- Tytuł:
- Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.
- Autorzy:
-
Kazimierczuk, Zygmunt
Upcroft, Jacqueline
Upcroft, Peter
Górska, Agata
Starościak, Bohdan
Laudy, Agnieszka - Powiązania:
- https://bibliotekanauki.pl/articles/1043825.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
antibacterial activity
antiprotozoal activity
benzimidazoles - Opis:
- Two series of benzimidazole derivatives were sythesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-substituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtained compounds was studied. Some thioalkyl derivatives showed remarkable activity against nosocomial strains of Stenotrophomonas malthophilia, and an activity comparable to that of metronidazole against Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole showed the most distinct antiprotozoal activity.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 1; 185-195
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł