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Tytuł:
Genetic risk factors of Alzheimer’s disease
Autorzy:
Skrzypa, Marzena
Potocka, Natalia
Bartosik-Psujek, Halina
Zawlik, Izabela
Powiązania:
https://bibliotekanauki.pl/articles/1597329.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
autosomal genetic mutations early-onset Alzheimer Disease genetic polymorphisms
late-onset Alzheimer Disease
Opis:
Introduction. Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases, which is a serious health problem for societies that live longer. Spontaneous dominant mutations and polymorphisms of selected genes play an important role in development of AD. Aim. Several polymorphisms in selected genes strongly associated with development of Alzheimer’s disease were highlighted in this review: APOE, CYP46, APP, PSEN1, PSEN2, UBQLN1, BACE1, PRND, APBB2, TOMM 40. These gene polymorphisms have a significant role in the development of Alzheimer’s disease and they have potential to be biomarkers. Researchers combine efforts to find significant polymorphisms that would ensure that a person is predisposed to the occurrence of disease symptoms. This topic is often taken up by scientists seeking to develop effective genetic tests for diagnosing AD. Material and methods. Analysis of literature from web of knowledge: Web of Science (all database), NCBI and PubMed. Results. We reviewed the selected important genes and polymorphisms which are most often associated with development of AD. Conclusion. It should be noted that nowadays scientists strive not to focus on only one polymorphism in the gene but on several polymorphisms in different genes concomitantly and above all on interactions between them to the diagnosis of this disease. Only this approach to AD will contribute to the creation of appropriate identification methods. Moreover, we should use the new generation tools - the platform for collecting data and personalized medicine.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 57-66
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Naming disorders in logopenic variant of Primary Progressive Aphasia
Autorzy:
Antczak-Kujawin, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/2106210.pdf
Data publikacji:
2019-04-30
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
anomia
spontaneous speech
Alzheimer's disease
Opis:
Language functions, particularly disordered lexical skills were diagnosed in the examined woman based on selected diagnostic tests of the Boston Diagnostic Aphasia Examination (BDAE). Furthermore, an experimental version of the author's original test for assessing lexical-semantic performance in dementia was used. The author presents a case study of a 79-year-old woman diagnosed with logopenic variant primary progressive aphasia (lvPPA) secondary to Alzheimer’s disease. The author describes the symptoms of anomie manifested by the study participant and the supplementary strategies she applied in the case of lexical deficits. The analysis of the findings obtained in the course of language function assessment allowed the author to assess the fluency of speech, speech comprehension, repetition and naming. The study participant diagnosed with lvPPA was observed to manifest the following: an absence of motor speech disorders, absence of characteristics of evident agrammatism, preserved comprehension of individual words, preserved semantic knowledge of objects, disordered retrieval of words in spontaneous speech and in attempts to name, and disordered repetition of sentences and phrases. The analysis of the discussed case study allowed the author to discuss the progressive lexical deficits manifested by the lvPPA patient and to record those supplementary strategies that were most frequently applied in the lexical difficulties experienced by the female patient diagnosed with lvPPA.
Źródło:
Acta Neuropsychologica; 2019, 17(1); 87-95
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CHARACTERISTICS OF ARABIC HANDWRITING ON GRAPHIC TABLET IN NEURODEGENERATIVE DISEASE: PRELIMINARY RESULTS BETWEEN PATIENTS WITH ALZHEIMER’S DISEASE AND HEALTHY CONTROLS
Autorzy:
Ghita, Aboulem
Ibtissame, Aouraghe
Alae, Ammour
Ghizlane, Khaissidi
Mostafa, Mrabti
Faouzi, Belahsen M
Powiązania:
https://bibliotekanauki.pl/articles/2138163.pdf
Data publikacji:
2022-03-21
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
Handwriting
neurodegenerative disease
Alzheimer's disease
graphics tablet
Opis:
Handwriting is a component of the complex language that came about late in the history of mankind and which develops late in human beings. Numerous works have raised changes in both the graphic and kinematic characteristics of writing. Although, age does not modify the lexical and syntactic parameters of language, it can however modify its spatial structure, especially pressure and speed. Many neurodegenerative pathologies, especially Alzheimer's disease, are characterized by a progressive disorganization of writing. Depending on the cognitive stage of the dementia, the graphic gesture deteriorates as does the spatial construction. Objective: Our study aims at assessing the characteristics of Arabic writing in a healthy Moroccan population and to compare it to people with mild to moderate Alzheimer's disease. Our objective is to help health professionals detect early cognitive deterioration in neurodegenerative diseases by analyzing the graphic gesture. Handwriting is captured on a graphic tablet (WACOM) and is analyzed "online" as a sequence of acquired signals (position, pressure, speed and pen inclination) in Moroccan patients with mild to moderate Alzheimer's disease and these were compared to those of normal volunteers. We performed a first analysis of the results from 18 Alzheimer's patients compared to 18 control subjects. The results reveal differences between the control and Alzheimer's groups. AD subjects had lower speeds and accelerations compared to the control subjects. The time spent on paper and in the air was significantly greater in the AD subjects. This preliminary analysis of the results allowed us to identify distinguishing characteristics through the analysis of different handwriting parameters in order to identify the two groups studied.
Źródło:
Acta Neuropsychologica; 2022, 20(1); 53-65
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimers disease
Autorzy:
Aly, Hanan
Metwally, Fateheya
Ahmed, Hanaa
Powiązania:
https://bibliotekanauki.pl/articles/1039841.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
dehydroepiandrosterone
Alzheimer's disease
apoptosis
oxidative stress
Opis:
The current study was undertaken to elucidate a possible neuroprotective role of dehydroepiandrosterone (DHEA) against the development of Alzheimer's disease in experimental rat model. Alzheimer's disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl3 (4.2 mg/kg body weight) daily for 12 weeks. Half of these animals also received orally DHEA (250 mg/kg body weight, three times weekly) for 18 weeks. Control groups of animals received either DHAE alone, or no DHEA, or were not ovariectomized. After such treatment the animals were analyzed for oxidative stress biomarkers such as hydrogen peroxide, nitric oxide and malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activities, antiapoptotic marker Bcl-2 and brain derived neurotrophic factor. Also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. The results revealed significant increase in oxidative stress parameters associated with significant decrease in the antioxidant enzyme activities in Al-intoxicated ovariectomized rats. Significant depletion in brain Bcl-2 and brain-derived neurotrophic factor levels were also detected. Moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. Significant amelioration in all investigated parameters was detected as a result of treatment of Al-intoxicated ovariectomized rats with DHEA. These results were confirmed by histological examination of brain sections. These results clearly indicate a neuroprotective effect of DHEA against Alzheimer's disease.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 513-520
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola edukacyjna pielęgniarki w opiece nad pacjentem z chorobą Alzheimera i jego rodziną
The educational role of nurses in the care of patients with Alzheimer’s disease and the family
Autorzy:
Antczak, Anna
Ślusarz, Robert
Powiązania:
https://bibliotekanauki.pl/articles/1030068.pdf
Data publikacji:
2016
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
the role of education
nurse
patient
alzheimer's disease
Opis:
Alzheimer's disease is of neurodegrading nature and belongs to progressive diseases. It is classified as the most common cause of dementia disease of old age. The incidence is rapidly increasing in the group of patients over 65 years of age. The characteristic symptoms include cognitive and functional disorders. As the disease progresses, and thus the severity of symptoms increases the scope of activities related to patient care grows. The role of nurses is conditioned by the patient's functional status and demand for professional care. The area of activities reflects deficits in carrying out self-service and the lack of caregivers’ knowledge. The nurse should identify patients’ problems and as well as those of their families, define the goals to be reached, implement appropriate measures and evaluate the actions. Patient’s education is a process of successive, logically and causally related steps that are being taken in order to induce changes in the behavior of the patient. In connection with the progression of the disease and, consequently, total reliance, it requires from nurses appropriate attitude adequate to the work performed and characterised by outstanding high morality. The educational role in the case of patients with AD and their families plays a significant role in the process of treatment. It provides a sense of security and psychological support. The patient at every stage of the disease is guaranteed to have adequate quality of life. Also, it prepares the family to the care of the patient at home and defines various ways to solve problems.
Choroba Alzheimera ma charakter neurodegradacyjny i należy do chorób postępujących. Zaliczana jest jako najczęstsza przyczyna choroby otępiennej wieku podeszłego. Częstość występowania gwałtownie wzrasta w grupie ludzi powyżej 65 roku życia. Charakterystycznymi objawami są zaburzenia funkcji poznawczych oraz funkcjonalnych. Wraz z postępem choroby, a tym samym nasileniem objawów zwiększa się zakres działań opiekuńczo-pielęgnacyjnych wobec pacjenta. Rola pielęgniarki uwarunkowana jest stanem funkcjonalnym pacjenta oraz zapotrzebowaniem na profesjonalną opiekę. Obszar działań odzwierciedla deficyty w wykonywaniu czynności samoobsługowych oraz brak wiedzy opiekunów. Pielęgniarka powinna określić problemy pacjenta i jego rodziny, postawić cele do wykonania, wdrożyć odpowiednie środki realizacji oraz ocenić działania. Edukacja pacjenta to proces kolejno następujących, powiązanych logicznie i przyczynowo czynności, które są podejmowane w celu wywołania zmian w zachowaniu pacjenta. W związku z progresją choroby i w konsekwencji całkowitej niesamodzielności, wymaga od pielęgniarki odpowiedniej postawy adekwatnej do wykonywanej pracy oraz wyróżniającej się dużą moralnością. Rola edukacyjna w przypadku pacjentów z AD oraz ich rodzin odgrywa znaczącą rolę w procesie leczenia. Zapewnia poczucie bezpieczeństwa oraz wsparcia psychicznego. Pacjent na każdym etapie choroby ma zapewnianą odpowiednią jakość życia. Poza tym przygotowuje rodzinę do opieki nad pacjentem w warunkach domowych oraz wskazuję różne drogi rozwiązania problemów.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2016, 1, 1; 91-102
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular cloning and sequencing of rabbit presenilin-1 cDNA fragment.
Autorzy:
Al-Khedhairy, Abdulaziz
Arfin, Misbahul
Bin Dukhyil, Abdul
Powiązania:
https://bibliotekanauki.pl/articles/1043709.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Alzheimer's disease
Oryctolagus cuniculus
presenilin-1 cDNA
rabbit
Opis:
Molecular cloning and sequencing of a cDNA encoding rabbit presenilin-1 (Ps1) fragment was performed by reverse transcription polymerase chain reaction (RT-PCR) using primers: 5'-GGA TGA GCA GCT AAT CTA TAC C-3' and 5'-TCC ATT CAG GGA GGT ACT TGA TA-3'. The cDNA fragment revealed 402 nucleotides. The sequence was well conserved and found to be 91, 90, 88, 87 and 78% homologous to that of human, lemur, rat, mouse and chicken, respectively. The cDNA translated into a 130 amino-acid protein fragment. The deduced amino-acid sequence was also well conserved in various species and exhibited 98% similarities with those of rat, lemur and human homologues. However, differences were noticed at residues 145, 168 and 212. This cDNA fragment is quite significant because it is the most conserved portion of Ps1 in various animals and encodes four transmembrane regions (TM2, 3, 4, 5) as defined in human Ps1. Moreover, it includes more than 50% of the sites at which substitutions have been reported in familial Alzheimer's disease (FAD). Therefore, it is suggested that the rabbit can be used as an experimental model for future studies on Ps1 and its physiological functions to work out possible pathways leading to FAD linked neurodegeneration.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 1013-1017
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New Trends in Non-Pharmacological Treatment of Alzeheimer’s Disease
Autorzy:
Tokovska, Miroslava
Rosenberg, Adriana
Powiązania:
https://bibliotekanauki.pl/articles/1197943.pdf
Data publikacji:
2018-02-01
Wydawca:
Akademia Ignatianum w Krakowie
Tematy:
non-pharmacological treatment
person centred care
Alzheimer's disease
Opis:
RESEARCH OBJECTIVE: The aim of this paper is to summarize the knowledge of non-pharmacological treatment in the care of people with Alzheimer’s disease. The contribution is theoretical and provides a suitable prerequisite for further examination of the subject matter, namely the need for quality education and the need to change the approach of care for people with Alzheimer’s disease. THE RESEARCH PROBLEM AND METHODS: The presented contribution approaches the preferred values of care such as coping, self-decision and identity from the clients perspective, as well as new trends in non-pharmacological treatment of Alzheimer’s. Based on the study of professional domestic and foreign literature of social, psychological and medical orientation, we approach selected non-pharmacological therapies. THE PROCESS OF ARGUMENTATION: After defining the goal of the contribution and the basic concepts of Alzheimer-type dementia, it follows (i) the theory of physical environment adaptation, (ii) Tom Kitwood’s approach to care and (iii) health promoting and preventive approach in the social-healthcare sector. A substantial part of the argumentation is the need to create a new culture of care provision. RESEARCH RESULTS: The result of this argumentation is the need for quality preparation of future generations of healthcare professionals and the need for a change in the philosophy and culture of providing care for people with dementia in the countries of Eastern and Central Europe. CONCLUSIONS, INNOVATIONS AND RECOMMENDATIONS: This analysis confirms the need to change the attitudes and self-reflection of helping professionals in the care of people with Alzheimer’s disease. There is also an urgent need to change the preparation of future generations of assisting professionals and further education in line with the latest research and knowledge on the provision of social and health care.
Źródło:
Horyzonty Wychowania; 2017, 16, 40; 97-111
1643-9171
2391-9485
Pojawia się w:
Horyzonty Wychowania
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Icariin as a new potential drug in Alzheimer disease treatment - a review
Autorzy:
Jasielski, P.P.
Piedel, F.
Petit, V.
Rejdak, K.
Powiązania:
https://bibliotekanauki.pl/articles/2098999.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
Alzheimer disease
Icariin
amyloid precursor protein
neuroprotective effect
Opis:
Introduction. Alzheimer disease (AD) is one of the best-known diseases. It is neurodegenerative disease characterized by gradual memory loss and dysfunction of behaviour. The pathogenesis of this disease is unclear. Icariin (ICA) is a flavonoid found in a Chinese medicinal herb. It is recognised for a wide range of biological and medical activities: anti-tumour and anti-inflammatory, and also has an impact on the nervous system: stimulates neuroproliferation and prevents neuron’s apoptosis. ICA may have a potential role in AD disease treatment. Objective. The purpose of this article is to review current knowledge about mechanisms and use of ICA in AD treatment. State of knowledge. AD does not present established pathomechanism, about which there are some hypotheses. Each hypothesis mentioned and checked in this review, with result that ICA may have a potential role. One well-known hypothesis is that about amylolytic which is associated with amyloid precursor protein (APP) gene mutation, which leads to amyloid beta (Aβ) protein accumulation and to occurenc of the disease. In this hypothesis, ICA may inhibit Aβ protein aggregation or alter APP expression. ICA may stifle neuronal apoptosis and promote neurogenesis and neuromodulation. According to other hypotheses, ICA could also impact on iron overload in the brain, harmful for neurons hyperhomocysteinaemia, disorder of the intracellular calcium management. Modification of theTau protein structure is another one theory of ICA action. Flavonoid from China may also have an influence on axonal transport. Conclusions. According to the literature there is no single mechanism of ICA action in slowing down AD progress. A wide range of therapeutic points is demonstrated by the broad effect of this substance. Further research is mandatory.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2019, 13, 4; 167-169
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Update on the study of Alzheimer’s disease through artificial intelligence techniques
Autorzy:
Garea-Llano, Eduardo
Powiązania:
https://bibliotekanauki.pl/articles/27314235.pdf
Data publikacji:
2023
Wydawca:
Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
Tematy:
Alzheimer's disease
detection
progression
artificial intelligence
deep learning
Opis:
Alzheimer’s disease is the most common form of dementia that can cause a brain neurological disorder with progressive memory loss as a result of brain cell damage. Prevention and treatment of disease is a key challenge in today’s aging society. Accurate diagnosis of Alzheimer’s disease plays an important role in patient management, especially in the early stages of the disease, because awareness of risk allows patients to undergo preventive measures even before irreversible brain damage occurs. Over the years, techniques such as statistical modeling or machine learning algorithms have been used to improve understanding of this condition. The objective of the work is the study of the methods of detection and progression of Alzheimer’s disease through artificial intelligence techniques that have been proposed in the last three years. The methodology used was based on the search, selection, review, and analysis of the state of the art and the most current articles published on the subject. The most representative works were analyzed, which allowed proposing a taxonomic classification of the studied methods and on this basis a possible solution strategy was proposed within the framework of the project developed by the Cuban Center for Neurosciences based on the conditions more convenient in terms of cost and effectiveness and the most current trends based on the use of artificial intelligence techniques.
Źródło:
Journal of Automation Mobile Robotics and Intelligent Systems; 2023, 17, 2; 51--60
1897-8649
2080-2145
Pojawia się w:
Journal of Automation Mobile Robotics and Intelligent Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Matching user needs to technology in dementia care: experiences with the Alma Supervisor Educational Program
Autorzy:
Holthe, Torhild
Wulff-Jacobsen, Ida
Powiązania:
https://bibliotekanauki.pl/articles/551779.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
activities of daily living
Alzheimer disease
self-help devices.
Źródło:
Family Medicine & Primary Care Review; 2016, 4; 492-496
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
„Podstawą obcowania jest pamięć”. Psychologiczny wymiar odczuwania czasu na przykładzie osoby z demencją typu Alzheimera
Autorzy:
Kamińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2046225.pdf
Data publikacji:
2015-03-31
Wydawca:
Wydawnictwo Adam Marszałek
Tematy:
Alzheimer disease
psychological time
temporal horizon
memory
temporal perspective.
Opis:
The article focuses on the analysis of the functioning of the category of the dimension of memory and psychological perception of time by a person suffering from dementia of the Alzheimer type. Our observations were related to the theoretical understanding of psychology researchers memory, psychological perception of time and neuropsychologists. Moving away from a clinical study for the analysis of expression resulting in interaction with investigating, while the participant conversation here is aware of the procedure. This research methodology allows us to grasp the dynamics of changes in the behavior of the test and explore the essence of co-occurring in this type of dementia, cognitive and language. In the first part of the approximate sketch is necessary to understand the practical part, the terminology concerning the psychology of memory, temporal horizon of human rights and basic definitions and assumptions Medical on Alzheimer’s. As part of the empirical analysis of the material shows that due to the disintegration of autobiographical memory adult has difficulty organizing his own experiences and events. As a result, systematically loses the ability to plan for the future, both the distant, perspective, and the next.
Źródło:
Kultura i Edukacja; 2015, 1(107); 210-227
1230-266X
Pojawia się w:
Kultura i Edukacja
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The nurse’s role in caring for Alzheimer’s patients
Rola pielęgniarki w pielęgnowaniu osób cierpiących na chorobę Alzheimera
Autorzy:
Ławnik, A.
Sakowicz, D.
Powiązania:
https://bibliotekanauki.pl/articles/2048841.pdf
Data publikacji:
2021
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
Alzheimer’s disease
nursing
care
Opis:
The number of Alzheimer’s disease (AD) patients is rapidly increasing. To date, there may be half a million Alzheimer’s patients in Poland. World Health Organization forecasts that the total number of patients with dementia will amount to 75.6 million in 2030 and increase to 135.5 million by 2050. Modern care includes health strengthening activities, disease prevention, shaping the ability to live with the disease or disability, and assisting in dignified and peaceful death. This paper aims to present a model method for nursing of an Alzheimer’s patient, taking into account external and internal factors. Problems with everyday activities arise in each stage of the disease. Yet, their largest number is observed in the third and final stage. A nurse providing professional help and support to caregivers of patients with AD formulates nursing and caring instructions accommodated to the disease stage. According to the authors, the adjustment of individual care to the specific stage of the disease improves the patient’s quality of life. The synthesis of nursing activities performed for Alzheimer’s patients should be focused on the cooperation between the nurse and the patient’s caregiver. The patient’s family and caregivers’ education should be emphasized as their awareness and knowledge of the disease will result in better care. Caregivers’ insufficiency of expertise concerning the appropriate care may deepen the patient’s illness and intensify its consequences. Patients with advanced AD need constant, day-and-night care. Creating such conditions is often connected with sacrificing one’s personal life. Therefore, apart from imparting the knowledge concerning the right care, a nurse provides mental support to Alzheimer’s patients’ caregivers.
Źródło:
Health Problems of Civilization; 2021, 15, 1; 23-28
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Review of traditional and natural methods of treating Alzheimer’s disease
Autorzy:
Mieczkowski, Maurycy
Sieja, Krzysztof
Stępień-Słodkowska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/1055246.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
Alzheimer disease
Herbal Medicine
Nutrition
Pharmacological Treatment
Physical Activity
Opis:
The most common form of dementia in the elderly population is Alzheimer’s disease (AD). World Health Organization (WHO) thus defines Alzheimer’s disease: “a set of neurodegenerative brain symptoms, resulting in progressive impairment of memory, thinking, cognition, counting, language, ability to learn and assessing situations, which disturb everyday life”. It usually develops in 65+-yearolds, and the risk of AD in 85+-year-olds is as high as 50%. It has become a considerable threat to the society, given the longer life expectancy and an increase in the retirement-aged population. AD prevention and treatment methods described in this paper are still being developed and perfected. Studies on genesis of the disease aim at comprehensive understanding of its causes. New, alternative treatment methods are still sough. Researchers develop and test biomarkers that could facilitate early diagnosis.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2016, 16, 4; 67-75
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The relationship between adherence to a Mediterranean Diet and cognitive impairment among the elderly in Morocco
Autorzy:
Talhaoui, Abdeljalil
Aboussaleh, Youssef
Bikri, Samir
Rouim, Fatima Zohra
Ahami, Ahmed
Powiązania:
https://bibliotekanauki.pl/articles/28763500.pdf
Data publikacji:
2023-04-28
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
Cognitive impairment
Mediterranean Diet
Alzheimer's disease
dietary behavior
older adult
Opis:
The Mediterranean Diet has long been regarded as one of the promising strategies for the prevention of cognitive impairment and Alzheimer's disease. Aim: This study aimed to determine the association between adherence to a MedDiet and the risk of cognitive impairment (CI) among the elderly in Morocco. Due to their complete data, a sample of 172 (56.4% men) from 237 subjects were included in our study. Cognitive functions were assessed by the MMSE test (Mini-Mental State Examination). Adherence to a MedDiet was assessed using a validated questionnaire based on weekly consumption of the seven main MedDiet foods: non-refined cereals, potatoes, fruits (whole or in juice), vegetables (cooked or as salad), legumes, fish, olive oil, and three foods consumed less frequently in a MedDiet: red meats, poultry, and full-fat dairy products. A binary logistic regression was performed, with cognitive function as the dependent variable MedDiet adherence score as well as the aliment consumption frequency associated with CI in the bivariate analysis as an independent variable. The binary logistic regression adjusted for confounding variables revealed that adherence to a MedDiet is not associated with a lower risk of cognitive impairment (ORa= 0.928; 95% CI; [0.831-1.037]) (ORa: Adjusted Odd Ratio; 95% CI: 95% of Confidence Interval). However, only Olive Oil consumption was a protective factor against CI (ORa= 0.882; 95% CI; [0.815-0.953]).
Źródło:
Acta Neuropsychologica; 2023, 21(2); 125-138
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular mechanisms initiating amyloid β-fibril formation in Alzheimers disease
Autorzy:
Kirkitadze, Marina
Kowalska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1041422.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
protein aggregation
fibrillogenesis
Alzheimer's disease
neurotoxicity
amyloid-β
APP mutations
Opis:
The deposition of aggregated amyloid β-protein (Aβ) in the human brain is a major lesion in Alzheimer' disease (AD). The process of Aβ fibril formation is associated with a cascade of neuropathogenic events that induces brain neurodegeneration leading to the cognitive and behavioral decline characteristic of AD. Although a detailed knowledge of Aβ assembly is crucial for the development of new therapeutic approaches, our understanding of the molecular mechanisms underlying the initiation of Aβ fibril formation remains very incomplete. The genetic defects responsible for familial AD influence fibrillogenesis. In a majority of familial cases determined by amyloid precursor protein (APP) and presenilin (PS) mutations, a significant overproduction of Aβ and an increase in the Aβ42/Aβ40 ratio are observed. Recently, it was shown that the two main alloforms of Aβ have distinct biological activity and behaviour at the earliest stage of assembly. In vitro studies demonstrated that Aβ42 monomers, but not Aβ40, form initial and minimal structures (pentamer/hexamer units called paranuclei) that can oligomerize to larger forms. It is now apparent that Aβ oligomers and protofibrils are more neurotoxic than mature Aβ fibrils or amyloid plaques. The neurotoxicity of the prefibrillar aggregates appears to result from their ability to impair fundamental cellular processes by interacting with the cellular membrane, causing oxidative stress and increasing free Ca^(2+)that eventually lead to apoptotic cell death.
Źródło:
Acta Biochimica Polonica; 2005, 52, 2; 417-423
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 101

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