- Tytuł:
- Cell-based screening for identification of novel vanadium complexes with multidirectional activity relative to cells associated with metabolic disorders
- Autorzy:
-
Kazek, Grzegorz
Głuch-Lutwin, Monika
Modryl, Barbara
Menaszek, Elżbieta
Szklarzewicz, Janusz
Gryboś, Ryszard
Papież, Monika - Powiązania:
- https://bibliotekanauki.pl/articles/93098.pdf
- Data publikacji:
- 2019
- Wydawca:
- Państwowa Wyższa Szkoła Zawodowa w Tarnowie
- Tematy:
-
vanadium complex
cell-based screening
anti-diabetic activity
kompleks wanadu
badanie przesiewowe oparte na komórkach
aktywność przeciwcukrzycowa - Opis:
- In this study, 110 newly synthesized vanadium complexes from different structural groups were screened in three cell-based models representing the main target tissues for anti-diabetic drugs. In glucose utilization in C2C12 myocyte experiments, 93% of vanadium complexes were shown to have equal or greater activity than bis(maltolato)oxovanadium(IV) (BMOV), the methyl analog of bis(ethylmaltolato)oxovanadium(IV) (BEOV) which has been tested in clinical trials. Moreover, 49% and 50% of these complexes were shown to have equal or greater activity than BMOV in lipid accumulation in 3T3-L1 adipocytes and insulin secretion in RINm5F beta cell experiments, respectively. These results were the basis for the selection of compounds for the subsequent steps in the characterization of anti-diabetic properties. This study provides strong support for the application of screening cell-based assays with a phenotypic approach for the discovery of novel anti-diabetic drugs from the vanadium complex class. This is especially desirable due to the multiple and not fully defined mechanisms of action vanadium compounds.
- Źródło:
-
Science, Technology and Innovation; 2019, 4, 1; 47-54
2544-9125 - Pojawia się w:
- Science, Technology and Innovation
- Dostawca treści:
- Biblioteka Nauki
Artykuł