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    Wyświetlanie 1-6 z 6
    Tytuł:
    N4-Amino-acid derivatives of 6-azacytidine: Structure-activity relationship.
    Autorzy:
    Alexeeva, I
    Palchikovskaya, L
    Shalamay, A
    Nosach, L
    Zhovnovataya, V
    Povnitsa, O
    Dyachenko, N
    Powiązania:
    https://bibliotekanauki.pl/articles/1044398.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    6-azacytidine
    6-azacytidine N4-derivatives
    adenovirus
    antiviral activity
    Opis:
    Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 1; 95-101
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Virus-like particles as vaccine
    Autorzy:
    Chroboczek, Jadwiga
    Szurgot, Inga
    Szolajska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1039260.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    virus-like particle
    VLP vaccine
    adenovirus dodecahedron
    antigen-presenting cells
    cell-mediated immunity
    Opis:
    This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they contain functional viral proteins responsible for cell penetration by the virus, ensuring efficient cell entry and thus tissue-specific targeting, determined by the origin of the virus. The foremost application of VLPs is in vaccinology, where they provide delivery systems that combine good safety profiles with strong immunogenicity and constitute a safe alternative to inactivated infectious viruses. These stable and versatile nanoparticles display excellent adjuvant properties capable of inducing innate and cognate immune responses. They present both, high-density B-cell epitopes, for antibody production and intracellular T- cell epitopes, thus inducing, respectively, potent humoral and cellular immune responses. Uptake of VLPs by antigen-presenting cells leads to efficient immune responses resulting in control of pathogenic microorganisms.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 531-539
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular analysis of a fragment of gene E1B 19K of canine adenovirus 2 (CAV-2) isolated from dogs with symptoms of cough
    Autorzy:
    Kalinowski, M.
    Adaszek, L.
    Miloszowska, P.
    Skrzypczak, M.
    Zietek-Barszcz, A.
    Kutrzuba, J.
    Gradzki, Z.
    Winiarczyk, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/31384.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    molecular analysis
    gene
    canine adenovirus 2
    isolation
    dog
    disease symptom
    cough
    upper respiratory tract infection
    Opis:
    The aim of this study was to perform molecular analysis of canine adenovirus 2 (CAV-2) E1B 19K gene fragment isolated from 20 dogs of various breeds (12 males and 8 females aged 1-9 years), with clinical symptoms of upper respiratory tract infections, from the Lubelszczyzna region. Nasal swabs were taken from dogs. DNA of CAV-2 was detected using the PCR method in 16 swabs. All PCR products were sequenced, and the obtained sequences were compared with each other and with the sequence of the E1B 19K gene of the CAV-2 strain from an online database of NCBI GenBank: AC 000003. Based on analysis of the obtained sequences, three polymorphic variants of CAV-2 (No.1-3) with homology of 78 - 100% were distinguished. The nucleotide and amino acid sequences of the most frequently represented polymorphic variant, No. 1, differed from the sequences of polymorphic variant No. 2 with one substitution. The nucleotide and amino acid sequence of the E1B 19K gene of CAV-2 AC 000003 differed from the analogous sequences of representatives of variant No. 1 with 44 nucleotide and 19 amino acid substitutions. The small number of nucleotide differences in the E1B 19K CAV-2 gene among the examined own isolates, compared with AC 000003, suggest that the infections in dogs were caused by a relatively genetically stable virus which occurs in eastern Poland.
    Źródło:
    Polish Journal of Veterinary Sciences; 2012, 15, 3
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibition of proteolytic processing of adenoviral proteins by ε-aminocaproic acid and ambenum in adenovirus-infected cells
    Autorzy:
    Nosach, Lidiya
    Dyachenko, Nataliya
    Zhovnovataya, Valentina
    Lozinskiy, Miron
    Lozitsky, Victor
    Powiązania:
    https://bibliotekanauki.pl/articles/1043708.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    adenoviral proteins
    ε-aminocaproic acid
    adenovirus
    ambenum
    Opis:
    Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs ε-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 1005-1012
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Targeting site-specific chromosome integration.
    Autorzy:
    Nuno-Gonzalez, Patricia
    Chao, Hsu
    Oka, Kazuhiro
    Powiązania:
    https://bibliotekanauki.pl/articles/1041401.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    adeno-associated virus
    phage C31 integrase
    helper-dependent adenovirus
    hybrid vector
    viral vector
    gene therapy
    Opis:
    The concept of gene therapy was introduced with great promise and high expectations. However, what appeared simple in theory has not translated into practice. Despite some success in clinical trials, the research community is still facing an old problem: namely, the need for a vector that can deliver a gene to target cells without adverse events while maintaining a long-term therapeutic effect. Some of these challenges are being addressed by the development of hybrid vectors which meld two different viral systems to incorporate efficient gene delivery and large cloning capacity with site-specific integration. The two known systems that integrate genes into specific sites in mammalian genomes are the adeno-associated virus and phage integrases. Recent experiments with hybrid vectors incorporating both of these systems are encouraging. However, extensive research should be directed towards the safety and efficacy of this approach before it will be available for gene therapy.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 285-291
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibition and regression of atherosclerotic lesions.
    Autorzy:
    Oka, Kazuhiro
    Chan, Lawrence
    Powiązania:
    https://bibliotekanauki.pl/articles/1041405.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    inflammation
    atherosclerosis
    helper-dependent adenovirus
    lesion regression
    inhibition of lesion progression
    gene therapy
    Opis:
    Atherosclerosis, once believed to be a result of a slow, irreversible process resulting from lipid accumulation in arterial walls, is now recognized as a dynamic process with reversibility. Liver-directed gene therapy for dyslipidemia aims to treat patients who are not responsive to currently available primary and secondary prevention. Moreover, gene therapy strategies have also proved valuable in studying the dynamics of atherosclerotic lesion formation, progression, and remodeling in experimental animals. Recent results on the long-term effect of gene therapy suggest that hepatic expression of therapeutic genes suppresses inflammation and has profound effects on the nature of the atherogenic process.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 311-319
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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