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Wyszukujesz frazę "atopic dermatitis" wg kryterium: Temat


Tytuł:
The study of canine atopic dermatitis involving the isolation of dogs
Autorzy:
Fujimura, M.
Powiązania:
https://bibliotekanauki.pl/articles/30142.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dog
animal disease
atopic dermatitis
dermatitis
isolation
atopic-like dermatitis
Opis:
Twenty-seven pruritic dogs were used in this study. When a hypoallergenic diet was fed to these 27 dogs for six weeks, none of the dogs showed improvement of the pruritus. These dogs had a history and clinical signs of atopic dermatitis (AD) as defined by Prelaud’s diagnostic criteria. Subsequently, the 27 dogs were isolated for observation for two weeks in the hospital. In the isolation room in the veterinary clinic, cages and tableware were all stainless steel, and carpet was not used. A hypoallergenic diet was continuously fed to the 27 dogs for two weeks, during which time they were kept in the isolation room. PVAS (Pruritus Visual Analog Scale) was performed prior to starting the isolation, at the start of the study and 2 weeks after starting the isolation. In 17dogs (63%) the pruritus improved in the isolation room. A statistically significant reduction (p<0.01) of PLS (Pruritus liners score) was recorded 2 weeks after isolation. It was hypothesized that the 17 dogs whose pruritus improved in the isolation room had AD caused by an environmental antigen that was not present in the isolation room. Pruritus of the remaining 10 dogs (37%) did not improve. For 6/10 dogs, the intradermal allergy testing was positive for an environmental antigen. For4/10 dogs, the intradermal allergy testing was negative for all environmental antigens. Dogs for which sensitivity to an environmental antigen was not identified were thought to have atopic-like dermatitis.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the clinical efficiencyof lokivetmab in client privately ownedatopic dogs – multicenter study
Autorzy:
Szczepanik, M.P.
Popiel, J.
Cekiera, A.
Pomorska-Handwerker, D.
Karaś-Tęcza, J.
Ściskalska, M.
Oczkowska, K.
Taube, M.
Olender, V.
Parys, P.
Powiązania:
https://bibliotekanauki.pl/articles/2087319.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
atopic dermatitis
dog
lokivetmab
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 191-195
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Coexistence of halo nevi, atopic dermatitis and hypothyroidism - a case study
Autorzy:
Drąg-Zalesińska, Małgorzata
Rembiałkowska, Nina
Borska, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/1075602.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
atopic dermatitis
halo nevus
hypothyroidism
Opis:
Coexistence of autoimmune diseases is increasingly observed. The relationship between type 1 diabetes and Hashimoto's disease and celiac disease is well documented. Reports from recent years also indicate a more frequent occurrence of Hashimoto's disease in patients with atopic dermatitis. In the presented case, we describe the occurrence of hypothyroidism in a girl with atopic dermatitis. Another symptom of the development of the immune process was formation of halo nevi from congenital and acquired nevus.
Źródło:
World Scientific News; 2019, 122; 242-248
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The evaluation of canine atopic dermatitis extent and severity index (CADESI) test in dogs with atopic dermatitis (AD) treated with cyclosporine or prednisone
Autorzy:
Taszkun, I.
Powiązania:
https://bibliotekanauki.pl/articles/32356.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
canine atopic dermatitis extent and severity index test
dog
atopic dermatitis
dermatitis
treatment
prednisone
cyclosporin
animal disease
Opis:
The purpose of this study was to assess the clinical state of dogs with atopic dermatitis (AD) by use of CADESI test in own modification during the first visit in the Dermatology Consult Room as well as during the treatment. The study was performed in two groups (I-E and II-C) of 20 dogs in each group. In dogs which were qualified to the I-E group, as antiallergic, anti-inflammatory and antipruritic treatment, prednisone (oral preparation Encorton – Polfa Pabianice) at dose 0.5 mg/kg b.w./day was administered, while in dogs qualified to the II-C group – cyclosporine (oral preparation Sandimmun Neoral – Novartis Pharma) at a dose of 5 mg/kg b.w./day; the treatment was continued for 6 weeks in both groups. During the study, skin lesions were assessed in 15 specified body areas using 4 parameters and 5-point scale. In group I-E and II-C the amount of received points in CADESI test was decreased by 82.26% and by 83% respectively, after the treatment. Statistical analyses of the results obtained revealed no statistically significant (P=0.05) differences between means of I-E and II-C groups in consecutive examinations, which indicates comparable clinical efficacy of both drugs. Statistically significant differences (P=0.05) of the parameters assessed were found after secondary dermatoses treatment, and after every two weeks of antipruritic and anti-inflammatory treatment.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Severe atopic dermatitis in children: therapeutic dilemmas
Atopowe zapalenie skóry o ciężkim przebiegu u dzieci: dylematy terapeutyczne
Autorzy:
Lis-Święty, Anna
Milewska-Wróbel, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/1034806.pdf
Data publikacji:
2018
Wydawca:
Medical Communications
Tematy:
adherence
atopic dermatitis
immunosuppressive drugs
therapy
Opis:
Atopic dermatitis is the most common skin disorder diagnosed in early childhood. Some children do not experience a relief of symptoms as they get older, and severe atopic dermatitis may develop, with manifestations including widespread skin lesions and unremitting itching. The disease is both physically and emotionally disabling, and significantly compromises the patient’s quality of life. Indications to intensify therapy include resistance to topical treatment and multidrug resistance. However, in many cases non-adherence to the treatment regimen, including inadequate skin care techniques, contribute to the development of severe or refractory atopic dermatitis. Persistent eczematous lesions may be a result of exacerbating environmental factors, secondary infection, and hypersensitivity reactions to topical treatments or other allergens. Wet-wrap treatment with topical corticosteroids, narrow-band UVB phototherapy and systemic immunosuppressive drugs, such as cyclosporine A, methotrexate, mycophenolate mofetil and azathioprine, are recommended for the treatment of severe atopic dermatitis in children. However, there are no evidence-based guidelines for using these agents. Systemic corticosteroids should be avoided, but they can be used for a short period of time for the immediate relief of acute flares before introducing other therapies. Patients need a holistic approach including education and modern biopsychosocial techniques. Paediatric studies are currently under way to test the safety and tolerability of dupilumab which was approved by the US Food and Drug Administration in 2017 for the treatment of adults with moderate-to-severe atopic dermatitis.
Atopowe zapalenie skóry jest najczęstszym schorzeniem skóry rozpoznawanym we wczesnym dzieciństwie. U części dzieci objawy nie łagodnieją w miarę dorastania, lecz rozwija się atopowe zapalenie skóry o ciężkim przebiegu z uogólnionymi zmianami skórnymi, uporczywym świądem; choroba przyczynia się do cierpienia fizycznego i psychicznego, znacząco pogarszając jakość życia. Sygnałem do intensyfikacji terapii powinna być oporność na leczenie zewnętrzne i wielolekowość. Jednak w wielu przypadkach przyczyną ciężkiego i opornego na terapię atopowego zapalenia skóry jest niedostosowanie się do zaleceń terapeutycznych (non-adherence), w tym nieprawidłowa pielęgnacja skóry. Uporczywość zmian wypryskowych może być także skutkiem narażenia na środowiskowe czynniki drażniące, wtórnej infekcji, reakcji nadwrażliwości na leki zewnętrzne czy inne alergeny. W ciężkim atopowym zapaleniu skóry u dzieci zaleca się stosowanie mokrych opatrunków z kortykosteroidami miejscowymi, fototerapii światłem wąskopasmowym UVB, ogólnoustrojowych leków immunosupresyjnych, takich jak cyklosporyna A, metotreksat, mykofenolan mofetylu i azatiopryna. Brak jest wytycznych opartych na dowodach naukowych dotyczących leczenia tymi lekami. Należy unikać kortykosteroidów ogólnych, ale można zastosować krótkotrwałą terapię w celu szybkiego opanowania dużych zaostrzeń przed wdrożeniem innych form leczenia. Pacjenci wymagają podejścia holistycznego, obejmującego edukację i stosowanie nowoczesnych technik biopsychospołecznych. W populacji pediatrycznej obecnie prowadzone są badania kliniczne oceniające bezpieczeństwo i tolerancję dupilumabu, leku biologicznego zaaprobowanego w 2017 roku przez amerykańską Agencję ds. Żywności i Leków w leczeniu umiarkowanego i ciężkiego atopowego zapalenia skóry u dorosłych.
Źródło:
Pediatria i Medycyna Rodzinna; 2018, 14, 4; 376-380
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparison of serum concentrations of environmental allergen-specific IgE in atopic and healthy (nonatopic) horses
Autorzy:
Gołyński, M.
Wilkołek, P.
Sitkowski, W.
Szczepanik, M.
Adamek, Ł.
Pluta, M.
Taszkun, I.
Malinowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087865.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
IgE
equine atopic dermatitis
healthy horses
immunology
allergens
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 789-794
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical effects of combined Lactobacillus paracasei and kestose on canine atopic dermatitis
Autorzy:
Kawano, K.
Iyori, K.
Kondo, N.
Yamakawa, S.
Fujii, T.
Funasaka, K.
Hirooka, Y.
Tochio, T.
Powiązania:
https://bibliotekanauki.pl/articles/16647507.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
canine atopic dermatitis
kestose
lactobacillus
prebiotics
probiotics
synbiotics
Opis:
Probiotics and prebiotics are viable bacteria with beneficial effects on the host and components that selectively act on the beneficial commensal bacteria, respectively. The combined use of probiotics and prebiotics is termed synbiotics. Probiotic intake improves dysbiosis in the intestinal microbiota and can positively affect canine atopic dermatitis (CAD). However, clinical studies on improvements in CAD using synbiotics remain limited. In this study, 15 dogs with CAD who received prednisolone, a synthetic glucocorticoid (GC) used in the treatment of CAD, for more than 90 days were continuously treated with Lactobacillus paracasei M-1 from fermented food as a probiotic, and trisaccharide kestose as a prebiotic, for 90 days to determine their synbiotic effects on CAD. The CAD symptoms were evaluated using the canine atopic dermatitis lesion index (CADLI) and pruritus visual analog scores (PVAS) at 30, 60 and 90 days after synbiotic administration. The total prednisolone use for 90 days pre- and post-administration was also evaluated. Synbiotic administration significantly reduced the CADLI (pre: median, 28.0 [22.0-32.0]; 30 days: median, 20.0 [20.0−28.0]; 60 days: median, 20.0 [10.0−21.0]; 90 days: median, 12.0 [10.0-19.0]) and PVAS (pre: median, 6.0 [5.0-7.0]; 30 days: median, 3.0 [3.0-3.5]; 60 days: median, 3.0 [3.0-3.5]; 90 days: median, 2.0 [2.0-3.5]) scores, and reduced the total prednisone use over 90 days (pre: 112.0 [25-450] mg; post: 80.0 [18.-300.0] mg; p<0.001) in the 15 dogs. Thus, the synbiotic activity of L. paracasei M-1 and trisaccharide kestose can improve CAD.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 131-136
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is atopic dermatitis a response to Malassezia overgrowth in dogs?
Autorzy:
Dworecka-Kaszak, B.
Kaszak, I.
Dabrowska, I.
Powiązania:
https://bibliotekanauki.pl/articles/6018.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
atopic dermatitis
dermatitis
Malassezia pachydermatis
dog
natural host
skin disease
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation between clinical efficacy on pruritus and serum interleukin-31 levels in dogs with atopic dermatitis treated with lokivetmab
Autorzy:
Calesso, J.R.
Marques, V.S.
de Carvalho, O.V.
Costa-Val, A.P.
Powiązania:
https://bibliotekanauki.pl/articles/16647579.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
atopic dermatitis
interleukin-31
lokivetmab
monoclonal antibody
pruritus
Opis:
Studies on serum interleukin (IL)-31 levels in dogs with atopic dermatitis (AD) and their correlation with disease severity are limited. To the author’s knowledge, there are no studies that measured serum IL-31 in dogs treated with lokivetmab injections, a selective inhibitor of this key cytokine in pruritus. The aim of the study was to evaluate serum IL-31 levels in dogs treated with lokivetmab and correlate it with the severity of canine atopic dermatitis using the pruritus visual analog scale (pVAS) and canine atopic dermatitis extent and severity index (CADESI-04). Ten client-owned dogs diagnosed with AD received two injections of lokivetmab four weeks apart. Disease severity was assessed using the pVAS and CADESI-04 scores before and after both injections. In addition, canine serum IL-31 levels were measured at the same moments. Serum IL-31 was detected in all dogs in the study. There was a significant reduction in pVAS scores and serum IL-31 after administrations. However, there was no difference in CADESI-04 scores, and there was no significant correlation between CADESI-04 scores and serum IL-31 in dogs diagnosed with AD. Nonetheless, a significant positive correlation was observed between the pVAS scores and serum IL-31 levels with lokivetmab therapy, which reinforces the role of IL-31 in the pathogenesis of pruritus in dogs with AD. The data presented here provide further evidence that IL-31 is directly involved in pruritus pathogenesis in dogs with AD. In addition, blocking IL-31 has a significant antipruritic effect, but has no influence on skin lesion severity and extension.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 231-238
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Importance of food allergy and food intolerance in allergic multimorbidity
Autorzy:
Skoczylas, D.
Gujski, M.
Bojar, I.
Raciborski, F.
Powiązania:
https://bibliotekanauki.pl/articles/2085952.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
multimorbidity
Polysensitization
food allergy
asthma
Rhinitis
atopic dermatitis
Opis:
Introduction. Allergy affects approximately one-third of the world’s population, and the rates are growing. In Europe, it has been noticed that the risk of asthma and allergy is lower in the rural as opposed to urban population. There is a tendency for several allergic diseases to be present in the same person at the same time. Objective. The aim of the study was to verify the co-occurrence of allergic multimorbidity and food allergy and intolerance in a group of children. Materials and method. The multicentre cross-sectional study enrolled 1,008 children and adolescence aged 6–18 years (51.2% boys, 48.8% girls). The study comprised a questionnaire (respondents’ declarations) and an outpatient examination (diagnostic examination followed by a medical diagnosis). The study was conducted as part of the 2016–2020 National Health Programme. Results. In the study group, allergic rhinitis (AR) was present in 46.4%, bronchial asthma (BA) in 11.2% and atopic dermatitis (AD) in 6%. Allergic multimorbidity (simultaneous presence of 2 or more of the allergic diseases AR, BA and AD) was diagnosed in 9.7%. A single allergic disease (of the 3) was diagnosed in 43.4%. A diagnosis of food allergy and food intolerance was reported respectively at 29.6% and 14.3% participants with doctor-diagnosed allergic multimorbidity. Among those without any of the 3 allergic diseases, the percentage were 14.4% and 9.1%, respectively. Conclusions. Food allergy or food intolerance was more common in subjects with allergic multimorbidity than in subjects diagnosed with one allergic disease or those free of allergic diseases.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 3; 413-417
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transepidermal water loss and skin hydration in healthy cats and cats with non-flea non-food hypersensitivity dermatitis (NFNFHD)
Autorzy:
Szczepanik, M.P.
Wilkołek, P.M.
Adamek, Ł.R.
Kalisz, G.
Gołyński, M.
Sitkowski, W.
Taszkun, I.
Powiązania:
https://bibliotekanauki.pl/articles/2087561.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cats
atopic dermatitis
transepidermal water loss
skin hydration
Źródło:
Polish Journal of Veterinary Sciences; 2019, 2; 237-242
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The results of intradermal skin tests (IDST) in dogs with atopic dermatitis from the Lublin voivodship
Autorzy:
Taszkun, I.
Powiązania:
https://bibliotekanauki.pl/articles/32510.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
aeroallergen
Lublin voivodship
allergen
atopic dermatitis
dog
intradermal test
skin test
skin disease
animal disease
allergic disease
canine atopic dermatitis
pollen allergen
Opis:
The purpose of this study was to assess the positive immediate reactions received from intradermal skin tests (IDST) which confirmed the presence of IgE-dependent hypersensitivity in dogs with atopic dermatitis, which were patients of the Dermatology Consulting Section at the University of Life Sciences in Lublin between 2007 and 2009. Intradermal skin tests were performed on 142 dogs (72 females and 70 males) from the Lublin voivodeship of different breeds ranging in age from 1 to 6 years (average 2.8 years). The allergen set used in this study was the Artuvetrin Test (ARTU Biologicals Europe B.V, Holland). The owners of 84 dogs observed the presence of skin lesions all year round regardless of season, while 58 dog owners noted them only in spring and summer. Most immediate positive reactions were ascertained from mite allergens (70.61%), fewer from pollen allergens (19.55%), and the fewest from animal (4.15%) and mould allergens (1.66%). Immediate positive reactions for a flea allergen (4.03% of all positive reactions) were also ascertained. In 98.6% of dogs polysensitization was found.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kosmetyki do pielęgnacji skóry atopowej
Cosmetics for atopic dermatitis
Autorzy:
Śliwa, K.
Sikora, E.
Ogonowski, J.
Powiązania:
https://bibliotekanauki.pl/articles/172043.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
atopowe zapalenie skóry
kosmetyki
emolienty
atopic dermatitis
cosmetics
emollients
Opis:
Atopic dermatitis (AD) is an inflammatory chronic, skin disorder with the multifactorial etiology. The major symptom of AD is pruritc [1]. The treatment is symptomatic and is being assisted with intensive skincare at the use of cosmetics. In the paper generally used methods of AD therapy and the skin care were discussed. Moreover the essential ingredients of products used to the atopic skin treating were described. Some examples of cosmetic formulations were also presented.
Źródło:
Wiadomości Chemiczne; 2011, 65, 7-8; 651-673
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The indirect costs of allergic diseases
Autorzy:
Stróżek, Joanna
Samoliński, Bolesław
Kłak, Anna
Gawińska-Drużba, Emilia
Izdebski, Radosław
Krzych-Fałta, Edyta
Raciborski, Filip
Powiązania:
https://bibliotekanauki.pl/articles/2161972.pdf
Data publikacji:
2019-06-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Atopic Dermatitis
asthma
allergy
allergic rhinitis
indirect costs
Europe
Opis:
It is estimated that every third person living in Europe suffers from allergic diseases. Allergies are a growing health problem in Poland where 40% of the population have allergy symptoms, including 12% afflicted with asthma. The actual cost of allergic diseases is difficult to estimate due to the lack or incompleteness of the relevant data. The aim of this review is to present estimates of the indirect costs of allergic diseases in Poland and globally, using asthma, allergic rhinitis and atopic dermatitis as examples. The analysis also includes the impact of allergic diseases on the costs to the social welfare system and employers. The literature review of the indirect costs of allergic diseases shows that the indirect costs of a disease, which substantially exceed the direct costs, increase with the disease activity and severity. Interestingly, some studies have found that the indirect costs of lost productivity due to hours missed from work to take care of a sick child could be threefold higher than those of absence due to a worker’s own illness. The indirect costs of a disease can be significantly reduced by early diagnosis and appropriate treatment. Int J Occup Med Environ Health. 2019;32(3):281–90
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2019, 32, 3; 281-290
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Atopowe zapalenie skóry – ciężka postać u 7-letniej dziewczynki – opis przypadku
Atopic dermatitis – a report of severe case at 7-year-old girl – case report
Autorzy:
Kalicki, Bolesław
Maślany, Anna
Placzyńska, Małgorzata
Rustecka, Agnieszka
Jung, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1031003.pdf
Data publikacji:
2011
Wydawca:
Medical Communications
Tematy:
atopic dermatitis
hiper-IgE syndrome
scabies
seborrheic dermatitis
treatment of atopic dermatitis
atopowe zapalenie skóry
zespół hiper-ige
łojotokowe zapalenie skóry
świerzb
leczenie atopowego zapalenia skóry
Opis:
Atopic dermatitis (AD) is a chronic, inflammatory dermatological disease with intermittent course, very dry skin and pruritus. Prevalence rates for atopic dermatitis in children is increasing and range from 1 to about 20%. The previous studies indicates that genetic factors, environmental factors, infectious factors and immunological mechanisms are important in the pathogenesis of atopic dermatitis. Depending of the child’s age we can distinguish three stages of the disease. Typical affected skin areas in infants include the face, chest and extensor surfaces of the extremities whereas in the older children lesions are seen mostly over the flexor surfaces (antecubital and popliteal fossa) around the wrists and ankles. The earliest lesions are in the form of papules with erythema and exudation, but with time it forms crusted plaques and repeated rubbing of the skin makes lichenification. The diagnosis is based on clinical feature. Hanifin and Rajka Diagnostic Criteria listed below are the most commonly used one. These are also the criteria proposed by the American Academy of Dermatology in 2003. The disease is often accompanied by eosinophilia, elevated immunoglobulin E and positive skin prick tests. In the thesis we have presented the most frequent diseases requiring differentiation from AD. Treatment of atopic dermatitis includes systematic skin moisturizing and, in acute phase, the use of anti-inflammatory drugs (glucocorticosteroids and calcineurin inhibitors), antibacterial medications and anti-histaminics. The paper also discusses the severe form of AD proceeding with extreme eosinophilia and hypergammaglobulinaemia E in 7-year-old girl hospitalised in the Department of Paediatrics WIM.
Atopowe zapalenie skóry (AZS) jest przewlekłym schorzeniem dermatologicznym o podłożu zapalnym, charakteryzującym się częstymi nawrotami zmian, wybitną suchością skóry oraz towarzyszącym świądem. Zapadalność na AZS w ostatnich latach rośnie, aktualnie dotyka ono 1% do 20% populacji dziecięcej. W patogenezie choroby rolę odrywają czynniki genetyczne, środowiskowe, infekcyjne oraz mechanizmy immunologiczne. W zależności od wieku dziecka wyróżniamy fazę niemowlęcą z typowym zajęciem skóry twarzy, tułowia i wyprostnych części kończyn, fazę dziecięcą z przewagą zmian w zgięciach łokciowych, podkolanowych, wokół nadgarstków i kostek oraz przewlekłą postać typu dorosłego. Początkowo zmiany mają charakter sączących się grudek na podłożu rumieniowym, wraz z długością trwania choroby tworzą się blaszki, a naskórek ulega lichenizacji. Podstawą do rozpoznania AZS jest obraz kliniczny. Najczęściej stosowane są w tym celu kryteria Hanifina i Rajki omówione poniżej, a także kryteria zaproponowane w 2003 roku przez American Academy of Dermatology. Chorobie towarzyszy często eozynofilia, zwiększone stężenie immunoglobulin E oraz dodatnie punktowe testy skórne. W pracy przedstawiono najczęstsze jednostki chorobowe wymagające różnicowania z AZS. Leczenie tego schorzenia obejmuje systematyczne nawilżanie skóry, a w fazie zaostrzenia stosowanie leków przeciwzapalnych – glikokortykosteroidów i inhibitorów kalcyneuryny oraz leków przeciwbakteryjnych i antyhistaminowych. W pracy omówiono również ciężką postać AZS przebiegającą z wybitną eozynofilią i hipergammaglobulinemią E u 7-letniej dziewczynki hospitalizowanej w Klinice Pediatrii WIM.
Źródło:
Pediatria i Medycyna Rodzinna; 2011, 7, 4; 394-400
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł

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