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Tytuł:
Caring for patients with Huntington disease - a survey of caregivers’ experiences and views
Autorzy:
Domaradzki, J.
Powiązania:
https://bibliotekanauki.pl/articles/3577.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Tematy:
carer
patient
human disease
neurodegenerative disease
Huntington's disease
brain disease
behavioural disturbance
experience
Opis:
Introduction. Despite the growing interest in the consequences of caring for patients with Huntington disease (pHD), little is known about the family caregivers of such patients in Poland. Identification of their needs can improve caregivers’ wellbeing, the quality of care and condition of pHD. The aim of this study was to understand the social functioning of family caregivers of pHD and their perception of the caregiving role. Materials and methods. Data was collected from 55 family caregivers of pHD. A structured questionnaire was used consisting of 86 questions subsumed into five domains: ‘Problems’ and ‘Feelings related to caregiving’, ‘Attitude toward caregiving’, ‘Satisfaction with life’ and ‘Perception of healthcare services’. Correlations between the different scales and other characteristics were measured as potential predictors of the burden. Non-parametric statistical methods were used in the analysis. Results. Most respondents experienced a high (50.9%) or moderate (30.95%) feeling of burden. Although 70.9% of caregivers perceived caregiving positively, for many it was a source of negative feelings. Only 10.9% of respondents declared that caregiving decreased their QoL. Carers’ perception of caregiving was mostly influenced by their negative experiences with the healthcare system. Respondents’ domicile, religious practices, age, income, marital status, time of diagnosis and of caregiving, patient’s age and stage of disease also influenced their experiences. Conclusions. Health professionals and policy planners should focus on monitoring caregivers’ health, identifying their needs, sources of distress, and supporting caregivers’ coping strategies. They should also be better educated about the clinical and practical aspects of HD.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2015, 09, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of Curcuma longa extract on the expression level of brain transporters in in vivo model
Autorzy:
Bukowska, M.
Bogacz, A.
Wolek, M.
Mikolajczak, P.L.
Olbromski, P.
Kaminski, A.
Czerny, B.
Powiązania:
https://bibliotekanauki.pl/articles/71600.pdf
Data publikacji:
2019
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
Curcuma longa
plant extract
expression level
brain
blood brain barrier
in vivo model
natural substance
synthetic substance
brain disease
treatment
Opis:
Introduction: Blood brain barrier and multidrug resistance phenomenon are subjects of many investigations. Mainly, because of their functions in protecting the central nervous system (CNS) by blocking the delivery of toxic substances to the brain. This special function has some disadvantages, like drug delivery to the brain in neurodegenerative diseases. Objective: The aim of this study was to examine how natural and synthetic substances affect the expression levels of genes (Mdr1a, Mdr1b, Mrp1, Mrp2, Oatp1a4, Oatp1a5 and Oatp1c1) that encode transporters in the blood-brain barrier. Methods: cDNA was synthesized from total RNA isolated from rat hippocampus. The expression level of genes was determined using real-time PCR (RT-PCR) method. Results: Our findings showed that verapamil, as a synthetic substance, caused the greatest reduction of mRNA level of genes studied. The standardized extract of Curcuma longa reduced the expression level for Mrp1 and Mrp2, whereas the increase of mRNA level was observed for Mdr1b, Oatp1a5 and Oatp1c1. Conclusions: These results suggests that herbal extracts may play an important role in overcoming the blood brain barrier during pharmacotherapy
Źródło:
Herba Polonica; 2019, 65, 1
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Psychiczno-moralne i społeczne skutki pornografii
Pornography and its implications for the mental, moral and social life
Autorzy:
Stelmach, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1047035.pdf
Data publikacji:
2020-06-30
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
pornography
brain disease
chemical changes in the brain
social implications of pornography
the cultural changes
the society of the future
pornografia
choroba mózgu
chemiczne zmiany w mózgu
społeczne skutki pornografii
zmiany w kulturze
społeczeństwo przyszłości
Opis:
Społeczne skutki pornografii są rzadko przedmiotem badania. Praca o psychicznych i społecznych skutkach pornografii stanowi syntezę konsekwencji emocjonalnych z ich przełożeniem na skutki społeczne. Połączenie tych płaszczyzn pokazuje rzeczywiste zagrożenie, jakie niesie za sobą masowa konsumpcja pornografii w dzisiejszych czasach. W pracy dokonano przeglądu prac naukowych z ostatnich lat, jakie ukazały się w literaturze. Wykazano też, jak niewiele tych informacji funkcjonuje w świadomości powszechnej. Stanowi to swoiste ostrzeżenie dla współczesnego człowieka. 
There are not many studies concerning the social implications of pornography. This paper shows how variuos implications of pronography are linked to each other; how its emotional consequences contribute to its social consequences. This aspect of pornography is commonly ingnored which makes it particularly dangerous. The paper also reviews what was recently written about pronography from this point of view. Thus it may be a form of an alert for the man who lives in the present western society.
Źródło:
Teologia i moralność; 2020, 15, 1(27); 121-134
1898-2964
2450-4602
Pojawia się w:
Teologia i moralność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of ademetionine and ipidacrine/phenibut on the NCAM distribution and behavior in the rat model of drug-induced liver injury
Autorzy:
Muraviova, Diana
Kharchenko, Yuliia
Pierzynowska, Kateryna
Pierzynowski, Stefan
Wolinski, Jarek
Dyomshyna, Olga
Zhyliuk, Volodymyr
Ushakova, Galyna
Powiązania:
https://bibliotekanauki.pl/articles/2038253.pdf
Data publikacji:
2020-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
ademetionine
brain
ipidacrine/phenibut, isoniazi
liver disease
NCAM
rifampicin
Opis:
Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs, including the brain. It causes an imbalance in biochemical and neurophysiological processes in the brain, ultimately giving the onset to the development of hepatic encephalopathy. Aim. The effects of rifampicin and isoniazid on the central nervous system have not been studied before and we aimed to evaluate the impact these two substances have on the neuronal cell adhesion molecules (NCAM) distribution and animal behavior in the rat model of DILI. Material and methods. The 24 male Wistar rats, weighing 180-220 g were used for the experiment and divided to the groups (n=6): 1 – control; 2 – rats with experimental DILI; 3 – rats with DILI plus the intravenous infusion of S-adenosyl-L-methionine at a dose of 35 mg/kg; 4 – rats with DILI plus a fixed combination of ipidacrine hydrochloride at a dose 1 mg/kg body weight and phenibut at a dose 60 mg/kg body weight daily for the last 14 days of the experiment. All experimental procedures were carried out in the accordance with the principles outlined in the current Guide to the Care and Use of Experimental Animals. The locomotor and research activities were studied in the open field test. The activity of aspartate aminotransferase (AST, ЕС 2.6.1.1) and alanine aminotransferase (ALT, ЕС 2.6.1.2) in the serum of rats were tested to confirm the liver damage. The quantitative analyses of soluble and membrane forms of NCAM were performed with ELISA. The ANOVA followed by a Tukey post-hoc test was used to assess statistical differences between groupsResults. Our investigation in the open field test revealed a significant decrease in the locomotor and research activity of rats after 28 days of rifampicin and isoniazid administration. The recovery of investigated parameters was observed in groups of animals treated with ademetionine (AD group) or combination of ipidacrine and phenibut (IP/PB group). We also observed that changes in rats’ behavior were consistent with alterations of the NCAM levels in the thalamus and hippocampus. Thus, the level of membrane NCAM was significantly decreased under DILI in both investigated brain regions (thalamus and hippocampus), while both AD and IP/PB treatments restored membrane NCAM levels towards those observed in the control group at least in the hippocampus. Conclusion. Obtained data suggests that both ademetionine and combinated drug containing ipidacrine and phenibut possesses neuroprotective properties and could prevent the decline in synaptic plasticity under antitubercular therapy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 3; 155-164
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Data mining and neural network simulations can help to improve deep brain stimulation effects in parkinson’s disease
Autorzy:
Szymański, A.
Kubis, A.
Przybyszewski, A. W.
Powiązania:
https://bibliotekanauki.pl/articles/952939.pdf
Data publikacji:
2015
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
deep brain stimulation
neural computation
data mining
Parkinson's disease
Opis:
Parkinson’s Disease (PD) is primary related to substantia nigra degeneration and, thus, dopamine insufficiency. L-DOPA as a precursor of dopamine is the standard medication in PD. However, disease progression causes L-DOPA therapy efficiency decay (on-off symptom fluctuation), and neurologists often decide to classify patients for DBS (Deep Brain Stimulation) surgery. DBS treatment is based on stimulating the specific subthalamic structure: subthalamic nucleus (STN) in our case. As STN consists of parts with different physiological functions, finding the appropriate placement of the DBS electrode contacts is challenging. In order to predict the neurological effects related to different electrodecontact stimulations, we have tracked connections between the stimulated part of STN and the cortex with the help of diffusion tensor imaging (DTI). By changing a contacts number and amplitude of stimulus (proportional in size to stimulated area), we have determined connections to cortical areas and related neurological effects. We have applied data mining methods to predict which contact (and at what amplitude) should be stimulated in order to improve a particular symptom. We have compared different data mining methods: Wekas Random Forest classifier and Rough Set Exploration System (RSES). We have demonstrated that the Weka classifier was more accurate when predicting the effects of stimulations on general neurological improvements, while RSES was more accurate when using specific neurological symptoms. We have simulated other effects of stimulation related to the interruption of pathological oscillation in the basal ganglia found in PD. Our model represents possible STN neural population with inhibitory and excitatory connections that have pathologically synchronized oscillations. High-frequency electrical stimulation has interrupted synchronization. something that is also observed in PD patients.
Źródło:
Computer Science; 2015, 16 (2); 199-215
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena jakości życia pacjentów ze schorzeniami układu pozapiramidowego po leczeniu stereotaktycznym oraz pozabiegowej rehabilitacji
The quality of life at patients with the extrapyramidal system diseases after stereotactic surgery and rehabilitation
Autorzy:
Pasek, Jarosław
Szajkowski, Sebastian
Suszyński, Krzysztof
Wiaderkiewicz, Jan
Kwiek, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1040004.pdf
Data publikacji:
2009
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
choroba parkinsona
głęboka stymulacja mózgu
fizjoterapia
parkinson disease
physiotherapy
deep brain stimulation
Opis:
INTRODUCTION Nowadays the functional neurosurgery makes up the recognized strategy of proceeding in the treatment: Parkinson diseases (PD), tremor, and generalized dystonia. According to directive line of American Physical Therapy Association´s the main role of physiotherapist is creating individual rehabilitation programs and their incessant modification in relation to changing condition of patient. MATERIAL AND METHODS Patients were hospitalized in Department of Neurosurgery Medical University of Silesia in Katowice. The surgical treatment of extrapyramidal system diseases and rehabilitation after surgery were applied to 36 persons. The average age was 58,8 years. The proportional part of diagnosis in the analyzed material: (PD)-58%, tremor-28%, dystonia-14%. The average period of the observation and length of disease were: 44,6 and 142,3 month. For evaluation of quality of life PDQ-39 questionnaire and EQ-5D (EuroQol) questionnaire were used. RESULTS The results of investigations were elaborated in the aim of comparison of the quality of life in relation to applied surgical treatment and after surgery rehabilitation. The results proved the statistically essential influence of rehabilitation on: mobility, pain and usual activities (EQ-5D) questionnaire. The regress analyses showed the essential, negative influence of length disease on EQ-5D assessment. CONCLUSIONS Rehabilitation and the type of diagnosis influence essentially on the quality of life at persons after stereotactic surgery performed because of extrapyramidal system diseases.
WSTĘP Neurochirurgia czynnościowa oraz następujący bezpośrednio po niej proces rehabilitacji, zgodny wytycznymi American Physical Therapy Association’s stanowią obecnie uznaną strategię postępowania w leczeniu choroby Parkinsona, drżenia i uogólnionych dystonii. MATERIAŁ I METODY Badaniem objęto 36 osób hospitalizowanych w Klinice Neurochirurgii SUM w Katowicach. Materiał badawczy stanowiło 21 chorych z chorobą Parkinsona w wieku średnio 60,3 lat, 10 osób z drżeniem samoistnym w wieku średnio 61,1 lat oraz 5 osób z dystonią, w wieku średnio 47,6. Okres obserwacji i czas trwania choroby wyniosły średnio: 44,6 i 142,3 miesiąca, odpowiednio: 27,7 i 144,5 - choroba Parkinsona, 41 i 130,2 - drżenie, 123,4 i 157,2 – dystonia. W pracy posłużono się subiektywnymi skalami oceny jakości życia: skalą EQ-5D (EuroQol ), oraz PDQ-39. WYNIKI Z przeprowadzonych badań wynika, że rodzaj rozpoznania (w szczególności choroba Parkinsona) wpływa istotnie na uzyskiwane przez pacjentów oceny jakości życia (PDQ-39, EQ-5D). Zauważono również znaczący wpływ rodzaju pooperacyjnej rehabilitacji na uzyskiwane wyniki. Nie stwierdzono bezpośredniego wpływu rodzaju zabiegu chirurgicznego na ostateczną ocenę jakości życia chorych. Uzyskane wyniki potwierdzają badania innych autorów dotyczące wpływu konkretnych metod oraz programów rehabilitacyjnych na odległe wyniki postępowania leczniczego u pacjentów z wyżej wymienionymi jednostkami chorobowymi. WNIOSKI Rehabilitacja oraz rodzaj postawionego rozpoznania warunkują jakość życia pacjentów ze schorzeniami układu pozapiramidowego po zastosowaniu nowoczesnych metod leczenia chirurgicznego.
Źródło:
Annales Academiae Medicae Silesiensis; 2009, 63, 6; 32-39
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radiosynthesis and biological evaluation of 123I-(±)-trans-2-hydroxy-5-((E)- -3-(iodo)allyloxy)-3-(4-phenyl-1-piperazinyl) tetralin
Autorzy:
Assaad, T.
Al Rayyes, A. H.
Powiązania:
https://bibliotekanauki.pl/articles/147888.pdf
Data publikacji:
2012
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
Alzheimer's disease
brain biodistribution
injected dose (ID)
radioiodination
vesamicol derivatives
vesicular acetylcholine transporter (VAChT)
Opis:
This work reports both the radiolabeling and preliminary biodistribution results in the rat brains of (±)-[123I]- -II. The novel benzovesamicol derivative (±)-[123I]-II was successfully labeled with iodine-123 from its corresponding n-tributyltin, with radiochemical purity greater than 97% and radiochemical yield in the range 50–55%. (±)-[123I]-II showed a higher accumulation in striatum than in the other regions studied. To determine if (±)-[123I]-II could provide an advantage compared to reference compound [125I]-IBVM a kinetic study was carried out, at each point of the kinetic study, (±)-[123I]-II showed a lower specific binding compared to [125I]-IBVM. Time activity curves of (±)-[123I]-II confirmed that this compound is inferior to [125I]-IBVM to explore the VAChT in vivo by SPECT. Moreover, it is well known that interaction at the VAChT binding site is enantioselective, and therefore, working with enantiomerically pure compounds, could improve the compound activity.
Źródło:
Nukleonika; 2012, 57, 1; 75-80
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Psychiatric disturbances after head-brain injury - selected problems of rehabilitation and disability benefit rulings
Zaburzenia psychiczne po urazach czaszkowo-mózgowych – wybrane problemy rehabilitacji i orzecznictwa
Autorzy:
Zyss, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1942927.pdf
Data publikacji:
2009
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
head-brain injury
psychiatric disturbances
disease outcome
urazy czaszkowo-mózgowe
zaburzenia psychiczne
zejscie
Opis:
Head-brain injuries are a complicated and multidimensional problem, which include acute and chronic therapy as well as varied aspects of rehabilitation. Patient treatment after head-brain injury requires co-operation between physicians of various specialties, as well as psychologists and physiotherapists. A patient’s treatment outcome depends on many factors, with some enhancing and others impeding the rehabilitation process. A knowledge of these factors helps one to optimize the whole therapy process as well as to prevent its unfavorable course. The paper describes several neuro-psychiatric aspects of head injuries – connected particularly with diagnostics as well as disability benefit rulings. Every patient to undergo rehabilitation requires diagnostic verification – particularly a ‘difficult’ patient with complex dysfunctions including neurogenic ones. The revision requires sometimes even the fact of the occurrence of a head-brain injury or its primary intensity. The absence of a head injury or mild concussion in principle cannot result in future in a severe psychoorganic brain syndrome. The diagnostic incoherencies relating to the results of additional investigations (psychological tests, MRI and CT of the brain) in outcome states and their influence on disability benefit rulings were discussed. The size of the structural changes of nerve brain tissue at times does not correspond with the intensity of clinical symptoms. For example, the valuation of possible intellectual deficits seems to be more important than a confirming of the organic substrate. The value of patient motivation that influences positively the processes of rehabilitation and healing, or that at times determines merely those activities for the obtainment of disability benefits, for example, were emphasised.
Źródło:
Medical Rehabilitation; 2009, 13(2); 32-39
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and in vivo evaluation of both (2R,3R)-[123I]- and (2S,3S)- -[123I]-trans-2-hydroxy-5-((E)-3-(iodo) allyloxy)-3-(4-phenyl-1-piperazinyl) tetralin as SPECT radiotracer
Autorzy:
Assaad, T.
Al Rayyes, A. H.
Powiązania:
https://bibliotekanauki.pl/articles/148128.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
Alzheimer's disease
benzovisamicol derivatives
brain biodistribution
enantiomeric resolution
radioiodination
vesicular acetylcholine transporter (VAChT)
Opis:
We report the synthesis of enantiopure benzovesamicol derivatives: (2R,3R)-[123I]-trans-2-hydroxy-5-((E)-3- -(iodo)allyloxy)-3-(4-phenyl-1-piperazinyl) tetralin and (2S,3S)-[123I]-trans-2-hydroxy-5-((E)-3-(iodo)allyloxy)-3-(4- phenyl-1-piperazinyl) tetralin; [(2R,3R)-[123I]-1 and (2S,3S)-[123I]-1]. Both compounds were obtained with radiochemical and optical purities greater than 97% and with radiochemical yields in the range of 50–60%. To determine whether these compounds could have potential advantage compared to [125I]-iodo benzovesamicol (IBVM), IBVM was also labelled and used as the reference compound in all in vivo experiments. Both (2R,3R)-[123I]-1 and (-)-[125I]-IBVM showed similar time activity curves (TACs) with the highest accumulations in the striatum region followed by the cortex, hippocampus and then cerebellum. While (2S,3S)-[123I]-1 showed an overall homogeneous brain distribution. However, time activity curves of (2R,3R)-[123I]-1 confirmed that this compound could be used to visualize the vesicular acetylcholine transporter (VAChT) in vivo, at each point of the kinetic study. Also (2R,3R)-[123I]-1 showed lower specific bindings compared to [125I]-IBVM. These results suggested that (2R,3R)-[123I]-1 is inferior in comparison with [125I]-IBVM for in vivo VAChT exploration.
Źródło:
Nukleonika; 2013, 58, 2; 261-267
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rapidly progressing dementia as a manifestation of the Creutzfeldt-Jakob disease: an analysis of two cases
Autorzy:
Bartosz, Seweryn
Leksa, Natalia
Uberman-Kluz, Dominika
Szymczak, Artur
Biesiadecki, Marek
Galiniak, Sabina
Powiązania:
https://bibliotekanauki.pl/articles/454939.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
14-3-3 protein
brain biopsy
cerebrospinal fluid
Creutzfeldt-Jakob disease
EEG
prion
Opis:
Introduction. Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disease of the central nervous system which is caused by an infectious protein called prion. Multiple forms of CJD have been classified including sporadic (more than 90% cases), familial, iatrogenic and variant type of disease. CJD, especially in its early stages, is a highly challenging illness to diagnose. Aim. Article aims to present cases of Creutzfeldt-Jackob disease with early symptoms of rapidly progressing dementia at the initial stage of CJD. Description of the cases. This paper describes two cases of patients with suspected CJD with a history of rapidly progressive dementia admitted to the Department of Neurology, MSWiA Hospital in Rzeszów. Conclusion. Despite the fact that CJD is an incurable illness and there is no cure guaranteeing recovery, it is important to make the right diagnosis. Assay of 14-3-3 protein in cerebrospinal fluid is a sensitive and specific marker which is helpful in the diagnosis of CJD. The only relevant method of correctly confirming a diagnosis of this disease is by performing a brain biopsy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 89-93
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and biodistribution of both (±)-5-[ 18F]-fluoroethoxy and (±)-5-[ 18F]-fluoropropoxy piperazine analogs of benzovesamicol as vesicular acetylcholine transporter ligands (VAChT)
Autorzy:
Assaad, T.
Al Rayyes, A. H.
Powiązania:
https://bibliotekanauki.pl/articles/147599.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
Alzheimer's disease (AD)
benzovisamicol derivatives
brain biodistribution
enantiomeric resolution
radiofluorination
vesicular acetylcholine transporter (VAChT)
Opis:
The radiosynthesis and preliminary biological evaluation in rats’ brain of two novel piperazine analogs of benzovesamicol as ligands for the vesicular acetylcholine transporter (VAChT) have been carried out. The novel benzovesamicol derivatives 5-(2-fluoroethoxy)-3-(4-phenylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol and 5-(3-fluoropropoxy)-3-(4-phenylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol [(±)-[18F]-6 and (±)-[18F]-7] were successfully labelled with fluorine-18 from their tosylate precursors, with radiochemical purities greater than 98% and with radiochemical yield in the range of 5–6%. To determine whether these compounds could have potential advantage compared to [125I]-iodo benzovesamicol (IBVM), IBVM was also labelled and used as the reference compound in all in vivo experiments. Both (±)-[18F]-6 and (±)-[18F]-7 showed lower specific binding in all brain areas explored 2 h post injection when compared to reference compound (-)-[125I] IBVM. Furthermore, defluorination indicated that (±)-[18F]-6 and (±)-[18F]-7 are not suitable as radioligands to explore the VAChT in vivo by PET. Moreover, it is well known that interaction at the VAChT binding site is enantioselective, and therefore, working with enantiomerically pure compounds, could improve the compound activity.
Źródło:
Nukleonika; 2013, 58, 2; 269-274
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative Analysis and Fusion of MRI and PET Images based on Wavelets for Clinical Diagnosis
Autorzy:
Sebastian, Jinu
King, Gnana
Powiązania:
https://bibliotekanauki.pl/articles/2200731.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
MRI
PET
multimodality medical image fusion
wavelet transform
brain tumor
Alzheimer’s disease
YUV color space
Opis:
Nowadays, Medical imaging modalities like Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Tomography (SPECT), and Computed Tomography (CT) play a crucial role in clinical diagnosis and treatment planning. The images obtained from each of these modalities contain complementary information of the organ imaged. Image fusion algorithms are employed to bring all of this disparate information together into a single image, allowing doctors to diagnose disorders quickly. This paper proposes a novel technique for the fusion of MRI and PET images based on YUV color space and wavelet transform. Quality assessment based on entropy showed that the method can achieve promising results for medical image fusion. The paper has done a comparative analysis of the fusion of MRI and PET images using different wavelet families at various decomposition levels for the detection of brain tumors as well as Alzheimer’s disease. The quality assessment and visual analysis showed that the Dmey wavelet at decomposition level 3 is optimum for the fusion of MRI and PET images. This paper also compared the results of several fusion rules such as average, maximum, and minimum, finding that the maximum fusion rule outperformed the other two.
Źródło:
International Journal of Electronics and Telecommunications; 2022, 68, 4; 867--873
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Innowacje w pedagogice osób z zaburzeniami neuropoznawczymi
Innovations in the Pedagogy of People with Neurocognitive Disorders
Autorzy:
Sikora-Balicka, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/461713.pdf
Data publikacji:
2018-02-17
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie. Instytut Spraw Społecznych
Tematy:
innovations in the pedagogy of people with neurocognitive disorders
Alzheimer’s disease
Frontotemporal Lobar degeneration
Lewy’s disease
vascular disease
traumatic brain injury
medicines / drugs use
HIV infection
Prion disease
Parkinson’s disease
Huntington’s disease
Opis:
This article describes new innovations for people with neurocognitive disorders, which are implemented not in England only but also throughout all the UK. Following the publication of a report in 2007 by the Comptroller and Auditor General National Audit Office on „Improving Services and Support for Persons with Dementia,” set up in 2009, the first National Dementia Strategy was launched under the theme „Living better with dementia. At this time, ambitious goals have been set that aim to improve the quality of life of people with dementia and their carers (Bourn, 2007). In 2012 Prime Minister David Cameron launched Prime Minister’s Challenge on Dementia. In response, the Alzheimer Society has launched a program to create a friendly environment for people with dementia under the banner of Dementia Friends. The English Department of Health has identified tasks for NHS Health EducationEngland to deliver the necessary skills to provide the best quality care for people with dementia (Health Education England, 2017) and the NHS England, which launched the Well Pathway for Dementia.
Źródło:
Labor et Educatio; 2017, 5; 197-212
2353-4745
2544-0179
Pojawia się w:
Labor et Educatio
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie biofeedbacku w rehabilitacji neurologicznej
Use of biofeedback in neurological rehabilitation
Autorzy:
Kwolek, Andrzej
Podgórska, Justyna
Rykała, Justyna
Leszczak, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/437806.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
biofeedback
neurorehabilitacja
udar mózgu
stwardnienie rozsiane
choroba Parkinsona
neurorehabilitation
brain stroke
multiple sclerosis
Parkinson’s disease
Opis:
Artykuł zawiera przegląd badań i wybranych rozwiązań zastosowania biofeedbacku we współczesnej neurorehabilitacji. Ich problematyka dotyczy osób dotkniętych chorobami neurologicznymi. Badania te wykonywane są coraz częściej, a zatem doniesienia naukowe, które są coraz liczniejsze wskazują na fakt, iż w dziedzinie neurorehabilitacji, w tym również poznawczej, odpowiednio skonstruowane programy terapeutyczne mogą poprawiać wyniki leczenia w przypadku wielu chorób neurologicznych. Dlatego coraz częściej dochodzi do „wzbogacania” tzw. tradycyjnego modelu postępowania o nowe metody terapeutyczne, czy udoskonalony sprzęt rehabilitacyjny. Wszystkie te modyfikacje mają na celu jak najszybszy powrót pacjenta do pełnej sprawności lub pełne wykorzystanie jego szeroko rozumianego potencjału funkcjonalnego. A zatem metoda biofeedbacku z powodzeniem powinna być stosowano nie tylko jako rozszerzenie standardowego postępowania terapeutycznego, ale również w wielu wypadkach powinna stać się jego integralną częścią. Dlatego też można stwierdzić, iż wiele z zaprezentowanych rozwiązań należy wprowadzić do nowoczesnego modelu postępowania z pacjentem neurologicznym.
This article includes a review of research and chosen solutions of use of biofeedback in contemporary neurorehabilitation. Their subject matter concerns persons suffering from neurological diseases. These kinds of research are performed increasingly, so the scientific reports that are more and more numerous indicate the fact that properly constructed therapeutic programs may improve the treatment results in case of many neurological problems in the field of neurorehabilitation, also the cognitive one. Therefore, so called traditional model of procedure is often “enriched” with new therapeutic methods or improved rehabilitation equipment. All these modifications aim at the faster recovery of patient or full use of his/her widely understood functioning potential. As one can see, the biofeedback method should be successfully used not only as an expansion of standard therapeutic procedure but in many cases also as its integral part. Therefore, one can state that many of the presented solutions shall be implemented to the contemporary model of proceeding with neurological patient.
Źródło:
Medical Review; 2013, 3; 379-388
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kilka uwag w kwestii nowych hipotez na temat stanu zdrowia Gajusza Juliusza Cezara
Autorzy:
Bartnik, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1550902.pdf
Data publikacji:
2021-08-18
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Cezar
udar
guz mózgu
choroba Hartnupów
epilepsja
gruźlica mózgu
choroba Meniera
Taenia solium
celiakia
Caesar
stroke
brain tumor
Hartnup disease
epilepsy
tuberculous meningitis
Meniere’s disease
coeliac disease
Opis:
Gajuszowi Juliuszowi Cezarowi poświęcono niezliczoną liczbę prac. Wszystkie aspekty życia wodza budziły zainteresowanie badaczy. Informacje na temat stanu zdrowia słynnego polityka przekazali m.in. Swetoniusz, Pliniusz Starszy, Appian z Aleksandrii, Plutarch z Cheronei czy Kasjusz Dion. Zachowane relacje są mocno fragmentaryczne, a ich autorzy nie byli medykami, co znacząco wpływa na jakość przekazu. Niemniej opisane przez antycznych pisarzy objawy jasno wskazują na problemy zdrowotne, z którymi musiał się borykać Cezar. Fragmentaryczność opisów oraz brak materiału kostnego uniemożliwiają jednoznaczne określenie, na jaką chorobę cierpiał słynny polityk. Z tego powodu powstał szereg hipotez dotyczących przyczyn opisywanych w źródłach ataków. Wśród najpopularniejszych wymieniano epilepsję, chorobę Meniera, guz mózgu, neurosyfilis, zakażenie pasożytami czy chorobę Hartnupów. W ostatnich latach wspominano także o celiakii. Ze względu na brak możliwości przebadania „pacjenta” wszystkie pozostają w sferze hipotez niemniej obecnie. Biorąc pod uwagę objawy zaobserwowane u Cezara, najbardziej prawdopodobną chorobą wydaje się guz mózgu lub seria mikroudarów. Niezwykle ciekawą i prawdopodobną opcją wydaje się choroba Hartnupów, ale ze względu na jej dziedziczny charakter problem należy przebadać i omówić szerzej, uwzględniając cały ród Juliuszów.
Countless works have been devoted to Gaius Julius Caesar. All the aspects of the leader’s life have captured the interest of researchers. Information on the health condition of the famous politician was provided, among others, by Suetonius, Pliny the Elder, Appian of Alexandria, Plutarch of Cheronea and Cassius Dio. The preserved messages are highly fragmented, and their authors were not medics, which significantly affects the quality of the information. Nevertheless, the symptoms described by the ancients clearly indicate the health problems that Caesar had to deal with. The fragmentary nature of the descriptions and the lack of bone material make it impossible to clearly define which disease he suffered from. For this reason, a number of hypotheses have arisen regarding the causes described in the sources of attacks. The most popular were epilepsy, Meniere’s disease, brain tumour, neurosyphilis, parasite infection and Hartnup disease. In recent years, celiac disease has also been mentioned. Due to the inability to test the “patient”, all of them remain within the sphere of hypotheses, but today, taking into account the symptoms observed in Caesar, the most likely disease seems to be a brain tumour or a series of micro-haemorrhages. Hartnup disease seems to be an extremely interesting and probable option, but due to its hereditary nature, the problem should be investigated and discussed more broadly, taking into account the entire Julius family.
Źródło:
Przegląd Nauk Historycznych; 2021, 20, 1; 27-45
1644-857X
2450-7660
Pojawia się w:
Przegląd Nauk Historycznych
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 19

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