- Tytuł:
- Cytotoxicity of anticancer aziridinyl-substituted benzoquinones in primary mice splenocytes
- Autorzy:
-
Miliukienė, Valė
Nivinskas, Henrikas
Čėnas, Narimantas - Powiązania:
- https://bibliotekanauki.pl/articles/1039227.pdf
- Data publikacji:
- 2014
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
aziridinyl-substituted quinones
cytotoxicity
oxidative stress - Opis:
- The anticancer activity of aziridinyl-quinones is mainly attributed to their NAD(P)H:quinone oxidoreductase 1 (NQO1)-catalyzed two-electron reduction into DNA-alkylating products. However, little is known about their cytotoxicity in primary cells, which may be important in understanding their side effects. We found that the cytotoxicity of aziridinyl-unsubstituted quinones (n = 12) in mice splenocytes with a low amount of NQO1, 4 nmol × mg-1 × min-1, was caused mainly by the oxidative stress. Aziridinyl-benzoquinones (n = 6) including a novel anticancer agent RH1 were more cytotoxic than aziridinyl-unsubstituted ones with the similar redox properties, and their cytotoxicity was not decreased by an inhibitor of NQO1, dicumarol. The possible reasons for their enhanced cytotoxicity are discussed.
- Źródło:
-
Acta Biochimica Polonica; 2014, 61, 4; 833-836
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł