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Wyszukujesz frazę "apolipoprotein (a)" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
The Role of Apolipoprotein (A) In Pathogenesis and Clinical Course of Deep Venous Thrombosis
Autorzy:
Chrapko, Marek
Skwarzyński, Adam
Karakuła, Wacław
Zubilewicz, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1395992.pdf
Data publikacji:
2015-02-03
Wydawca:
Index Copernicus International
Tematy:
fibrinolysis
apolipoprotein (a)
deep venous thrombosis
Opis:
Deep venous thrombosis is widespread disease, which complications, like: pulmonary embolism and postphlebitis syndrome areimportant social problem. There are many well-known and accurately described risk factors, though in many cases etiology remains unexplained. Further research into causes of deep venous thrombosis seem to be fully justified. The aim of the study was the evaluation of the influence of apolipoprotein (a) serum level in patients with deep venous thrombosis and the changes of its concentration during the treatment. Materials and methods. 26 patients with newly diagnosed deep venous thrombosis (DVT) were enrolled to the study. Diagnosis of DVT was established by use of physical examination and duplex Doppler. Measurements of apolipoprotein (a) and D-dimers serum level were recorded on the following days, starting from the day of the initial diagnosis: 1, 7, 14 and 84. Results. Statistically significant increase of the level of serum apolipoprotein (a) has been found during properly conducted treatment. Conclusions. Alterations of the concentration of serum apoliprotein (a) during the deep venous thrombosis treatment, indicates the involvement of apolipoprotein (a) in pathogenesis of deep venous thrombosis.
Źródło:
Polish Journal of Surgery; 2014, 86, 11; 518-522
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pre-analytical-related variability influencing serum peptide profiles demonstrated in a mass spectrometry-based search for colorectal and prostate cancer biomarkers
Autorzy:
Karczmarski, Jakub
Rubel, Tymon
Mikula, Michal
Wolski, Jan
Rutkowski, Andrzej
Zagorowicz, Edyta
Dadlez, Michal
Ostrowski, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1039544.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mass spectrometry; peptidome; serum; cancer; fibrinopeptide A
apolipoprotein A-IV
Opis:
Although the degradome, which comprises proteolytic fragments of blood proteins, presents a potential source of diagnostic biomarkers, studies on cancer peptide biomarkers have provided inconsistent conclusions. In the present study, we reevaluated the usefulness of serum degradome analyses for searching peptide cancer biomarker candidates. Particular attention was paid to pre-analytical factors influencing the variability of determined peptide levels, including clotting time and control group selection. Studies were conducted on 44 and 86 serum samples collected from cancer patients and healthy individuals, respectively, using liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)-based analyses. We identified 1373 unique peptides, nearly 40% of which originated from five blood proteins: fibrinogen alpha chain, apolipoprotein A-IV (APOA4), complement C3, apolipoprotein A-I, and alpha-1-antitrypsin. A set of 118 and 88 peptides exhibited highly significant differences (adjusted p-value ≤ 0.01 and fold change ≥ 2) in pair-wise comparisons of control vs. prostate cancer and control vs. colorectal cancer, respectively, with 37 peptides displaying a consistent direction of change for these pair-wise comparisons. The levels of 67 peptides differed significantly in serum samples collected from healthy individuals immediately prior to colonoscopy and those who underwent colonoscopic examination at least four weeks earlier. Of them, 49 peptides originated from APOA4. Whereas earlier studies, including ours, have utilized fragments of fibrinopeptide A (FPA) to distinguish cancer from healthy cases, here we show that their absolute abundance is a sensitive indicator of clotting time. These observations may have implications for future serum peptidome studies since these issues have not previously been recognized.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 417-425
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Beneficial effect of predominantly coconut oil consumption on lipid profile: a study of a rare population in Indonesia
Autorzy:
Nugraha, Gaga Irawan
Hutabarat, Astri
Regina, Natalia
Kurnia, Irma Susan
Rachmi, Cut Novianti
Powiązania:
https://bibliotekanauki.pl/articles/1166079.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Apolipoprotein A1
Cocos nucifera
Indonesia
LDL-c/HDL-c ratio
coconut oil
profil lipid
Opis:
Coconut oil is a source of fat which still sparks controversies when it comes to function. Some stated it can worsen lipid profile which then play an important role as a risk factor of cardiovascular disease. This cross sectional study was conducted in Indonesia involving 57 participants who used coconut oil as a predominant source of fat. Body mass index, physical activity and dietary intake were considered as subject characteristics. Serum concentrations of total cholesterol, triglyceride, LDL-c, HDL-c were determined by using the enzymatic method and Apo A1 were determined by using immunoturbidometry method. Result implied normal range of lipid profile and 78.95% of the subjects have optimal LDL-c/HDL-c ratio. Majority of the subjects (61.4%) have acceptable level of Apo A1, it showed that they have good HDL-c level. These results are consistent with other studies that support beneficial effect of coconut oil on lipid profile.
Źródło:
World Scientific News; 2018, 106; 131-140
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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