Temat: adenoviruses - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: A complete analysis of Relative Synonymous Codon Usage in HVRs1-4 region in adenovirus genome
Autorzy:: Niczyporuk, J.S.
Powiązania:: https://bibliotekanauki.pl/articles/2087655.pdf
Data publikacji:: 2018
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: fowl adenoviruses
genome
codon usage
HVRs
Źródło:: Polish Journal of Veterinary Sciences; 2018, 21, 3; 459-468
1505-1773
Pojawia się w:: Polish Journal of Veterinary Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Helper-dependent adenoviral vectors in experimental gene therapy
Autorzy:: Józkowicz, Alicja
Dulak, Józef
Powiązania:: https://bibliotekanauki.pl/articles/1041362.pdf
Data publikacji:: 2005
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: helper-dependent adenoviral vectors
adenoviruses
gene therapy
Opis:: In the majority of potential applications gene therapy will require an effective transfer of a transgene in vivo resulting in high-level and long-term transgene expression, all in the absence of significant toxicity or inflammatory responses. The most efficient vehicles for delivery of foreign genes to the target tissues are modified adenoviruses. Adenoviral vectors of the first generation, despite the high infection efficacy, have an essential drawback: they induce strong immune response, which leads to short term expression of the transgene, and limits their usefulness in clinical trials. In contrast, helper-dependent adenoviral vectors (HdAd) lacking all viral coding sequences display only minimal immunogenicity and negligible side-effects, allowing for long-term transgene expression. Thus, HdAd vehicles have become the carrier of choice for adenoviral vector-mediated experimental gene therapy, effectively used in animal models for delivery of transgenes into the liver, skeletal muscle, myocardium or brain. Strong and long-lasting expression of therapeutic genes has allowed for successful treatment of dyslipidemias, muscular dystrophy, obesity, hemophilia, and diabetes. Additionally, the large cloning capacity of HdAd, up to 37 kb, facilitates the use of physiologically regulated, endogenous promoters, instead of artificial viral promoter sequences. This enables also generation of the single vectors expressing multiple genes, which can be potentially useful for treatment of polygenic diseases. In this review we characterize the basic features of HdAd vectors and describe some of their experimental and potential clinical applications.
Źródło:: Acta Biochimica Polonica; 2005, 52, 3; 589-599
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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