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    Wyświetlanie 1-4 z 4
    Tytuł:
    Cell adhesion molecules and their possible role in the pathology of the peripheral nerves – a review of the literature
    Autorzy:
    Niezgoda, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/552657.pdf
    Data publikacji:
    2015
    Wydawca:
    Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
    Tematy:
    cell adhesion molecules
    demyelination
    polyneuropathies.
    Źródło:
    Family Medicine & Primary Care Review; 2015, 4; 323-326
    1734-3402
    Pojawia się w:
    Family Medicine & Primary Care Review
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Genetic Variations of the CTNNA1 And The CTNNB1 Genes in Sporadic Colorectal Cancer in Polish Population
    Autorzy:
    Sygut, Andrzej
    Przybyłowska, Karolina
    Ferenc, Tomasz
    Dziki, Łukasz
    Spychalski, Michał
    Mik, Michał
    Dziki, Adam
    Powiązania:
    https://bibliotekanauki.pl/articles/1396892.pdf
    Data publikacji:
    2012-12-01
    Wydawca:
    Index Copernicus International
    Tematy:
    sporadic colorectal cancer
    muations
    catenin gene
    adhesion molecules
    Opis:
    Experimental as well as clinical observations have demonstrated that the E-cadherin/catenin complex is a powerful inhibitor of invasion. Abrogation of this pathway is implicated in the carcinogenesis of several malignancies, especially colorectal cancer. The aim of the study was to determine the CTNNA1 and the CTNNB1 mutations and its relationship to clinical and pathological features of sporadic colorectal cancer (CRC) in Polish patients. Material and methods. Paired tumor and normal tissue samples from 110 sporadic CRC patients undergoing resective surgery were prospectively studied for the alpha catenin (CTNNA1) gene and beta catenin (CTNNB1)gene mutations by PCR/single strand conformation polymorphism (SSCP). Results. The CTNNA1 gene alteration in exon 7 were detected in 4 samples and in exon 3 of CTNNB1 gene were found in 3 samples. There was a trend at the limit of statistical significance associating younger age at diagnosis (<50) with CTNNA1 and the CTNNB1 mutations. The mutation of CTNNB1 seemed to occur more frequently in the proximal colon than distal. The CRC patients with CTNNA1 mutation had a significantly increased lymph node metastasis. On the other hand, there was no correlation between mutations and the other clinical variables (e.g. sex, grade and depth of invasion). Conclusion. Although we found a low frequency of mutations in the CTNNA1 and the CTNNB1 genes, but the analysis the relationship with clinical and pathological features of CRC patients may indicated an association of these mutations with the risk and progression of CRC.
    Źródło:
    Polish Journal of Surgery; 2012, 84, 11; 560-564
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Markers of endothelial dysfunction in young non-overweight women - effect of serum lipids, body measures and nutrition
    Autorzy:
    Witkowska, AM.
    Zujko, ME.
    Powiązania:
    https://bibliotekanauki.pl/articles/1916451.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    endothelial dysfunction
    cellular adhesion molecules
    lipids
    nutrition
    body measures,
    women
    Opis:
    Purpose: Since endothelial dysfunction can develop early in the adulthood, the purpose of the study was to determine how serum lipids, body measures and dietary habits affect serum markers of vascular activation in young women. Materials and methods: Twenty five healthy women, aged 19-22 years, were enrolled in the study. Serum lipids profile (total cholesterol, HDL-cholesterol, triglycerides) was assayed with laboratory test kits. Concentrations of sICAM-1, sVCAM-1 and E-selectin were determined with the ELISA technique. Anthropometric measurements were taken including skinfold thickness and waist circumference. Food consumption data were collected using 3 repeats of 24-hour dietary recalls. Dietary habits of the women were assessed with a 9-point alternate Mediterranean Diet score (a-MED). Results: Sixty eight percent of the subjects had their HDL-cholesterol levels below the desirable concentration, 20% had LDL-cholesterol elevated, and 32% demonstrated increased total triacylglycerols (TAG). The levels of serum TAG >199 mg/dL were associated with a significant rise in the VCAM-1 concentration. Dietary wholegrain products seem to reduce the serum E-selectin. Conclusions: The results suggest that young women of normal body mass, but demonstrating increased levels of serum TAG, may be at risk of developing endothelial dysfunction. An implementation of the wholegrain products consumption into their dietary practices would possibly be of health benefit.
    Źródło:
    Progress in Health Sciences; 2014, 4, 1; 24-30
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of cell adhesion molecule in cancer progression and its application in cancer therapy.
    Autorzy:
    Okegawa, Takatsugu
    Pong, Rey-Chen
    Li, Yingming
    Hsieh, Jer-Tsong
    Powiązania:
    https://bibliotekanauki.pl/articles/1043281.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cancer gene therapy
    gene
    cell adhesion molecules
    tumor progression
    tumor suppressor
    Opis:
    Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins has been identified that mediates the cell-cell and cell-extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 2; 445-457
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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