nowotworów dochodzi do zmian w ekspresji białek GLUT1 i SGLT1 oraz pokazały, że zmiany te mogą mieć bezpośredni związek z zaawansowaniem choroby i rokowaniem dla pacjentów. Niniejsza praca ma charakter przeglądowy i stanowi zestawienie zmian w poziomie ekspresji transporterów glukozy w niektórych typach nowotworów. Określenie poziomu ekspresji tych białek w komórkach nowotworowych może mieć kluczowe znaczenie dla spersonalizowanej terapii przeciwnowotworowej.
Due to imbalance between proliferation, differentiation and maturation, cancer cells grow rapidly and require elevated levels of oxygen and glucose. The main strategy of cancer cells is to prevent starvation is the anaerobic adaptation of cellular metabolism known as the Warburg’s effect. Increased glucose uptake is maintained by alterating the level and the pattern of glucose transporters expression, mainly GLUT1 and SGLT1. In many cancer types, these proteins are present despite their absence in healthy tissue. Previous researches revealed cancer types in which GLUT1 and SGLT1 expression are altered. There is a strong direct correlation between their expression pattern, cancer stage and prognosis for the patient. This review provides an overview of changes in the level of glucose transporters expression in some cancer types. Determination of glucose transporters expression levels in cancer cells could be crucial for personalized cancer treatment.
Źródło:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna; 2017, 23, 2; 133-146
1234-5563
Pojawia się w:
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 35

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