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    Wyświetlanie 1-4 z 4
    Tytuł:
    Wpływ lasalocidu na przebieg kokcydiozy i efekty produkcyjne u jagniąt
    Effect of the ionophorus antibiotic Lasalocid on coccidiosis and productivity in lambs
    Autorzy:
    Ramisz, A.
    Serwin, J.
    Ramisz, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2152597.pdf
    Data publikacji:
    1988
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    parazytologia weterynaryjna
    jagnieta
    choroby pasozytnicze
    kokcydioza
    przebieg choroby
    efekty produkcyjne
    przyrost masy ciala
    lasalocid
    antybiotyki jonoforowe
    kokcydiostatyki jonoforowe
    Opis:
    Six species of Eimeria were found in sheep from the mountain region of Poland: E. parva, E. pallida, E. nina-kohl-yakimovi, E. faurei, E. intricata and E. arloingi. E. parva (36.1%), E. nina-kohl-yakimovi (33.5%) and E. Faurei (30.2%) were frequently found. Seasonal dynamie of coccidiosis in lambs nontreated and treated with Lasalocid (20 mg/kg fodder) was obserwed. The maximum extensity and intensity in nontreated animals were found in the period from July to October (85-90% infected lambs). In lambs treated with Lasalocid the extensity was very low, i.e. only in 5-10% of treated animals single oocysts were found. Final weight was higher by about 5.4 kg and wool piroductivity by about 0.32 kg in the Lasalocid treated, compared with the control, nontreated group.
    Źródło:
    Wiadomości Parazytologiczne; 1988, 34, 2; 213-218
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ lasalocidu na przebieg kokcydiozy i efekty produkcyjne u jagniąt
    Effect of the ionophorus antibiotic Lasalocid on coccidiosis and productivity in lambs
    Autorzy:
    Ramisz, A.
    Serwin, J.
    Ramisz, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/839896.pdf
    Data publikacji:
    1988
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    parazytologia weterynaryjna
    jagnieta
    choroby pasozytnicze
    kokcydioza
    przebieg choroby
    efekty produkcyjne
    przyrost masy ciala
    lasalocid
    antybiotyki jonoforowe
    kokcydiostatyki jonoforowe
    Opis:
    Six species of Eimeria were found in sheep from the mountain region of Poland: E. parva, E. pallida, E. nina-kohl-yakimovi, E. faurei, E. intricata and E. arloingi. E. parva (36.1%), E. nina-kohl-yakimovi (33.5%) and E. Faurei (30.2%) were frequently found. Seasonal dynamie of coccidiosis in lambs nontreated and treated with Lasalocid (20 mg/kg fodder) was obserwed. The maximum extensity and intensity in nontreated animals were found in the period from July to October (85-90% infected lambs). In lambs treated with Lasalocid the extensity was very low, i.e. only in 5-10% of treated animals single oocysts were found. Final weight was higher by about 5.4 kg and wool piroductivity by about 0.32 kg in the Lasalocid treated, compared with the control, nontreated group.
    Źródło:
    Annals of Parasitology; 1988, 34, 2
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biokoniugaty antybiotykow jonoforowych : cele, strategie syntezy i właściwości
    Bioconjugates of ionophore antibiotics : goals, synthesis strategies and properties
    Autorzy:
    Antoszczak, M.
    Kordylas, M.
    Huczyński, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/172178.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antybiotyki jonoforowe
    jonofory
    biokoniugacja
    hybrydy
    aktywność przeciwbakteryjna
    aktywność przeciwnowotworowa
    ionophore antibiotics
    ionophores
    bioconjugation
    hybrids
    antibacterial
    activity
    anticancer activity
    Opis:
    Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipophilic compounds which are able to form complexes with the metal cations and transport them across the lipid membranes. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, and leads to the mitochondrial damages, cell swelling, vacuolization and finally to apoptosis process. For this reason, ionophores are commonly used in veterinary medicine as the non-hormonal growth-promoting as well as coccidiostatic agents. In this group particularly interesting are monensin and salinomycin (Fig. 1) because of their proved anti-tumour activity, including efficiency against multidrug- -resistant cancer cells and cancer stem cells of different origin. Improved synthetic derivatives of both polyether ionophores are thus of considerable current interest. Selective derivatization of these structures whose display multiple reactive functional groups and, in the case of salinomycin, a sensitive tricyclic spiroketal ring system is however non-trivial. Even so, semi-synthetic analogs reported to date includes i.a. selective derivatization of the carboxyl group, the three hydroxyl groups, the ketone group, the alkene, and epimerization of the characteristic tricyclic salinomycin unit (for more details see: M. Antoszczak, A. Huczyński, B. Brzezinski, Wiad. Chem., 2017, 71, 629). On the other hand, as part of the original program to develop innovatory anti- -cancer pro-drugs and prompted by the idea that cancer cells may be individually effectively killed by monensin and salinomycin, a very interesting direction of research is bioconjugation of these ionophores. In this context, our review article is focused on the possible role of hybrids of both ionophore antibiotics with other biologically active substances (natural amino acids, Cinchona alkaloids, flavonoids, nucleosides) in anti-bacterial and anti-cancer treatment, and gives an overview of their properties.
    Źródło:
    Wiadomości Chemiczne; 2018, 72, 1-2; 1-28
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza i aktywność biologiczna pochodnych salinomycyny
    Synthesis and biological activity of salinomycin derivatives
    Autorzy:
    Antoszczak, M.
    Huczyński, A.
    Brzezinski, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/171728.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antybiotyki jonoforowe
    jonofory
    struktura molekularna
    aktywność przeciwbakteryjna
    aktywność przeciwnowotworowa
    ionophore antibiotics
    ionophores
    molecular structure
    antibacterial activity
    anticancer activity
    Opis:
    Polyether ionophore antibiotics (ionophores) represent a large group of naturally- occurring lipid-soluble compounds isolated from actinomycetes strains of Streptomyces genus. Ionophores are able to form complexes with the metal cations, especially sodium and potassium, and transport them across the lipid membranes according to electroneutral or electrogenic transport mechanism. This process disturbs the intercellular Na+/K+ concentration gradient and intracellular pH, leads to the mitochondrial injuries, cell swelling, vacuolization and finally to programmed cell death (apoptosis). For this reason, ionophore antibiotics found commercial use in veterinary medicine as coccidiostatic agents and non-hormonal growth promoters. In addition to the industrial use of ionophores, some of them effectively and selectively inhibit properties of different cancer cells as well as enhance the anti-cancer effects of radio- and/or chemotherapy. In this group, particularly interesting is salinomycin because of its potent anti-microbial and anti-cancer activity, including efficiency against multi-drug resistant cancer cells and cancer stem cells. A very interesting direction of research is the chemical modification of ionophore antibiotics, which can lead to obtaining various derivatives with better biological activity and lower toxicity than those of the starting substances. Because biological activity of ionophore antibiotics and their derivatives is strictly connected with the ability to form characteristic pseudocyclic structures around the complexed cations (host-guest complex), it is also important to establish the detailed information on these structures. In this context, our review article is focused on the possible role of salinomycin and its derivatives in anti-microbial as well as anti-cancer therapy, and gives an overview of the properties of this antibiotic.
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 7-8; 629-661
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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