Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę "bladder" wg kryterium: Temat


Wyświetlanie 1-60 z 60
Tytuł:
Laparoscopic cholecystectomy in the treatment of gallbladder polypoid lesions – 15 years of experience
Autorzy:
Matłok, Maciej
Migaczewski, Marcin
Major, Piotr
Pędziwiatr, Michał
Budzyński, Piotr
Winiarski, Marek
Ostachowski, Mateusz
Budzyński, Andrzej
Rembiasz, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1396486.pdf
Data publikacji:
2013-11-01
Wydawca:
Index Copernicus International
Tematy:
gall-bladder polyps
laparoscopic cholecystectomy
gall-bladder cancer
gall-bladder ultrasound
Opis:
Due to the constant increase of public health awareness and widespread “cancerophobia”, the progressively larger number of incidentally diagnosed gall-bladder polyps became the source of anxiety, which leads patients and physicians to undertake therapeutic decisions, despite the absence of symptoms. The majority of gall-bladder polyps are benign. It is estimated that only 3 to 5% of polyps are malignant. Currently, there is lack of randomized control trials based on which the clear-cut criteria of qualification of patients with gall-bladder polyps for surgical procedure can be created. The aim of the study was to analyze gall-bladder polyps in patients who underwent laparoscopic cholecystectomy in the 2nd Department of General Surgery, Jagiellonian University Collegium Medicum. Material and methods. The retrospective study was conducted on 5369 patients who underwent laparoscopic cholecystectomy in the 2nd Department of General Surgery, Jagiellonian University Collegium Medicum with special attention to 152 (2.8%) patients in whom gall-bladder polyps were diagnosed preoperatively. Qualification criteria for surgery, surgical treatment results, and histopathological examination results were also analyzed. Results. Amongst the 5369 patients qualified for laparoscopic cholecystectomy, 152 (2.8%) were diagnosed with gall-bladder polyps during the preoperative ultrasound examinations. Postoperative histopathological examinations of 41 (27%) patients confirmed the presence of gall-bladder polyps. In 102 (67%) patients, only gall-stones were diagnosed without previously described polyps during the ultrasound examination. Analysis of the histopathological examination results revealed the presence of benign lesions in 35 (23.35%) patients. In 5 (3%) patients the presence of an adenoma, and in one (0.65%) the presence of adenocarcinoma were confirmed. Conclusions. Based on the conducted study and previous personal experience in the treatment of patients with gall-bladder polyps, we believe that due to the potential risk of neoplastic transformation, patients with polyps larger than 10 mm in diameter and polyps of proven rapid growth should be qualified for laparoscopic cholecystectomy. Indications for surgical treatment also seem reasonable in case of patients with present polyps and coexisting right upper quadrant pain, even though the above-mentioned is connected with gall-bladder deposits.
Źródło:
Polish Journal of Surgery; 2013, 85, 11; 625-629
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tuberculosis of gall-bladder mimicking malignancy – a case report
Autorzy:
Dahiya, Divya
Kaman, Lileswar
Rajendran, Jayapal
Garg, Mandeep
Powiązania:
https://bibliotekanauki.pl/articles/1393918.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
gall-bladder tuberculosis
gall-bladder cancer
hepatobiliary tuberculosis
tuberculosis
Opis:
A correct preoperative diagnosis of gall-bladder tuberculosis is exceptionally unusual in the absence of pathognomic features both on clinical presentation and on imaging. Herein we present a case of 50 year female who was operated with a provisional diagnosis of gall-bladder malignancy and was found to have tuberculosis of gall-bladder on histopathology
Źródło:
Polish Journal of Surgery; 2016, 88, 5; 504-509
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrasound measurement of the gallbladder wall thickness in the assessment of the risk of conversion from elective laparoscopic cholecystectomy to open surgery — Olkusz county experience
Autorzy:
Kania, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1393735.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
laparoscopic cholecystectomy
conversion
gall-bladder wall thickness
gall-bladder ultrasound
Opis:
The aim of the study was to assess the risk of intraoperative difficulties, conversion and biliaryintestinal fistula during laparoscopic cholecystectomy on the basis of an ultrasound-measured gallbladder wall thickness. Material and methods. A prospective study was conducted in 50 patients undergoing laparoscopic cholecystectomy for chronic gallstone-induced cholecystitis. To calculate the relationships between categorical variables, a chi-square (χ2 ) independence test was used, and the results were interpreted for the significance threshold of α = 0.05. Results. The relationship between the gall-bladder wall thickness and the occurrence of intraoperative difficulties in the analysed set is deterministic (AUC = 1), and the wall thickness of ≥ 5 mm allows to predict their occurrence as soon as at the stage of diagnostic evaluation (p < 0.001). In addition, the ultrasound-measured GB wall thickness is a good predictor of conversion (AUC = 0.976; 95% CI 0.444–0.975; p < 0.001) and biliary-intestinal fistula (AUC = 0.935; 95% CI 0.121–0.738; p = 0.001). Conclusions. The results allow prediction of technically difficult laparoscopic cholecystectomies in patients with CCh, and selection of the right surgical team helps to reduce the number of conversions and possible complications. In addition, bearing in mind the above results in everyday practice should facilitate planning and increase effectiveness in the operating room.
Źródło:
Polish Journal of Surgery; 2016, 88, 6; 587-607
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Guzy i zmiany guzopodobne imitujące raka pęcherza moczowego w badaniu ultrasonograficznym
Sonography of tumors and tumor-like lesions that mimic carcinoma of the urinary bladder
Autorzy:
Smereczyński, Andrzej
Szopiński, Tomasz
Gołąbek, Tomasz
Ostasz, Oksana
Bojko, Stefania
Powiązania:
https://bibliotekanauki.pl/articles/1058049.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
bladder pseudotumors
bladder tumors
ultrasound imaging
urinary bladder neoplasms
guzy pęcherza moczowego
guzy rzekome pęcherza moczowego
nowotwory pęcherza moczowego
ultrasonografia
Opis:
One of the basic abdominal organs that is assessed during transabdominal ultrasound examination for urological reasons is the urinary bladder. The bladder must be fi lled with urine. This is a prerequisite for a reliable assessment and, at the same time, an acoustic window in examining adjacent structures and organs, for instance the prostate gland. In some cases, doubts occur with respect to the nature of lesions detected. The paper presents anatomic lesions, defects and pathologies which might be erroneously interpreted as tumors of the urinary bladder, i.e. transitional cell carcinoma of the urinary bladder. The following lesions are discussed: 1) anatomic defects (including urachus remnants, ligaments that stabilize the bladder or cyst in the opening of the ureter into the bladder – ureterocele); 2) tumorlike lesions in the lumen of the urinary bladder (such as blood clots, fungus balls, stones or foreign bodies); 3) bladder wall pathologies (i.e. cystitis or endometriosis), focal decidual transformation of stromal cells or infl ammatory pseudotumor; 4) lesions impressing on the bladder from the outside (the mesentery of the sigmoid colon, the bowel, pathological lesions in organs adjacent to the urinary bladder, infl ammatory infi ltration, vasogenic compression of the bladder, pelvic lipomatosis, pathological lesions of the pubic symphysis); 5) postoperative lesions. All these lesions may mimic carcinoma of the urinary bladder in sonography. Bearing this fact in mind is signifi cant in establishing a diagnosis. Due to the malignant character of carcinoma of the urinary bladder and the need for aggressive surgical treatment, a correct diagnosis of this disease is essential for patients, particularly because the lack of adequate treatment and delayed treatment considerably affect prognosis.
Jednym z podstawowych narządów jamy brzusznej ocenianych w trakcie badania ultrasonografi cznego przez powłoki jamy brzusznej wykonywanego ze wskazań urologicznych jest pęcherz moczowy. Jego dobre wypełnienie moczem stanowi bezwzględny warunek wiarygodnej oceny, a zarazem okno akustyczne w diagnostyce innych sąsiadujących struktur i narządów, np. stercza. W niektórych przypadkach pojawiają się wątpliwości co do natury wykrytych zmian. W pracy przedstawiono zmiany anatomiczne, wady oraz stany chorobowe, które można mylnie zinterpretować jako guz pęcherza moczowego, czyli rak przejściowokomórkowy pęcherza moczowego. Kolejno omówiono następujące zmiany: 1) wady anatomiczne (w tym pozostałości moczownika, więzadła stabilizujące pęcherz moczowy, torbiel ujścia pęcherzowego moczowodu – ureterocele); 2) zmiany guzopodobne w świetle pęcherza moczowego (tj. skrzepy krwi, kule grzybicze, złogi, ciała obce); 3) patologie ściany pęcherza (tzn. zapalenie pęcherza moczowego, gruczolistość macicy zewnętrzną – endometriozę), ogniskową przemianę doczesnową komórek podścieliska, guza rzekomego zapalnego; 4) zmiany modelujące od zewnątrz pęcherz moczowy (krezkę okrężnicy esowatej, jelito, zmiany chorobowe w narządach przylegających do pęcherza moczowego, naciek zapalny, ucisk pęcherza naczyniopochodny, otłuszczenie miednicy, zmiany patologiczne spojenia łonowego); 5) zmiany pooperacyjne. Wszystkie powyższe zmiany mogą dać obraz ultrasonografi czny imitujący raka pęcherza moczowego. Znajomość tego faktu jest istotna w diagnostyce. Ze względu na złośliwy charakter raka pęcherza moczowego oraz konieczność agresywnego leczenia operacyjnego właściwe rozpoznanie tej choroby ma ogromne znaczenie dla pacjenta, zwłaszcza że nie tylko brak odpowiedniej terapii, ale również jej odwleczenie w czasie znacznie pogarsza rokowanie.
Źródło:
Journal of Ultrasonography; 2014, 14, 56; 36-48
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bladder Mullerianosis – a case report
Autorzy:
Ostańska, Elżbieta
Aebisher, David
Kaznowska, Ewa
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454913.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
endocericosis
endosalpingiasis
mullerianosis
urinary bladder
Opis:
Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 277-280
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Differences of α3β1 integrin glycans from different human bladder cell lines.
Autorzy:
Lityńska, Anna
Przybyło, Małgorzata
Książek, Dorota
Laidler, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1044370.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
integrins
bladder cell lines
oligosaccharides
Opis:
Expression as well as properties of integrins are altered upon transformation. Cell adhesion regulated by integrins is modulated by glycosylation, one of the most frequent biochemical alteration associated with tumorogenesis. Characterisation of carbohydrate moieties of α3β1 integrin on the cultured human bladder carcinoma (T-24, Hu456, HCV 29T) and human normal ureter and bladder epithelium (HCV 29, Hu609) cell lines was carried out after an electrophoresis and blotting, followed by immunochemical identification of α3 and β1 integrin chains and analysis of their carbohydrates moieties using highly specific digoxigenin-labelled lectins. In all the studied cell lines α3β1 integrin was glycosylated although in general each subunit differently. Basic structures recognized in β1 subunit were tri- or tetraantennary complex type glycans in some cases sialylated (T-24, HCV 29, HCV 29T) and fucosylated (Hu609, HCV 29T). Positive reaction with Phaseolus vulgaris agglutinin and Datura stramonium agglutinin suggesting the presence of β1-6 branched N-linked oligosaccharides was found in cancerous cell lines (T-24, Hu456) as well as in normal bladder epithelium cells (Hu609). High mannose type glycan was found only in β1 subunit from Hu456 transitional cell cancer line. On the other hand α3 subunit was much less glycosylated except the invasive cancer cell line T-24 where high mannose as well as sialylated tri- or tetraantennary complex type glycans were detected. This observation suggests that changes in glycosylation profile attributed to invasive phenotype are rather associated with α3 not β1 subunit.
Źródło:
Acta Biochimica Polonica; 2000, 47, 2; 427-434
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chromium in urothelial carcinoma of the bladder
Autorzy:
Gołąbek, Tomasz
Socha, Katarzyna
Kudelski, Jacek
Darewicz, Barbara
Markiewicz-Zukowska, Renata
Chłosta, Piotr
Borawska, Maria
Powiązania:
https://bibliotekanauki.pl/articles/987066.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
chromium
bladder cancer
heavy metals
Opis:
Introduction and objectives. Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, the involvement of heavy metals in tumourigenesis of urothelial carcinoma of the bladder has been poorly investigated. Therefore, the aim of this study was to examine the relationship between chromium (Cr) and bladder cancer. Materials and methods. Chromium concentration in two 36-sample series of bladder cancer tissue and sera from patients with this neoplasm were matched with those of a control group. The amount of trace elements in every tissue sample was determined using atomic absorption spectrometry. This was correlated with tumour stage. Results. While the median chromium concentration levels reached statistically higher values in the bladder cancer tissue, compared with the non-cancer tissue (99.632ng/g and 33.144ng/g, respectively; p<0.001), the median Cr levels in the sera of the patients with this carcinoma showed no statistical difference when compared to those of the control group (0.511μg/l and 0.710μg/l, respectively; p=0.408). The median levels of Cr in the bladder tissue, depending on the stage of the tumour, compared with the tissue without the neoplasm, observed the same relationship for both non-muscle invasive and muscleinvasive tumours (p<0.001 and p<0.01, respectively). Conclusions. This study shows that patients with urothelial carcinoma of the bladder had higher tissue Cr levels than people without tumour, while no difference was found in the Cr serum levels between the two groups of patients under investigation.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bladder leiomyoma: diagnostics, laparoscopy, and treatment
Autorzy:
Godlewski, Dominik
Pszczółkowski, Patryk
Fedus, Tadeusz
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/2038414.pdf
Data publikacji:
2020-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
bladder leiomyoma
endometriosis
laparoscopic surgery
Opis:
Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leiomyoma. Description of the cases. Case 1. The work contains a diagnosis based on transvaginal ultrasound (TVUS), cystoscopy and computed tomography (CT), as well as partial laparoscopic bladder re section of leiomyoma in young women. Case 2. The case of young women with the histopathological result confirmed bladder leiomyoma. Conclusions. Leiomyoma is a rare bladder cancer. Laparoscopic bladder resection is a safe method that leads to healing
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 3; 237-241
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comprehensive review of primary gall bladder tuberculosis
Autorzy:
Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj
Powiązania:
https://bibliotekanauki.pl/articles/1392422.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
Gall bladder
Tuberculosis
Antitubercular drugs
Opis:
Tuberculosis (TB) is an infectious disease that can involve any organ system of the body. Abdominal TB can be gastrointestinal, lymph-nodal, visceral or peritoneal. Gall bladder (GB) is rarely involved as a primary organ in abdominal TB. On extensive research, the literature on gall bladder TB is limited to case reports. There has been no review on this rare abdominal pathology. The GB tuberculosis is difficult to diagnose preoperatively. It is a rare differential among the more common gall bladder pathologies like cholelithiasis, or a gall bladder malignancy. Standard histopathology of a resected specimen helps in this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers a chance to cure. Through this review the authors have tried to provide an insight into this entity.
Źródło:
Polish Journal of Surgery; 2018, 90, 4; 52-54
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spontaneous, idiopathic urinary bladder perforation – case report
Autorzy:
Wieloch, Maria
Bazylińska, Kamila
Ziemniak, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1396516.pdf
Data publikacji:
2013-12-01
Wydawca:
Index Copernicus International
Tematy:
spontaneous urinary bladder perforation
peritonitis
Opis:
Spontaneous, idiopathic urinary bladder rupture is a very rare disease entity, which may face the problem of proper preoperative diagnosis. In many cases the medical history, physical examination, and additional tests raise false suspicion of gastrointestinal perforation. The study presented a case of a female patient with spontaneous urinary bladder perforation, paying particular attention to the diagnostic difficulties associated with the above-mentioned pathology. The aim of the study was to analyse the presence of symptoms and imaging and laboratory results observed in case of spontaneous urinary bladder rupture, as well as differentiate the above-mentioned pathology with gastrointestinal perforation. Whenever diagnosing a patient with acute peritonitis symptoms, in whom the predominating symptoms include sudden abdominal pain, peritoneal cavity fluid presence, hematuria, oliguria, and coexisting increased urea, creatinine, and potassium levels, one should consider the possibility of urinary bladder rupture.
Źródło:
Polish Journal of Surgery; 2013, 85, 12; 727-729
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The macrostructure and microstructure of the urinary bladder and urethral mucosain dogs with lower urinary tract diseases
Autorzy:
Kubiak, K.
Grzegory, M.
Jankowski, M.
Spużak, J.
Glińska-Suchocka, K.
Hałoń, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087882.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bladder
urethra
urethrocystoscopy
histopathology
dog
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 713-721
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is Gall-Bladder Polyp Equivalent to Cancer? An Analysis of Material From 1196 Cholecystectomies - A Comparison of the Ultrasound and Histopathological Results
Autorzy:
Maciejewski, Piotr
Strzelczyk, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1395825.pdf
Data publikacji:
2014-05-01
Wydawca:
Index Copernicus International
Tematy:
polyp
gall-bladder
ultrasound
histopathologic score
Opis:
Polyps of the gall-bladder has long been a serious diagnostic problem. Their detection in routine ultrasound is not yet satisfactory and often does not allow you to select the proper method of operating the gall-bladder. The aim of the study was to assess the accuracy of ultrasound diagnosis of polypoid lesions of the gall-bladder through its verification by histopathology in patients treated with cholecystectomy. Material and methods. In the years 2010-2013, 1196 patients underwent surgery due to diseases of the gall-bladder at the Department of General and Transplant Surgery, Medical University in Łódź. The study evaluated the sensitivity of ultrasound in detecting polyps of the gallbladder and histopathological findings of the formulations investigated. Results. Preoperative ultrasound examination (USG) revealed a polypoid lesion in 64 patients; only in 29 of them (44.6%) this diagnosis was confirmed by histopathological examination. In the other cases, cholecystolithiasis or inflammatory lesions were found. The most common histopathological findings included cholesterol polyps, adenomatous polyps, and inflammatory polyps. Malignant lesions (gall-bladder cancer) were found in five patients preoperatively diagnosed with a polypoid lesion, i.e 7.8% of patients preoperatively diagnosed with a polyp and 0.4% of all patients who received surgical treatment. Patients qualified for surgery due to polyps diagnosed by means of ultrasound examination constitued 5.4% of all patients who underwent cholecystectomy. On histopathological examination, the presence of polyps was confirmed in 2.4% patients treated with excision of the gall-bladder. Conclusions. Detection of gall-bladder polyp on ultrasound examination is an indication for cholecystectomy, in particular when the polyp diameter exceeds 10 mm. In each case of a polyp, cholecystolithiasis should also be taken into account and the presence (or absence) of indications for cholecystectomy should be discussed with the patient
Źródło:
Polish Journal of Surgery; 2014, 86, 5; 218-222
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gall-Bladder and Hepatoduodenal Ligament Lymphangioma – Case Report and Literature Review
Autorzy:
Nazarewski, Łukasz
Patkowski, Waldemar
Pacho, Ryszard
Marczewska, Maja
Krawczyk, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1396019.pdf
Data publikacji:
2013-01-01
Wydawca:
Index Copernicus International
Tematy:
lymphangioma
gall-bladder
cholecystectomy
lymphatic vessels
Opis:
Lymphangiomas are rare benign lesions of the lymphatic vessels that are most commonly diagnosed in childhood. Intraperitoneal localization is unusual as, typically, they are located in the head and neck areas. In general, abdominal lymphangiomas seem to be asymptomatic, however, patients may occasionally suffer from acute abdominal symptoms, due to intestinal obstruction or peritonitis. The study presented a case of a 41-year-old female patient, clinically asymptomatic, who was accidentally diagnosed with a multiseptated cystic lesion of the right liver lobe surrounding the gall-bladder fossa in a routine ultrasound examination. Further examinations including computed tomography and magnetic resonance (MR) aroused suspicion of a polycystic lesion of the gall-bladder and hepatoduodenal ligament. The cystic lesion of the gall-bladder and hepatoduodenal ligament filled with lymphatic fluid was diagnosed intraoperatively. Simultaneous cholecystectomy and radical resection of the cystic lesion was undertaken. The histopathological examination revealed the presence of a lymphangioma. Additionally, the authors of the study reviewed literature data concerning gall-bladder lymphangiomas.
Źródło:
Polish Journal of Surgery; 2013, 85, 1; 39-43
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Asymptomatic bladder leiomyoma: a report of three cases treated with minimal invasive techniques and a review of literature
Autorzy:
Przudzik, Maciej
Derkaczew, Maria
Łesiów, Mirosław
Roslan, Marek
Powiązania:
https://bibliotekanauki.pl/articles/3200722.pdf
Data publikacji:
2022-09-30
Wydawca:
Medical Education
Tematy:
bladder
leiomyoma
EBRT
laparoscopic partial cystectomy
Opis:
We report a rare case of metastatic gastric cancer from invasive carcinoma of the breast (BC) as the first symptom of disease-mimicking primary gastric linitis plastica.
Źródło:
OncoReview; 2022, 12, 3; 59-64
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adhesion properties of human bladder cell lines with extracellular matrix components: the role of integrins and glycosylation.
Autorzy:
Lityńska, Anna
Przybyło, Małgorzata
Pocheć, Ewa
Laidler, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1043727.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
glycosylation
integrins
bladder cell lines
adhesion
Opis:
Integrin subunits present on human bladder cells displayed heterogeneous functional specificity in adhesion to extracellular matrix proteins (ECM). The non-malignant cell line (HCV29) showed significantly higher adhesion efficiency to collagen IV, laminin (LN) and fibronectin (FN) than cancer (T24, Hu456) and v-raf transfected (BC3726) cell lines. Specific antibodies to the α2, a5 and β1 integrin subunits inhibited adhesion of the non-malignant cells, indicating these integrin participation in the adhesion to ECM proteins. In contrast, adhesion of cancer cells was not inhibited by specific antibodies to the β1 integrin subunit. Antibodies to α3 integrin increased adhesion of cancer cells to collagen, LN and FN, but also of the HCV29 line with colagen. It seems that α3 subunit plays a major role in modulation of other integrin receptors especially in cancer cells. Differences in adhesion to ECM proteins between the non-malignant and cancer cell lines in response to Gal and Fuc were not evident, except for the v-raf transfected cell line which showed a distinct about 6-fold increased adhesion to LN on addition of both saccharides. N-Acetylneuraminic acid inhibited adhesion of all cell lines to LN and FN irrespective of their malignancy.
Źródło:
Acta Biochimica Polonica; 2002, 49, 3; 643-650
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spontaneous Cholecystocutaneous Fistula: A rare clinical Entity
Autorzy:
Gupta, Amit
Joshua, Manoj
Kumar, Navin
Chauhan, Udit
Gupta, Sweety
Powiązania:
https://bibliotekanauki.pl/articles/1391316.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
cutaneous
fistula spontaneous
gall bladder stone
Opis:
Introduction: Spontaneous Cholecystocutaneous Fistula occurs as a result of complication from untreated gall bladder stone disease infrequently seen in surgical practice due to early diagnosis of gall stone disease with imaging and appropriate and prompt antibiotic and surgical treatment. Case report: We report our experience with a 40-year-old woman who presented with a yellowish discharge from the umbilicus. Abdominal examination revealed a sinus opening at the umbilicus with the yellowish discharge and a vague mass in the right hypochondrium. CT fistulogram showed tract extending form the umbilicus to the gall bladder. Open cholecystectomy with excision of the fistulous tract was carried out. Histopathological examination showed chronic inflammation of the gall bladder with the fistulous tract lined by inflammatory granulation tissue. Post-operative recovery was normal and uneventful. The patient was normal in follow-up. Cholecystocutaneous fistula is a rare clinical entity. The diagnosis is established with CT and MRCP. Surgery remains the mainstay of treatment.
Źródło:
Polish Journal of Surgery; 2021, 93, 2; 62-65
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gall-Bladder Duplication - Case Report
Autorzy:
Koszman, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/1395844.pdf
Data publikacji:
2014-12-18
Wydawca:
Index Copernicus International
Tematy:
digestive system abnormalities
gall-bladder
cholecystectomy
Opis:
Gall-bladder duplication is a rare anatomical variation, which can affect safe performance of cholecystectomy and be a cause of persistent symptoms and a need for reoperation in case of accessory gall-bladder omission. A case of successfully performed elective laparoscopic cholecystectomy in a patient with duplicated gall-bladder accidentally intraoperatively disclosed is presented. The identified anomaly was classified according to the Harlaftis Classification of Multiple Gall-bladders. Attention was drawn to the uneffectivenes of ultrasound scanning in multiple gall-bladders preoperative detecting, and presence of other non-biliary anatomical variation in the same individual as well.
Źródło:
Polish Journal of Surgery; 2014, 86, 9; 433-435
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An unusual case of a tuberculous granuloma of the liver presenting thirteen years after intravesical BCG – therapy for bladder cancer
Autorzy:
Szczęsny, Wojciech
Szylberg, Łukasz
Słupski, Maciej
Marszałek, Andrzej
Szmytkowski, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1391514.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
BCG therapy
bladder carcinoma
liver
tuberculous granuloma
Opis:
The authors present the case of a female patient with a tumor of segment VII of the liver, which was postoperatively identified as a tuberculous granuloma. The patient was admitted for elective surgery for a liver tumor, which had been diagnosed a few months before. Computed tomography and nuclear magnetic resonance were performed, based on which focal nodular hyperplasia was suspected. Thirteen years prior to admission the patient had undergone a transurethral resection of superficial bladder carcinoma, followed by adjuvant intravesical Bacillus Calmette-Guérin (BCG-therapy). Upon surgery, segment VII of the liver was resected; postoperative course was uneventful. After the identification of granuloma, the patient was referred to a phthysiatric clinic for further diagnostics and treatment. The authors have deemed this case worthy of reporting primarily due to the exceptionally long period between the completion of BCG therapy and the onset of hepatic tumor.
Źródło:
Polish Journal of Surgery; 2021, 93, 5; 1-5
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmental risk factors for bladder cancer
Środowiskowe czynniki ryzyka rozwoju raka pęcherza moczowego
Autorzy:
Menzel, Fryderyk
Drabik, Aleksandra
Hackemer, Paweł
Otlewska, Anna
Pawlas, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1035228.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
"bladder cancer"
"environmental risk factors"
"epidemiology"
"etiology"
Opis:
Bladder cancer is a disease characterized by an abnormal growth of cells in the urinary bladder. Potentially, it can infiltrate nearby tissues and metastasize to distant organs. It affects more than 3 million people, with over 430,000 new cases a year. Environmental risk factors have significant impact on the development of bladder cancer, with tobacco smoke being the single most significant risk factor. Arsenic, nitrates, and chlorine in drinking water are also potentially associated with an elevated risk of this disease. In this paper, we review most significant environmental risk factors for primary bladder cancer and analyze prevention methods.
Rak pęcherza moczowego jest schorzeniem charakteryzującym się nieprawidłowym wzrostem komórek w pęcherzu moczowym. Potencjalnie może naciekać okoliczne tkanki i dawać przerzuty do odległych narządów. Rak pęcherza moczowego dotyka ponad 3 miliony ludzi na świecie, a co roku diagnozowanych jest ponad 430 tysięcy nowych przypadków. Środowiskowe czynniki ryzyka mają znaczący wpływ na rozwój raka pęcherza. Dym papierosowy jest czynnikiem ryzyka o największym znaczeniu. Arsen, azotany i związki chloru zawarte w wodzie pitnej są prawdopodobnie związane z podwyższonym ryzykiem raka pęcherza moczowego. Celem tego artykułu jest przegląd środowiskowych czynników ryzyka pierwotnego raka pęcherza moczowego oraz analiza metod zapobiegania.
Źródło:
Medycyna Środowiskowa - Environmental Medicine; 2018, 21, 2; 43-47
1505-7054
2084-6312
Pojawia się w:
Medycyna Środowiskowa - Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The activity of class I, II, III and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in the sera of bladder cancer patients
Autorzy:
Orywal, Karolina
Jelski, Wojciech
Werel, Tadeusz
Szmitkowski, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1038688.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
alcohol dehydrogenase isoenzymes
aldehyde dehydrogenase
bladder cancer
Opis:
Objectives. Studies on alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity in the sera of patients with malignant neoplasms show that cancer cells in many organs may release ADH isoenzymes into the blood. The aim of this study was to investigate the differences in the activity of ADH isoenzymes and ALDH in the sera of patients with bladder cancer (BCa), and with different grades of the disease. Material and Methods. Blood samples were taken from 39 patients with BCa (15 patients with low-grade and 24 with high-grade BCa) and from 60 healthy subjects. Class III and IV of ADH and total ADH activity were measured using the photometric method, while class I and II ADH and ALDH activity using the fluorometric method with class-specific fluorogenic substrates. Results. The activity of the class I ADH isoenzyme and total ADH was significantly higher in the sera of BCa patients as compared to control group. Analysis of ALDH activity did not show statistically significant differences between the tested groups. Significantly higher total activity of ADH in comparison to control was found in both, low-grade and high-grade BCa group. The activity of ADH class I was also significantly higher in high-grade BCa group when compared to low-grade patients and controls. Conclusion. The increase of total ADH activity in the sera of BCa patients seems to be caused by isoenzymes released from cancerous cells. The higher activity of ADH I probably resulted from metastatic tumors as significant increase was detected only in the sera of high-grade bladder cancer patients.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 81-84
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Folate and homocysteine status in children with neurogenic bladder due to meningomyelocele
Autorzy:
Korzeniecka–Kozerska, A.
Okurowska-Zawada, B.
Bagińska, J.
Powiązania:
https://bibliotekanauki.pl/articles/1916582.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
folic acid
homocysteine
neurogenic bladder
urodynamic investigation
Opis:
Introduction: Meningomyelocele (MMC) is the most severe form of spina bifida caused by both genetic and environmental components. It is well known that status of folate plays an important role in the risk of neural tube defects. High homocysteine (Hc) level may be associated with disturbed sensory and motor peripheral nerve function and is lowering after folic acid (FA) fortification. Purpose: To explore possible links of FA (folic acid) and Hc (Homocysteine) and to correlate them with renal and bladder function (based on urodynamics) as well as physical activity in patients with NB (neurogenic bladder) after MMC (myelomeningocele). Materials and methods: The investigation was conducted on two groups: group 1- 30 children with neurogenic bladder, group 2 - 20 healthy children with no abnormalities in urinary and nervous systems. The Hc concentration in urine and serum was estimated using the ELISA set and FA was measured in serum using electro-chemiluminescence method. FA/Hc ratio was calculated in all children. Results: The median serum and urine Hc were higher compared with reference group. Median FA/Hc ratio was statistically significantly lower in MMC group compared to reference group. There were no differences in serum FA between studied groups. We found statistically significant correlations between urodynamics parameters and FA and Hc. Conclusions: Hyperhomocyteinemia and hyper-homocysteinuria could be considered as factors influencing bladder function in MMC patients. Although serum FA level was in normal range in MMC patients it does not exclude disturbed folic acid status.
Źródło:
Progress in Health Sciences; 2014, 4, 2; 37-44
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between the high risk occupations and bladder cancer in Iran: A case-control study
Autorzy:
Khoubi, Jamshid
Pourabdian, Siamak
Mohebbi, Iraj
Tajvidi, Mina
Zaroorian, Omid
Giahi, Omid
Powiązania:
https://bibliotekanauki.pl/articles/2179768.pdf
Data publikacji:
2013-04-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
high risk occupation
bladder cancer
Iran
occupational health
Opis:
Objectives: The objective of this work was to identify the high-risk occupations in Iran and to re-inspect occupations that were related to bladder cancer. Materials and Methods: In the study, 300 patients suffering from bladder cancer and 500 control individuals were interviewed. Demographic information, occupational history, and history of exposure to chemical compounds such as aromatic amines for each participant were collected. ORs and 95% CIs were calculated using unconditional logistic regression for each occupation. Results: There was a significantly increased risk of bladder cancer among truck and bus drivers (OR = 11.3), skilled agricultural, forestry and fishery workers (OR = 6.0), metal industry workers (OR = 6.0), domestic housekeepers (OR = 5.9), and construction workers (OR = 3.8). Conclusions: The study showed a strong correlation between truck and bus drivers, skilled agricultural, forestry and fishery workers, metal industry workers, domestic housekeepers, as well as construction workers and the increased risk of bladder cancer in these occupations.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 2; 205-213
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Primary pure squamous cell carcinoma of the gall bladder – a case report of rare and aggressive entity with adverse prognosis
Autorzy:
Bargotya, Mona
Mehta, Ankita
Das, Payel
Sachan, Ashish
Powiązania:
https://bibliotekanauki.pl/articles/454981.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
adenocarcinoma
cholecystectomy
gall bladder
pure squamous cell carcinoma
Opis:
Introduction. The most common malignancy of the biliary tract is gall bladder carcinoma and the main subtype according to the histological classification is Adenocarcinoma. Pure squamous cell carcinoma of the gall bladder is very rare entity accounting for only 1.1-3.7% of the gall bladder carcinomas.It is highly malignant with poor prognosis due to high proliferative rate and local invasiveness to the adjacent organs. The patients are usually diagnosed at an advanced stage with a bulky tumor owing to its aggressive behavior. Aim. In this paper, we describe a female patient with primary pure squamous cell carcinoma of the gall bladder. Description of the case. A 42-year old female patient presented with chief complaints of pain in abdomen associated with nausea and vomiting and gradually progressive jaundice since 02 months. Contrast Enhancing Computed Tomography (CECT) abdomen showed an enhancing mass lesion in gall bladder involving adjacent organs for which she underwent extended cholecystectomy with pancreaticoduodenectomy. Conclusion. Diagnosis as well as the management of this exceptionally rare type of tumour is undoubtedly challenging because of non-specific clinical as well as imaging findings. This case report is an attempt to add to the literary evidence for better pathological as well as clinical understanding of this rare and aggressive entity thereby providing additional material for the early diagnosis as well as the development of effective targeted therapies which will certainly help in increasing the lifespan of these patients.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 59-63
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Matrix metalloproteinases in urinary system tumors. Part II - Matrix metalloproteinases in urinary bladder carcinoma
Autorzy:
Młynarczyk, G.
Kudelski, J.
Darewicz, B.
Galewska, Z.
Romanowicz, L.
Powiązania:
https://bibliotekanauki.pl/articles/1918522.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
matrix metalloproteinases
urinary tract tumors
urinary bladder carcinoma
Opis:
Matrix metalloproteinases (MMPs), also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of the extracellular matrix, resulting in its continuous remodeling. Their activity is regulated at multiple levels, while tissue inhibitors of metalloproteinases play a major role in this process. Metalloproteinases play a significant part in neoplastic processes due to their contribution to local tumor invasion, the formation of distant metastases, as well as to angiogenesis Urinary tract tumors pose a significant diagnostic and therapeutic challenge and their incidence tends to grow every year. The aim of this second part of the review is to describe the urinary system structure and function, and to highlight the contribution of matrix metalloproteinases to the development of urinary bladder tumors
Źródło:
Progress in Health Sciences; 2017, 7(1); 169-174
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Local involvement of the lower urinary tract in primary colorectal cancer – outcome after en-blocresection
Autorzy:
F.Hartwig, Morten
Bulut, Orhan
Niebuhr, Malene
Thind, Peter
Steven, Kenneth
Bülow, Steffen
Powiązania:
https://bibliotekanauki.pl/articles/1393939.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
en-bloc resection
colorectal cancer
bladder
prostate
cystoprostatectomy
cystectomy
Opis:
Invasion of urinary organs due to advanced colorectal cancer can comprise a surgical challenge in achieving negative resection margins. The aim of the study was to asses the outcome of patients with colorectal cancer invading the lower urinary organs. Material and methods. This is a cohort study that retrospectively evaluated the surgical and pathological findings after the resection of colorectal cancer with adjacent urological organs due to advanced colorectal cancer. Patients with primary colorectal cancer invading urological organs where primary resection was attempted were included. Results. The study included 31 patients who underwent surgery in our department between 1997 and 2012. Median age was 65 years (range 44‑77 years). Seventeen patients underwent partial cystectomy, one had partial prostatectomy performed, eight patients underwent cystoprostatectomy, two had cystectomy performed and three had prostatectomy performed. Overall morbidity rate was 71% (95% Confidence Interval (CI): 55‑84%, n=22). The 30-day mortality rate was 10% (95% CI: 0‑23%, n=3). Twentyseven of 31 patients had free resection margins. Four of 28 patients developed distant metastasis (14%, 95% CI: 4‑29%), 11% developed local recurrence (95% CI: 0‑25%, n=3). Median follow-up was 41 months (range 0‑150 months). Histopathological examination revealed tumour invasion in 52% (95% CI: 35‑69%, n=15) of the resected urological organs. The overall five-year survival rate was 70%. The five-year survival rate in the radical resection group was 74%. Conclusions. En-bloc resection of colorectal cancer with adjacent urological organs has a high morbidity rate. However it is still possible to achieve negative resection margins in most cases.
Źródło:
Polish Journal of Surgery; 2016, 88, 2; 99-105
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibres supplying the porcine urinary bladder wall
Autorzy:
Lepiarczyk, E.
Bossowska, A.
Kaleczyc, J.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/32489.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
botulinic toxin type A
immunohistochemistry
noradrenergic nerve fibre
cholinergic nerve fibre
nerve fibre
pig
urinary bladder
bladder wall
botulinum toxin
neurotoxin
autonomic neuron
Opis:
Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY- or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic polymorphism of Klotho gene and bladder cancer risk
Polimorfizm genu Klotho a ryzyko raka pęcherza moczowego
Autorzy:
Szymczak, Agnieszka
Forma, Ewa
Krześlak, Anna
Jóźwiak, Paweł
Bryś, Magdalena
Madej, Adam
Różański, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/1032775.pdf
Data publikacji:
2012
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
genetic polymorphism
klotho
bladder cancer
snp
polimorfizm genów
rak pęcherza
Opis:
Introduction: Bladder cancer is the most frequent tumor of the urinary tract in Poland. Klotho gene can act as an suppressor gene. Therefore, variability of this gene might be implicated in the carcinogenesis of urinary bladder. The aim of the study was analysis of the association between the g.33590184 G>A (rs1207568), g.33634983 C>T (rs564481), g.33628193 G>C (rs9527025) polymorphisms of the Klotho gene and bladder cancer risk. Materials and methods: The study included 96 patients diagnosed with transitional cell carcinoma of the bladder (TCC) and 114 healthy, cancer-free individuals. Three selected polymorphisms were typed by PCR with confronting two-pair primers (PCR-CTPP) and Real Time PCR with TaqMan probes. Results: The GA and AA genotypes of the rs1207568 polymorphism increased the risk of bladder cancer (OR = 1.86, 95% CI [1.04-3.33], p = 0.03 and OR = 6.58, 95% CI [1.27-34.02], p = 0.01, respectively). Individuals who were heterozygous and homozygous for the A variant had 2.10-fold higher risk of bladder cancer (OR = 2.10, 95% CI [1.20-3.65], p = 0.009). On the other hand, heterozygous subjects and homozygous carriers of the wild-type allele (G) had a decreased bladder cancer risk (OR = 0.19, 95% CI [0.04-0.95], p = 0.043). Also, the occurrence of bladder cancer was positively correlated with the presence of the GC genotype of the rs9527025 polymorphism (OR = 2.84, 95% CI [1.57-5.15], p = 0.0001). Conclusions: Two polymorphisms of Klotho gene (rs1207568 and rs9527025) may play a role in susceptibility to bladder cancer.
Wstęp: Rak pęcherza moczowego jest najczęściej występującym nowotworem układu moczowego w Polsce. Sugeruje się, że gen Klotho może pełnić funkcje genu supresorowego. W związku z tym, polimorfizm genu Klotho może mieć wpływ na proces transformacji nowotworowej pęcherza moczowego. Celem przedstawionych badań był analiza związku pomiędzy występowaniem wybranych polimorfizmów pojedynczych nukleotydów g.33590184 G>A (rs1207568), g.33634983 C>T (rs564481), g.33628193 G>C (rs9527025) a ryzykiem zachorowania na raka pęcherza moczowego. Materiały i metody: Do badań włączono 96 pacjentów ze zdiagnozowanym przejściowokomórkowym rakiem pęcherza moczowego (TCC; transitional cell carcinoma) oraz 114 osób zdrowych, u których nie stwierdzono choroby nowotworowej. Występowanie trzech wybranych polimorfizmów analizowano przy użyciu techniki PCR z dwiema parami przeciwstawnych starterów (PCR-CTPP; PCR with confronting two-pair primers) oraz metody Real Time PCR z sondami fluorescencyjnymi TaqMan. Wyniki: Genotypy GA i AA polimorfizmu rs1207568 wpływają na wzrost ryzyka zachorowania na przejściowokomórkowego raka pęcherza moczowego (OR = 1,86, 95% PU [1,04-3,33], p = 0,03 oraz OR = 6,58, 95% CI [1,27-34,02], p = 0,01, odpowiednio). U osób będących heterozygotami lub homozygotami pod względem allela A wykazano ponad 2-krotnie wyższe ryzyko zachorowania na raka pęcherza moczowego (OR = 2,10, 95% PU [1,20-3,65], p = 0,009). Natomiast w przypadku nosicieli allela G, w układzie homozygotycznym lub heterozygotycznym, obserwowano spadek ryzyka zachorowania na badany nowotwór (OR = 0,19, 95% PU [0,04-0,95], p = 0,043). W przypadku polimorfizmu rs952705 wykazano, że genotyp GC zwiększa ryzyko zachorowania na przejściowokomórkowego raka pęcherza moczowego (OR = 2,84, 95% PU [1,57-5,15], p = 0,0001).Wnioski: Dwa spośród badanych polimorfizmów genu Klotho (rs1207568 i rs9527025) mogą mieć wpływ na predyspozycję do zachorowania na przejściowokomórkowego raka pęcherza moczowego.
Źródło:
Folia Medica Lodziensia; 2012, 39, 2; 189-205
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inflammatory and oxidative status in neurogenic bladder children after meningomyelocele
Autorzy:
Korzeniecka–Kozerska, A.
Liszewska, A.
Powiązania:
https://bibliotekanauki.pl/articles/1916710.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Uric Acid
bladder function
C-Reactive Protein
Urodynamics
thiol staus
Opis:
Introduction: Neurogenic bladder (NB) most often is caused by meningomyelocele (MMC) and manifests with various lower urinary tract dysfunctions. Condition of NB is worsened by inflammatory process or oxidative status imbalance. Purpose: To estimate of urinary uric acid (UA), hs-CRP, thiol status in association with NB function in MMC patients.Materials/Methods: 33 MMC children and 20 healthy individuals were included into the study. The first daytime urine samples were collected from all examined participants and urinary thiol status, hs CRP and UA were measured.Results: MMC children presented higher urinary UA level. The median hs-CRP level were also higher in MMC patients compared to the reference. Thiol status were lower in MMC individuals compared to reference group. We found positive correlation between serum creatinine, serum UA and urine creatinine and negative between serum creatinine and GFR. Correlations between urinary UA and physical development parameters, renal function, hsCRP, thiol status and urodynamic findings in MMC and reference groups were found.Conclusions: UA is a marker potentially having direct effect on the bladder function. Disturbed oxidative status and increased markers of inflammation may be a potentially modifiable factors affecting function of lower urinary tract in MMC children.
Źródło:
Progress in Health Sciences; 2015, 5, 1; 22-28
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
2-naphthylamine toxicity
Autorzy:
Czubacka, Ewelina
Czerczak, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/2085462.pdf
Data publikacji:
2020-03-30
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
bladder cancer
occupational health
carcinogen
toxicology
health effects
2-naphthylamine
Opis:
In the past, 2-naphthylamine (2-NA) was used for the production of azo dyes, as an antioxidant in the cable industry and in the rubber industry. Despite the fact that 2-NA is not produced on an industrial scale, it is still used in small quantities as a model bladder carcinogen in laboratories, and also for sewage control, water analysis and oxytocinase assays. In addition, it is detected in the air in coke ovens, where it is formed as one of the pyrolysis products. The main aim of this work is to provide an actual literature review for health risk assessments related to 2-NA which is still used in laboratories. Occupational exposure to 2-NA is important for the respiratory tract, mucous membranes and the skin, and, to a lesser extent, for absorption from the gastrointestinal tract. It is absorbed into the body through the skin and by inhalation, and then undergoes metabolic changes. Most of the absorbed 2-NA dose is excreted in the urine, in the form of metabolites, metabolites conjugated to acids, and even in an unchanged form. Based on literature data, the effects of 2-NA toxicity in sub-chronic and chronic exposure include contact dermatitis, chronic cystitis and bladder cancer. The authors have concluded that it is recommended to determine the occupational exposure limit which will allow preparing the exposure assessment of people at work. Med Pr. 2020;71(2):205–20
Źródło:
Medycyna Pracy; 2020, 71, 2; 205-220
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gene-occupation interactions: a review of the literature on bladder and prostate cancer
Autorzy:
Wieczorek, Edyta
Wolniakowska, Anna
Roszak, Joanna
Rodrigues, Robim M.
Vanhaecke, Tamara
Reszka, Edyta
Powiązania:
https://bibliotekanauki.pl/articles/2203023.pdf
Data publikacji:
2023-05-19
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
bladder cancer
gene
genetic susceptibility
occupational exposure
prostate cancer
workplace
Opis:
Bladder cancer (BCa) and prostate cancer (PCa) are genitourinary cancers which constitute significant health problems in men and in which environmental factors play an important role. Understanding the genetic susceptibility to BCa or PCa and occupational exposure is paramount to improving cancer prevention and early detection. The aim of this review article was to address the scientific evidence on the genetic risk factors and occupational exposure associated with the occurrence of BCa and PCa. The authors identified relevant original articles that have been published between 1994 and 2023. Variations of the following search terms: “gene” and “occupational” combined with one of the following terms: “bladder cancer” or “prostate cancer” were applied for the search purpose. The authors found 342 publications of which 50 population studies met their requirements for gene-occupation interactions. In total, 34 full-text manuscripts were about BCa and 16 about PCa. These research examines the genes involved in detoxification processes of xenobiotics (glutathione S-transferase, N-acetyltransferase, cytochrome P450, UDP-glucuronosyltransferase), oxidative stress (glutathione peroxidase 1, manganese superoxide dismutase, catalase), altering DNA repair capacity (X-ray repair cross-complementing 1, base excision repair, nucleotide excision repair), tumour suppression (TP53 gene), and vitamin D pathway (vitamin D receptor gene). The role of genetic factors in the occupational exposure has not been conclusively established, but it appears the possibility of genetic involvement. Determination of environmentally responsive genes provides important mechanistic implications for the etiology of occupational cancers, and valuable input in occupational exposure limits set by taking genetic susceptibility into account. More genetic research is needed to corroborate these findings and assess their significance in the workplace. Med Pr. 2023;74(2):127–44
Źródło:
Medycyna Pracy; 2023, 74, 2; 127-144
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution and chemical coding of urinary bladder apex-projecting neurons in aorticorenal and testicular ganglia of the male pig
Autorzy:
Pidsudko, Z.
Listowska, Ż.
Franke-Radowiecka, A.
Klimczuk, M.
Załęcki, M.
Kaleczyc, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087510.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
prevertebral ganglia
urinary bladder apex
immunohistochemistry
retrogradetracing
neuropeptides
male pig
Źródło:
Polish Journal of Veterinary Sciences; 2019, 2; 427-430
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-histone nuclear protein HMGN2 differently regulates the urothelium barrier function by altering expression of antimicrobial peptides and tight junction protein genes in UPEC J96-infected bladder epithelial cell monolayer
Autorzy:
Tian, Hanwen
Miao, Junming
Zhang, Fumei
Xiong, Feng
Zhu, Feimei
Li, Jinyu
Wang, Xiaoying
Chen, Shanzhe
Chen, Junli
Huang, Ning
Wang, Yi
Powiązania:
https://bibliotekanauki.pl/articles/1038529.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
HMGN2
UPEC
BECs 5637
bladder epithelium
tight junction
antimicrobial peptides
Opis:
The urinary tract is vulnerable to frequent challenges from environmental microflora. Uropathogenic Escherichia coli (UPEC) makes a major contribution to urinary tract infection (UTI). Previous studies have characterized positive roles of non-histone nuclear protein HMGN2 in lung epithelial innate immune response. In the study presented here, we found HMGN2 expression was up-regulated in UPEC J96-infected urothelium. Surprisingly, over-expression of HMGN2 promoted disruption of BECs 5637 cells' intercellular junctions by down-regulating tight junction (TJs) components' expression and physical structure under J96 infection. Further investigation showed that BECs 5637 monolayer, in which HMGN2 was over-expressed, had significantly increased permeability to J96. Our study systemically explored the regulatory roles of HMGN2 in BECs barrier function during UPEC infection and suggested different modulations of intracellular and paracellular routes through which UPEC invades the bladder epithelium.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 93-100
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surgical trap of a routine procedure. Scrotal hernia with concomitant sliding of the urinary bladder – case report
Autorzy:
Cybułka, Bartosz
Podgórny, Marek
Rapeła, Jacek
Wach, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1394320.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
scrotal hernia
sliding hernia
sliding of the urinary bladder
scrotal cystocele
Opis:
The content of the hernial sac may comprise peritoneal cavity elements, such as small and large bowel loops, visceral adipose tissue, the greater omentum, appendix (amyand hernia), and Meckel's diverticulum. The sliding of part of the urinary bladder wall to the inguinal canal is rare, being observed in 1%-4% (0.5%-3%) of inguinal hernia cases. Complete migration of the urinary bladder to the scrotum is considered a rare anomaly. As of today, 100 such cases have been described.
Źródło:
Polish Journal of Surgery; 2015, 87, 11; 587-591
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Renal Carcinoma Metachronous Metastases to the Gall-Bladder and Pancreas - Case Report
Autorzy:
Zygulska, Aneta
Wójcik, Adrian
Richter, Piotr
Krzesiwo, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1396695.pdf
Data publikacji:
2012-06-01
Wydawca:
Index Copernicus International
Tematy:
clear cell renal carcinoma
metastasis to the gall-bladder and pancreas
Opis:
Renal carcinoma metastases to the gastrointestinal tract are seldom reported in medical literature. The study presented a case of a 76-year old female patient who underwent nephrectomy, due to T2N0M0 clear cell renal carcinoma and was additionally diagnosed with two metachronous metastases to the gall-bladder and pancreas. Abdominal ultrasound performed 32 months after nephrectomy demonstrated the presence of cholelithiasis and gall-bladder polyp. Laparoscopic cholecystectomy was performed. Clear cell renal carcinoma metastasis restricted to the gall-bladder mucosa was diagnosed on the basis of the histopathological examination. After surgery the patient remained under follow-up. In December, 2009 (47 months after nephrectomy) abdominal computer tomography (CT) revealed the presence of a tumor located in the tail of the pancreas. Distal pancreatic resection and splenectomy was performed. The histopathological examination confirmed the presence of clear cell renal carcinoma metastasis. The patient is in good general condition, under follow-up at the Oncological Outpatient Clinic.
Źródło:
Polish Journal of Surgery; 2012, 84, 6; 313-316
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The distribution and chemical coding of urinary bladder trigone-projecting neurons in testicular and aorticorenal ganglia in male pigs
Autorzy:
Pidsudko, Z.
Godlewski, J.
Wąsowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/16539341.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
prevertebral ganglia
urinary bladder trigone
immunohistochemistry
retrograde tracing
neuropeptides
male pig
Opis:
Combined retrograde tracing and double-labelling immunofluorescence were used to investigate the distribution and chemical coding of neurons in testicular (TG) and aorticoerenal (ARG) ganglia supplying the urinary bladder trigone (UBT) in juvenile male pigs (n=4, 12 kg. of body weight). Retrograde fluorescent tracer Fast Blue (FB) was injected into the wall of the bladder trigone under pentobarbital anesthesia. After three weeks all the pigs were deeply anesthetized and transcardially perfused with 4% buffered paraformaldehyde. TG and ARG, were collected and processed for double-labelling immunofluorescence. The expression of tyrosine hydroxylase (TH) or dopamine beta-hydroxylase (DBH), neuropeptide Y (NPY), somatostatin (SOM), galanin (GAL), nitric oxide synthase (NOS) and vesicular acetylcholine transporter (VAChT) were investigated. The cryostat sections were examined with a Zeiss LSM 710 confocal microscope equipped with adequate filter blocks. The TG and ARG were found to contain many FB-positive neurons projecting to the UBT (UBT-PN). The UBT-PN were distributed in both TG and ARG. The majority of them were found in the right ganglia, mostly in TG. Immunohistochemistry disclosed that the vast majority of UBT-PN were noradrenergic (TH- and/or DBH-positive). Many noradrenergic neurons contained also immunoreactivity to NPY, SOM or GAL. Most of the UBT-PN were supplied with VAChT-, or NOS- IR (immunoreactive) varicose nerve fibres. This study has revealed a relatively large population of differently coded prevertebral neurons projecting to the porcine urinary bladder. As judged from their neurochemical organization these nerve cells constitute an important element of the complex neuro-endocrine system involved in the regulation of the porcine urogenital organ function.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 3; 483-487
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rak pęcherza moczowego – epidemiologia, diagnostyka i leczenie w XXI wieku
Urinary bladder cancer – epidemiology, diagnostics and treatment in XXIst century
Autorzy:
Jabłonowski, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1032741.pdf
Data publikacji:
2013
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
rak pęcherza moczowego
epidemiologia
diagnostyka
leczenie
urinary bladder cancer
epidemiology
diagnostics
treatment
Opis:
Urinary bladder cancer is one of the most common cancers occurring in those aged older, especially between 60 and 80 years of age. In Poland, it is the fourth (after lung, prostate, and colon cancers) on/in the incidence of cancer in men and thirteenth in women. Epidemiological indicators of bladder cancer in Poland are disturbing to other European countries, where a decrease is observed in both morbidity and mortality. In the years 1991-2006 in Poland a very dynamic increase in the incidence of bladder cancer (reaching 59%) was recorded. What's more, our country ranks second, after Spain, in Europe in terms of mortality from this cancer. In the coming years the number of cases and deaths from bladder cancer in Poland is expected to increase. This article discusses new information/data on the epidemiology, methods of diagnosis and treatment of patients with bladder cancer.
Źródło:
Folia Medica Lodziensia; 2013, 40, 1; 31-52
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cystektomia radykalna w Polsce – co się zmieniło przez 15 lat. Ocena porównawcza według skali pTNM na podstawie wybranych prac
Radical cystectomy in Poland – what has been changed during 15 years. Comparative evaluation of publications based on pTNM classification
Autorzy:
Borkowski, Krzysztof
Różański, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/970199.pdf
Data publikacji:
2020
Wydawca:
Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
Tematy:
bladder cancer
radical cystectomy
classification pTNM
rak pęcherza moczowego
cystektomia radykalna
klasyfikacja pTNM
Opis:
Radical cystectomy is the gold standard of therapy in bladder cancer that infiltrates muscularis mucosae. The nature of changes in the form of bladder cancer treatment was assessed in scientific papers based on the pTNM scale in Poland over a 15-year period (2002–2017). Simple statistical tools were used for that purpose on the basis of publications of eleven academic and other centers. The number of patients was 1502 and the average age of the patients who underwent the surgical operation was 64,5 years. Despite the passage of years locally advanced forms of pT3 and pT4 neoplasm, that constitute more than 50% of cases, are still treated with surgery. The forms of muscularis mucosae that infiltrate bladder cancer with good prognoses – pT2 – do not exceed 30% of the patients operated on.
Złotym standardem w leczeniu raka pęcherza moczowego naciekającego mięśniówkę jest cystektomia radykalna. W pracy oceniono charakter zmian formy leczenia raka pęcherza moczowego na podstawie skali pTNM w Polsce w okresie 15 lat (2002–2017). W tym celu zastosowano opisywanie danych oparte na szeregu statystycznym na podstawie wybranych publikacji z jedenastu ośrodków urologicznych. Liczba chorych wynosiła 1502, a średnia wieku operowanych – 64,5 lat. Mimo upływu lat nadal chirurgicznie operuje się postaci zaawansowane lokalnie nowotworów pT3 i pT4, które stanowią ponad 50% przypadków. Postaci raka pęcherza moczowego naciekającego mięśniówkę dobrze rokujące – pT2 – nie przekraczają 30% operowanych chorych.
Źródło:
Państwo i Społeczeństwo; 2020, 2; 83-90
1643-8299
2451-0858
Pojawia się w:
Państwo i Społeczeństwo
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism and smoking on bladder cancer risk: Two meta-analyses
Autorzy:
Wang, Xiao-Chun
Wang, Jian
Tao, Hui-Hui
Zhang, Chao
Xu, Li-Fa
Powiązania:
https://bibliotekanauki.pl/articles/2161894.pdf
Data publikacji:
2017-07-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
polymorphisms
meta-analysis
NQO1
urinary bladder neoplasms
smoking
SULT1A1
Opis:
Objectives Objectives: Cigarette smoking is the major risk factor of bladder cancer via exposure to chemical carcinogens. Nicotinamide adenine dinucleotide phosphate (NADP+): quinine oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) have been reported to involve in the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Therefore, the risk of bladder cancer (BC) may be influenced by polymorphisms in the genes that modulate metabolic detoxification in particular by interacting with cigarette smoking. Considering the limited power by the individual studies with a relatively small sample size, especially when analyzing the combined effect of polymorphisms in NQO1 and SULT1A1 genes and smoking, these 2 meta-analyses have aimed to clarify the combined effects of them on BC risk by integrating related studies. Material and Methods Two meta-analyses included 1341 cases and 1346 controls concerning NQO1 Pro187Ser and smoking, and 1921 cases and 1882 controls on SULT1A1 Arg213His and smoking were performed. Odds ratios (OR) and 95% confidence intervals (CI) were used for assessing the strength of the association. Results The result has demonstrated that smokers with NQO1 Pro/Ser or Ser/Ser genotypes have a prominent association with the risk of BC as compared with non-smokers with NQO1 Pro/Pro genotype, with OR equal to 3.71 (95% CI: 2.87–4.78, $ \text{p}_\text{heterogeneity} $ = 0.376). Besides, smokers carrying SULT1A1 Arg/Arg genotypes were observed to confer 2.38 fold increased risk of BC (95% CI: 1.44–3.93, $ \text{p}_\text{heterogeneity} $ = 0.001) when compared with non-smokers with SULT1A1 Arg/Arg or His/His genotypes. Conclusions These findings have suggested that the NQO1 Pro187Ser or SULT1A1 Arg213His polymorphism combination with smoking significantly confer susceptibility to BC. Int J Occup Med Environ Health 2017;30(5):791–802
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2017, 30, 5; 791-802
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Description of Triangulamyxa psittaca sp. n. (Myxozoa: Myxosporea), a new parasite in the urinary bladder of Colomesus psittacus (Teleostei) from the Amazon River, with emphasis on the ultrastructure of plasmodial stages
Autorzy:
Rocha, Sónia
Casal, Graça
Matos, Patrícia
Matos, Edilson
Dkhil, Mohamed A.
AZEVEDO, Carlos
Powiązania:
https://bibliotekanauki.pl/articles/763644.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Ultrastructure, plasmodia, myxosporean, Triangulamyxa psittaca sp. nov., parasite, urinary bladder, freshwater fish, Colomesus psittacus
Opis:
A fish-infecting myxosporean was found in the urinary bladder of the teleostean Colomesus psittacus, collected from the Amazon River, Brazil. Specimens were sampled in three different periods: May and June, with water temperature ranging from 18–23ºC; August, with water temperature ranging from 24–28ºC; and November and December, with water temperature ranging from 29–32ºC. Upon observation, several fish displayed abnormal behaviour, consisting of erratic movements, and mortality was recorded among them. Necropsy of all sampled fishes revealed hypertrophy of the urinary bladder only among specimens previously displaying the irregular behaviour. Microscopic analysis of this organ confirmed the parasitic infection, resulting in the observation of spores floating free in the urine, and numerous plasmodia attached to the epithelium of the urinary bladder. Light and ultrastructural studies allowed recognition of the spores and plasmodia morphological characteristics. Coelozoic plasmodia were polysporic with varying organizational structure, according to the sampling period. Spores were equilaterally triangular with rounded ends in valvar view, measuring 8.8 ± 0.4 μm (n = 30) in length and 8.4 ± 0.5 μm (n = 30) in width, and displaying a ridge surface pattern. Two polar capsules were observed in the anterior end of the spores, measuring 3.1–3.2 μm in diameter. The spores were morphologically identified as belonging to the recently described genus Triangulamyxa. Further observation and comparison to the morphological features described for Triangulamyxa amazonica, the only other species within this genus, allowed us to conclude our parasite as a new species, herein named Triangulamyxa psittaca sp. nov. from the Amazon River, Brazil. Also, three different stages were distinguished in the plasmodium evolution, based on the observed morphological features at the three sampling periods. Fish sampled during May and June displayed small plasmodia (up to ~ 15–20 μm long), containing early stages of sporogenic development. Fish sampled during November and December presented larger plasmodia (up to ~ 850 μm long), which appeared flattened against and lining the urinary bladder epithelial cells and contained the later stages of sporogenic development, including some mature spores. Fish sampled during August presented plasmodia displaying intermediate morphological features between those observed in infected fish from the other sampling periods. Several immature and mature spores were among the different developmental stages. The parasite-host interface evolution is described throughout the different observed stages, with emphasis on the formation of septate junctions. Considering several previous reports, as well as the different environmental conditions during the sampling periods, the plasmodium development here described appears to be influenced by environmental factors, namely water temperature.
Źródło:
Acta Protozoologica; 2011, 50, 4
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of DNA methyltransferase and histone deacetylase inhibitors on αKlotho gene expression in bladder cancer T24 cell line
Wpływ inhibiotorów metylotransferaz DNA oraz deacetylaz białek histonowych na kspresję genu αKlotho w komórkach raka pęcherza moczowego linii T24
Autorzy:
Szymczyk, Agnieszka
Forma, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1032842.pdf
Data publikacji:
2014
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
bladder cancer
klotho
dna methylation
histone deacetylation
rak pęcherza moczowego
metylacja dna
deacetylacja histonów
Opis:
Introduction: αKlotho gene was originally identified as a putative agesuppressing gene in mice. Recently it is known that αKlotho gene functions as a tumor suppressor in many types of cancer, including breast, pancreas, gastric, colon, lung and cervical cancer. The downregulation of αKlotho expression was associated with CpG hipermethylation of promoter region and histone deacetylation. Bladder cancer is the most common cancer of the urinary tract in Polish population. The aim of this study was the analysis of the effect of DNA methyltransferase and histone deacetylase inhibitors on αKlotho gene expression in bladder cancer cells. Materials and methods: In this study T24 bladder cancer cell line was used. The analysis of the effect of DNA methyltransferase and histone deacetylase inhibitors on αKlotho gene expression was performed using Real Time PCR method with TaqMan probes. To determine the methylation profile of αKlotho gene promoter region quantitive Methylation-Specific Polymerase Chain Reaction technique was used. Results: The treatment of T24 cells with DNA methyltransferase inhibitor (AZA) restored the expression of αKlotho gene. After AZA treatment, the methylation level of CpG island in the promoter region of αKlotho gene was nearly half lower (p<0.05) than control cells. In case of the treatment of T24 cells with histone deacetylase inhibitor (TSA) we did not observe any changes in αKL gene expression in respect to the control cells. Treatment cells with both the inhibitors led to the significant increase of mRNA αKlotho gene expression level (p<0.001). Conclusions: The changes in αKlotho gene expression on mRNA level are associated with epigenetic changes.
Wstęp: Gen αKlotho pierwotnie zidentyfikowany został u myszy jako gen, którego ekspresja wpływa na długość ich życia. Obecnie wiadomo, że αKlotho spełnia funkcję genu supresorowego w przypadku wielu typów nowotworów, m.in. w raku piersi, trzustki, żołądka, płuc, okrężnicy i raku szyjki macicy. Wykazano, że spadek ekspresji genu αKlotho związany jest z hipermetylacją wysp CpG w obrębie regionu promotorowego oraz deacetylacją histonów. Rak pęcherza moczowego jest najczęściej występującym nowotworem układu moczowego w Polsce. Celem prowadzonych badań była analiza wpływ inhibitorów metylotransferaz DNA oraz deacetylaz białek histonowych na ekspresję genu αKlotho w komórkach raka pęcherza moczowego. Materiały i metody: Materiał do badań stanowiła linia komórek raka pęcherza moczowego T24. Analizę wpływu inhibitorów metylotransferaz DNA oraz deacetylaz białek histonowych na ekspresję genu αKlotho prowadzono techniką Real Time PCR z użyciem sond fluorescencyjnych TaqMan. Ocenę stopnia metylacji regionu promotorowego badanego genu prowadzono przy użyciu techniki ilościowego MSP-PCR (ang. Methylation-Specific Polymerase Chain Reaction). Wyniki: W wyniku traktowania komórek linii T24 inhibitorem metylotransferaz DNA (AZA) obserwowano przywrócenie ekspresji genu αKlotho. W porównaniu do komórek kontrolnych, komórki traktowane 5-aza-2′-deoksycytydyną wykazywały blisko o połowę niższy stopień metylacji wysp CpG w regionie promotorowym genu αKlotho (p<0,05). W wyniku traktowania komórek inhibitorem deacetylaz białek histonowych (TSA) nie obserwowano zmian w ekspresji genu αKL. Zastosowanie obu inhibitorów prowadziło do istotnego wzrostu ekspresji genu αKlotho na poziomie mRNA (p<0,001). Wnioski: Zmiany ekspresji genu αKlotho na poziomie mRNA związane są ze zmianami we wzorze modyfikacji epigenetycznych.
Źródło:
Folia Medica Lodziensia; 2014, 41, 2; 111-119
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stratification conditions determining seed dormancy release of European bladder nut [Staphylea pinnata L.]
Autorzy:
Tylkowski, T
Powiązania:
https://bibliotekanauki.pl/articles/57767.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
Staphylea pinnata
stratification condition
botany
sowing pretreatment
European bladder nut
germination
seed dormancy
shrub
Opis:
European bladder nut has its northern limit in Poland and is legally protected. Climatic conditions, edible seeds attractive for small animals and seed dormancy to a large extent affect its restocking under natural conditions. The aim of this study was to determine conditions for seed dormancy release. Nuts dried after collection to ca 11% of moisture content (fresh weight basis) may be stored without loss of seed viability for over 1 year in a cold store at the temperature of -3oC. For the purpose of seed dormancy release nuts need to be stratified. Seed dormancy release was found highest after the application of warm-followed-by-cold stratification, first for 4-6 weeks at the temperature of 15oC or at cyclically alternating temperature of 10~20oC (24+24 h/cycle), followed by 16-18 weeks at 3oC. Seeds germinate at 3oC with the same rate as at cyclically alternating temperature of 3~15oC (16+8 h/day). Drying of nuts at room temperature to approx. 11% during the warm stratification phase (after 2 or 4 weeks) and further stratification resulted in a significant increase in seed germinability. In some seed lots scarification of nuts (dried during the warm stratification phase) contributes to a further significant increase of seed germinability.
Źródło:
Acta Societatis Botanicorum Poloniae; 2007, 76, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nieinwazyjne biomarkery do wykrywania raka pęcherza moczowego
Non-invasive biomarkers for detection of bladder cancer
Autorzy:
Gruba, Natalia
Powiązania:
https://bibliotekanauki.pl/articles/2200430.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
biomarkery
nowotwór pęcherza moczowego
testy diagnostyczne
choroby nowotworowe
biomarkers
bladder cancer
diagnostic tests
cancerous diseases
Opis:
Bladder cancer (BC) is one of the most common cancer in the world. About 3% of all new cancer diagnoses are due to urinary bladder cancer. BC is also a leading cause of cancer-related death, as 2.1% of all cancer deaths are caused by bladder cancer. However, lack of a reliable biomarker is the biggest issue for BC diagnosis, prognosis and treatment. Development of non-invasive, quick and economical methods in bladder cancer diagnosis still remains a great challenge. Highly specific, easy-to-perform tests are really needed. Ideally if they can identify the presence of a tumor before the first symptoms appear, as time plays an important role in cancer. In this article, an overview of the current established diagnostic tests and newly identified biomarkers will be provided.
Źródło:
Wiadomości Chemiczne; 2022, 76, 9-10; 719--734
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Are agricultural and natural sources of bio-products important for modern regenerative medicine? A review
Autorzy:
Nowacki, Maciej
Nowacka, Katarzyna
Kloskowski, Tomasz
Pokrywczyńska, Marta
Tyloch, Dominik
Rasmus, Marta
Warda, Karolina
Drewa, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/989866.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
cellulose
plant extract
alginate
chitosan
porcine scaffold
small intestine submusocsa (sis)
bladder acellular matrix (bam)
Opis:
Introduction and objectives. As tissue engineering and regenerative medicine have continued to evolve within the field of biomedicine, the fundamental importance of bio-products has become increasingly apparent. This true not only in cases where they are derived directly from the natural environment, but also when animals and plants are specially bred and cultivated for their production. Objective. The study aims to present and assess the global influence and importance of selected bio-products in current regenerative medicine via a broad review of the existing literature. In particular, attention is paid to the matrices, substances and grafts created from plants and animals which could potentially be used in experimental and clinical regeneration, or in reconstructive procedures. Summary. Evolving trends in agriculture are likely to play a key role in the future development of a number of systemic and local medical procedures within tissue engineering and regenerative medicine. This is in addition to the use of bio-products derived from the natural environment which are found to deliver positive results in the treatment of prospective patients.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of resiniferatoxin on the chemical coding of neurons in dorsal root ganglia supplying the urinary bladder in the female pig
Autorzy:
Bossowska, A.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/30452.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
resiniferatoxin
chemical coding
neuron
dorsal root ganglion
urinary bladder
female
pig
sensory innervation
immunohistochemistry
neuropeptide
Opis:
Although resiniferatoxin (RTX) becomes more often used in experimental therapies of sensory system disorders, so far there is no data concerning the influence of RTX on the chemical coding of neurons in dorsal root ganglia (DRG) supplying the urinary bladder in the pig, an animal species considered as a reliable animal model for investigation dealing with human lower urinary tract disorders. Retrograde tracer Fast Blue (FB) was injected into the wall of the right half of the urinary bladder in six juvenile female pigs, and three weeks later, bladder instillation of RTX (500 nmol per animal) was carried out in all the animals. After a week, DRGs were harvested from all the pigs and the neurochemical characterization of FB+ neurons was performed using routine single-immunofluorescence labeling technique on 10-μm-thick cryostat sections. RTX instillation resulted in a distinct decrease in the numbers of FB+ cells containing calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), somatostatin (SOM) and calbindin (CB) when compared with those found in the healthy animals (18% vs. 36%, 1% vs. 6%, 0.8% vs. 4% and 0.5% vs. 3%, respectively), and an increase in the number of pituitary adenylate cyclase-activating polypeptide (PACAP)- and galanin (GAL)-immunoreactive (IR) nerve cells (51% vs. 26% and 47% vs. 6.5%). The results obtained suggest that RTX could be taken into consideration when the neuroactive agents are planned to be used in experimental therapies of selected neurogenic bladder illnesses.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Conantokin G-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder
Autorzy:
Bossowska, A.
Majewski, M.
Powiązania:
https://bibliotekanauki.pl/articles/31315.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conantokin G
chemical coding
urinary bladder
dorsal root ganglion
neuron
sensory innervation
immunohistochemistry
neuropeptide
pig
Opis:
Conantokin G (CTG), isolated from the venom of the marine cone snail Conus geographus, is an antagonist of N-methyl-d-aspartate receptors (NMDARs), the activation of which, especially those located on the central afferent terminals and dorsal horn neurons, leads to hypersensitivity and pain. Thus, CTG blocking of NMDARs, has an antinociceptive effect, particularly in the case of neurogenic pain treatment. As many urinary bladder disorders are caused by hyperactivity of sensory bladder innervation, it seems useful to estimate the influence of CTG on the plasticity of sensory neurons supplying the organ. Retrograde tracer Fast Blue (FB) was injected into the urinary bladder wall of six juvenile female pigs. Three weeks later, intramural bladder injections of CTG (120 μg per animal) were carried out in all animals. After a week, dorsal root ganglia of interest were harvested from all animals and neurochemical characterization of FB+ neurons was performed using a routine double-immunofluorescence labeling technique on 10-μm-thick cryostat sections. CTG injections led to a significant decrease in the number of FB+ neurons containing substance P (SP), pituitary adenylate cyclase activating polypeptide (PACAP), somatostatin (SOM), calbindin (CB) and nitric oxide synthase (NOS) when compared with healthy animals (20% vs. 45%, 13% vs. 26%, 1.3% vs. 3%, 1.2 vs. 4% and 0.9% vs. 6% respectively) and to an increase in the number of cells immunolabelled for galanin (GAL, 39% vs. 6.5%). These data demonstrated that CTG changed the chemical coding of bladder sensory neurons, thus indicating that CTG could eventually be used in the therapy of selected neurogenic bladder illnesses.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Joint effect of N-acetyltransferase 2 gene and smoking status on bladder carcinogenesis in Algerian population
Autorzy:
Ribouh-Arras, A.
Chaoui-Kherouatou, N.
Hireche, A.
Abadi, N.
Satta, D.
Powiązania:
https://bibliotekanauki.pl/articles/80202.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
N-acetyltransferase 2 gene
genetic polymorphism
malignancy
bladder cancer
single nucleotide polymorphism
phenotype
smoking
Algerian population
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of arylamine N-acetyltransferase [NAT1 and NAT2] genotypes with urinary bladder cancer risk
Autorzy:
Jaskula-Sztul, R
Sokolowski, W.
Gajecka, M.
Szyfter, K.
Powiązania:
https://bibliotekanauki.pl/articles/2041980.pdf
Data publikacji:
2001
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
tobacco smoking
human genetics
genotype
urinary bladder
polymerase chain reaction
cancer
acetylator genotype
arylamine N-acetyltransferase
Źródło:
Journal of Applied Genetics; 2001, 42, 2; 223-231
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Problem z wadami gazowymi w odlewni żeliwa
Problem with Castings Gas Defects in Iron Foundry
Autorzy:
Kołodziej, R.
Kostrzewski, Ł.
Szajnar, J.
Powiązania:
https://bibliotekanauki.pl/articles/379736.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
żeliwo sferoidalne
wada gazowa
pęcherz zewnętrzny
odlewnia żeliwa
ductile cast iron
gas defect
external bladder
iron foundry
Opis:
Przedstawione w artykule zagadnienia dotykają problemu wad gazowych występujących w Odlewni Żeliwa. Obejmują one genezę nakłuć oraz pęcherzy zewnętrznych pojawiających się na odlewach z żeliwa EN-GJS-400-15. Pokazano w jaki sposób w warunkach przemysłowych odlewni dokonano analizy pochodzenia tych wad. Przedstawiono wyniki badań próbek pobranych z problematycznych odlewów oraz metody ich badań. Wskazano również w jaką niezbędną aparaturę pomiarową należy zaopatrzyć Odlewnię aby w przyszłości na etapie przygotowania procesu, można było prognozować i redukować występowanie nakłuć oraz pęcherzy zewnętrznych.
Presented paper concerns the issues of gas defects occurring during casting manufacturing in a foundry. These include the origin of pinholes and external bladders that appear on the external surface of EN-GJS-400-15 grade cast iron castings. The paper shows how, in industrial conditions, such defects are analyzed. Examinations results for samples taken from the problematic castings were shown together with applied methods description. It was also indicated, what kind of measuring equipment is necessary to predict and reduce the occurrence of gas defects in the future production.
Źródło:
Archives of Foundry Engineering; 2013, 13, 3 spec.; 75-78
1897-3310
2299-2944
Pojawia się w:
Archives of Foundry Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Contemporary diagnostic methods of the urinary system in patients after spinal injury with subsequent neurological deficits: Diagnostics of the lower urinary tract
Współczesne metody oceny układu wydalniczego u osób po urazie kręgosłupa powikłanym zaburzeniami neurologicznymi – diagnostyka dolnych dróg moczowych
Autorzy:
Tederko, Piotr
Krasuski, Marek
Kiwerski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1938546.pdf
Data publikacji:
2007
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
Spin
injury
complications
diagnostics
neurogenic bladder
lower urinary tract
Kregosłup
uraz
powikłania
diagnostyka
pecherz neurogenny
dolne drogi moczowe
Opis:
Introduction: Spinal injury with neurological deficit usually results in a neurogenic bladder disorder. The problem may range from total lack of micturition during the spinal shock phase to various forms of detrusor-sphincter dyssynergia. Typical consequences include increased intra-vesical pressure, inability to effectively empty the bladder, increased risk of vesico-ureteral reflux, infection, bladder or kidney stones, neoplastic complications within the urinary tract and renal failure. Proper diagnostics of urinary tract function and morphology enables choosing adequate bladder emptying strategy, early diagnosis and effective treatment of urinary complications in patients after spinal injury with neurological deficit.Study purpose: Presentation of contemporary methods of functional, imaging and endoscopic diagnostic tests of the lower urinary tract in patients with spinal injury with neurological deficit. We discuss clinical value and accuracy of particular diagnostic methods in prevention and monitoring of the therapy of urinary complications.Study form: Literature review.Conclusions: Although urodynamic studies serve as the principal tool among the modern methods of the lower urinary tract function assessment, simple functional tests such as measurement of residual urine volume measurement or cystometrogram may be helpful in clinical practice, particularly during the early post-traumatic phase. Ultrasonographic examination is the first choice imaging study. Clinical validity of screening cystoscopy in spinal injury with neurological deficit patients remains doubtful, but this procedure is of unquestionable value in cases with haematuria.
Źródło:
Medical Rehabilitation; 2007, 11(2); 21-26
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
O możliwości wykorzystania morszczynu pęcherzykowatego (Fucus vesiculosus L.)
O vozmozhnosti ispolzovanija vodorosta Fucus vesiculosus L.
On the possibility of utilizing Fucus vesiculosus L.
Autorzy:
Bulinski, R.
Artamonow, E.
Powiązania:
https://bibliotekanauki.pl/articles/874019.pdf
Data publikacji:
1957
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
morszczyn pecherzykowaty
Fucus vesiculosus
sklad chemiczny
przyswajalnosc
wykorzystanie
badania na zwierzetach
bladder wrack
chemical compound
digestibility
utilization
animal test
Źródło:
Roczniki Państwowego Zakładu Higieny; 1957, 08, 1
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Solitary cerebellar metastasis from bladder cancer
Pojedynczy przerzut móżdżkowy jako pierwotna manifestacja raka pęcherza moczowego
Autorzy:
Majcherczyk, Konrad
Marcinek, Mateusz
Nowak, Marcel
Tkocz, Michał
Powiązania:
https://bibliotekanauki.pl/articles/1916238.pdf
Data publikacji:
2021-12-30
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
bladder cancer
central nervous system
transitional cell carcinoma
cerebellar metastasis
rak pęcherza
ośrodkowy układ nerwowy
rak przejściowokomórkowy
przerzut móżdżkowy
Opis:
Brain metastases are quite rare in the course of bladder cancer and occur in only 1–7% of these patients. In most cases, cerebral metastases are secondary to visceral and lymph node metastases. A single cerebellar metastasis as the primary manifestation of transitional cell carcinoma (TCC) has only been reported in few cases. A 55-year-old man presented to the hospital with persistent headaches, accompanied by nausea and balance disturbance lasting for three weeks. Computed tomography (CT) of the head revealed a nodular lesion measuring 28 x 24 x 22 mm in diameter, located in the cerebellar vermis. Subsequently, a CT scan conducted of the chest, abdominal cavity and lesser pelvis revealed a tumor in the urinary bladder with concomitant right hydronephrosis. No lymphadenopathy nor signs of other metastases were found. Craniotomy with complete tumor resection and external ventricular drainage was performed. The patient underwent transurethral electroresection of the bladder tumor involving the right part of the bladder trigone with the right ureteral orifice and the right bladder wall. The histopathological and immunohistochemical examination of both the cerebellar and bladder tumors confirmed high grade muscle invasive bladder cancer (T2, HG). Based on these findings, the patient was diagnosed with cerebellar metastasis from primary bladder cancer. The patient did not consent to the proposed cystectomy and was transferred to the oncology department where he was qualified for brain and pelvic radiotherapy and subsequent systemic chemotherapy. This case is an example that bladder cancer (stage T2) may develop without urologic symptoms.
Pośród pacjentów z rakiem pęcherza moczowego przerzuty do mózgu są rzadko spotykane i dotyczą około 1–7% chorych z naciekającym rakiem pęcherza. W większości przypadków przerzuty mózgowe są wtórne do obecnych już przerzutów w narządach trzewnych i węzłach chłonnych. Pierwotna manifestacja raka przejściowokomórkowego (transitional cell carcinoma – TCC) jako pojedynczy przerzut móżdżkowy została opisana w pojedynczych artykułach. Mężczyzna 55-letni zgłosił się do szpitala z powodu uporczywych dolegliwości bólowych głowy z towarzyszącymi nudnościami. Objawom towarzyszyły zaburzenia równowagi. Tomografia komputerowa (TK) głowy wykazała obecność zmiany guzowatej o wymiarach 28 x 24 x 22 mm w górnej części robaka móżdżku. Badanie TK klatki piersiowej, jamy brzusznej i miednicy małej uwidoczniło zmianę guzowatą w obrębie pęcherza moczowego z poszerzeniem układu kielichowo-miedniczkowego nerki prawej. Nie stwierdzono powiększonych węzłów chłonnych ani cech innych przerzutów. Wykonano kraniotomię i zewnętrzny drenaż komór mózgu, usuwając guz. Pacjenta zakwalifikowano do przezcewkowej elektroresekcji zmiany guzowatej w obrębie pęcherza. Guz obejmował część trójkąta pęcherza moczowego wraz z ujściem prawego moczowodu i większą część prawej ściany pęcherza. Badania histopatologiczne i immunohistochemiczne obu tkanek guzowatych (móżdżku i pęcherza) potwierdziły obecność komórek raka przejściowokomórkowego o wysokim stopniu złośliwości (high grade – HG) z inwazją mięśniową w obrębie wypieracza pęcherza (T2, HG). Na tej podstawie u chorego rozpoznano naciekającego raka pęcherza z przerzutem do móżdżku. Pacjent nie wyraził zgody na cystektomię i został przekazany na oddział onkologii, gdzie zakwalifikowano go do radioterapii głowy i miednicy oraz następowej chemioterapii. W pracy opisano przypadek rozległego guza pęcherza moczowego T2, który rozwinął się bez typowych objawów urologicznych.
Źródło:
Annales Academiae Medicae Silesiensis; 2021, 75; 123-127
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adaptacyjna radioterapia u chorych z powodu raka pęcherza moczowego
Adaptive radiotherapy for bladder cancer
Autorzy:
Poncyljusz, Maria
Bulski, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2146788.pdf
Data publikacji:
2020
Wydawca:
Indygo Zahir Media
Tematy:
radioterapia adaptacyjna
rak pęcherza moczowego
biblioteka planów leczenia
ochrona tkanek zdrowych
adaptive radiotherapy
bladder cancer
treatment plan library
normal tissue sparing
Opis:
Strategia adaptacyjnej radioterapii stosowana w grupie pacjentów chorych z powodu raka pęcherza moczowego polega na przygotowaniu biblioteki planów leczenia. Przed napromienianiem wykonywane jest badanie obrazowe tomografii komputerowej wiązką stożkową, a następnie wybierany jest odpowiedni plan. Metoda ta zapewnia podwyższenie precyzji w dostarczeniu przepisanej dawki do obszaru leczonego i poprawę ochrony organów krytycznych, w szczególności jelit. Przed wprowadzeniem adaptacyjnej radioterapii konieczne jest wybranie odpowiedniej techniki przygotowania biblioteki planów, która będzie możliwa do zrealizowania w ośrodku. Niezbędne jest również przeszkolenie personelu i przygotowanie procedur minimalizujących ryzyko wystąpienia błędu.
The strategy of adaptive radiotherapy for bladder cancer patients consists in preparing treatment plan library. After performing the cone beam CT imaging preceding the irradiation, an appropriate plan is selected. This method results in an improvement in the clinical target volume coverage and a dose reduction to the organs at risk, particularly the small bowel. Before introducing adaptive radiotherapy it is necessary to select the appropriate technique for preparing treatment plan library that will be possible to implement in the clinic. It is also crucial to train personnel and prepare procedures for minimizing the risk of error.
Źródło:
Inżynier i Fizyk Medyczny; 2020, 9, 6; 441--444
2300-1410
Pojawia się w:
Inżynier i Fizyk Medyczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metabolomic analysis of biological material using LC-MS in the quest for urinary system cancer biomarkers - review
Autorzy:
Szuberla, Wiktoria
Wrona, Maria
Powiązania:
https://bibliotekanauki.pl/articles/31342652.pdf
Data publikacji:
2024
Wydawca:
Politechnika Rzeszowska im. Ignacego Łukasiewicza. Oficyna Wydawnicza
Tematy:
mass spectrometry
metabolomics
LC-MS
kidney cancer
renal cell carcinoma
bladder cancer
spektrometria mas
metabolomika
rak nerki
rak nerkowokomórkowy
rak pęcherza moczowego
Opis:
Renal cell carcinoma (RCC) and bladder cancer (BC) are among the most frequently diagnosed urinary system cancers worldwide. They are characterized by high mortality and recurrence rates. In response to the rising incidence and mortality rates, scientists are exploring innovative diagnostic and therapeutic methods. Metabolomics, which analyzes metabolite levels, may enable early diagnosis and monitoring of therapy progress. Compared to other omics technologies, it focuses on the outcomes of metabolite activity, providing a unique perspective on processes occurring in cancer cells. Metabolomic analyses utilize techniques such as mass spectrometry. These methods allow the identification of biomarkers and precise determination of the chemical composition of biological samples. However, the most commonly used method is liquid chromatography-mass spectrometry (LC-MS), which enables the most comprehensive screening of cancer metabolomes. Recent studies show significant progress in recognizing characteristic metabolites associated with urological cancers, although this area remains partially unexplored. Research on circulating metabolites, especially those present in easily accessible samples like blood or urine, demonstrates promising potential in clinical practice. Study results reveal differences in metabolic profiles between various stages of cancer development, which may have clinical significance. The future of this field involves an increasing number of clinical cohorts, standardization of sample preparation, and further improvements in instrument sensitivity and speed. LC-MS-based metabolomics has the potential to contribute to the improvement of diagnostics, therapy, and the quality of life of patients with some urological cancers. However, challenges, such as the lack of uniform methodologies and understanding of metabolite determinants, require further research and innovation.
Źródło:
Chemical Technology & Biotechnology; 2024, 4; 70-75
2720-6793
Pojawia się w:
Chemical Technology & Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Herbivory on macro-algae affects colonization of beach-cast algal wrack by detritivores but not its decomposition
Autorzy:
Eereveld, P.
Hubner, L.
Schaefer, G.
Zimmer, M.
Powiązania:
https://bibliotekanauki.pl/articles/48932.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
macroalga
food web
supralittoral zone
marine alga
wrack
herbivore
isopod
Idotea balthica
bladder wrack
Fucus vesiculosus
brown alga
macrophyte
nutritive value
coastal water
Źródło:
Oceanologia; 2013, 55, 2
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improving quality of cytological screening in early detection of malignancy associated changes
Autorzy:
Piętka, B. D.
Dulewicz, A. M.
Kupis, P.
Powiązania:
https://bibliotekanauki.pl/articles/333426.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
przesiewowe badania cytologiczne
bazy danych obrazu
wczesne wykrycie raka pęcherza
cytological screening
image databases
early detection of bladder cancer
content-based image retrieval (CBIR)
Opis:
The paper deals with an image database organization and utilization in computer-aided cytology. To illustrate the idea we take as an example the problem of bladder cancer early detection based on urine cytology. In spite of its diagnostic potential for discovering malignancy associated changes (MAC) at the cell level it seems to be underestimated. There is common view that sensitivity of the method, especially for early cancer stages, is relatively low. We depict here just one but significant direction of our works that aims to support pathologists making the diagnosis more accurate and reliable. The key idea relies on automatic searching for MAC by comparing nuclear chromatin structure of objects in a smear with a collection of sample patterns contained in a pathomorphological image database.
Źródło:
Journal of Medical Informatics & Technologies; 2012, 19; 85-91
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena funkcji układu moczowego oraz komfortu życia kobiet po skojarzonym leczeniu raka endometrium
An assessment of the urinary function and the comfort of life in patients after endometrial cancer combined treatment
Autorzy:
Opławski, Marcin
Kosobudzki, Radosław
Kwiatkowski, Michał
Kojs, Zbigniew
Powiązania:
https://bibliotekanauki.pl/articles/1030404.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
brachytherapy
endometrial cancer
mixed incontinence
overactive bladder
stress urinary incontinence
urodynamic testing
badanie urodynamiczne
brachyterapia
mieszane nietrzymanie moczu
pęcherz nadreaktywny
rak endometrium
wysiłkowe nietrzymanie moczu
Opis:
Endometrial cancer is currently the most common form of female reproductive tract tumors. The efficacy of treatment, which involves surgery, radiotherapy and systemic therapy, is increasing and the assessment of the quality of life of patients is subject to careful analysis. Difficulty in urination represents a major factor reducing the quality of life of patients. The aim of the study was to collect data on the urinary functioning and the quality of life in endometrial cancer patients considered cured after a combined treatment compared to patients after non-oncological hysterectomy. A total of 46 females divided into two groups were included in the study. Group I (study group) included 23 endometrial cancer patients (stage IA, G1–G2) after combined treatment, who received surgical treatment and adjuvant brachytherapy; group II (control group) included 23 patients after non-oncological hysterectomy and uterine appendage removal. The patients were assessed once, between month 6 and 12 after treatment termination. Medical history, gynecologic examination, urodynamic testing and life quality assessment were performed in all patients. Statistical analysis showed a significant difference between the two groups in terms of urogynecologic outcomes (p = 0.0193). The proportion of women without any disturbances was definitely higher in the control group (only 22%) vs. study group. Stress urinary incontinence, mixed incontinence and overactive bladder were more common in the study group compared to controls. Furthermore, a significant difference in the quality of life was shown between the compared groups of patients (p = 0.0270). Reduced quality of life was significantly more common in the study group (57% vs. 26% of controls). Improvement of life quality was less common in the study group (13%) compared to controls (28%). Brachytherapy increases the severity of genitourinary disorders, which adversely affects the quality of life in patients after cancer therapy.
Rak endometrium to obecnie najczęstszy nowotwór narządu rodnego. Leczenie – wykorzystujące zabieg operacyjny, radioterapię i terapię systemową – jest coraz skuteczniejsze, a ocenę komfortu życia pacjentek poddaje się dokładnej analizie. Głównym czynnikiem obniżającym jakość życia chorych stają się problemy z oddawaniem moczu. Celem badania było uzyskanie informacji na temat funkcjonowania układu moczowego i jakości życia kobiet uznanych za wyleczone po skojarzonym leczeniu raka endometrium w porównaniu z tymi, którym macicę usunięto z przyczyn nieonkologicznych. Badaniu poddano 46 kobiet podzielonych na dwie grupy. Grupa pierwsza (badana) składała się z 23 pacjentek po skojarzonym leczeniu raka endometrium (IA, G1–G2), leczonych chirurgicznie i uzupełniającą brachyterapią, a grupa druga (kontrolna) – z 23 pacjentek po usunięciu macicy z przydatkami z powodów nieonkologicznych. Kobiety badano jednorazowo, między 6. a 12. miesiącem po zakończeniu leczenia. We wszystkich przypadkach przeprowadzono wywiad lekarski, badanie ginekologiczne, badanie urodynamiczne i badanie jakości życia. Analiza statystyczna wykazała istotną różnicę wyników badania uroginekologicznego między grupami (p = 0,0193). Odsetek kobiet, u których nie stwierdzono zmian, był zdecydowanie większy w grupie kontrolnej niż grupie badanej, gdzie wyniósł zaledwie 22%. W grupie badanej częściej niż w kontrolnej notowano przypadki wysiłkowego nietrzymania moczu, postaci mieszanej nietrzymania moczu i pęcherza nadreaktywnego. Okazało się także, że jakość życia pacjentek z porównywanych grup istotnie się różni (p = 0,0270). Jej spadek stwierdzano znacząco częściej w grupie badanej – u 57% kobiet (w grupie kontrolnej – u 26%). Polepszenie jakości życia notowano w grupie badanej rzadziej (13%) niż w grupie kontrolnej (28%). Brachyterapia powoduje nasilenie zaburzeń w układzie moczowo-płciowym, co negatywnie wpływa na komfort życia po leczeniu onkologicznym.
Źródło:
Current Gynecologic Oncology; 2015, 13, 2; 78-84
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Survey of cysticercus (bladder worm) in meat sold for consumption in Bukuru, Plateau State, Nigeria
Autorzy:
Kaze, P.D.
Gam, K.P.
Powiązania:
https://bibliotekanauki.pl/articles/11119.pdf
Data publikacji:
2013
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
survey
Cysticercus tenuicollis
bladder worm
meat
consumption
cysticercosis
larval stage
tapeworm
Taenia solium
clinical syndrome
parasite
beef meat
pig meat
dog meat
Bukuru town
Plateau State
Nigeria
Opis:
A cross – sectional study of bovine, porcine and dog cysticercosis was carried out in Bukuru Plateau State Nigeria,in 2010 using Gyel Bukuru abattoir, Fwagul and Kuru trade centre slaughtering abattoir, as study areas. Two hundred and twenty-five samples were collected at random comprising of seventy-five samples each from cattle, dog and pig respectively, where twenty-five samples were taking for raw meat, cooked meat and feaces in relation to the sex of the animals examined. The overall prevalence rate of 28 (12.44 %) was recorded out of the total sample of 225. Raw meat records 10 (4.44 %), cooked meat record 7 (3.11 %) and feaces records 11 (4.98 %) infection rate. X2 analysis show no significant difference in the prevalence rate of cysticercus in meat and cyst in feaces of the examined animals (p > 0.05). There was no record of infection in cattle, both in beef and feaces in different sexes of the cattle examined, sex specific incidence rate obtained in both studies did not differ significantly (p > 0.05). The female animal studied had the highest infection rate of 17 (60.71 %).There was significant difference in tapeworms encountered with the meat and feaces examined (p < 0.05) Taenia solium had the highest infection rate of 14 (6.22 %), Dipylidium caninum had 12 (5.33 %) with the least infestatioin recorded in T. hydatigena 2 (0.89 %). Hence no record of T. saginata infection was encountered in the present study. However mixed infection was recorded in Dog with T. hydatigena & D. caninum.
Źródło:
International Letters of Natural Sciences; 2013, 02
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nematodes of the intestine and swim bladder of the European eel Anguilla anguilla [L.] ascending Pomeranian rivers
Autorzy:
Pilecka-Rapacz, M.
Sobecka, E.
Powiązania:
https://bibliotekanauki.pl/articles/2146435.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Paraquimperia tennerima
Pomeranian region
swim bladder
eel
Anguilla anguilla
Wieprza River
Rega River
European eel
parasite
Radew River
Raphidascaris acus
intestine
river
Spinitectus inermis
nematode
intestinal parasite
Opis:
The study focused on the eel (length and weight averaging 23.1 cm and 13.7 g, respectively) ascending Pomeranian rivers in summers of 1999-2003. The swim bladder was examined in 322 individuals, the intestine being examined in 272 fish. Anguillicola crassus was present in the swim bladder of 184 fish. Infection prevalence varied between the rivers, the highest prevalence being recorded in the eel caught in the Radew (65.6%) and the lowest in the Wieprza (41.7%). The intensity of infection was generally low, the mean values varying from 2. l in the Rega to 1.3 in the Wieprza. The coefficient of infection was low (0,11 to 0,12). Spinitectus-inermis was present, with low intensity, in the intestine of 18 fish (6.6%). The nematode had not been recorded in the eel in Poland for 70 years. In addition, the intestine of the eel under study was found to house Raphidascaris acus and Paraquimperia tennerima, each present as a single larva. This is the first record of the latter in Poland. The infection of eel from the Radew river that stayed in the fresh water for a longer time was higher than that of the eel found in the Rega and Wieprza.
Źródło:
Wiadomości Parazytologiczne; 2004, 50, 1; 19-28
0043-5163
Pojawia się w:
Wiadomości Parazytologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
2-Naftyloamina i jej sole – w przeliczeniu na 2-naftyloaminę : dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego
2-Naphthylamine and its salts – calculated as 2-naphthylamine : documentation of proposed values of occupational exposure limits (OELs)
Autorzy:
Czubacka, Ewelina
Czerczak, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/137270.pdf
Data publikacji:
2020
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
2-naftyloamina
NDS
dopuszczalny poziom narażenia zawodowego
toksyczność
narażenie zawodowe
kancerogen
rak pęcherza moczowego
nauki o zdrowiu
inżynieria środowiska
2-naphthylamine
OEL
MAC
toxicity
occupational exposure
carcinogen
bladder cancer
health sciences
environmental engineering
Opis:
2-Naftyloamina (2-NA) występuje w postaci bezbarwnych kryształów o słabym, aromatycznym zapachu, które różowieją pod wpływem światła. Substancja nie występuje naturalnie w przyrodzie. Obecnie produkcja 2-naftyloaminy dla zastosowań przemysłowych jest prawnie zakazana w państwach Unii Europejskiej. W przeszłości substancję wykorzystywano do wytwarzania barwników azowych, jako przeciwutleniacz w przemyśle gumowym oraz w wytwórniach kabli. Obecnie jest stosowana w niewielkich ilościach głównie w laboratoriach badawczych. Narażonych na 2-naftyloaminę i jej sole w zakładach pracy w Polsce w 2017 r. według Centralnego Rejestru Danych o Narażeniu na Substancje Chemiczne, ich Mieszaniny, Czynniki lub Procesy Technologiczne o Działaniu Rakotwórczym lub Mutagennym było 208 osób, przy czym były to praktycznie tylko osoby pracujące w: laboratoriach wyższych uczelni, instytutach, inspekcjach, urzędach kontrolnych, jak również w laboratoriach zakładów farmaceutycznych i zakładu produkującego farby. Zgodnie z załącznikiem XVII do rozporządzenia REACH stosowanie 2-naftyloaminy podlega następującym ograniczeniom: nie może być ona wprowadzana do obrotu ani stosowana jako substancja lub w mieszaninach o stężeniach większych niż 0,1% masowo. Przy narażeniu zawodowym na 2-naftyloaminę i jej sole większe znaczenie ma oddziaływanie na drogi oddechowe oraz skórę niż wchłanianie z przewodu pokarmowego. Większość wchłoniętej dawki 2-naftyloaminy jest wydalana głównie z moczem. Mediany dawek lub stężeń śmiertelnych 2-naftyloaminy, które uzyskano w badaniach na zwierzętach doświadczalnych, wskazują, że jest to substancja szkodliwa po połknięciu. Główne objawy zatrucia ostrego to zaczerwienienie spojówek, łzawienie oczu, sinoniebieskie zabarwienie błon śluzowych, paznokci i skóry, ból i zawroty głowy oraz duszności. Na podstawie wyników badań dostępnych w piśmiennictwie do skutków działania toksycznego 2-naftyloaminy w warunkach narażenia podprzewlekłego i przewlekłego można zaliczyć kontaktowe zapalenie skóry, przewlekłe zapalenie pęcherza moczowego oraz raki pęcherza moczowego. 2-Naftyloamina i jej sole to przede wszystkim związki o potwierdzonym działaniu rakotwórczym na ludzi. W 1974 r. Międzynarodowa Agencja Badań nad Rakiem (IARC) uznała 2-naftyloaminę za czynnik rakotwórczy dla ludzi (grupa 1.) na podstawie wystarczających dowodów działania rakotwórczego na ludzi. Zgodnie z rozporządzeniem CLP 2-naftyloaminę i jej sole klasyfikuje się jako substancje rakotwórcze kategorii zagrożenia 1A z przypisanym kodem zwrotu wskazującym rodzaj zagrożenia H350 (Może powodować raka) oraz jako substancje o toksyczności ostrej kategorii zagrożenia 4 z przypisanym kodem zwrotu wskazującym rodzaj zagrożenia H302 (Działa szkodliwie po połknięciu). W Polsce wartość najwyższego dopuszczalnego stężenia (NDS) dla 2-naftyloaminy ustalono na poziomie 0 mg/m³ . Spośród pozostałych państw Unii Europejskiej jedynie Francja ma wyznaczoną wartość dopuszczalną na poziomie 0,005 mg/m³ , a Węgry i Włochy wartość chwilową na poziomie odpowiednio 0,005 mg/m³ i 0,001 mg/m³ . Przyjmując współczynnik Slope Factor (współczynnik kierunkowy prostej dawka-odpowiedź) dla człowieka opublikowany przez California EPA i biorąc pod uwagę wartość akceptowanego ryzyka 10-4 dla wystąpienia dodatkowych przypadków raka pęcherza moczowego, zaproponowano wartość NDS dla 2-naftyloaminy i jej soli na poziomie 0,003 mg/m³ . Zaleca się oznakowanie substancji jako „Carc. 1A”, co oznacza substancję rakotwórczą kategorii zagrożenia 1A (substancja wykazuje potencjalne działanie rakotwórcze na ludzi). Zakres tematyczny artykułu obejmuje zagadnienia zdrowia oraz bezpieczeństwa i higieny środowiska pracy będące przedmiotem badań z zakresu nauk o zdrowiu oraz inżynierii środowiska.
2-Naphthylamine (2-NA) occurs in a form of colourless crystals with a weak, aromatic odour, which turn pink under the influence of light. The substance does not occur naturally in nature. The production of the 2-naphthylamine on an industrial scale is now banned in the UE. In the past this substance was used in the production of azo dyes, as an antioxidant in the rubber industry and in cable factories. 2-Naphthylamine is used in small amounts mainly in research laboratories. According to the data from the Polish Registry on Exposure to Chemicals, Their Mixtures, Factors or Technological Processes on Carcinogenic or Mutagenic Effects, 208 workers working in university laboratories, institutes, inspections, control offices as well as in laboratories of pharmaceutical and paint production plant were exposed to 2-NA and its salts in Poland in 2017. According to Annex XVII of REACH Regulation, 2-naphthylamine and its salts shall not be placed on the market, or used, as substances or in mixtures in concentrations greater than 0,1 % by weight. In occupational exposure to 2-naphthylamine and its salts, respiratory tract and skin are more important than gastrointestinal absorption. Most of the absorbed dose of 2-naphthylamine is mainly excreted in the urine. Median doses or lethal concentrations of 2-naphthylamine that were obtained in experimental animal studies indicate that it is harmful if swallowed. The main symptoms of acute intoxication are conjunctival redness, watery eyes, blue mucosa, nails, skin, pain and dizziness, shortness of breath. Based on the results of studies available in the literature, the effects of 2-naphthylamine under subchronic and chronic exposure may include contact dermatitis, chronic cystitis and bladder cancers. 2-Naphthylamine and its salts are compounds with proven carcinogenic humans. In 1974, The International Agency for Research on Cancer recognized 2-naphthylamine as a human carcinogen (group 1) based on sufficient evidence of a carcinogenic effect on humans. According to the CLP Regulation, 2-naphthylamine and its salts are classified as carcinogenic category 1A substances with the assigned hazard code H350 (May cause cancer) and as acute toxicity category 4 with the hazard code H302 assigned (Harmful if swallowed). In Poland, MAC (Maximum Admissible Concentration) value for 2-naphthylamine was set at 0 mg/m³ . In other EU countries, only France has set a MAC value of 0.005 mg/m³ while Hungary and Italy have a short-term value of 0.005 mg/m³ and 0.001 mg/m³ , respectively. Taking the Slope Factor for humans published by the California EPA and taking into account the accepted risk value of 10-4 for the occurrence of additional cases for bladder cancer, the MAC value for 2-naphthylamine and its salts is proposed to be 0.003 mg/m³ . The letters “Carc. 1A” should be used – the substance has carcinogenic potential for humans. This article discussess the problems of occupational safety and health, which are covered by health sciences and environmental engineering.
Źródło:
Podstawy i Metody Oceny Środowiska Pracy; 2020, 2 (104); 5-38
1231-868X
Pojawia się w:
Podstawy i Metody Oceny Środowiska Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Błędy w diagnostyce ultrasonograficznej nerek, moczowodów oraz pęcherza moczowego
Errors in the ultrasound diagnosis of the kidneys, ureters and urinary bladder
Autorzy:
Paweł Wieczorek, Andrzej
Woźniak, Magdalena Maria
Tyloch, Janusz F.
Powiązania:
https://bibliotekanauki.pl/articles/1058540.pdf
Data publikacji:
2013
Wydawca:
Medical Communications
Tematy:
errors in ultrasound examination of the urinary system
kidney ultrasound examination
renal pseudotumors
urinary bladder ultrasound examination
urinary system ultrasound
badanie ultrasonograficzne nerek
badanie ultrasonograficzne pęcherza
badanie ultrasonograficzne układu moczowego
błędy w badaniu ultrasonograficznym układu moczowego
guzy rzekome nerek
Opis:
The article presents the most frequent errors made in the ultrasound diagnosis of the urinary system. They usually result from improper technique of ultrasound examination or its erroneous interpretation. Such errors are frequent effects of insufficient experience of the ultrasonographer, inadequate class of the scanner, insufficient knowledge of its operation as well as of wrong preparation of patients, their constitution, severe condition and the lack of cooperation during the examination. The reasons for misinterpretations of ultrasound images of the urinary system may lie in a large polymorphism of the kidney (defects and developmental variants) and may result from improper access to the organ as well as from the presence of artefacts. Errors may also result from the lack of knowledge concerning clinical and laboratory data. Moreover, mistakes in ultrasound diagnosis of the urinary system are frequently related to the lack of knowledge of the management algorithms and diagnostic possibilities of other imaging modalities. The paper lists errors in ultrasound diagnosis of the urinary system divided into: errors resulting from improper technique of examination, artefacts caused by incorrect preparation of patients for the examination or their constitution and errors resulting from misinterpretation of ultrasound images of the kidneys (such as their number, size, fluid spaces, pathological lesions and others), ureters and urinary bladder. Each physician performing kidney or bladder ultrasound examination should possess the knowledge of the most frequent errors and their causes which might help to avoid them.
W artykule omówiono najczęściej popełniane błędy w diagnostyce ultrasonograficznej układu moczowego. Zazwyczaj są one efektem nieprawidłowo wykonanego badania ultrasonograficznego lub też jego błędnej interpretacji. Z reguły wynikają z niedostatecznego doświadczenia klinicznego ultrasonografisty, klasy stosowanej aparatury ultrasonograficznej, niedostatecznej znajomości obsługi aparatu ultrasonograficznego, ale także ze złego przygotowania, konstytucji, ciężkiego stanu pacjenta oraz braku jego współpracy w trakcie wykonywania badania. Błędy w interpretacji obrazu ultrasonograficznego układu moczowego mogą mieć swoją przyczynę w dużym polimorfizmie budowy nerek (wady i odmiany rozwojowe), mogą wynikać z niewłaściwego dostępu do badanego narządu, jak również z obecności artefaktów. Błędna interpretacja badania może być także wynikiem nieznajomości danych klinicznych i laboratoryjnych. Ponadto błędy w diagnostyce ultrasonograficznej układu moczowego często wynikają z nieznajomości algorytmów postępowania i możliwości diagnostycznych innych metod obrazowania. Poniżej wymieniono błędy w diagnostyce ultrasonograficznej układu moczowego w podziale na: błędy wynikające z niewłaściwej metody badania, artefakty wynikające z niewłaściwego przygotowania pacjenta do badania lub konstytucji pacjenta oraz błędy wynikające z nieprawidłowej interpretacji obrazu ultrasonograficznego nerek (m.in. ich liczby, wielkości, przestrzeni płynowych, zmian patologicznych, inne), moczowodów i pęcherza moczowego. Każdy lekarz wykonujący badanie ultrasonograficzne nerek i pęcherza moczowego powinien posiadać wiedzę o najczęściej popełnianych błędach, przyczynach ich powstawania, co pozwoli na ich uniknięcie.
Źródło:
Journal of Ultrasonography; 2013, 13, 54; 308-318
2451-070X
Pojawia się w:
Journal of Ultrasonography
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-60 z 60

    Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies