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    Wyświetlanie 1-15 z 15
    Tytuł:
    Utilisation of peptides against microbial infections – a review
    Autorzy:
    Mirski, T.
    Niemcewicz, M.
    Bartoszcze, M.
    Gryko, R.
    Michalski, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2081601.pdf
    Data publikacji:
    2018
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    antimicrobial peptides
    infections
    drugs
    therapy
    Opis:
    The emergence of resistance in microorganisms on a global scale has made it necessary to search for new antimicrobial factors. Antimicrobial peptides (AMPs) seem to meet these expectations. AMPs are produced by bacteria, viruses, plants, and animals, and may be considered as a new class of drugs intended for the prophylaxis and treatment of both systemic and topical infections. The aim of this study is to review the results of studies on the use of peptides to combat infections in vivo. Antimicrobial peptides may be applied topically and systemically. Among the peptides used topically, a very important area for their application is ophthalmology. AMPs in ophthalmology may be used mainly for the protection of contact lenses from ocular pathogens. Many AMPs are in clinical trials for application in the therapy of local infections. There may be mentioned such preparations as: pexiganan (magainin analogue), MX-226 (based on indolicidin), NEUPREX (isolated from human BPI (bactericidal/permeability-increasing) protein), IB-367 (variant of porcine protegrin), P113 (based on histatin), daptomycin, polymyxins, as well as peptidomimetics. In the combat against systemic infections are used such peptides as: P113D (modified P113 peptide containing D-amino acids), colistin, peptoids, and peptides containing non-typical amino acids or non-peptide elements. AMPs are also used as antiprotozoal, antifungal, antitoxic and immunostimulatory agents. The limitations in the use of peptides in the treatment of infections, such as susceptibility to proteolysis, and resistance of microorganisms to the peptides, are also discussed. AMPs are a promising strategy in the fight against microbial infections.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 205-210
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
    Autorzy:
    Koszałka, Patrycja
    Kamysz, Elżbieta
    Wejda, Magdalena
    Kamysz, Wojciech
    Bigda, Jacek
    Powiązania:
    https://bibliotekanauki.pl/articles/1039961.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    U937 cells
    lipopeptide
    antimicrobial peptides
    Opis:
    We investigated cytotoxic activity of antimicrobial peptides of different origin (both naturally occurring and synthetic), structure and known mechanisms of action against human histiocytic lymphoma cell line U937. The strongest cytotoxic activity against U937 cell line was shown by Pexiganan MSI-78, followed by Citropin 1.1, Protegrin 1 and a synthetic lipopeptide, N-α-palmitoyl-l-lysyl-l-lysine amide (Pal-Lys-Lys-NH2). The cytotoxic activity of the peptides was more dependent on the time of incubation than concentration. Only for the lipopeptide, whose mode of action was restricted to disruption of electric potential of the cell membrane, the correlation between cytotoxicity and concentration was almost linear. The high cytotoxicity of Pexiganan MSI-78, Protegrin 1 and the lipopeptide could be basically explained by their membranolytic activity leading to necrosis. However, in the case of Citropin 1.1, the cell membrane integrity was disrupted only slightly and independently of the peptide concentration. Therefore, some other mechanism of action might be responsible for its strong dose-dependent cytotoxic activity, e.g., membranolytic activity leading to apoptosis. Furthermore, TNF-α production due to LPS (lipopolysaccharide) stimulation was suppressed by the presence of Citropin 1.1, Pexiganan MSI-78 or Protegrin 1, but not by Buforin 2 or the lipopeptide. Our experiments have shown that cytotoxic activity is not limited to some specific molecular structure of a peptide, but rather to the length of the peptide chain as it is likely to affect the efficiency of the tumor cell membrane disruption and interaction with LPS.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 111-117
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of antimicrobial peptides by using eigenvectors
    Autorzy:
    Polanco, Carlos
    Powiązania:
    https://bibliotekanauki.pl/articles/1038767.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    antimicrobial peptides
    supervised methods
    structural bioinformatics
    Opis:
    Antibacterial peptides are subject to broad research due to their potential application and the benefit they can provide for a wide range of diseases. In this work, a mathematical-computational method, called the Polarity Vector Method, is introduced that has a high discriminative level (>70%) to identify peptides associated with Gram (-) bacteria, Gram (+) bacteria, cancer cells, fungi, insects, mammalian cells, parasites, and viruses, taken from the Antimicrobial Peptides Database. This supervised method uses only eigenvectors from the incident polar matrix of the group studied. It was verified with a comparative study with another extensively verified method developed previously by our team, the Polarity Index Method. The number of positive hits of both methods was up to 98% in all the tests conducted.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 483-491
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Novel properties of antimicrobial peptides.
    Autorzy:
    Kamysz, Wojciech
    Okrój, Marcin
    Łukasiak, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1043622.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    tumour
    cells
    mitogen
    immunity
    signalling pathways
    antimicrobial peptides
    Opis:
    Endogenous peptide antibiotics are known as evolutionarily old components of innate immunity. Due to interaction with cell membrane these peptides cause permeabilization of the membrane and lysis of invading microbes. However, some studies proved that antimicrobial peptides are universal multifunctional molecules and their functions extend far beyond simple antibiotics. In this review we present an overview of the general mechanism of action of antimicrobial peptides and discuss some of their additional properties, like antitumour activity, mitogenic activity, role in signal transduction pathways and adaptive immune response.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 461-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bacteriophages, phage endolysins and antimicrobial peptides - the possibilities for their common use to combat infections and in the design of new drugs
    Autorzy:
    Mirski, T.
    Mizak, L.
    Nakonieczna, A.
    Gryko, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/2083224.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    bacteriophages
    phage endolysins
    antimicrobial peptides
    synergy
    bacterial infections
    Opis:
    The antibiotic resistance in many pathogenic bacteria has become a major clinical problem, therefore, the necessity arises to search for new therapeutic strategies. The most promising solution lies in bacteriophages, phage endolysins and antimicrobial peptides. The aim of this study is to review the possibilities for the common use of bacteriophages, phage endolysins and antimicrobial peptides, both in the form of combined therapies and new strategies for the production of peptide drugs. Bacteriophages are viruses that specifically infect and destroy pathogenic bacteria by penetration into bacterial cells, causing metabolism disorders and, consequently, cell lysis. Phage-encoded endolysins are bacteriolytic proteins produced at the end of the phage lytic cycle that destroy elements of bacterial cell wall and enable the release of phage progeny from host cells. Antimicrobial peptides (AMPs) constitute an element of the innate immunity of living organisms and are characterized by the activity against a broad spectrum of bacteria. In the literature, there are only a few reports on the direct interaction of bacteriophages, phage endolysins and antimicrobial peptides against pathogenic bacteria. In each of them, a synergistic effect was observed, and Phage-encoded antimicrobial peptides as a specific group of AMPs have were also discussed. Phage-display technique was also reviewed in terms of its applications to produce and deliver biologically active peptides. The literature data also suggest that bacteriophages, phage endolysins and antimicrobial peptides can be used in combined therapy, thus negating many of the limitations resulting from their specificity as a single antimicrobial agent.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 203-209
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Non-histone nuclear protein HMGN2 differently regulates the urothelium barrier function by altering expression of antimicrobial peptides and tight junction protein genes in UPEC J96-infected bladder epithelial cell monolayer
    Autorzy:
    Tian, Hanwen
    Miao, Junming
    Zhang, Fumei
    Xiong, Feng
    Zhu, Feimei
    Li, Jinyu
    Wang, Xiaoying
    Chen, Shanzhe
    Chen, Junli
    Huang, Ning
    Wang, Yi
    Powiązania:
    https://bibliotekanauki.pl/articles/1038529.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HMGN2
    UPEC
    BECs 5637
    bladder epithelium
    tight junction
    antimicrobial peptides
    Opis:
    The urinary tract is vulnerable to frequent challenges from environmental microflora. Uropathogenic Escherichia coli (UPEC) makes a major contribution to urinary tract infection (UTI). Previous studies have characterized positive roles of non-histone nuclear protein HMGN2 in lung epithelial innate immune response. In the study presented here, we found HMGN2 expression was up-regulated in UPEC J96-infected urothelium. Surprisingly, over-expression of HMGN2 promoted disruption of BECs 5637 cells' intercellular junctions by down-regulating tight junction (TJs) components' expression and physical structure under J96 infection. Further investigation showed that BECs 5637 monolayer, in which HMGN2 was over-expressed, had significantly increased permeability to J96. Our study systemically explored the regulatory roles of HMGN2 in BECs barrier function during UPEC infection and suggested different modulations of intracellular and paracellular routes through which UPEC invades the bladder epithelium.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 93-100
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The action of ten secreted aspartic proteases of pathogenic yeast Candida albicans on major human salivary antimicrobial peptide, histatin 5
    Autorzy:
    Bochenska, Oliwia
    Rapala-Kozik, Maria
    Wolak, Natalia
    Aoki, Wataru
    Ueda, Mitsuyoshi
    Kozik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1038755.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    secreted aspartic proteases
    Sap
    Candida albicans
    antimicrobial peptides
    histatin 5
    candidiasis
    Opis:
    Candida albicans, belonging to the most common fungal pathogens of humans, exploits many virulence factors to infect the host, of which the most important is a family of ten secreted aspartic proteases (Saps) that cleave numerous peptides and proteins, often deregulating the host's biochemical homeostasis. It was recently shown that C. albicans cells can inactivate histatin5 (His5), a salivary histidine-rich anticandidal peptide, through the hydrolytic action of Saps. However, the current data on this subject are incomplete as only four out of ten Saps have been studied with respect to hydrolytic processing of His5 (Sap2, Sap5, Sap9-10). The aim of the study was to investigate the action of all Saps on His5 and to characterize this process in terms of peptide chemistry. It was shown that His5 was degraded by seven out of ten Saps (Sap1-4, Sap7-9) over a broad range of pH. The cleavage rate decreased in an order of Sap2>Sap9>Sap3>Sap7>Sap4>Sap1>Sap8. The degradation profiles for Sap2 and Sap9 were similar to those previously reported; however, in contrast to the previous study, Sap10 was shown to be unable to cleave His5. On a long-time scale, the peptide was completely degraded and lost its antimicrobial potential but after a short period of Sap treatment several shorter peptides (His1-13, His1-17, His1-21) that still decreased fungal survival were released. The results, presented hereby, provide extended characteristics of the action of C. albicans extracellular proteases on His5. Our study contribute to deepening the knowledge on the interactions between fungal pathogens and the human host.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 403-410
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Oddziaływanie przeciwdrobnoustrojowych peptydów z jonami metali : relacja między chemią koordynacyjną, strukturą, termodynamiką a sposobem działania
    The interaction of antimicrobal peptides with metal ions : the relationship between coordination chemistry, structure, thermodynamics and mode of action
    Autorzy:
    Dudek, Dorota
    Garstka, Kinga
    Miller, Adriana
    Dzień, Emilia
    Wątły, Joanna
    Hecel, Aleksandra
    Kozłowski, Henryk
    Rowińska-Żyrek, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/2200586.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    antimicrobial peptides
    metal coordination
    antibiotic resistance
    peptydy przeciwdrobnoustrojowe
    koordynacja metali
    antybiotykooporność
    Opis:
    Increasing bacterial and fungal drug resistance makes novel, effective antimicrobial treatments actively sought. Because of the general lack of resistance towards antimicrobial peptides (AMPs), they are being relied on as a novel class of therapeutics aimed to conquer drug-resistant bacteria and fungi. There are numerous ways in which AMPs might interact with pathogens, such as membrane disruption, production of reactive oxygen species, inhibition of cell wall, nucleic acid and protein synthesis or by the withdrawal of essential metal ions. Biologically indispensable metal ions, such as Zn(II) and Cu(II), which are the key players of this project, have a dual effect on the activity of antimicrobial peptides: (i) AMPs bind them, so that microbes cannot get enough metals essential for their life and virulence (withdrawal of metal ions, nutritional immunity) or (ii) AMPs need the given metal ion as a booster of their antimicrobial activity (metal ions affect the AMP charge and/or structure). In this chapter, we discuss the impact of the coordination of Cu(II) and Zn(II) to several antimicrobial peptides, focusing on the thermodynamics, structure and coordination chemistry. The comparison of these data to the outcome of biological growth studies (determination of minimal inhibitory concentration (MIC) of metalAMP complexes and their derivatives allows to draw conclusions about the relationship between the metal-antimicrobial peptide complex structure, stability mode of action and efficacy. In the nearest future, the most efficient complexes may serve as templates for a rational design of novel, more potent AMP-based therapeutics. Further improvement can be reached through the modification of the most promising AMP complexes using (i) specifically targeted antimicrobial peptides, in which the AMP will be covalently linked to a targeting peptide (Figure 1) or (ii) chimeric compounds comprising AMPs bound to conventional antimicrobials or peptidomimetic modifications (Figure 2).
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 5-6; 365--391
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of autologous and heterologous extract of antimicrobial peptides on leukocytes isolated during titanium implant insertion in rabbit and ovine model
    Autorzy:
    Zdziennicka, Joanna
    Szponder, Tomasz
    Latalski, Michał
    Żylińska, Beata
    Sobczyńska-Rak, Aleksandra
    Wessely-Szponder, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1844870.pdf
    Data publikacji:
    2021
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    titanium implants
    neutrophil extract
    implantation of biomaterial
    neutrophils
    monocyte- -derived macrophages
    natural antimicrobial peptides
    Opis:
    This study evaluated the in vitro leukocyte response to titanium implants in the presence of autologous or heterologous antimicrobial peptides extracts. Antimicrobial peptides (AMPs) appeared to be a new approach both against microorganisms and for regulation of inflammatory and repair processes. To evaluate their potential usefulness in regenerative medicine, we prepared different extracts of neutrophil-derived AMPs from rabbit, ovine or porcine blood which contained AMPs of different compositions, mainly defensins, cathelicidins and fragments thereof. Then, we assessed in vitro the influence of different AMPs extracts on the neutrophils and monocyte-derived macrophages (MDM) activity. For this purpose, these cells were obtained from experimental animals, rabbits, or sheep submitted to insertion of a titanium implant into the tibial defect. The cultured cells stimulation was autologous or heterologous, dependently on the AMPs extract origin and the experimental animal species. The neutrophil activity was assessed on the basis of the enzymes release from azurophilic and secondary granules and the free radicals generation. The MDM functional assessment was based on the NO and superoxide generation and arginase activity. Additionally, morphological changes were evaluated in the cell cultures. Our results indicated that the origin of AMPs extract is crucial for its activity. The autologous extracts stimulated anti-inflammatory responses, whereas the heterologous extracts displayed pro-inflammatory effect on neutrophils and macrophages. These results might be considered during the introduction of new preparations in regenerative medicine.
    Źródło:
    Engineering of Biomaterials; 2021, 24, 159; 24-30
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Possibility of using defensins in medicine
    Możliwość wykorzystania defensyn w medycynie
    Autorzy:
    Grudlewska, Katarzyna
    Sysakiewicz, Martyna
    Buda, Kamil
    Sobecka, Monika
    Alska, Ewa
    Żukow, Walery
    Sokołowski, Remigiusz
    Ciesielska, Natalia
    Powiązania:
    https://bibliotekanauki.pl/articles/1032187.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Kazimierza Wielkiego w Bydgoszczy
    Tematy:
    antibiotics
    antimicrobial peptides
    defensins
    treatment of infections
    hiv
    antybiotyki
    peptydy antydrobnoustrojowe
    defensyny
    leczenie zakażeń
    Opis:
    Introduction. Antimicrobial proteins (antimicrobial peptides - AMP) probably belong to one of the oldest and most primitive defense mechanisms of the body. It is now known about 800 types of AMP present in plants, insects and animals. Two main types of AMP is likely to occur in mammalian defensins and cathelicidin antimicrobial activity showing. Defensins are small cationic proteins that are part of the innate immunity, humoral immunity. Among of mammalian defensins can be distinguished: defensin α, β defensins and θ defensins. Human defensins are located in various tissues, mainly synthesized in neutrophils and other immune cells. Purpose. Provide an overview of the literature on the construction, function and possible use of defensins in the treatment of infections. Materials and methods. Using the key words: antibiotics, Antimicrobial peptides, defensins, treatment of infections, HIV searched bibliographic databases: Medline, Science Direct, Ebsco, Springer Link, Wiley Online Library. Results. Selected articles were used to describe the structure and function of defensins. Discusses the latest news on the possible use of defensins in the treatment of infections and the state of knowledge about their function in the course of infection with human immunodeficiency virus (HIV) and infections involving multidrug-resistant bacteria. Conclusions. The literature review shows the important function of defensins they play in the course of infection. Defensins through a variety of properties are an attractive alternative to traditional methods of treating infections caused by pathogenic microorganisms. It is necessary to better understand the mechanism of action of these substances in vivo models.
    Wstęp. Białka antydrobnoustrojowe (antimicrobial peptides – AMP) prawdopodobnie należą do jednych z najstarszych i najbardziej prymitywnych mechanizmów obronnych organizmu. Obecnie jest znanych około 800 rodzajów AMP występujących u roślin, owadów oraz zwierząt. Dwa główne rodzaje AMP występujące u ssaków to katelicydyny oraz defensyny wykazujące działanie przeciwdrobnoustrojowe. Defensyny to małe białka kationowe, które są elementem odporności nieswoistej, humoralnej. Wśród defensyn występujących u ssaków można wyróżnić: defensyny α, defensyny β oraz defensyny θ. Ludzkie defensyny zlokalizowane są w różnorodnych tkankach, głównie syntetyzowane w neutrofilach i innych komórkach układu odpornościowego. Cel. Przedstawienie przeglądu literatury na temat budowy, funkcji oraz możliwości wykorzystania defensyn w leczeniu zakażeń. Materiały i metody. Posługując się kluczowymi słowami: antybiotyki, peptydy antydrobnoustrojowe, defensyny, leczenie zakażeń, HIV przeszukano bazy bibliograficzne: Medline, ScienceDirect, Ebsco, SpringerLink, Wiley Online Library. Wyniki. Wybrane artykuły wykorzystano do opisu budowy oraz funkcji defensyn. Omówiono najnowsze doniesienia na temat możliwości wykorzystania defensyn w leczeniu zakażeń oraz stan wiedzy na temat ich funkcji w przebiegu zakażenia ludzkim wirusem niedoboru odporności (HIV) oraz zakażeń z udziałem wielolekoopornych bakterii. Wnioski. Przegląd literatury ukazuje ważną funkcję defensyn jaką pełnią w przebiegu zakażeń. Defensyny dzięki różnorodnym właściwościom stanowią atrakcyjną alternatywę dla tradycyjnych metod leczenia zakażeń wywołanych patogennymi mikroorganizmami. Konieczne jest lepsze poznanie mechanizmu działania tych substancji w modelach in vivo.
    Źródło:
    Journal of Health Sciences; 2014, 4, 7; 11-17
    1429-9623
    Pojawia się w:
    Journal of Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    różnorodność peptydów przeciwdrobnoustrojowych bezkręgowców
    Diversity of antimicrobial peptides in invertebrates
    Autorzy:
    Zdybicka-Barabas, Agnieszka
    Cytryńska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1033992.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Tematy:
    antimicrobial peptides
    cecropins
    defense peptides
    defensins
    innate immunity
    invertebrates
    bezkręgowce
    cekropiny
    defensyny
    odporność wrodzona
    peptydy odpornościowe
    peptydy przeciwdrobnoustrojowe
    Opis:
    Peptydy przeciwdrobnoustrojowe są kluczowymi efektorami odporności wrodzonej. Wykazują działanie przeciwbakteryjne, przeciwgrzybowe, przeciwpierwotniacze, a często przeciwwirusowe i przeciwnowotworowe. Wiele z nich zaangażowanych jest w neutralizację endotoksyn patogenów oraz ma właściwości immunomodulacyjne, stąd określane są również jako peptydy odpornościowe. O bogactwie i różnorodności naturalnie występujących peptydów przeciwdrobnoustrojowych świadczy ich liczba zgromadzona w bazie Antimicrobial Peptide Database (aps.unmc.edu/AP/main.php), która zawiera dane dotyczące ponad 2100 peptydów zidentyfikowanych u zwierząt. Spośród nich ponad 570 to peptydy odpornościowe bezkręgowców, w tym 495 opisanych u stawonogów. Niezwykle szerokie występowanie peptydów przeciwdrobnoustrojowych u przedstawicieli wszystkich królestw jednoznacznie wskazuje na ich fundamentalną rolę w sukcesie ewolucyjnym złożonych organizmów wielokomórkowych. Ich zasadnicze znaczenie w odporności bezkręgowców podkreśla ponadto fakt, że większość opisanych pod tym względem gatunków wytwarza zestaw peptydów zróżnicowanych pod względem struktury przestrzennej, właściwości biochemicznych, mechanizmu działania oraz spektrum aktywności przeciwdrobnoustrojowej.
    Antimicrobial peptides (AMPs) are the key effectors of innate immunity. They exhibit antimicrobial, antifungal, antiprotozoal, and often antiviral and anticancer activities. Many of them are involved in neutralization of pathogen endotoxins, have immunomodulatory properties, and are therefore referred to as defense peptides (host defense peptides). The wealth and diversity of naturally occurring AMPs is evidenced by their numbers in the Antimicrobial Peptide Database (aps.unmc.edu/AP/main.php), which contains data on over 2100 peptides identified in animals. Of these, over 570 are invertebrate peptides, including 495 described in arthropods. The unusually widespread presence of AMPs in all kingdoms clearly indicates their fundamental role in the evolutionary success of complex multicellular organisms. Their essential role in invertebrate immunity further emphasizes the fact that most species produce a set of defense peptides varied in terms of spatial structure, biochemical properties, mechanism of action and spectrum of antimicrobial activity.
    Źródło:
    Kosmos; 2017, 66, 4; 563-574
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Electronegativity and intrinsic disorder of preeclampsia-related proteins
    Autorzy:
    Polanco, Carlos
    Castañón-González, Jorge
    Uversky, Vladimir
    Buhse, Thomas
    Samaniego Mendoza, José
    Calva, Juan
    Powiązania:
    https://bibliotekanauki.pl/articles/1038693.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    preeclampsia
    intrinsically disordered proteins
    structural proteomics
    bioinformatics
    antimicrobial peptides
    polarity index method
    lipoproteins
    angiogenesis proteins
    Opis:
    Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 99-111
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Natural preservatives in meat products
    Autorzy:
    Sośnicka, Marta
    Powiązania:
    https://bibliotekanauki.pl/articles/410410.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Łódzka. Wydawnictwo Politechniki Łódzkiej
    Tematy:
    natural preservatives
    essential oils
    plant extract
    antimicrobial peptides
    naturalne konserwanty
    olejki eteryczne
    ekstrakt roślinny
    peptydy przeciwdrobnoustrojowe
    Opis:
    The use of preservatives in industrial food production is now common practice. However, there is growing concern among consumers over the harmful effects of common chemical preservatives. As a result, there is increased demand for food that that has undergone little or no processing. In recent years, there has therefore been great interest in finding alternatives to chemical preservatives for use in the meat industry, in the form of natural ingredients. Possible solutions include the use of plant extracts, essential oils or antimicrobial peptides. This paper provides a review of research on the replacement of artificial preservatives in meat products with traditional chemical compounds of natural origin.
    Źródło:
    Biotechnology and Food Science; 2019, 83, 2; 107-120
    2084-0136
    2299-6818
    Pojawia się w:
    Biotechnology and Food Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biodegradowalne poliuretanowe nośniki citropiny - otrzymywanie, badania fizykochemiczne i biologiczne
    Biodegradable polyurethane carriers of citropin - preparation, physicochemical and biological characterization
    Autorzy:
    Piotrowska, U.
    Sobczak, M.
    Dębek, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/284038.pdf
    Data publikacji:
    2014
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    poliuretany biodegradowalne
    citropina
    peptydy przeciwdrobnoustrojowe
    polimery przeciwbakteryjne
    kontrolowane uwalnianie substancji przeciwbakteryjnych
    biodegradable polyurethanes
    citropin
    peptides with antimicrobial activity
    antibacterial polymers
    antibacterial substances controlled release
    Opis:
    Poważnym problemem współczesnej medycyny jest rosnąca lekooporność mikroorganizmów. W związku z powyższym, w ostatnich latach technologia polimerowych materiałów o właściwościach przeciwdrobnoustrojowych jest jednym z najszybciej rozwijających się obszarów farmacji i inżynierii biomedycznej. Biomateriały te są stosowane w wielu aplikacjach, szczególnie w urządzeniach medycznych oraz technologii systemów dostarczania leków. Peptydy stanowią perspektywiczną grupę związków o właściwościach przeciwdrobnoustrojowych, które mogą być stosowane w technologii wspomnianych materiałów. W niniejszej pracy, otrzymano nowe porowate poliuretanowe nośniki citropiny (CT). Nietoksyczne biodegradowalne poliuretany (PU) zsyntetyzowano przy użyciu dioli poli(ε-kaprolaktonu), polilaktydu i poli(adypinianu etylenu) oraz 1,6-diizocyjanianu heksametylenu i butano-1,4-diolu. Otrzymane PU zostały scharakteryzowane za pomocą technik 1H i 13C NMR. Wyznaczono masę cząsteczkową i właściwości mechaniczne zsyntetyzowanych biomateriałów. Przeprowadzono badania uwalniania CT z porowatych PU w warunkach in vitro. Stwierdzono, że wszystkie otrzymane matryce PU są nietoksyczne w stosunku do bakterii luminescencyjnych V. fischeri oraz pierwotniaków S. ambiguum i T. termophila. Procent uwolnionej CT z uzyskanych porowatych PU, w ciągu 8 tygodni procesu biodegradacji, wynosił od 29% do 79%. Ponadto, wykazano dobrą korelację pomiędzy kinetyką uwalniania CT z matryc a ubytkiem masy porowatych PU. Podsumowując, można stwierdzić, że szybkość uwalniania CT z porowatych materiałów zależy głównie od rodzaju poliolu użytego w syntezie PU. Uzyskane wstępne wyniki badań sugerują, że otrzymane układy stanowią nowe, obiecujące biomateriały jako potencjalne systemy kontrolowanego uwalniania substancji przeciwdrobnoustrojowych.
    Particularly problematic of the present medicine are more and more growing drug-resistant microorganisms. Therefore, in the recent years technology of polymeric materials with antimicrobial activity represents one of the most rapidly advancing areas in pharmacy and biomedical engineering. These biomaterials are used in many fields, particularly in medical devices and technology of drug delivery systems. One of the perspective group of antimicrobial substances, which could be used in technology of these materials, are peptides. New porous polyurethane carriers of citropin (CT) were obtained. Non-toxic biodegradable polyurethane (PU) were synthesized from poly(ε-caprolactone), polylactide or poly(ethylene adipate) diols, 1,6-hexamethylene diisocyanate and butanediol. The obtained PU was characterized by 1H and 13C NMR techniques. The molecular weight and mechanical properties of the obtained biomaterials were reported. The controlled release of CT from porous PU was studied in vitro. It was found that all prepared PU matrices are non toxic to the luminescent bacteria V. fischeri and two ciliated protozoa S. ambiguum and T. termophila. The percentage of CT released from prepared porous PU was 29% to 79% after 8 weeks. Moreover, the results directly comparing CT release with mass loss of obtained porous PU studies follow the same trend. Summing up, the release rates of the CT from porous materials were shown to be directly dependent on the nature of polyol used in the synthesis of PU. The preliminary results suggest that these novel biomaterials are promising for application as antimicrobial substance delivery systems.
    Źródło:
    Engineering of Biomaterials; 2014, 17, 124; 29-35
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aminokwasy, glikany, peptydy i białka w ścieżkach diagnostycznych i terapeutycznych chorób cywilizacyjnych XXI wieku : projektowanie i charakterystyka fizykochemiczna oraz strukturalna
    Amino acids, glycans, peptides and proteins in the diagnostic and therapeutic pathways of the 21st century civilization diseases : design, physicochemical and structural characterisation
    Autorzy:
    Bylińska, Irena
    Dzierżyńska, Maria
    Giżyńska, Małgorzata
    Guzow, Katarzyna
    Jankowska, Elżbieta
    Jurczak, Przemysław
    Kaczyński, Zbigniew
    Karska, Natalia
    Kowalczyk, Agnieszka
    Kuncewicz, Katarzyna
    Orlikowska, Marta
    Sawicka, Justyna
    Spodzieja, Marta
    Szpakowska, Nikola
    Szymańska, Aneta
    Wieczerzak, Ewa
    Witkowska, Julia
    Rodziewicz-Motowidło, Sylwia
    Powiązania:
    https://bibliotekanauki.pl/articles/2200549.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    fluorophores
    fluorescence spectroscopy
    antimicrobial activity
    anticancer activity
    Cystapep
    Stahylococcus aureus
    antimicrobial compounds
    amyloidogenic protein
    mutagenesis
    fibrilization
    proteasome
    aging
    neurodegeneration
    self-assembling peptides
    tissue engineering
    biomaterials
    immune checkpoints
    peptide inhibitors
    immunotherapy
    ligands of TAP protein
    viral diseases
    NMR structure of the UL49.5 protein
    glycans
    glycoconjugates
    fluorofory
    spektroskopia fluorescencyjna
    aktywność przeciwdrobnoustrojowa
    aktywność antynowotworowa
    Staphylococcus aureus
    związki przeciwbakteryjne
    białko amyloidogenne
    mutageneza
    fibrylizacja
    proteasom
    procesy starzeniowe
    neurodegeneracja
    peptydy samoorganizujące
    inżynieria tkankowa
    biomateriały
    punkty kontrolne układu immunologicznego
    inhibitory peptydowe
    immunoterapia
    ligandy białka TAP
    choroby wirusowe,
    struktura NMR białka UL49.5
    glikany
    glikokoniugaty
    Opis:
    The civilization diseases of the 21st century are non-infectious disorders, affecting a large part of modern society. They are associated with the significant development of industry and technology, and hence with environmental pollution and an unhealthy lifestyle. These factors have led to the development of many civilization diseases, which currently include: cardiovascular diseases, respiratory diseases, diabetes, obesity, malignant tumors, gastrointestinal diseases, mental disorders and allergic diseases. The development of technologies, including modern therapies and new drugs, resulted in increase in life expectancy. This creates a global problem of an aging population with an increasing number of diseases of the old age, i.e. dementias. In addition, sedentary lifestyles and changing diets are the reasons why more and more people develop metabolic diseases, as well as neurological and cognitive disorders characterized by progressive damage to nerve cells and dementia. Currently, problem on a global scale is also the growing resistance to existing antimicrobial drugs. Therefore, the scientists face many challenges related to searching for the causes of these diseases, their diagnosis and treatment. Scientific research conducted at the Department of Biomedical Chemistry at the Faculty of Chemistry of the University of Gdańsk is part of this research trend. In this publication, we discuss various research topics with the long-term aim of solving the problems associated with the diseases mentioned above. The following chapters are dedicated to (i) looking for new effective fluorophores with diagnostic and anti-cancer activity; (ii) designing of new compounds with antibacterial and antiviral activity and their synthesis; (iii) investigating the mechanisms of amyloid deposit formation by human cystatin C and possibilities of inhibition of this process; (iv) designing and studies of compounds activating the proteasome with the potential to suppress the development of neurodegenerative diseases; (v) designing peptide fibrils and hydrogels as drug carriers; (vi) searching for peptide inhibitors of immune checkpoint as potential drugs for immunotherapy; (vii) studying the mechanism of action of selected herpesviruses by determining the structure of viral proteins and (viii) studying the composition of natural glycans and glycoconjugates in order to better understand the mechanisms of interaction of bacteria with the environment or with the host.
    Źródło:
    Wiadomości Chemiczne; 2022, 76, 5-6; 393--431
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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