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Wyszukujesz frazę "betulinic acid" wg kryterium: Temat

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    Wyświetlanie 1-2 z 2
    Tytuł:
    Betulin and its derivatives – precursors of new drugs
    Autorzy:
    Drąg-Zalesińska, Małgorzata
    Borska, Sylwia
    Powiązania:
    https://bibliotekanauki.pl/articles/1062829.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    betulin
    betulinic acid
    bevirimat
    episalvan
    oleogel-S10
    Opis:
    White birch bark extract, used in traditional medicine, has many medical properties. Its main components are betulin and betulinic acid - lupane type pentacyclic triterpenes. The discovery of the anti-tumor and anti-viral properties of betulinic acid has become an impulse to modify the structures of these compounds in order to obtain better activity. Over twenty years of research, several derivatives have been selected that have significantly better anti-tumor or antiviral properties than their precursors. This paper presents all new derivatives of betulin and betulinic acid, which have been tested in phase I, II or III of clinical trials. Clinical experiments on animals with natural cancers have also been described. The results obtained by various research teams give hope for the potential use of these compounds in therapy. At the same time, the presented analysis shows that the implementation of the new drug on the market is a process that lasts 10-15 years, which, despite the involvement of huge financial and human resources, does not guarantee success.
    Źródło:
    World Scientific News; 2019, 127, 3; 123-138
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of coconut extract on callus growth and ultrasound waves on production of betulin and betulinic acid in in-vitro culture conditions of Betula pendula Roth species
    Autorzy:
    Payamnoor, Vahide
    Hajati, Razieh Jafari
    Khodadai, Negar
    Powiązania:
    https://bibliotekanauki.pl/articles/2045716.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Badawczy Leśnictwa
    Tematy:
    betulin
    betulinic acid
    Betula pendula Roth
    callus induction
    Opis:
    To determine the effect of coconut extract on callogenesis of Betula pendula, Roth stem barks were cultured in NT (Nagata and Takebe) basic culture media in two individual experiments: i) cultivation explant in different treatments of coconut extracts combined with 1 mg l-1 2, 4-D (2, 4-Dichlorophenoxyacetic acid) and ii) callogenesis in NT media containing 1.5 mg l-1 2,4-D and 0.5 mg l-1 BAP (6-Benzylaminopurine) and then cultivation under the first experiment treatments. The first experiment demonstrated that not all concentrations of coconut extracts lead to callus induction individually, but callus induction increased 84% in a culture containing 5% coconut extract plus 1 mg l-1 2, 4-D. Based on the results of the second experiment, this treatment also significantly increased the wet and dry weights of the produced calluses. The possibility of increasing the betulinic acid and betulin by ultrasound was also studied. Samples cultivated in the selected culture medium were exposed to ultrasound waves in two forms of 1) one exposure and 2) twice exposure (repetition with 24 hr interval) in steps of 20, 60, 100, and 160 sec, and one treatment as the control. Betulin and the betulinic acid amount were determined using HPLC (High-Performance Liquid Chromatography). The maximum betulinic acid and betulin were obtained in 100 sec in once exposure (2.3 mg g-1 DW) and 160 sec in the twice exposure (0.75 mg g-1 DW) to ultrasound. The results showed that betulinic acid content was more than betulin.
    Źródło:
    Folia Forestalia Polonica. Series A . Forestry; 2018, 60, 4; 261-268
    0071-6677
    Pojawia się w:
    Folia Forestalia Polonica. Series A . Forestry
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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