Temat: antisense oligonucleotide - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: The role of dopamine D2 receptor in the behavioral effects of imipramine - study with the use of antisense oligonucleotides
Autorzy:: Dziedzicka-Wasylewska, M.
Kolasiewicz, W.
Rogoz, Z.
Margas, W.
Maj, J.
Powiązania:: https://bibliotekanauki.pl/articles/70213.pdf
Data publikacji:: 2000
Wydawca:: Polskie Towarzystwo Fizjologiczne
Tematy:: antisense oligonucleotide
locomotor activity
drug
mRNA
dopamine D2 receptor
limbic forebrain
antidepressant drug
imipramine
Źródło:: Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:: Journal of Physiology and Pharmacology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: A primary attempt of Leptinotarsa decemlineata control using contact DNA insecticide based on short antisense oligonucleotide of its CYP6B gene
Autorzy:: Oberemok, V.
Laikova, K.
Shumskykh, M.
Kenyo, I.
Kasich, I.
Deri, K.
Seidosmanova, E.
Krasnodubets, A.
Bekirova, V.
Gal'chinsky, N.
Powiązania:: https://bibliotekanauki.pl/articles/66808.pdf
Data publikacji:: 2018
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: Leptinotarsa decemlineata
pest control
DNA insecticide
insecticide
antisense oligonucleotide
cytochrome P450
CYP6B gene
potato
Opis:: Effective control of Leptinotarsa decemlineata remains an urgent problem for agriculture worldwide. Minimization of the use of non-selective neonicotinoid insecticides, such as thiomethoxam, is an actual vector of development of potato cultivation. In this rapid communication, we show the prospect of the topical use of short unmodified antisense fragment of L. decemlineata CYP6B gene as a DNA insecticide. Investigated parameters, namely, number of larvae per plant, aboveground biomass, yield and number of potatoes produced per plant indicate the possibility of this post-genomic approach as a safe and effective method of L. decemlineata control.
Źródło:: Journal of Plant Protection Research; 2018, 58, 1
1427-4345
Pojawia się w:: Journal of Plant Protection Research
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Synteza modyfikowanych oligonukleotydów zawierających stereozdefiniowane internukleotydowe wiązania tiofosforanowe
Synthesis of modified oligonucleotides containing stereodefined internucleotide phosphorothioate bonds
Autorzy:: Radzikowska, E.
Kaczmarek, R.
Baraniak, J.
Powiązania:: https://bibliotekanauki.pl/articles/172219.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: oligonukleozydotiofosforany
oligonukleotydy antysensowe
synteza modyfikowanych oligonukleotydów
synteza stereospecyficzna
oligo(deoxy)ribonucleoside phosphorothioates
antisense oligonucleotides
synthesis of modified oligonucleotide
stereospecific synthesis
Opis:: Synthetic oligonucleotides constitute an important class of compounds which can exhibit biological activity. As potential drugs they could be employed in antisense strategy by acting on the pathogenic mRNA, causing inactivation of the target molecules during the translation process [1]. Ideal antisense agent (ASO) should be resistant to exo and/or endonucleases, exhibit a suitable pharmacological and pharmacokinetic profile and exhibits high binding affinity towards the target mRNA. To improve some properties of the ASO plethora of the chemical modifications introduced within the nucleobase, sugar unit and internucleotide linkage are investigated [3]. Among them, phosphorothioate oligonucleotides (PS-oligo), created by replacing one of the nonbridging oxygen atoms with a sulfur atom, are the major representatives of DNA analogs. PS-oligo display several attractive features like nuclease resistance, activation of RNase H, and good pharmacokinetic properties [1]. Replacement of one of two nonbridging oxygens at phosphorus by sulfur induces asymmetry at the phosphorus atom. Hence, the synthesized oligo(nucleoside phosphorothioate) is a mixture of 2n diastereomers (where n is the number of internucleotide phosphorothioate functions). Therefore the actual biological activity of the P-chiral oligonucleotide analogues, (e.g., interactions with proteins or nucleic acids) may depend on stereochemical factors [7]. One has to keep in mind that the phosphoramidite [5] and H-phosphonate [32] methodologies (commonly used to prepare PS-oligo) are nonstereospecific and give a mixture of 2n diastereomers. Thus, various methods have been elaborated to synthesize these P-chiral oligonucleotide analogs in a stereocontrolled manner [15, 17], among them the oxathiaphospholane method developed by Stec et al. [18], the method utilizing nucleoside 3’-O-(3-N-acyl)oxazaphospholidine derivatives as monomer units [19], and the method based on a stereoselective synthesis of nucleoside 3’-O-oxazaphospholidine monomers [21, 22] are the most significant.
Źródło:: Wiadomości Chemiczne; 2015, 69, 11-12; 957-981
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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