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    Wyświetlanie 1-12 z 12
    Tytuł:
    The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia.
    Autorzy:
    Styczyński, Jan
    Wysocki, Mariusz
    Dębski, Robert
    Kurylak, Andrzej
    Balwierz, Walentyna
    Rokicka-Milewska, Roma
    Matysiak, Michał
    Balcerska, Anna
    Kowalczyk, Jerzy
    Wachowiak, Jacek
    Sońta-Jakimczyk, Danuta
    Chybicka, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1043814.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    P-glycoprotein
    acute myeloblastic leukemia
    anthracyclines
    acute lymphoblastic leukemia
    drug resistance
    Opis:
    Uptake and efflux of two anthracyclines, idarubicin (IDA) and daunorubicin (DNR), was studied in childhood acute leukemia samples. A comparison of IDA and DNR transport phenomena in relation to drug cytotoxicity and expression of P-glycoprotein (PGP) was made. Intracellular content of IDA/DNR was determined by flow cytometry using the fluorescent properties of the drugs. In vitro drug cytotoxicity was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. PGP expression was analysed by flow cytometry. The uptake and efflux rates were non-significantly higher for IDA than DNR. There were no differences between three types of leukemia with respect to drug content during accumulation and retention. After correction for the cell volume, intracellular concentration of both drugs in each moment of uptake and efflux was significantly lower in relapsed ALL and AML samples in comparison with initial ALL cells. Efflux, but not uptake, of both drugs was inversely correlated with PGP expression and IDA, but not DNR, cytotoxicity. The cytotoxicity was correlated with drug accumulation for both drugs and with drug retention for IDA. In conclusion, it seems that (1) intracellular content was related to the lipophilic properties of the drugs rather than to the type of leukemia, (2) decreased intracellular concentration of both drugs might have an impact on compromised therapy results in AML and relapsed ALL children, (3) IDA presents higher cytotoxicity, which possibly might be decreased by the presence of PGP. These results might have a practical impact on the rational design of new chemotherapy protocols.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 99-107
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nursing care of a child with acute lymphoblastic leukemia
    Autorzy:
    Ślifirczyk, A.
    Piszcz, P.
    Ślifirczyk, M.
    Michalczuk, T.
    Urbańczuk, M.
    Celiński, M.
    Bytys, M.
    Domańska, D.
    Nikoniuk, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1918640.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Medyczny w Białymstoku
    Tematy:
    Acute lymphoblastic leukemia
    cancer
    care
    Opis:
    Every year a very large number of children in the world suffer from acute lymphoblastic leukemia, and for years there has been a steady increase in the number of new cases. Acute lymphoblastic leukemia accounts for 75% of leukemia cases in the world. Lymphoblastic leukemia is a cancer disease that originates in B or T cell lymphocytes, which expansion takes place in blood and in the bone marrow. The etiology of the disease is not fully understood because it consists of several factors conditioning its formation. The most important element is the early detection and taking actions resulting in effective disease control through treatment and care of the patient. The nursing process should allow the patient to be involved in and accept the ongoing cancer process, and medical personnel, family and specialists in such fields as psychology and psychiatry should participate.
    Źródło:
    Progress in Health Sciences; 2018, 8(2); 168-173
    2083-1617
    Pojawia się w:
    Progress in Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report.
    Autorzy:
    Styczyński, Jan
    Wysocki, Mariusz
    Dębski, Robert
    Balwierz, Walentyna
    Rokicka-Milewska, Roma
    Matysiak, Michał
    Balcerska, Anna
    Kowalczyk, Jerzy
    Wachowiak, Jacek
    Sońta-Jakimczyk, Danuta
    Chybicka, Alicja
    Powiązania:
    https://bibliotekanauki.pl/articles/1043813.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cross-resistance
    ALL
    sensitivity
    acute leukemia
    MTT assay
    AML
    glucocorticoid resistance
    Opis:
    In vitro antileukemic activity of five glucocorticoids and their cross-resistance pattern in childhood acute lymphoblastic and non-lymphoblastic leukemia were determined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 μM hydrocortisone (HC), 8 μM prednisolone (PRE), 1.5 μM methylprednisolone (MPR), 0.44 μM dexamethasone (DX) and 0.22 μM betamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX (> 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). The AML cell samples were even more resistant to: PRE (>85-fold, p=0.001), DX (> 34-fold, p = 0.004), MPR (> 69-fold, p = 0.036), BET (> 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A significant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 1; 93-98
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Reversal of drug resistance by silencing Survivin gene expression in acute myeloid leukemia cells
    Autorzy:
    Wu, Yao-Hui
    You, Yong
    Chen, Zhi-Chao
    Zou, Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1040668.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    chemotherapeutic resistance
    Survivin
    acute myeloid leukemia
    shRNA
    apoptosis
    Opis:
    The role of Survivin in the pathogenesis of leukemia was explored in order to discover the effective avenues for gene therapy. Most primary leukemia cells isolated from patients as well as three leukemia cell lines (HL-60, K562, and U937) all expressed Survivin gene. To investigate the relationship between Survivin and chemotherapeutic resistance, HL-60 cells were treated with daunorubicin (DNR), mitoxantrone (MIT) or arsenious oxide (As2O3), and it was found that after 24 h the level of Survivin mRNA was decreased by 9.7%, 41.0% and 27.5%, respectively. At 72 h, the level of Survivin mRNA was increased by 21.2% and 65.2% in HL-60 cells treated with DNR or MIT, but decreased by 33.2% in those treated with As2O3 as compared with that in the cells treated for 24 h. These results showed that DNR and MIT could initally decrease the expression of Survivin and then increase it, but As2O3 could decrease the Survivin expression continually. Furthermore, shRNA plasmids targeting the Survivin gene (pEGFP-Survivin), which can silence the expression of Survivin with a high specificity, were constructed. pEGFP-Survivin and pEGFP-H1 were transfected into HL-60 cells via electroporation and selected by G418, and HL-60/Survivin and HL-60/EGFP cells were obtained. After treatment with DNR, the cell survival rate and IC50 of DNR in HL-60/Survivin cells were decreased substantially as compared with those of HL-60/EGFP and HL-60 cells (IC50 of DNR: 18.3 ± 2.45 vs 40.8 ± 6.37 and 39.2 ± 5.91 ng/ml, respectively), and the apoptosis rate was elevated ((84.3 ± 19.7)% vs (45.8 ± 13.8)% and (50.9 ± 12.4)%, respectively). These results suggest that shRNA can down-regulate the expression of Survivin in HL-60 cells substantially and improve their sensitivity to DNR. They also further explain the pathogenesis of leukemia drug resistance and provide new theory in the design of clinical therapies.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 4; 673-680
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    High incidence of acute leukemia in the proximity of some industrial facilities in El Bierzo, northwestern Spain
    Autorzy:
    Rodríguez-García, José A.
    Ramos, Fernando
    Powiązania:
    https://bibliotekanauki.pl/articles/2180111.pdf
    Data publikacji:
    2012-03-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    acute leukemia
    Benzo(a)pyrene
    industrial facilities
    electromagnetic radiation
    power lines
    thermoelectric power plant
    Opis:
    Objectives: To estimate the incidence of acute leukemia (AL) in El Bierzo (BZ) and to carry out a cross-association analysis in order to suggest some etiological clues. Materials and Methods: We registered all new AL cases diagnosed 2000–2005. Annual standardized incidence rate (SIR) was calculated by the direct method. A cross-association analysis was performed by non-parametric methods and we checked the potential interaction between putative etiological factors by calculating Chi-square-for-trend. Results: SIR was 5.1 cases per 100 000, surpassing the Spanish, European and world average figures and heterogeneous throughout the region. We detected a negative correlation between acute myeloblastic leukemia (AML) SIR in every municipality and both the air distance to the nearest thermoelectric power plant (TPP) (Rho = –0.409; p = 0.01) and to the point of maximum density of the high-power lines (HPL) network (Rho = –0.329; p = 0.04). Accordingly, SIR was higher in the municipalities situated < 7.5 km away from TPP (9.58 vs. 1.72; p = 0.004) or < 10 km away from HPL (3.90 vs. 3.19; p = 0.045). A positive relation between both factors was observed (Chi-square-for-trend = 9.209; p = 0.006). Conclusions: SIR of AL in BZ is higher than the Spanish average and that of most countries in the world. Residing near TPP or HPL confers a higher risk of AML, with synergistic effect between both factors.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2012, 25, 1; 22-30
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mucormycosis in a patient with acute myeloblastic leukemia following liver transplantation for Wilson’s disease
    Autorzy:
    Łanocha, A.A.
    Guzicka-Kazimierczak, R.
    Zdziarska, B.
    Wawrzynowicz-Syczewska, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085182.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Mucormycosis
    acute myeloblastic leukemia
    Willson’s disease
    liver transplantation
    Opis:
    A case is presented of mucormycosis in a patient with acute myeloblastic leukemia following liver transplantation for Wilson’s disease. A 58-year-old female was admitted to the Department of Haematology with deterioration of her general condition, loss of appetite, tiredness and difficulty with mental contact for a few days. Blood and urine cultures for bacteria and fungus, galactomannan antigen were negative. Whole body computed tomography demonstrated bilateral hilar lymphadenopathy with necrotic lesions: splenomegaly with a hypodensive lesion 13 × 20 × 19 mm and lower pulmonary infiltrates suggested fungal etiology. Magnetic resonance imaging of the brain showed thickened meninges. Finally, mucormycosis was diagnosed. Treatment with amphotericin B lipid complex was started, resulting in an partial improvement of the general condition and decreased level of inflammatory markers. However, the patient’s condition continued to deteriorate, with sepsis etiology Escherichia coli, and despite the intensive managements she eventually died.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 4; 665-668
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    L-asparaginase: An ultimate anti-neoplastic enzyme
    Autorzy:
    Prasad Talluri, V.S.S.L.
    Bhavana, M.
    Mahesh Kumar, M.V.S.
    Rajagopal, S.V.
    Powiązania:
    https://bibliotekanauki.pl/articles/11250.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    L-asparaginase
    anti-neoplastic enzyme
    enzyme
    acute lymphoblastic leukemia
    chemotherapeutic drug
    Opis:
    The objective of the study described the importance of L-asparaginase and its importance in the field of medicine. Different types of enzymes are produced based on the adaptation to the environment where the living organisms live to tune the metabolic pathways according to their adapted changes. The enzymes present in various organs are produced by many cell types in multicellular organisms. Except ribosomes all other known enzymes are proteinaceous in nature. L-asparaginase is a potential therapeutic agent for acute lymphoblastic leukemia (ALL) and chronic myelogenous leukemia which is approved by FDA & WHO. L-asparaginase catalyzes the deamination of L-asparagine to L-aspartic acid & ammonia. Unlike normal cells, malignant cells require large amount of L-asparagine for protein synthesis and cell division. From this background the present review is an effort to gather the information on the mechanism, sources, molecular details and application of L-asparaginase enzyme.
    Źródło:
    International Letters of Natural Sciences; 2014, 10
    2300-9675
    Pojawia się w:
    International Letters of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells
    Autorzy:
    Łuczyński, Włodzimierz
    Stasiak-Barmuta, Anna
    Iłendo, Elżbieta
    Krawczuk-Rybak, Maryna
    Malinowska, Iwona
    Mitura-Lesiuk, Małgorzata
    Parfieńczyk, Adam
    Szymański, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1041252.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunotherapy
    T-lymphocytes
    CD40L
    acute lymphoblastic leukemia
    dendritic cells
    Opis:
    Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory molecules and are poor antigen presenting cells (APCs) for T-cell activation. CD40/40L interaction stimulates B-cells to proliferate, differentiate, upregulate costimulatory molecules and increase antigen presentation. The aim of the study was to test the hypothesis that ALL cells can be turned into professional APCs by CD40L activation. Children with B-cell precursor ALL were enrolled into the study. Mononuclear cells from bone marrow or peripheral blood were stimulated with CD40L and interleukin 4. Results: 1) after culture we noted upregulation of all assessed costimulatory, adhesion and activatory molecules i.e. CD1a, CD11c, CD40, CD54, CD80, CD83, CD86, CD123, HLA class I and II; 2) CD40L activated ALL cells induced proliferation of allogeneic T-cells (measured by [3H]thymidine incorporation). These results confirm the possibility of enhancing the immunogenicity of ALL cells with the CD40L system and indicate that this approach can be used in immunotherapeutic trials.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 2; 377-382
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Natural products as potential inhibitors of FLT3 for acute myeloid leukemia: HTVS, docking, and molecular dynamic simulation
    Autorzy:
    Salah, Salsabeel
    Sami, Najat
    Ali, Sarah
    Khalid, Teemah-Alrahman
    Alnajjar, Radwan
    Powiązania:
    https://bibliotekanauki.pl/articles/35500319.pdf
    Data publikacji:
    2023
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    acute myeloid leukemia
    drug design
    anticancer
    CADD
    FLT3
    ostra białaczka szpikowa
    projektowanie leków
    terapia antynowotworowa
    Opis:
    Cancer is one the most common health issues worldwide, with cancer-related mortality of 9.5 million in 2018, with an expectation to become 29.5 by 2040. Among others, acute myeloid leukemia (AML) is common among older people. FLT3 mutations are one of the most common genetic aberrations found in Acute Myeloid Leukemia and are associated with poor prognosis. Herein, we attempt to identify natural compounds as potential candidates to treat AML by targeting the FLT3 kinase domain using in silico approaches. The COCONUT database, which contains 407,270 natural compounds, was HTVS against the FLT3 kinase domain active site, and promising compounds were subject to molecular docking. Finally, frontier compounds were validated further using molecular dynamic simulation. In total, ten compounds were identified with docking scores higher than Quizartinib (-11.606 kcal/mol), with the best three compounds showing a docking score of -18.052, -15.772, and -16.767 kcal, respectively, and compound 2 showing excellent stability in molecular dynamic simulation.
    Źródło:
    Scientiae Radices; 2023, 2, 4; 325-346
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanism, detection and significance of some chromosomal rearrangements in chronic myeloid leukaemia [CML] and acute lymphoblastic leukaemia [ALL]
    Autorzy:
    Ladon, D
    Witt, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2043432.pdf
    Data publikacji:
    2000
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    translocation
    minimal residual disease
    in situ
    hybridization
    fluorescence
    chronic myeloid leukemia
    chromosome aberration
    mixed chimerism
    detection
    cytogenetic evolution
    acute lymphoblastic leukemia
    Źródło:
    Journal of Applied Genetics; 2000, 41, 3; 187-197
    1234-1983
    Pojawia się w:
    Journal of Applied Genetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparison of the WHO classification (5th edition) 2022 and the International Consensus Classification (ICC) 2022 for diagnosis of acute myeloid leukemia
    Autorzy:
    Al-Nakkash, Naba
    Frenzel, Lukas P.
    Powiązania:
    https://bibliotekanauki.pl/articles/35505928.pdf
    Data publikacji:
    2024
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    AML
    WHO
    ICC
    acute myeloid leukemia
    World Health Organisation
    International Consensus Classification
    ostra białaczka szpikowa
    Światowa Organizacja Zdrowia
    Opis:
    In 2022, two classifications were published to define the diagnosis of patients with acute myeloid leukemia (AML). The World Health Organisation (WHO) 5th edition and the International Consensus Classification (ICC) provide an updated summary of current knowledge of the diseases and construct a framework for physicians. Two differing classifications result in discrepancies, which change the definition of AML subtypes and present a challenge in clinical settings. This work summarizes the updated classification systems and discusses their significance in clinical settings while considering the latest findings. Relevant changes affect the i) required blast percentage, ii) AML harbouring CEBPA mutations, iii) AML with KMT2A and MECOM rearrangements, iv) AML with myelodysplasia-related characteristics and in association with this entity AML with mutated RUNX1, and lastly v) AML with TP53 mutation. In summary, a unified classification system would be desirable to achieve harmonized diagnosis and treatment of AML).
    Źródło:
    Scientiae Radices; 2024, 3, 1; 14-29
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Monitoring of cellular chimerism in patients after sex-mismatched bone marrow transplantation: technical report
    Autorzy:
    Jolkowska, J
    Ladon, D.
    Wachowiak, J.
    Witt, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2043435.pdf
    Data publikacji:
    2000
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    in situ
    allogeneic transplantation
    chimerism
    molecular analysis
    transplantation
    minimal residual disease
    acute myeloblastic leukemia
    polymorphic microsatellite
    bone marrow
    hybridization
    polymerase chain reaction
    DNA
    detection
    Źródło:
    Journal of Applied Genetics; 2000, 41, 3; 209-212
    1234-1983
    Pojawia się w:
    Journal of Applied Genetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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