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Wyszukujesz frazę "anti-tumor activity" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Cytotoxic and anti-cancer activity of the Cistus species of herbal plants
Autorzy:
Stępień, Agnieszka Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454781.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
anti-tumor activity
Cistus species
cytotoxic activity
phytotherapeutics
Opis:
Aim. The aim of this paper is to provide an overview of the cytotoxic and anti-cancer properties of the major species of the genus Cistus. Materials and methods. Thirty four papers that discuss the medicinal history and current research of Cistus species as phytotherapeutics were used for this discussion. Literature analysis.The growing popularity of the Cistus species of herbs is mainly due to its anti-inflammatory, antimicrobial, antifungal and antioxidant properties. The results of in vitro studies indicate that the presence of pear extract significantly affects leukemia, leukemia, breast, colon, ovarian, pancreatic, and melanoma carcinomas. The significant growth inhibition of these cells, underlines its valuable anti-tumor properties and allows for the possibility of use as a therapeutic aid.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 2; 165-168
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Two Gln187 mutants of human soluble APRIL inhibit proliferation of lung carcinoma A549 cells
Autorzy:
Dai, Shuangshuang
Zheng, Yingru
Chen, Bin
Gao, Min
Zhang, Yan
Zhang, Li
Gong, Wei
He, Fengtain
Powiązania:
https://bibliotekanauki.pl/articles/1040492.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
APRIL
Gln187 mutant of sAPRIL
anti-tumor activity
Opis:
Soluble APRIL (sAPRIL), the active form of a proliferation-inducing ligand (APRIL), is implicated in the proliferation of tumor cells. Suppressing APRIL function has been considered as a potential strategy for the therapy of APRIL-associated tumors. In the present study, we generated human sAPRIL and its two mutants, Gln187-D-sAPRIL (Gln187 deleted) and Gly187-sAPRIL (Gln187 replaced by Gly). In vitro experiments showed that the two mutants had similar specific binding capacity to lung carcinoma A549 cells compared to the wild-type sAPRIL, and both, especially Gly187-sAPRIL, exhibited significant antagonistic effect on sAPRIL-induced tumor cell proliferation in a dose-dependent manner, which might be predominantly mediated by blocking sAPRIL-induced MEK and ERK phosphorylation but not p38MAPK or JNK signaling. In vivo experiments with nude mice bearing A549 cell-derived xenograft tumor showed that only the Gly187-sAPRIL mutant could significantly suppress the tumor growth. These results suggest that Gln187 may be a crucial amino acid in APRIL-mediated tumor cell proliferation via the MEK-ERK signaling pathway and that the sAPRIL mutants may serve as novel potential antagonists of APRIL for the therapy of APRIL-associated cancers.
Źródło:
Acta Biochimica Polonica; 2009, 56, 4; 703-710
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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