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    Wyświetlanie 1-8 z 8
    Tytuł:
    Metabolism of bradykinin in aorta of hypertensive rats
    Autorzy:
    Bujak-Giżycka, Beata
    Olszanecki, Rafał
    Madej, Józef
    Suski, Maciej
    Gębska, Anna
    Korbut, Ryszard
    Powiązania:
    https://bibliotekanauki.pl/articles/1039915.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    bradykinin
    angiotensin converting enzyme
    mass spectrometry
    bioactive peptides
    Opis:
    Alterations in the formation and metabolism of bradykinin (Bk) are hypothesized to play a role in the pathophysiology of hypertension, atherosclerosis and vascular complications of diabetes. However, despite its prominent role in cardiovascular regulation, studies on bradykinin have been limited by various difficulties in accurate measurements of this peptide in biological samples. In this study, using the LC-ESI-MS method we estimated the conversion of exogenous Bk to its main metabolites - Bk-(1-5) and Bk-(1-7) - in endothelial cell culture and in fragments of aorta of normotensive (WKY) and hypertensive rats (SHR). The effects of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitors were more pronounced in SHR: perindoprilat inhibited Bk-(1-5) formation by 49 % and 76 % in WKY and SHR rats, respectively, and tiorphan tended to decrease formation of Bk-(1-5) in both groups of animals. The degradation of bradykinin and generation of both metabolites were significantly higher in the aorta of SHR rats than in WKY controls. Our results show that even in relatively early hypertension (in 4-month old SHR rats) inactivation of Bk by aorta wall is enhanced.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 2; 199-202
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
    Autorzy:
    Radović, Jelena
    Leković, Aleksandra
    Tačić, Ana
    Dodevska, Margarita
    Stanojković, Tatjana
    Marinković, Tijana
    Jelić, Čedomir
    Kundakovic-Vasović, Tatjana
    Powiązania:
    https://bibliotekanauki.pl/articles/2051038.pdf
    Data publikacji:
    2022-06-06
    Wydawca:
    Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
    Tematy:
    Craterellus cornucopioides
    β-glucan
    nutrients
    angiotensin converting enzyme inhibition
    cytotoxicity
    Opis:
    Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5’-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5’-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3–155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.
    Źródło:
    Polish Journal of Food and Nutrition Sciences; 2022, 72, 2; 171-181
    1230-0322
    2083-6007
    Pojawia się w:
    Polish Journal of Food and Nutrition Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Computational study of ACE and AGT gene of RAAS pathway
    Autorzy:
    Nisha, Nisha
    Kaur, Satbir
    Kaur, Sumanpreet
    Kumar, Sandeep
    Galhna, Kiranjeet Kaur
    Kaur, Kamaljeet
    Powiązania:
    https://bibliotekanauki.pl/articles/1112240.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Angiotensin converting enzyme
    Angiotensinogen
    Hypertension
    Renin angiotensin aldosterone system
    Single nucleotide polymorphism
    Opis:
    Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein respectively. The angiotensin convertase enzyme convert inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to imbalance in this pathway may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT gene. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT gene by SIFT and I-Mutant2.0. The total number of SNPs predicted to be deleterious by both tools were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further the result output of both the softwares were also compared.
    Źródło:
    World News of Natural Sciences; 2018, 19; 65-77
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Angiotensin converting enzyme inhibitors and atherosclerosis
    Autorzy:
    Andersson, R G G
    Jacobsson, L.
    Persson, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/71073.pdf
    Data publikacji:
    1994
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    fosinopril
    mini-pig
    angiotensin converting enzyme inhibitor
    morphometry
    captopril
    cholesterol
    atherosclerosis
    Źródło:
    Journal of Physiology and Pharmacology; 1994, 45, 1
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method
    Autorzy:
    Ramos, Paweł
    Juszczak, Anna
    Szczołko, Wojciech
    Pilawa, Barbara
    Stanisz, Beata J.
    Powiązania:
    https://bibliotekanauki.pl/articles/895342.pdf
    Data publikacji:
    2019-04-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    free radicals
    antioxidant
    UV-Vis spectrophotometry
    angiotensin-converting enzyme inhibitors (ACE-I)
    Opis:
    A negative impact of radicals on human’s health is responsible for growing research interest in antioxidant properties of substances, which protect organisms from the damaging influence of these reactive species. Angiotensin-converting enzyme inhibitors (ACE-I) are the most popular drugs used in cardiovascular diseases. There are a lot of clinical reports that ACE-I have antioxidant properties, due to the fact, that prolonged use improves conditions of patients with neurodegenerative disorders and slow inflammatory processes. The paper shows the antioxidant properties of a selected ACE-I: cilazapril, ramipril, imidapril, lisinopril, perindopril, and quinapril. Among numerous methods for antioxidant activity estimation, DPPH reduction is the most popular and commonly used one due to its ease, speed, sensitivity and the usage of stable radicals. UV-Vis spectrophotometry was used to examine interactions of chosen ACE-I with model-free radicals. Absorption of UV-Vis spectra of DPPH (reference), and DPPH interacting with the tested ACE-I were compared. For all tested ACE-I kinetics of their interaction with DPPH, up to 30 minutes, were obtained. The strongest interaction with DPPH was observed for imidapril and cilazapril and the lowest interaction for lisinopril. Studies have shown usefulness UV-Vis spectrophotometry for obtaining information on interactions of ACE-I with model-free radicals.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 233-239
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677→T transition in the MTHFR gene.
    Autorzy:
    Żak, Iwona
    Niemiec, Paweł
    Sarecka, Beata
    Balcerzyk, Anna
    Ciemniewski, Zbigniew
    Rudowska, Ewa
    Dyląg, Stanisław
    Powiązania:
    https://bibliotekanauki.pl/articles/1043632.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    angiotensin converting enzyme gene (ACE)
    coronary artery disease
    methylenetetrahydrofolate reductase gene (MTHFR)
    polymorphisms
    Opis:
    Angiotensin I-converting enzyme (ACE), which plays an important role in blood pressure regulation, and methylenetetrahydrofolate reductase (MTHFR) involved in homocysteine metabolism belong to a large group of polypeptides which may be potential risk factors for atherosclerosis and coronary artery disease (CAD). To assess whether polymorphisms of the genes encoding these peptides are associated with CAD in Silesian we conducted a study among 68 individuals suffering from CAD (including 52 cases after myocardial infarction), 51 subjects with positive family history of CAD and 111 controls. We analysed the distribution of genotypes and allele frequencies of the insertion/deletion (I/D) polymorphism in the ACE gene using PCR amplification, and the C677→T polymorphism in the MTHFR gene using PCR-RFLP analysis. We found that D allele frequency was significantly higher in CAD patients (61%) than in controls (43%) (P = 0.001, OR = 2.06). The D allele carriers (DD + ID genotypes) were more frequent in the CAD patients (85%) compared to control group (65%) (P = 0.003, OR = 3.14), whereas the familial CAD risk group shows the highest frequency of the ID genotype (57% vs 43% in controls). In contrast, the MTHFR polymorphism does not seem to be associated with the disease. Our data indicate that in Silesian CAD patients the disease is strongly associated with carrier-state of the ACE D allele, but not with the C677→T transition in the MTHFR gene.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 2; 527-534
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Study of molecular docking to detect antihypertensive phytochemicals of Oxalis corniculata Linn. against angiotensin converting enzyme
    Autorzy:
    Mondal, Satinath
    Talukdar, Partha
    Mondal, Tarit Kumar
    Powiązania:
    https://bibliotekanauki.pl/articles/1162851.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Angiotensin-converting enzyme
    Antihypertensive phytochemicals
    Molecular docking and interaction
    Oxalis corniculata
    Receptor-ligand binding
    Opis:
    The locally available medicinal plant, Oxalis corniculata Linn. is a common weed and used by villagers to prevent several diseases. The objective of the present study was to detect receptor-ligand binding energy and interaction through molecular docking for phytocompounds established in O. corniculata against angiotensin converting enzyme (ACE) (PDB ID: 1O86). Molecular docking was performed by using PyRx (Version 0.8) for the structure-based virtual screening and visualized the interaction in the MGL tool (Version 1.5.6). Among 16 phytochemicals and 4 antihypertensive synthetic drugs, highest binding energy value (Kcal/mol) was obtained in Apigenin (-8.9) compared to other four drugs such as Lisinopril (-7.7), Temocapril (-7.6), Enalapril (-7.5) and Captopril (-5.7). The binding interaction of target protein with this phytocompound found binding at active site may be showed as competitive inhibitor. In conclusion, phytoligand Apigenin can be a suitable lead compound for antihypertensive agent and an alternative of synthetic drug as per binding energy value and molecular interaction. It is suggesting further pharmacological and toxicological assay with this phytoligand after extraction from O. corniculata to validate the present results of computational screening.
    Źródło:
    World Scientific News; 2018, 110; 42-55
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ polimorfizmu insercyjno-delecyjnego ACE na występowanie chorób sercowo-naczyniowych i udarów mózgu w ocenie współczesnych badaczy
    Influence of insertion/deletion polymorphism of ACE on the incidence of cardiovascular diseases and stroke – modern scientists’ opinion
    Autorzy:
    Gaweł, Barbara
    Gałka, Sabina
    Wajgt, Andrzej
    Mazurek, Urszula
    Chłopicki, Bartosz
    Głogowska-Ligus, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1061204.pdf
    Data publikacji:
    2006
    Wydawca:
    Medical Communications
    Tematy:
    angiotensin II
    angiotensyna II
    cardiovascular diseases
    cerebral stroke
    polymorphism of angiotensin-converting enzyme
    risk factors
    czynniki ryzyka
    udar mózgu
    choroby sercowo-naczyniowe
    polimorfizm genu kodującego konwertazę angiotensyny
    Opis:
    For many years strokes have been a priority research subject. The genetic background of strokes has been of particular interest during the last decade. Intensive research is conducted into the role of polymorphism of the genes whose protein products are involved in the mechanisms of the renin-angiotensin system. Especially interesting is the insertion/deletion (ID) polymorphism of the gene responsible for the encoding of the angiotensin- converting enzyme (ACE). The enzyme is a dipeptidyl carboxypeptidase transforming angiotensin I (Ang I) into angiotensin II (Ang II) and inactivating bradykinin. The gene of ACE was found in chromosome 17 in 1988 year. In 1990 Rigat et al. discovered polymorphism in the area of 3’ 16 intron of the ACE gene, located in band q23 of chromosome 17. DD homozygotes demonstrate a twice increased activity of the enzyme in plasma than II homozygotes, while ID heterozygotes demonstrate intermediate activity. The percentage of persons with high serum convertase activity (>40 nmol/min) is significantly greater among patients with arterial hypertension than in health persons. According to some researchers, the genotype DD, which is accompanied by higher ACE activity, may be an independent myocardial infarction risk factor, hyperplastic and dilatation cardiomyopathy, sudden cardiac death, and some complications of arterial hypertension. The D allele is a inconsiderable but independent risk factor for ischemic stroke. The investigation led among Polish population is evidenced that D allele is an independent risk factor for hemorrhage stroke.
    W ostatnim dziesięcioleciu szczególne zainteresowanie budzi podłoże genetyczne udarów. Intensywne badania prowadzi się nad rolą polimorfizmu genów, których produkty białkowe są zaangażowane w mechanizmy działania układu renina-angiotensyna. Szczególne zainteresowanie wzbudził polimorfizm insercyjno-delecyjny (I/D) genu kodującego enzym konwertazę angiotensyny (ACE). Enzym jest dipeptydylokarboksypeptydazą przekształcającą angiotensynę I (Ang I) w angiotensynę II (Ang II) oraz inaktywującą bradykininę. Gen kodujący ACE zlokalizowany został w chromosomie 17. w roku 1988. W 1990 roku Rigat i wsp. wykryli istnienie polimorfizmu w okolicy 3’ 16. intronu genu dla ACE, zlokalizowanego w prążku q23 chromosomu 17. Homozygoty DD wykazują dwukrotnie większą aktywność enzymu w osoczu aniżeli homozygoty II, podczas gdy heterozygoty ID wykazują pośrednie aktywności. Odsetek osób z wysoką aktywnością konwertazy w surowicy (>40 nmol/min) jest znacząco większy u chorych na nadciśnienie tętnicze aniżeli u osób zdrowych. Według niektórych badaczy genotyp DD, któremu towarzyszy wyższa aktywność enzymu ACE, może być niezależnym czynnikiem ryzyka zawału serca, kardiomiopatii przerostowej i roztrzeniowej, nagłego zgonu sercowego oraz niektórych powikłań nadciśnienia tętniczego. Allel D jest nieznacznym, ale niezależnym czynnikiem ryzyka udarów niedokrwiennych mózgu. Badania przeprowadzone w populacji Polaków wykazały, że allel D jest niezależnym czynnikiem ryzyka udarów krwotocznych mózgu.
    Źródło:
    Aktualności Neurologiczne; 2006, 6, 1; 44-47
    1641-9227
    2451-0696
    Pojawia się w:
    Aktualności Neurologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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