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Tytuł:
Effect of non-pharmacological treatment on pain in women with breast cancer
Wpływ leczenia niefarmakologicznego na ból u kobiet z nowotworem piersi
Autorzy:
Obročníkova, Andrea
Majerníková, Ľudmila
Hudáková, Anna
Powiązania:
https://bibliotekanauki.pl/articles/30148304.pdf
Data publikacji:
2024
Wydawca:
Akademia Bialska im. Jana Pawła II
Tematy:
non-pharmacological interventions
Yoga
pain treatment
acupuncture
pain
breast cancer
interwencje niefarmakologiczne
leczenie bólu
akupunktura
rak piersi
ból
Opis:
Pain is the most dreaded symptom of breast cancer that significantly affects the patient’s quality of life. The aim of this article was to present non-pharmacological interventions used to effectively manage pain in breast cancer patients. This is a review article; studies were researched in the PubMed database. Using the keywords: non-pharmacological AND intervention AND pain AND breast cancer OR breast neoplasms, 6 relevant studies were selected that met the specified criteria on non-pharmacological interventions for pain relief in women with breast cancer. Yoga, acupuncture and electroacupuncture in women with breast cancer appear to be promising non-pharmacological interventions in pain reduction. Other studies on cognitive-behavioral therapy and massage therapies have similarly demonstrated significant reductions in pain in women with breast cancer, whether induced by systemic therapy, hormone therapy, or surgery. Non-pharmacological interventions have been shown to be an appropriate adjunctive alternative in the management of pain in cancer patients, but can be applied alongside standard pharmacological treatment under professional supervision to improve the patient’s quality of life.
Ból jest najbardziej przerażającym objawem raka piersi, który w istotny sposób wpływa na jakość życia pacjentki. Celem artykułu było przedstawienie niefarmakologicznych interwencji stosowanych w skutecznym leczeniu bólu u osób z rakiem piersi. Artykuł ma charakter poglądowy; badania zostały wyselekcjonowane w bazie PubMed. Używając słów kluczowych: niefarmakologiczna ORAZ interwencja ORAZ ból ORAZ rak sutka/piersi LUB nowotwory sutka/piersi, wybrano 6 odpowiednich badań, które spełniały określone kryteria dotyczące niefarmakologicznych interwencji łagodzących ból u kobiet cierpiących na raka piersi. Joga, akupunktura i elektroakupunktura u kobiet chorych na raka piersi wydają się obiecującymi interwencjami niefarmakologicznymi w zmniejszaniu bólu. Inne badania dotyczące terapii poznawczo-behawioralnej i masażu wykazały podobnie istotną redukcję bólu u kobiet chorych na raka piersi, niezależnie od tego, czy jest on wywołany terapią ogólnoustrojową, terapią hormonalną czy zabiegiem chirurgicznym. Wykazano, że interwencje niefarmakologiczne stanowią odpowiednią alternatywę wspomagającą w leczeniu bólu u pacjentów chorych na nowotwory, ale można je stosować równolegle ze standardowym leczeniem farmakologicznym pod profesjonalnym nadzorem, w celu poprawy jakości życia pacjenta.
Źródło:
Health Problems of Civilization; 2024, 18, 1; 28-42
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the Quality of Life of Women after Mastectomy
Autorzy:
Bolach, Bartosz
Walowska, Jagoda
Juskowiak, Ewa
Stępień-Słodkowska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/32443961.pdf
Data publikacji:
2024
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
rehabilitation
mastectomy
breast cancer
quality of life
mental health
social function
Opis:
Purpose The most frequent cancer among women in Poland and worldwide is breast cancer. The aim of the study was to assess the quality of women's life after unilateral and bilateral breast amputation. Research process The study included 47 women - 24 women after bilateral amputation and 23 unilateral amputees. Two questionnaires were used: European Organization for Research and Treatment of Cancer - Quality of Life Questionnaire: general and breast cancer module to measure the quality of life of patients treated for cancer. Results From among the assessed areas of quality of life, the sphere of emotional functioning was significantly disturbed. The passage of time improved the quality of life of the surveyed women. Thanks to early detection and treatment survival time is extended, however the disease becomes a chronic disorder affecting the psychosomatic sphere that changes the quality of life of these women.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2024, 45; 55-64
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Uwarunkowania profilaktyki raka piersi w grupie kobiet z podejrzeniem nowotworu
Determinants of breast cancer prevention in a group of women with cancer suspicion
Autorzy:
Kwilosz, Edyta
Grzesik-Gąsior, Joanna
Dobrowolska, Patrycja
Powiązania:
https://bibliotekanauki.pl/articles/30147320.pdf
Data publikacji:
2024-03-20
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
rak piersi
profilaktyka
samobadanie piersi
zdrowie kobiet
breast cancer
prevention
breast self-examination
women’s health
Opis:
WSTĘP: W związku ze stałym wzrostem zachorowalności na raka sutka na świecie coraz ważniejsze staje się monitorowanie działań profilaktycznych oraz zwiększanie prozdrowotnej świadomości społeczeństw w zakresie nowotworów piersi, szczególnie w grupie osób, u których prawdopodobieństwo wystąpienia problemu onkologicznego jest duże. Celem badania była analiza wybranych czynników determinujących podejmowanie przez kobiety działań w zakresie profilaktyki raka piersi. MATERIAŁ I METODY: Badanie prowadzono metodą sondażu diagnostycznego wśród 121 kobiet, pacjentek poradni onkologicznej Podkarpackiego Ośrodka Onkologicznego w Brzozowie. Ocenie poddano wiedzę kobiet, wskaźniki socjodemograficzne oraz dodatni wywiad rodzinny w kierunku raka piersi. Narzędzie stanowił autorski kwestionariusz ankiety. Do weryfikacji hipotez wykorzystano test chi-kwadrat (χ2). Przyjęto poziom istotności p < 0,05. WYNIKI: Najczęstszym źródłem wiedzy na temat profilaktyki raka piersi był Internet (52,89%), a głównym powodem rezygnacji z badań profilaktycznych brak świadomości o zagrożeniu, jakie niesie ze sobą choroba (38,84%). U ponad 30% badanych stwierdzono niski poziom wiedzy, który był zróżnicowany statystycznie w zależności od wykształcenia (p < 0,001) oraz wieku badanych (p = 0,01). Kobiety młodsze oraz lepiej wykształcone wykazywały wyższy poziom wiedzy, który był związany z regularnością podejmowanych działań profilaktycznych (p = 0,048) oraz wykonywaniem samobadania piersi (p < 0,001). Wystąpienie raka piersi w rodzinie miało wpływ na regularność samobadania oraz wykonywanie badań diagnostycznych w kierunku raka piersi (p < 0,001). WNIOSKI: Poziom wiedzy na temat profilaktyki raka piersi w badanej grupie nie był w pełni zadowalający i wymaga uzupełnienia. Wskazanie przez kobiety Internetu jako głównego źródła wiedzy wskazuje na konieczność zwiększenia udziału specjalistów medycznych w edukacji onkologicznej. Najważniejszymi predyktorami regularnie podejmowanych działań profilaktycznych są młody wiek, wyższy poziom wiedzy, wyższe wykształcenie oraz dodatni wywiad rodzinny (nowotwór piersi).
INTRODUCTION: Due to constant increase incidence of breast cancer in the world, the most important aspect is monitoring of preventive actions and increasing the health awareness of breast cancer in societies, especially in the group of people with high probability of oncological problems. The aim of the study was to analyze selected factors determining women’s uptake of breast cancer prevention activities. MATERIAL AND METHODS: The study was conducted by diagnostic survey among 121 women, patients of the oncology clinic in Brzozów. Women’s knowledge, sociodemographic indicators and positive family history of breast cancer were assessed. Research tool was the proprietary questionnaire. The chi-square (χ2) test was used to verify the hypotheses. A significance level of p < 0.05 was assumed. RESULTS: The most common source of knowledge about breast cancer prevention was the Internet (52.89%), and the main reason for forgoing preventive examinations was lack of awareness of the disease’s risks (38.84%). Over 30% of the respondents had a low level of knowledge which was statistically diverse in terms of education (p < 0.001) and respondents age (p = 0.01). Younger and better educated women have a higher level of knowledge, which was related to the regularity of preventive actions (p = 0.048) and breast self-examination (p < 0.001). The occurrence of breast cancer in the family was impact to regulary self-examination and diagnostic tests (p < 0.001). CONCLUSIONS: The level of knowledge in the term of breast cancer prevention wasn’t satisfactory and need supplementing. The most frequently indicated source of information was Internet what show need to increase the participation of medical specialists in oncology education. The most important predictors of taking regularly preventive actions were young age, higher level of knowledge, higher education and a positive family history (breast cancer).
Źródło:
Annales Academiae Medicae Silesiensis; 2024, 78; 73-81
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Emotional and social functioning aspects of women undergoing chemotherapy and mastectomy with varied time elapses from treatment completion
Autorzy:
Bury-Kamińska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/28763504.pdf
Data publikacji:
2023-07-11
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
quality of life
depression
chemotherapy
mastectomy
breast cancer
Opis:
The aim of the study was a comparison of two groups of women who suffered from breast cancer in the past, selected on the basis of the time elapsed since treatment completion (<7 and >7 years). The specific areas of interest were the quality of life, sense of control, and level of depression. Results from 37 women were analysed. The average age in the research sample was 57. The study was conducted with the use of EORTC QLQ-C30, MHLC, and Depression Assessment Questionnaire. Women in whose case the time elapsed since the completion of anticancer treatment is no more than 7 years have a more negative assessment of the quality of life aspects, that is physical and social functioning, in comparison to persons in whose case the adaptation time to changes, following cancer and treatment, is longer (more than 7 years). The studied persons with a shorter period elapsed since the completion of anticancer therapy hold stronger beliefs concerning their own influence on their health in comparison to women who have not undergone oncological treatment for at least 7 years. The author’s own research highlights the trend pertaining to the differences in the intensity of experiencing guilt and anxiety between the groups. However, it requires further research involving a larger group of studied patients. Despite the progress in the diagnostics and treatment of breast cancer, patients with this type of cancer still experience long-term subjective difficulties in areas making up their physical, mental, and social well-being. The research proves the differences in functioning of women depending on the time that has elapsed since the completion of anticancer treatment.
Źródło:
Acta Neuropsychologica; 2023, 21(3); 237-250
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ensemble of classifiers based on deep learning for medical image recognition
Autorzy:
Gil, Fabian
Osowski, Stanisław
Świderski, Bartosz
Słowińska, Monika
Powiązania:
https://bibliotekanauki.pl/articles/2203370.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
breast cancer
CNN
deep learning
ensemble of classifiers
feature selection
melanoma
Opis:
The paper presents special forms of an ensemble of classifiers for analysis of medical images based on application of deep learning. The study analyzes different structures of convolutional neural networks applied in the recognition of two types of medical images: dermoscopic images for melanoma and mammograms for breast cancer. Two approaches to ensemble creation are proposed. In the first approach, the images are processed by a convolutional neural network and the flattened vector of image descriptors is subjected to feature selection by applying different selection methods. As a result, different sets of a limited number of diagnostic features are generated. In the next stage, these sets of features represent input attributes for the classical classifiers: support vector machine, a random forest of decision trees, and softmax. By combining different selection methods with these classifiers an ensemble classification system is created and integrated by majority voting. In the second approach, different structures of convolutional neural networks are directly applied as the members of the ensemble. The efficiency of the proposed classification systems is investigated and compared to medical data representing dermoscopic images of melanoma and breast cancer mammogram images. Thanks to fusion of the results of many classifiers forming an ensemble, accuracy and all other quality measures have been significantly increased for both types of medical images.
Źródło:
Metrology and Measurement Systems; 2023, 30, 1; 139--156
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical Simulation of Breast Cancer in the Early Diagnosis with Actual Dimension and Characteristics Using Photoacoustic Tomography
Autorzy:
Ahangar Darband, Maryam
Najafi Aghdam, Esmaeil
Gharibi, Arash
Powiązania:
https://bibliotekanauki.pl/articles/31339923.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
photoacoustic
PA
photoacoustic imaging
PAI
photoacoustic tomography
breast cancer
early diagnosis
Opis:
A numerical study and simulation of breast imaging in the early detection of tumors using the photoacoustic (PA) phenomenon are presented. There have been various reports on the simulation of the PA phenomenon in the breast, which are not in the real dimensions of the tissue. Furthermore, the different layers of the breast have not been considered. Therefore, it has not been possible to rely on the values and characteristics of the resulting data and to compare it with the actual state. Here, the real dimensions of the breast at three-dimensional and different constituent layers have been considered. After reviewing simulation methods and software for different stages of the PA phenomenon, a single suitable platform, which is commercially available finite element software (COMSOL), has been selected for simulating. The optical, thermal, elastic, and acoustic characteristics of different layers of breast and tumor at radiated laser wavelength (800 nm) were accurately calculated or obtained from a reliable source. Finally, by defining an array of 32 ultrasonic sensors on the breast cup at the defined arcs of the 2D slices, the PA waves can be collected and transmitted to MATLAB software to reconstruct the images. We can study the resulting PA wave and its changes in more detail using our scenarios.
Źródło:
Archives of Acoustics; 2023, 48, 1; 25-38
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Practicing Sport in the Age Group 21-34 and the Risk of Breast Cancer - Analysis of the Results of a Retrospective Study
Autorzy:
Kładna, Aleksandra
Skołozdrzy, Tomasz
Wojciechowski, Jan
Tadaj, Bartosz
Kawka, Martyna
Kellas, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/24202860.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
breast cancer
retrospective study
physical activity
prevention
Opis:
Breast cancer is the most common malignant tumor in women, so it is important to study the factors that can protect against it. One of them is physical activity, which has become the area of our interest, especially the practice of sports by women aged between 21 and 34. The aim of this retrospective study was to check how practice of sport in the age group of 21-34 in women from the research group diagnosed with breast cancer and in the control group (healthy women from families burdened with this cancer) influences the risk of developing breast cancer. The study showed that healthy women from families with a burden of breast cancer practiced sports in the age range 21-34 more frequently and intensively than women who had a history of breast cancer. (Sport 1-highest intensity P = 0.002 Sport 2-medium intensity P < 0.001 Sport 3-the lowest intensity P < 0.001.) It can be concluded that practicing sport in the age group of 21-34 is an important factor in the prevention of breast cancer, although the influence of other protective factors in women from the control group cannot be ruled out.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2023, 43; 53-61
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of Life of Women with Breast Cancer and Support of Self-Help Groups: Pilot Study
Jakość życia kobiet z rakiem piersi i wsparcie grup samopomocowych: badanie pilotażowe
Autorzy:
Majerníková, Ľudmila
Obročníková, Andrea
Hudáková, Anna
Powiązania:
https://bibliotekanauki.pl/articles/24987736.pdf
Data publikacji:
2023-12-19
Wydawca:
Akademia Bialska im. Jana Pawła II
Tematy:
social support
breast cancer
oncology
quality of life
nursing
wsparcie społeczne
rak piersi
onkologia
jakość życia
pielęgniarstwo
Opis:
Background. Assessment of quality of life (QoL) is important for cancer survival and can be influenced by positive social support. The aim of the study was to compare the QoL of patients with breast cancer in terms of using the support of a self-help group (SG) in relation to quality of life. Material and methods. The research group consisted of 135 respondents, who were the patients with malignant breast cancer. The first comparative sample of respondents, who did not attend the SG, was numbered 70. The second comparative sample of respondents, who attended the SG, consisted of 65 patients. Results. In mental health QoL, body image was rated better in patients who attended the SG; in relationship QoL, positive significance was shown in the sphere of sexual life and social support in the SG patients. In the environmental area, QoL was statistically significant in the availability of health services in favor of the SG patients. When comparing the individual domains of the questionnaire, we found more significant differences in the sphere of mental experience and social relationships for the SG patients. Conclusions. Social intervention has a positive effect on treatment outcome, length of life and the life quality of breast cancer survivors and contributes significantly to coping with changes in social ties, sexual intimacy in marriages and partnerships, family relationships and has a positive effect on improving mental and physical health.
Wprowadzenie. Ocena jakości życia (JŻ) jest ważna dla przeżywalności nowotworu i może być kształtowana za sprawą pozytywnego wsparcia społecznego. Celem badania było porównanie jakości życia pacjentek z rakiem piersi w zakresie korzystania ze wsparcia grupy samopomocowej (GS) w odniesieniu do jakości życia. Materiał i metody. Grupa badawcza składała się ze 135 respondentek, które były pacjentkami z nowotworem złośliwym piersi. Pierwsza próba porównawcza respondentek, które nie uczestniczyły w GS, liczyła 70 osób. Druga próba porównawcza respondentek, które uczestniczyły w GS, składała się z 65 pacjentek. Wyniki. Jeśli chodzi o JŻ w aspekcie zdrowia psychicznego, postrzeganie własnego ciała było lepiej oceniane przez te pacjentki, które uczęszczały na spotkania GS, a jeśli chodzi o JŻ w aspekcie relacji, w grupie pacjentek z GS wykazano pozytywne znaczenie w sferze życia seksualnego i wsparcia społecznego. W sferze środowiskowej JŻ była statystycznie znacząco lepsza wśród pacjentek z GS, jeśli chodzi o dostępność świadczeń zdrowotnych. Porównując poszczególne partie kwestionariusza stwierdziliśmy bardziej znaczące różnice w sferze doświadczeń psychicznych i relacji społecznych u pacjentek z GS. Wnioski. Interwencja społeczna ma pozytywny wpływ na wynik leczenia, długość życia i jakość życia osób, które przeżyły raka piersi i znacznie przyczynia się do radzenia sobie ze zmianami więzi społecznych, intymności seksualnej w małżeństwie i związkach partnerskich, relacji rodzinnych, jak również ma pozytywny wpływ na poprawę zdrowia psychicznego i fizycznego.
Źródło:
Health Problems of Civilization; 2023, 17, 4; 318-327
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of chemo-induced menopause on the quality of life of young women with non-metastatic breast cancer in Algeria
Autorzy:
Bedhrani, Imene
Nesrine, Sidi Mousa
Mulondo, Samuel
Powiązania:
https://bibliotekanauki.pl/articles/3200748.pdf
Data publikacji:
2023-01-24
Wydawca:
Medical Education
Tematy:
breast cancer
chemo-induced menopause
quality of life
young women
Opis:
Background: Breast cancer is the most common cancer in females worldwide. Young women with breast cancer are treated with chemotherapy, which may exhibit gonadotoxicity thus inducing chemo- induced menopause with a risk of deterioration in their quality of life. Method: A prospective study first of its kind in Algeria was carried out on 57 patients aged between 30 and 49 years that went for consultation at the oncology department of Pierre and Marie Curie Medical Centre Algiers. The medical files obtained and criteria of questionnaires: Quality of Life Questionnaire for Breast Cancer (QLQ-BR23) and the Quality of Life Questionnaire-Core 30 (QLQ-C30) were used to assess the quality of life in patients. Results: From the medical files, patients had a dominant histological type of invasive ductal carcinoma at 96% and Scarff-Bloom-Richardson (SBR) II grade and luminal B profile were the most frequent. The (QLQ-C30) having averages of global health status, symptom score, and functional score with 56.34, 63.7, and 45.75 respectively. QLQ-BR23 having averages for symptom, functional score of 61.6 and 49.71 respectively. Conclusion: Chemotherapy induces gonadotoxicity, which results in chemo-induced menopause that has a negative impact on the quality of life of young women. QLQ-BR23 is more suitable than QLQ-C30 to access the context of this study.
Źródło:
OncoReview; 2022, 12, 4; 69-74
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of silver nanoparticles on the process of epithelial transition in the context of cancer metastases
Autorzy:
Matysiak-Kucharek, Magdalena
Sawicki, Krzysztof
Kurzepa, Jacek
Wojtyła-Buciora, Paulina
Kapka-Skrzypczak, Lucyna
Powiązania:
https://bibliotekanauki.pl/articles/28411038.pdf
Data publikacji:
2023-12-29
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
breast cancer
metastasis
silver nanoparticles
nanotoxicology
epithelial-mesenchymal transition
MDA-MB-436
Opis:
Background Exposure to nanoparticles (NPs) can occur in a variety of occupational situations. Ultrafine particles of natural and anthropological origin toxicity has been described in epidemiological studies. Meanwhile, the risks associated with NPs exposure are not comprehensively assessed. A wide spectrum of NPs toxicity has been demonstrated, mainly through the induction of oxidative stress and inflammatory mediators. Among the newly described mechanisms of NPs toxicity is the induction of fibrosis via the epithelial-mesenchymal transition (EMT), which is also a key mechanism of cancer metastasis. The effect of NPs on EMT in the context of metastasis has not been sufficiently described so far, and the results of studies do not allow for the formulation of unambiguous conclusions. Therefore, the aim of the work was to determine the biological activity of silver NPs against MDA-MB-436 triple-negative breast cancer cells. Material and Methods Reverse transcription real-time polymerase chain reaction was used to examine mRNA expression of EMT markers. The QCM Chemotaxis Cell Migration Assay and QCM ECMatrix Cell Invasion Assay were used to assess the level of cell migration and invasion. The tumor growth factor beta 1 (TGF-beta 1) secretion was determined by the immunoenzymatic method using the Human TGF-beta 1 ELISA Kit. Results Silver nanoparticles (AgNPs) cause a statistically significant increase in relative expression of all tested mesenchymal EMT markers – cadherin 2, vimentin, matrix metalloproteinase 2 and matrix metalloproteinase 9. At the same time, reduction of epithelial cadherin 1 expression was observed. The level of MDA-MB-436 migration and TGF-beta 1 secretion was slighty increased in AgNPs-treated cells, with no influence on invasion potential. Conclusions Potentially prometastatic effect of AgNPs encourages further work on the safety of nanomaterials.
Źródło:
Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 6; 541-548
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy. Workers’ Health and Safety
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ radioterapii na jakość życia pacjentek w trakcie leczenia nowotworu piersi w zakładzie radioterapii we Włocławku
The impact of radiotherapy on the quality of life of patients during breast cancer treatment at the Radiotherapy Department in Włocławek
Autorzy:
Kurtys, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/18797162.pdf
Data publikacji:
2023-09-29
Wydawca:
Państwowa Akademia Nauk Stosowanych we Włocławku
Tematy:
jakość życia
rak piersi
radioterapia
leczenie systemowe
powikłania radioterapii
quality of life
breast cancer
radiotherapy
systemic treatment
complications of radiotherapy
Opis:
Wstęp. Radioterapia tak jak i inne metody leczenia onkologicznego wiążą się ze znaczącym pogorszeniem codziennego funkcjonowania chorych we wszystkich sferach życia. Cel. Celem pracy była ocena wpływu radioterapii na jakość życia pacjentek w trakcie leczenia nowotworu piersi. Materiał i metody. Materiał badawczy, który posłużył do opracowania pracy uzyskano korzystając z metody badawczej jaką jest sondaż diagnostyczny. Badaniem objęto kobiety w trakcie leczenia nowotworu piersi w wieku od 18 do 70 roku życia. Badania przeprowadzono w terminie od 01.09- 30.10.2022 roku. W pracy oparto się na ankiecie własnej i wykorzystano standaryzowane kwestionariusze EORTC QLQ-C30 i EORTC QLQ-BR2. Wyniki. W trakcie radioterapii pacjentki wskazywały na znaczne problemy podczas wykonywania męczących czynności. Odczuwały również znaczne ograniczenia podczas wykonywanej pracy i przy realizowaniu hobby. Podczas radioterapii kobiety trochę odczuwały problemy związane z funkcjonowaniem poznawczym. Radioterapia wpłynęła na funkcjonowanie społeczne i emocjonalne pacjentek. Naświetlanie znacznie wpłynęło na odczuwanie bólu, duszności, trudności ze snem, brak apetytu, zaparcia, biegunki i na kłopoty finansowe. Wystąpiły także efekty uboczne leczenia. Wnioski. Badania wykazały, że jakość życia pacjentek uległa zmianie podczas radioterapii i w znacznym stopniu uległa pogorszeniu w aspekcie poznawczym, emocjonalnym i społecznym.
Introduction. Radiotherapy, like other oncological treatment methods, is associated with a significant deterioration in the daily functioning of patients in all spheres of life. Aim. The aim of the study was to assess the impact of radiotherapy on the quality of life of patients during breast cancer treatment. Material and methods. The research material that was used to develop the work was obtained using the research method, which is a diagnostic survey. The study included women undergoing breast cancer treatment between the ages of 18 and 70. The research was carried out from 01.09 to 30.10.2022. The paper was based on a self-survey and standardized questionnaires EORTC QLQ-C30 and EORTC QLQ-BR2 were used. Results. The assumed hypotheses were confirmed. During radiotherapy, patients indicated significant problems when performing strenuous activities. They also felt significant limitations during their work and hobbies. During radiation therapy, women experienced some problems related to cognitive functioning. Radiation therapy affected the social and emotional functioning of the patients. Radiation significantly affected the sensation of pain, shortness of breath, difficulty sleeping, lack of appetite, constipation, diarrhoea and financial problems. There were also side effects of the treatment. Conclusions. The study showed that the patients' quality of life changed during radiotherapy and significantly deteriorated cognitively, emotionally, and socially.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2023, 8, 3; 7-28
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-breast cancer potential of honey: a narrative review
Autorzy:
Qadirifard, Mohammad Sadegh
Fathabadi, Amirhossein
Hajishah, Hamed
Gholami, Kosar
Abbasi, Mohammadmehdi
Sami, Nafiseh
Zo, Mostafa Mahmoudi
Kadkhodaei, Fateme
Sina, Mahla
Ansari, Arina
Rahimi, Zahra
Deravi, Niloofar
Powiązania:
https://bibliotekanauki.pl/articles/2047807.pdf
Data publikacji:
2022-03-31
Wydawca:
Medical Education
Tematy:
honey
breast cancer
anticancer
complementary medicine
Opis:
Cancer is responsible for the death of millions of people all around the world. Among the large group of cancers, the prevalence of breast cancer is highest in women. Therapeutic interventions, including removal surgery, radiation therapy, hormone therapy, and chemotherapy which is largely used, may cause adverse effects on the quality of patients’ life. This fact has encouraged researchers to find natural substances such as honey to overcome harmful effects. Nowadays, honey is recommended for plenty of abnormalities because of its antioxidant, anti-inflammatory, and antimicrobial properties. Various studies have been conducted to explore the anticancer benefits of different types of honey from different origins. In this review, we are going to summarize in-vitro, animal, and human studies on the anti-breast cancer potential of honey.
Źródło:
OncoReview; 2022, 12, 1; 5-15
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cancer therapeutics strategy using nano-carrier mediated natural drugs
Autorzy:
Shaw, S.
Singh, P.
Mishra, R.
Singh, R.
Nayak, R.
Bose, S.
Powiązania:
https://bibliotekanauki.pl/articles/2201053.pdf
Data publikacji:
2022
Wydawca:
Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
Tematy:
breast cancer
porous silicon nanocarrier
quercetin
nucleolin
targeted therapy
rak piersi
krzem porowaty
nanonośniki
kwercetyna
terapia celowana
Opis:
Purpose Nucleolin is a multifactorial protein, having a significant role in chromatin remodelling, mRNA stability, ribosome biogenesis, stemness, angiogenesis, etc., thus, it is potential therapeutic target in cancer. The purpose of this paper is to study porous silicon (pSi) nanocarrier-based natural drug delivery system targeting dysregulated nucleolin expression for cancer therapeutics. Design/methodology/approach Quercetin was loaded in pre-synthesized and characterized pSi nanoparticles, and release kinetics was studied. The study compared the inhibitory concentration (IC50) of quercetin, synthetic drug doxorubicin, and quercetin-loaded pSi nanoparticles. Further, mRNA expression of a target gene, nucleolin, was tested with a quercetin treated breast cancer cell line (MCF-7). Findings Quercetin-loaded pSi nanoparticles followed first-order release kinetics. IC50 was determined at concentrations of 312 nM, 160 µM, and 50 µM against doxorubicin, quercetin, and quercetin-loaded pSi nanoparticles, respectively. The results further indicated 16-fold downregulation of nucleolin mRNA expression after 48h of quercetin treatment of exponentially growing MCF-7 cells. Research limitations/implications Whether pSi nanoparticle loaded quercetin can significantly downregulate nucleolin protein expression and its impact on apoptosis, cell proliferation, and angiogenic pathways need further investigation. Practical implications The practical application of the proposed nanocarrier-based drug delivery system potentially lays out a path for developing targeted therapy against nucleolin-dysregulated cancer using natural products to minimize the side effects of conventional chemotherapeutic drugs. Originality/value Inhibition of nucleolin and nucleolin regulated pathways using natural compounds and its targeted delivery with nanocarrier is not yet done.
Źródło:
Journal of Achievements in Materials and Manufacturing Engineering; 2022, 114, 1; 32--41
1734-8412
Pojawia się w:
Journal of Achievements in Materials and Manufacturing Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histopathology image classification using hybrid parallel structured DEEP-CNN models
Autorzy:
Dsouza, Kevin Joy
Ansari, Zahid Ahmed
Powiązania:
https://bibliotekanauki.pl/articles/2097423.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
breast cancer CNN
loss
accuracy
precision
confusion matrix
Opis:
The healthcare industry is one of the many out there that could majorly benefit from advancement in the technology it utilizes. Artificial intelligence (AI) technologies are especially integral and specifically deep learning (DL); a highly useful data-driven technology. It is applied in a variety of different methods but it mainly depends on the structure of the available data. However, with varying applications, this technology produces data in different contexts with particular connotations. Reports which are the images of scans play a great role in identifying the existence of the disease in a patient. Further, the automation in processing these images using technology like CNN-based models makes it highly efficient in reducing human errors otherwise resulting in large data. Hence this study presents a hybrid deep learning architecture to classify the histopathology images to identify the presence of cancer in a patient. Further, the proposed models are parallelized using the TensorFlow-GPU framework to accelerate the training of these deep CNN (Convolution Neural Networks) archi-tectures. This study uses the transfer learning technique during training and early stopping criteria are used to avoid overfitting during the training phase. these models use LSTM parallel layer imposed in the model to experiment with four considered architectures such as MobileNet, VGG16, and ResNet with 101 and 152 layers. The experimental results produced by these hybrid models show that the capability of Hybrid ResNet101 and Hybrid ResNet152 architectures are highly suitable with an accuracy of 90% and 92%. Finally, this study concludes that the proposed Hybrid ResNet-152 architecture is highly efficient in classifying the histopathology images. The proposed study has conducted a well-focused and detailed experimental study which will further help researchers to understand the deep CNN architectures to be applied in application development.
Źródło:
Applied Computer Science; 2022, 18, 1; 20--36
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ionizing radiation and volumetric mammographic density
Autorzy:
Pepłońska, Beata
Mirowski, Mateusz
Kałużny, Paweł
Domienik-Andrzejewska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/2152984.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
breast cancer
ionizing radiation
mammography
effective dose
mammographic density
organ dose
Opis:
Objectives Mammographic density (MD) refers to the percentage of dense tissue of an entire breast and was proposed to be used as a surrogate marker for breast cancer. High-dose ionizing radiation (IR) has been recognized as a breast cancer risk factor. The aim of our study was to investigate association between lifetime low dose ionizing radiation (LDIR) and MD. Material and Methods A cross-sectional study included 467 women aged 40–60 years who underwent screening mammography in Łódź, Poland. The digital mammography examination of the breasts included both craniocaudal and mediolateral oblique views. The volumetric breast density (VBD) (%) and fibrograndular tissue volume (FG) (cm3) were determined based on the analysis of mammographic image (“for processing”) using Volpara Imaging Software. The exposure to IR was estimated for each individual, based on the data from interviews about diagnostic or therapeutic medical procedures performed in the area of the neck, chest, abdomen and spine, which involved X-rays and γ rays and the data about the doses derived from literature. Linear and logistic regression were fitted with VBD and FG as the outcomes and organ breast dose, effective dose and number of mammographies as the determinants, adjusted for major confounders. Results The analyses showed no association between VBD or FG and the breast organ dose or the effective dose. The only significant finding observed concerned the association between the number of mammographies and the FG volume with β coefficient: 0.028 (95% CI: 0.012–0.043), and predicted mean FG volume >13.4 cm3 among the women with >3 mammographies when compared to those with none. Conclusions This study does not, in general, provide support for the positive association between LDIR and MD. The weak association of the FG volume with the number of mammographies warrants further verification in larger independent studies.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 5; 635-649
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 236

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