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Tytuł:
The influence of selenium and vitamin E supplementation on cytological assessment of red blood cell line of bone marrow in fallow deer kept in captivity
Autorzy:
Snarska, A.
Wysocka, D.
Rytel, L.
Żarczyńska, K.
Sobiech, P.
Gonkowski, S.
Powiązania:
https://bibliotekanauki.pl/articles/2087707.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone marrow
hematopoiesis
erythroblast
selenium
vitamin E
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 431-436
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of algorithms for detection of active inflammatory lesions in sacroiliitis
Autorzy:
Gawłowski, Igor
Ożga, Joanna
Raczko, Agata
Powiązania:
https://bibliotekanauki.pl/articles/40521367.pdf
Data publikacji:
2024
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
artificial intelligence
axial spondyloarthritis
bone marrow edema
Opis:
Introduction. Artificial intelligence is increasingly being used in the medicine, particularly in radiological diagnosis of diseases such as an axial spondyloarthritis (axSpA). The aim of this study is to compare the available algorithms designed to detect active sacroiliitis in patients with axSpA. Material and methods. Four algorithms, two semi-automated and two full-automated for the assessment of bone marrow edema (BME) on magnetic resonance imaging (MRI) of the sacroiliac joints (SIJs) were included in the study. They were described and compared in terms of specificity, sensitivity, and correlation of BME detection findings between AI and experts. Analysis of the literature. Among all automated algorithms, the one created by Bressem et al. had the highest number of examinations analyzed in the study, involving 593 MRIs of SIJs. The sensitivity and specificity, as well as the correlation between the AI’s detection of BME versus manual, were not calculated for each algorithm. Rzecki’s algorithm had the greatest sensitivity and specificity for BME detection reaching 0.95 and 0.96, respectively. In addition, its Speraman’s coefficient of correlation between manual and automated measurements was 0.866. Conclusion. Each of described algorithms is certainly useful in assessing BME in the MRI examinations of SIJs.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 188-193
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of acetylsalicylic acid on hematotoxicity of benzene
Autorzy:
Kowalówka-Zawieja, Joanna
Zielińska-Psuja, Barbara
Przystanowicz, Jędrzej
Sommerfeld, Karina
Powiązania:
https://bibliotekanauki.pl/articles/2179057.pdf
Data publikacji:
2013-10-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
benzene
acetylsalicylic acid
interactions
hematotoxicity
blood
bone marrow
Opis:
Objectives: The aim of the study was to evaluate the influence of acetylsalicylic acid (ASA) on benzene hematotoxicity in rats. Materials and Methods: The study was carried out on rats exposed for 2, 4 and 8 weeks to benzene vapour at a conentration of 1.5 or 4.5 mmol/m³ of air (5 days per week, 6 hours per day) alone or together with ASA at the doses of 5, 150 or 300 mg/kg body weight (per os). Results: Benzene at a concentration of 4.5 mmol/m³ caused a slight lymphopenia, granulocytosis and reticulocytosis in blood. In bone marrow traits of megaloblastic renewal, presence of undifferentiated cells and giant forms of granulocytes as well as an increase in myeloperoxidase and decrease in chloroacetate esterase activity and lipids content were noted. ASA (150 and 300 mg/kg b.w.) influenced some of hematological parameters, altered by benzene intoxication. ASA limited the solvent-induced alteration in blood reticulocyte count and in the case of bone marrow in the erythroblasts count. Traits of megaloblastic renewal in bone marrow were less pronounced. Besides, higher activity of myeloperoxidase and the decrease in the level of lipids in granulocytes were noted. Conclusion: Our results suggest that ASA limited the benzene-induced hematotoxicity.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 5; 802-812
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Regulatory function of stress in the process of leukemia patients’ recovery after bone marrow transplantation
Autorzy:
Wrona-Polańska, Helena
Powiązania:
https://bibliotekanauki.pl/articles/2128261.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
resources
health
coping
bone marrow transplantation
stress
illness
Opis:
The theoretical rationale was the author’s Functional Model of Health (FMH), where health is construed as a function of creative coping with stress. Participants in the study were 141 patients with blood cancer (80 men and 61 women) treated with bone marrow transplantation at the Hematology Clinic, Jagiellonian University Collegium Medicum. Besides a standardized interview the following instruments were used: STAI by Spielberger, CISS and CHIP by Endler and Parker, and SOC-29 by Antonovsky. Health status was operationalized using 10-point self-rating scales to assess the patients’ perceived health and sense of calmness, while their objective health was rated by a medical expert - hematologist. In the statistical analyses significant correlations were found between stress level and the patients’ subjective health (-0.34, p<0.001). The following variables predicted stress intensity: anxious personality (.585), distraction coping strategy (-.202), female sex (.201), and sense of meaningfulness (-.190). Subjective health predictors of leukemia patients are: objective health (ß = .413), level of stress (ß = -.285), by the patient’s sense of meaningfulness (ß = .244) and focusing on negative emotions (ß = -.193). To promote patients’ health moreover, their sense of meaningfulness in life and in being active should be supported and enhanced.
Źródło:
Polish Psychological Bulletin; 2017, 3; 328-337
0079-2993
Pojawia się w:
Polish Psychological Bulletin
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of innovative biopolymers designed for bone regeneration applications and in vitro study of their biocompatibility and osteogenic capacity on human bone marrow mesenchymal stem cells
Autorzy:
Basile, M. S.
Gomez d'Ayala, G.
Laurienzo, P.
Malinconico, M.
Oliva, A.
Powiązania:
https://bibliotekanauki.pl/articles/284365.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
functionalization of poly(ε-caprolactone)
bone marrow mesenchymal stem cells
Opis:
In the frame of a project aiming to the improvement of the properties of biodegradable polyester-based devices, designed for bone regeneration, we have prepared and characterized novel composites based on poly(ε-caprolactone) (PCL). In particular, we report in this paper the functional changes made through radical grafting on PCL to obtain the less hydrophobic derivatives, PCL-MA-GMA [maleic anhydride (MA)-glycidylmethacrylate (GMA)] and PCL-DMAEA [N-(dimethyl-amino)ethylacrylate]. In addition, we studied in vitro the biocompatibility and the osteogenic capacity of these novel polyesters on human bone marrow (BM) mesenchymal stem cells (MSC).
Źródło:
Engineering of Biomaterials; 2012, 15, 113; 13-15
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of specific lytic and latent transcripts can help to predict the status of Epstein-Barr virus infection in transplant recipients with high virus load
Autorzy:
Zawilinska, Barbara
Kosinska, Anna
Lenart, Marzena
Kopec, Jolanta
Piatkowska-Jakubas, Beata
Skotnicki, Aleksander
Kosz-Vnenchak, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1040672.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bone marrow transplantation
Epstein-Barr virus
latency
EBV-lymphoproliferative disorder
productive infection
Opis:
Epstein-Barr virus (EBV), a member of the family Herpesviridae, is widely spread in the human population and has the ability to establish lifelong latent infection. In immunocompetent individuals the virus reactivation is usually harmless and unnoticeable. In immunocompromised patients productive infection or type III latency may lead to EBV-associated post-transplant lymphoproliferative disorder (PTLD). The aim of our research was to investigate the utility of PCR-based methods in the diagnosis and monitoring of EBV infections in bone marrow transplant recipients. Thirty-eight peripheral blood leukocyte samples obtained from 16 patients were analysed, in which EBV DNA was confirmed by PCR. We used semi-quantitative PCR to estimate the viral load and reverse-transcription PCR (RT-PCR) to differentiate between latent and productive EBV infection. In 14 patients we confirmed productive viral infection. We observed a correlation between higher number of EBV genome copies and the presence of transcripts specific for type III latency as well as clinical symptoms.
Źródło:
Acta Biochimica Polonica; 2008, 55, 4; 693-699
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of cat bone marrow and adipose tissue cell cultures
Autorzy:
Mazurkevych, A.
Malyuk, M.
Kovpak, V.
Kovpak, O.
Kharkevych, Y.
Jakubczak, A.
Gryzinska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087658.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
stem cells
bone marrow cell culture
adipose tissue cell culture
cytogenetic assays
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 549-557
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
17 beta-estradiol affects proliferation and apoptosis of canine bone marrow mesenchymal stem cells in vitro
Autorzy:
Zhou, Z.-H.
Gu, C.-W.
Li, J.
Huang, X.-Y.
Deng, J.-Q.
Shen, L.-H.
Cao, S.-Z.
Deng, J.-L.
Zuo, Z.-C.
Wang, Y.
Ma, X.-P.
Ren, Z.-H.
Yu, S.-M.
Powiązania:
https://bibliotekanauki.pl/articles/2087308.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
apoptosis
bone marrow mesenchymal stem cells (BMSCs)
canine
proliferation
17 beta-estradiol (E2)
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 235-245
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Telomerase enhances osteogenic ifferentiation of sheep bone marrow mesenchymal stem cells (BMSCs) by up-regulating PI3K/Akt pathway in vitro
Autorzy:
Zhu, X.
Zhou, L.
Liu, Z.
Chen, X.
Wei, L.
Zhang, Z.
Liu, Y.
Zhu, Y.
Wang, Y.
Yang, X.
Han, Y.
Powiązania:
https://bibliotekanauki.pl/articles/2087304.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone marrow mesenchymal stem cells
telomerase
proliferation
osteogenic differentiation
PI3K/Akt signalling pathway
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 3; 359-372
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Perspectives of use of bone marrow cells in future therapy of brain diseases
Możliwosci wykorzystania komórek szpiku kostnego w przyszłej terapii chorób mózgu
Autorzy:
Opydo-Chanek, Małgorzata
Pasiut, Szymon
Powiązania:
https://bibliotekanauki.pl/articles/1938534.pdf
Data publikacji:
2007
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
Bone Marrow Cells
cell therapy
Brain
Transplantation
Rehabilitation
komórki szpiku kostnego
terapia komórkowa
mózg
transplantacja
rehabilitacja
Opis:
Medical problems associated with the increasing number of patients suffering from brain diseases have resulted in a constant search for effective therapeutics. Considering the complicated pathological processes occurring in diseases of the central nervous system and the limited capability of the neural tissue to regenerate, therapy of neurological diseases is extremely difficult. The lack of efficient medical treatment results in complex problems associated with rehabilitation and thus in functional disturbances, which prevent patients from restoring their independence and returning to complete, also professional, activity, Cell therapy has recently been considered as a possible approach in the treatment of brain diseases. Its aim is to supply pathologically changed brain tissue with factors promoting regeneration and with cells that may replace the damaged ones. Bone marrow cells have become a potential source of cells in this type of therapy. Bone marrow contains at least two major kinds of stem cells: haematopoietic stem cells, which give rise to the blood cells and mesenchymal stem cells, which can differentiate into cells of mesenchymal lineage and produce an array of growth factors essential for repair. The review presents the achievements of studies on use of bone marrow cells in the therapy of various brain diseases of traumatic or neurodegenerative aetiology.
Źródło:
Medical Rehabilitation; 2007, 11(1); 31-39
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasonografia w diagnostyce krwotocznego zapalenia pęcherza moczowego po przeszczepach szpiku kostnego u dzieci
Ultrasonography in the diagnosis of hemorrhagic cystitis – a complication of bone marrow transplantation in pediatric oncology patients
Autorzy:
Zaleska-Dorobisz, Urszula
Biel, Anna
Sokołowska-Dąbek, Dąbrówka
Olchowy, Cyprian
Łasecki, Mateusz
Powiązania:
https://bibliotekanauki.pl/articles/1057896.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
bone marrow transplantation
diagnostics
hemorrhagic cystitis
ultrasound
diagnostyka
krwotoczne zapalenie pęcherza moczowego
przeszczep szpiku kostnego
ultrasonografia
Opis:
Objective: The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. Material and methods: The study involved an analysis of clinical material and the results of imaging tests performed in 334 patients who underwent hematopoietic cell transplantation. Ultrasonographic findings in 42 patients with hemorrhagic cystitis were analyzed in detail. The ultrasound images served to assess the severity of hemorrhagic cystitis and the results were compared with the clinical assessment of the disease on the Droller scale, as well as the laboratory and endoscopic tests. Results: In the studied group of patients hemorrhagic cystitis following allogeneic transplantation was diagnosed in 12.5% cases. 73.8% patients received transplants from unrelated donors, 26.2% – from compatible siblings. The study revealed a higher incidence of hemorrhagic cystitis in children above 10 years of age. Grade 3 according to the Droller was diagnosed in 42.9%, grade 2 – in 30.9%, grade 4 – in 14.3%, and grade 1 – in 11.9% patients. The number of ultrasound examinations depended on the clinical symptoms, severity, duration and co-occurrence of other complications following the transplantation and was within the 1–15 range (average: 4.6). Grades 3 and 4 were related to the poor clinical condition of the patients and to their longer hospitalization. During this period there was an increased risk of renal malfunction and acute renal failure, post-inflammatory narrowing of the ureters, hydronephrosis, and in grade 4 the fibrosis of the bladder with reduced bladder capacity. Analyses demonstrated a significant correlation between the ultrasound image of the bladder wall and the clinical severity. Conclusions: Ultrasound with Doppler options remains the primary diagnostic tool in the evaluation of hemorrhagic cystitis, and is useful in terms of its diagnosis, determination of the severity, and monitoring of the treatment.
Cel: Celem pracy była ocena przydatności ultrasonografii w diagnostyce krwotocznego zapalenia pęcherza moczowego, dość częstego powikłania po przeszczepach szpiku kostnego u dzieci. Materiał i metoda: W pracy przeanalizowano materiał kliniczny i wyniki badań obrazowych 334 pacjentów po transplantacji komórek hematopoetycznych. Analizie poddano wyniki badań ultrasonograficznych wykonanych u 42 dzieci z krwotocznym zapaleniem pęcherza moczowego. Na podstawie USG oceniano stopień zaawansowania krwotocznego zapalenia pęcherza moczowego, a wyniki porównywano z oceną kliniczną procesu w skali Drollera, badaniami laboratoryjnymi i endoskopowymi. Wyniki: W analizowanej grupie dzieci krwotoczne zapalenie pęcherza moczowego rozpoznano po transplantacjach allogenicznych u 12,5% badanych, u 73,8% był to przeszczep od dawcy niespokrewnionego, u 26,2% – od zgodnego rodzeństwa. Wykazano częstsze występowanie krwotocznego zapalenia pęcherza moczowego u dzieci starszych, powyżej 10. roku życia. Stopień 3. w skali Drollera stwierdzono u 42,9% dzieci, stopień 2. – u 30,9%, stopień 4. – u 14,3%, a stopień 1. – u 11,9% dzieci. Liczba badań ultrasonograficznych i rozpoznanie zależały od objawów klinicznych, stopnia zaawansowania, czasu trwania oraz współwystępowania innych powikłań po transplantacji i wynosiła 1–15 (średnio 4,6). Trzeci i czwarty stopień wiązały się ze złym stanem klinicznym chorych, a także wydłużeniem czasu hospitalizacji. W okresie tym wzrastało ryzyko uszkodzenia czynności nerek i ostrej niewydolności nerek, pozapalnego zwężenia moczowodów, wodonercza, a w końcowym stadium zwłóknienia pęcherza moczowego. Stwierdzono istotną zależność obrazu ultrasonograficznego zmienionej w przebiegu zapalenia ściany pęcherza moczowego, ze stopniem klinicznego zaawansowania. Wnioski: Badanie ultrasonograficzne z opcjami dopplerowskimi pozostaje podstawowym badaniem diagnostycznym w ocenie krwotocznego zapalenia pęcherza moczowego, jest przydatne w rozpoznawaniu, określaniu stopnia zaawansowania choroby i monitorowaniu leczenia.
Źródło:
Journal of Ultrasonography; 2014, 14, 58; 258-272
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Trudności opiniodawcze w ustalaniu ojcostwa spowodowane transplantacją szpiku kostnego u biologicznego ojca. Praca kazuistyczna
Opinion-forming difficulties in disputed paternity cases resulting from bone marrow transplantation in biological father. A case report
Autorzy:
Droździok, Kornelia
Kabiesz, Jadwiga
Tomsia, Marcin
Rębała, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1373969.pdf
Data publikacji:
2014
Wydawca:
Centralne Laboratorium Kryminalistyczne Policji
Tematy:
ustalanie ojcostwa
transplantacja szpiku kostnego biologicznego ojca
trudności opiniodawcze
disputed paternity cases
allogeneic bone marrow transplantation
Opis:
W pracy przedstawiono przypadek spornego ojcostwa z udziałem pozwanego, który 2 i pół roku wcześniej przeszedł allogeniczną transplantację szpiku kostnego. Dziecko miało pół roku. Z uwagi na utratę owłosienia w wyniku terapii farmakologicznej, do badania pobrano wymaz z jamy ustnej i krew obwodową. We krwi uzyskano profil genetyczny dawcy (kobieta), natomiast w wymazie z jamy ustnej mieszaninę profili genetycznych dawcy i biorcy. Z mieszaniny wygenerowano profil genetyczny pozwanego. U dziecka we wszystkich badanych loci stwierdzono cechę wspólną z pozwanym. W żadnym z markerów nie uzyskano wyniku, który wykluczałby ojcostwo pozwanego. W badaniu loci z chromosomu Y u dziecka i pozwanego uzyskano pełną zgodność profili. Niniejsza praca podkreśla rolę wywiadu w prawidłowym protokole pobrania materiału, co chroni przed wydaniem fałszywej opinii.
In the Department of Forensic Medicine and Medico-Legal Toxicology, Medical University of Silesia, Katowice, Poland before blood or buccal swab sampling for disputed paternity testing the parties are routinely asked whether they had bone marrow transplantation or not. The authors report the disputed paternity case in which the male defendant had hallogeneic bone marrow transplantation. In the tested trio, the child was six months old. For disputed paternity testing blood and buccal swab samples were taken from the defendant. As he had lost all his hair because of antineoplastic therapy, no hair follicles were taken. A female genetic profile (donor) was determined from the blood sample of the defendant, whereas the mixture of two profiles ( donor and recipient) in the buccal swab one. From the mixture a genetic profile of the male defendant was finally distinguished. In all tested loci the child had genetic markers which appeared also in the defendant. There was no paternity exclusion in any of the tested markers. Moreover, there was full genetic agreement between profiles of the child and the defendant. The report emphasizes the importance of the detailed history taking before biological material sampling for disputed paternity testing, which can prevent forming a false opinion.
Źródło:
Problemy Kryminalistyki; 2014, 286; 27-32
0552-2153
Pojawia się w:
Problemy Kryminalistyki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka zażyciowych i pośmiertnych przemian karbamazepiny oraz wybranych rodzajów alternatywnego materiału biologicznego na potrzeby analiz toksykologiczno-sądowych
Characteristics of perimortem and postmortem transformations of carbamazepine and selected alternative biological matrices for the purpose of forensic toxicological analyses
Autorzy:
Lendor, S.
Powiązania:
https://bibliotekanauki.pl/articles/171576.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
karbamazepina
metabolizm pośmiertny
alternatywne materiały biologiczne
szpik kostny
kości
carbamazepine
postmortem metabolism
alternative biological matrices
bone marrow
bones
Opis:
This article is focused on the data concerning properties of carbamazepine, an antiepileptic drug commonly used in everyday medical practice but also frequently misused leading to many reported cases of intoxication. Due to high prevalence of this drug detailed data concerning its pharmacokinetics and prahmacodynamics can be found as well as metabolic paths that have been proven or have not been confirmed yet. For the purpose of toxicological analyses of samples collected postmortem it is also essential to know the possible transformations of an analyte due to microbial metabolism and postmortem changes of the sample matrix. In forensic cases of unavailable or unusable blood samples when advanced stage of decomposition processes in the found body occurs, alternative matrices are required. Presented review describes three types of such matrices: bones, bone marrow and grease in the context of their postmortem changes and suitability as the source of toxicological information.
Źródło:
Wiadomości Chemiczne; 2015, 69, 7-8; 585-603
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells
Autorzy:
Morita, Y.
Yamashita, T.
Toku, Y.
Yu, Y.
Powiązania:
https://bibliotekanauki.pl/articles/307018.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
różnicowanie
kości
stymulacja mechaniczna
hBMSC
cyclic stretch
differentiation
differentiation time
human bone marrow-derived mesenchymal stem cell
mechanical stimulus
tenocyte
Opis:
There is a need for efficient stem cell-to-tenocyte differentiation techniques for tendon tissue engineering. More than 1 week is required for tenogenic differentiation with chemical stimuli, including co-culturing. Research has begun to examine the utility of mechanical stimuli, which reduces the differentiation time to several days. However, the precise length of time required to differentiate human bone marrow-derived mesenchymal stem cells (hBMSCs) into tenocytes has not been clarified. Understanding the precise time required is important for future tissue engineering projects. Therefore, in this study, a method was developed to more precisely determine the length of time required to differentiate hBMSCs into tenocytes with cyclic stretching stimulus. Methods: First, it had to be determined how stretching stimulation affected the cells. Microgrooved culture membranes were used to suppress cell orientation behavior. Then, only cells oriented parallel to the microgrooves were selected and evaluated for protein synthesis levels for differentiation. Results: The results revealed that growing cells on the microgrooved membrane and selecting optimally-oriented cells for measurement improved the accuracy of the differentiation evaluation, and that hBMSCs differentiated into tenocytes in approximately 10 h. Conclusions: The differentiation time corresponded to the time required for cellular cytoskeleton reorganization and cellular morphology alterations. This suggests that cells, when subjected to mechanical stimulus, secrete mRNAs and proteins for both cytoskeleton reorganization and differentiation.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 1; 3-10
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The alterations in genetic apparatus of somatic and generative cells of the host caused by helminths metabolites
Autorzy:
Bekish, V J
Powiązania:
https://bibliotekanauki.pl/articles/838630.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
metabolite
alteration
mice
cell
helminth
host
generative cell
mouse
bone marrow
testicle
Ascaris suum
genetic apparatus
somatic cell
Hymenolepis nana
Toxocara canis
Opis:
Alterations in the genetic apparatus of mice bone marrow cells and testicles caused by Hymenolepis nana, Ascaris suum and Toxocara canis metabolites have been investigated by means of micronuclear test application. The activity of spermatogenesis has been investigated at experimental hymenolepidosis, migrating ascariasis and toxocarosis with the use of ³H-timidine. Helminths metabolites have been established to exert a mutagenie effect on somatic cells of bone marrow, spermatogonies and also on the generative cells (spermatides) of helminths in invaded mice. The concurrent increase in micronucleus number in erythrocytes, spermatogonies and in spermatides (to a lesser degree) of invaded mice has been revealed. The decrease in spermatogenesis activity has been established in experimental hymenolepidosis, migrating ascariasis and toxocarosis in invaded mice.
Źródło:
Annals of Parasitology; 2001, 47, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 28

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