- Tytuł:
- Effect of a bicarbonate-buffered peritoneal dialysis solution on clinical and laboratory indices of dialysis adequacy
- Autorzy:
-
Chmielewski, Michał
Bielińska-Ogrodnik, Dorota
Jagodziński, Piotr
Lichodziejewska-Niemierko, Monika - Powiązania:
- https://bibliotekanauki.pl/articles/895747.pdf
- Data publikacji:
- 2020-05-29
- Wydawca:
- Gdański Uniwersytet Medyczny
- Tematy:
-
peritoneal dialysis
acid-base balance
end-stage renal failure
bicarbonate-based solutions - Opis:
- Background: Biocompatible fluids were introduced to improve dialysis and patient outcome in end-stage renal disease. However, being buffered with lactate, they may insufficiently correct metabolic acidosis, and lead to changes in peritoneum structure. Bicarbonate buffered fluids might mitigate these complications. The aim of the study was to evaluate the influence of a bicarbonate dialysis fluid on clinical and laboratory indices of dialysis adequacy. Material and methods: 20 prevalent peritoneal dialysis (PD) patients created two groups. One group continued on lactate fluid, the other changed to bicarbonate solution. Clinical and laboratory indices of dialysis adequacy were evaluated at baseline, and at six weeks intervals for 24 weeks. Results: In bicarbonate group, pH was 7.36±0.03, HCO3 22.1±1.8 mmol/l at baseline and 7.36±0.04 and 21.2± 2.3 mmol/l at 24 weeks, while in controls pH equaled 7.35±0.12, HCO3 22.2±1.4 mmol/l, at baseline, and 7.40±0.03, and 22.3±1.8 mmol/l, at 24 weeks, with no significant differences. Dialysis adequacy (urea Kt/V), urine output and dialysis ultrafiltration did not differ between the groups, either at baseline or at study termination. Conclusions: Bicarbonate PD solution appears to be similar to standard fluid in the impact on hydration status and on acid/base balance. Longitudinal studies are needed to assess long-term advantages of these biocompatible solutions.
- Źródło:
-
European Journal of Translational and Clinical Medicine; 2020, 3, 1; 11-15
2657-3148
2657-3156 - Pojawia się w:
- European Journal of Translational and Clinical Medicine
- Dostawca treści:
- Biblioteka Nauki
Artykuł