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Wyświetlanie 1-15 z 37
Tytuł:
Virus-like particles as drug delivery vectors
Autorzy:
Zdanowicz, Michał
Chroboczek, Jadwiga
Powiązania:
https://bibliotekanauki.pl/articles/1038765.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
VLPs
vaccines
virus
Opis:
Virus-like particles (VLPs) assemble spontaneously during the viral cycle or in heterologous systems during expression of viral structural protein. Depending on the complexity of the VLPs, they can be obtained by expression in prokaryotic or eukaryotic expression system from the suitable recombinant vectors, or formed in cell-free conditions. Moreover, they can be built from proteins of a single virus, or can present the proteins or peptides derived from a virus or cell on a platform derived from any other single virus, thus forming chimeric VLPs. VLPs are best known for their immunogenic properties, but the versatility of VLPs allows a wide variety of applications. They are lately in the centre of investigations in vaccinology, drug delivery and gene therapy. This review focuses on utilization of VLPs for drug delivery.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 469-473
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Attitude and acceptance of Covid-19 vaccine amongst medical and dental fraternity - a questionnaire survey
Autorzy:
Kaur, A.
Kaur, G.
Kashyap, A.
Singh, G.
Singh Sandhu, H.
Khilji, I.
Singh Gambhir, R.
Powiązania:
https://bibliotekanauki.pl/articles/2086225.pdf
Data publikacji:
2021
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
COVID-19
safety
emergencies
health
vaccines
Opis:
Background. The second wave of Novel Coronavirus disease (COVID-19, SARS-CoV-2) is proving more disastrous than the first because of the new mutant stains. Under these circumstances, vaccination is the only effective solution that can save millions of lives across the globe. Objectives. The present study was conducted to assess the attitude and acceptance/willingness of health care professionals (medical and dental) towards COVID-19 vaccine. Materials and Methods. An online questionnaire survey was conducted among medical and dental professionals working in different hospitals of two states of India. A total of 520 subjects constituted the final sample size. A self-constructed questionnaire (divided into 2 parts) containing 12 questions was administered to obtain information from the subjects regarding their attitude and willingness towards COVID 19 vaccine. Statistical analysis was done using chi-square test and multiple liner regression analysis. Odds ratio with 95% CI were also generated. Statistical significance was set at p≤0.05. Results. Majority of the subjects (67% of dental and 73% of medical) had full confidence on the effectiveness of COVID-19 vaccine. Willingness to get vaccinated was shown by 63% of subjects and 65% had positive attitude towards vaccine. Some subjects (45.5% dental and 48.4% medical) showed concern regarding unforeseen effects of the vaccine. Willingness to get vaccinated was 3.45 higher in subjects who were involved in COVID duties. Subjects giving less preference to natural immunity over vaccine showed more willingness (OR: 2.98) towards getting the vaccine. Conclusion. The findings of the study showed that acceptance and attitude of subjects regarding COVID 19 vaccine was suboptimal as there were various factors which contributed towards subjects’ hesitancy to get vaccinated. There is an utmost need to address various issues regarding vaccine safety to promote high uptake.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2021, 72, 2; 185-191
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Access to vaccination in the Greater Poland (Poland)
Autorzy:
Zaprutko, Tomasz
Kopciuch, Dorota
Paczkowska, Anna
Sawicka, Dominika
Stachowiak, Zuzanna
Bogdaniec, Patrycja
Kus, Krzysztof
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895651.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
poland
vaccines
access
pharmaceutical market
pharmacies
Opis:
Immunization is a very effective health intervention. Moreover, the global vaccines market has been growing rapidly and costs of full children immunization are dramatically higher nowadays than 30 years ago. High vaccine prices may limit affordability of vaccination which is why we attempted an evaluation of availability and affordability of 7 and non-reimbursed vaccines mostly used in children in Poland. The study was conducted between October 2016 and October 2017 using a specially designed anonymous questionnaire comprising three closed-ended questions. The study tool was distributed by direct contact or via the Internet. Eventually, answers from 505 pharmacies from the Greater Poland region and 10 primary care clinics were included. 5 out of 7 vaccines were available in all types of facilities. There were some issues, however, with availability of Bexsero® and Nimenrix®. Considering prices, the highest difference (of more than 100%) was found for Infanrix hexa® and the lowest (38.5%), for Infanrix IPV+HIB®. In 88.17% of pharmacies included, patients were informed about a thermo-insulating package. 48.39% of respondents indicated that such package is free of charge, while in other pharmacies an average price for the package was EUR 0.48. Although availability and affordability of medicines are crucial objectives of the public health policy, it seems that access to vaccines in Poland might be an area for improvement. Thus, prices of non-reimbursed vaccines could be regulated in Poland nationwide. Moreover, to provide trustworthy information concerning vaccination, healthcare decision makers should consider social education about immunization as an important issue.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 195-201
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza vaccination among healthcare workers – realization, promotion
Autorzy:
Tomaszewski, Mateusz
Łuniewski, Michał
Kulczyński, Marcin
Olender, Alina
Powiązania:
https://bibliotekanauki.pl/articles/1179527.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Vaccines
healthcare workers
infectious disease prevention
influenza
Opis:
Influenza vaccination is the most important component of prevention of occurring and spreading of this disease. 80% vaccination coverage of healthcare personnel provides a substantial reduction of transmission; each and every next vaccinated person results in a decrease of morbidity, especially amongst elder or immunocompromised patients. In the analyzed studies most common reasons of insufficient vaccination coverage among healthcare workers were fear of side effects, lack of knowledge, conviction of vaccine inefficiency, lack of feeling of social responsibility, and inadequate accessibility of vaccine. Healthcare workers who were vaccinated regularly did it mostly in order to provide safety to themselves, their relatives and patients; they did it also due to the knowledge of vaccination efficiency. The most effective actions to improve vaccination coverage were: vaccination requirement by the employer, active encouragement, effective promotion, better vaccine accessibility and promotion of vaccination as prosocial behavior. Offering surgical masks as an alternative did not improve vaccination rate in most analyzed studies. In conclusion, most important reasons of declining influenza vaccination by healthcare workers are lack of knowledge and low accessibility of vaccination, so evidently education, promotion and facilitating the vaccination in workplace are the most effective ways causing the growth of vaccination rate.
Źródło:
World Scientific News; 2017, 76; 50-59
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Never–Ending Story of the Use of Vaccines Derived from Aborted Infants. Part I: Critique of Teleological Proportionalism and Consequentialism from the Perspective of Moral Theology
Autorzy:
Balák, René
Powiązania:
https://bibliotekanauki.pl/articles/2037716.pdf
Data publikacji:
2017
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
papal teaching
vaccines
proportionalism
consequentialism
teleological methodology
Opis:
The standard obligatory use of unethical vaccines derived from aborted human foetuses is currently a significant moral theological problem. It forms a serious dilemma of conscience especially when people become aware of the connection between their own actions and the morally wrong act committed by another person. However, a few years after the release of the declaration of Pontifical Academy for Life Moral Reflections on Vaccines Prepared from Cells Derived from Aborted Human Foetuses (5th May 2005), this serious problem was pushed into oblivion. Moral assessment is still dominated by consequentionalism and proportionalism which reject papal Magisterium ordinarium. DOI: http://dx.doi.org/10.18290/rt.2017.64.3-7
Źródło:
Roczniki Teologiczne; 2017, 64, 3 English Online Version; 75-92
2353-7272
Pojawia się w:
Roczniki Teologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dlaczego katolik nie ma obowiązku zaszczepić się przeciw COVID-19? Perspektywa etyczna
Why does a Catholic have no obligation to get vaccinated against COVID-19? Ethical Perspective
Autorzy:
Ferdynus, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/30146453.pdf
Data publikacji:
2022-06-30
Wydawca:
Wydawnictwo Diecezjalne Adalbertinum
Tematy:
vaccines
COVID-19
precautionary principle
medical experiment
Opis:
The author of the article claims that a Catholic has no moral obligation to get vaccinated against COVID-19. Firstly, a Catholic can acknowledge the experimental nature of vaccines. Secondly, a Catholic can appeal to the precautionary principle and to the risk assessment principle concerning possibility of losing health or life as a result of serious adverse vaccine reactions. Thirdly, a Catholic can acknowledge the vaccines as extraordinary medical means. Finally, a Catholic has the right to be guided by the official position of the Catholic Church on voluntarity of vaccinations.
Źródło:
Studia Ełckie; 2022, 24, 2; 229-247
1896-6896
2353-1274
Pojawia się w:
Studia Ełckie
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A review of approved COVID-19 vaccines
Autorzy:
Jamkhande, A.
Khairnar, M.R.
Gavali, N.
Patil, Y.
Kapare, S.S.
Bhosale, K.P.
Powiązania:
https://bibliotekanauki.pl/articles/2085930.pdf
Data publikacji:
2021
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
Covid-19 vaccines
immunization
SARS-CoV-2 pandemic
Opis:
In the past one and half year elapsed since the identification of the SARS-CoV-2 virus and its genome, an extraordinary effort by the scientific community has led to the development of many vaccine projects. More than ten vaccine candidates throughout the world have been granted approval for emergency use. Existing data suggest that these vaccines have the potential to protect individuals and curb the spread of COVID-19 pandemic. However, long term side-effects and certain unresolved issues associated with vaccine use need to be assessed as the time passes. This study reviews the most recent data of 12 vaccines which have been approved for use and presents information on their doses, composition, mechanism of action, side effects, etc.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2021, 72, 3; 245-252
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression and immunogenicity study of a novel mhp183 gene fragment of Mycoplasma hyopneumoniae
Autorzy:
Xu, M.
Zheng, J.
Hu, S.
Wang, G.
Powiązania:
https://bibliotekanauki.pl/articles/2087132.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Mycoplasma hyopneumoniae
Mhp183 gene
new generation vaccines
Źródło:
Polish Journal of Veterinary Sciences; 2021, 24, 4; 553-561
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cancer immunotherapy using cells modified with cytokine genes.
Autorzy:
Kowalczyk, Dariusz
Wysocki, Piotr
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043434.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cancer
cancer vaccines
cytokines
dendritic cells
gene therapy
Opis:
The ability of various cytokines to hamper tumor growth or to induce anti-tumor immune response has resulted in their study as antitumor agents in gene therapy approaches. In this review we will concentrate on the costimulation of antitumor immune responses using modification of various cell types by cytokine genes. Several strategies have emerged such as (i) modification of tumor cells with cytokine genes ex vivo (whole tumor cell vaccines), (ii) ex vivo modification of other cell types for cytokine gene delivery, (iii) delivery of cytokine genes into tumor microenvironment in vivo, (iv) modification of dendritic cells with cytokine genes ex vivo. Originally single cytokine genes were used. Subsequently, multiple cytokine genes were applied simultaneously, or in combination with other factors such as chemokines, membrane bound co-stimulatory molecules, or tumor associated antigens. In this review we discuss these strategies and their use in cancer treatment as well as the promises and limitations of cytokine based cancer gene therapy. Clinical trials, including our own experience, employing the above strategies are discussed.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 613-624
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Knowledge and compliance with recommendations for seasonal influenza vaccination among medical and dental students
Autorzy:
Kawalec, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1178226.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
dental students
influenza vaccines
medical staff
medical students
Opis:
Vaccination against seasonal influenza is recommended for everyone older than 6 months. It is underlined, that healthcare workers and students may contribute to nosocomial influenza transmission, however, flu vaccination rate among medical stuff remains low. The aim of this study was the assessment of knowledge of flu vaccination recommendations and compliance with them among medical and dental students in conjunction with analysis of potential differences according to the type of faculty. The study was conducted from 10th to 16th October 2017 with the use of anonymous survey among 203 healthcare students of Wroclaw Medical University (131 medical students, 72 dentistry students). The questionnaire was divided into 3 sections: demographic data, vaccination status, knowledge of recommendations. Obtained data showed that declared vaccination rate in season 2016/2017 was 15.82%, and 13.92% in 2015/2016. Although we observed that influenza vaccination coverage was higher among dental students, the difference was statistically insignificant. Knowledge of recommendations was good, 78% of students knew, that influenza vaccination is recommended for healthcare workers, and 73% answered, that it also concerns healthcare students. Significant differences in identification of groups, for which flu vaccination is especially recommended, were observed. Dental students more frequently chose all correct answers (p-value 0,006). Also sources of knowledge differed (p-value 0,007), medical students more often declared using professional medical journals, while dental students more frequently indicated impact of family. Although the knowledge of recommendations for influenza vaccination is rather good among students, vaccination coverage remains low. Identification of gaps in students' knowledge and differences according to faculty, may suggest directions in which activities promoting regular vaccination against influenza should concentrate.
Źródło:
World Scientific News; 2018, 93; 50-59
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A new strategy: high level expression and immunogenicity analysis of triplicate repeated multigenes in Mycoplasma hyopneumoniae
Autorzy:
Li, J.
Wang, G.
Powiązania:
https://bibliotekanauki.pl/articles/16647587.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
multi-epitope fusion protein
Mycoplasma hyopneumoniae
new generation vaccines
Opis:
Highly immunogenic nucleotide fragments from 3 genes of Mycoplasma hyopneumoniae strain 232 were selected using information software technology. After repeating each fragment three times, a total of 9 nucleotide fragments were joined together to form a new nucleotide sequence called Mhp2321092bp. Mhp2321092bp was directly synthesized and cloned into a pET100 vector and expressed in Escherichia coli. After purification, the proteins were successfully validated by SDS-PAGE and Western blotting using mouse His-tag antibody and pig anti-Mhp serum. BALB/c mice were intraperitoneally injected with purified proteins in the high-dose (100 µg), medium-dose group (50 µg) and low-dose (10 µg) groups. Mice in each group were injected on day 1, day 8 and day 15 of feeding, respectively. Serum samples were collected from all mice on the day before immunization and on day 22 after immunization. The antibody level in the mouse serum was detected using western blotting using purified expressed proteins as antigens. IL-2, TNF-α and IFN-γ were simultaneously detected in the mouse serum by ELISA. The results showed that the 60 kDa protein was successfully expressed and reacted specifically with the specific serum Mhp His-Tag mouse monoclonal antibody and pig anti-Mhp serum. From day 0 to day 22 of immunization, IFN-γ increased from 269.52 to 467.74 pg/mL, IL-2 increased from 14.03 to 145.16 pg/mL, and TNF-α increased from 6.86 to 12.37 pg/mL. The IgG antibody in mice increased significantly from 0 day to day 22 after immunization. This study suggests that the expressed recombinant protein may serve as one of the novel vaccine candidates for Mhp.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 275-283
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histopathological characteristics of myocarditis following COVID-19 vaccination: a scoping review
Autorzy:
Kalali, Datis
Anestakis, Doxakis
Powiązania:
https://bibliotekanauki.pl/articles/24987723.pdf
Data publikacji:
2023-10-09
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
histopathology
myocarditis
myocardial inflammation
COVID-19 vaccine
mRNA vaccines
Opis:
Introduction: Cases of myocarditis in people who were vaccinated against COVID-19 have been reported in the recent years. Nevertheless, the histopathological features and the pathomechanisms in these cases are still unclear. Hence, a scoping review of existing literature was performed to discover the histopathological features of myocarditis induced by the above-mentioned vaccine. Material and Methods: A search was performed in the PubMed, Scopus and EMBASE databases to retrieve the relevant records, involving analyses of biopsy and autopsy specimens. Baseline characteristics of the patients and the histopathological characteristics of the respective specimens were extracted and recorded. Results: Overall, 24 case reports and case series (involving a total of 54 patients) were included in this scoping review. The following signs of inflammation were present in the specimens: lymphocyte infiltration (64.8%), eosinophilic infiltration (29.6%), neutrophil infiltration (3.7%) and giant-cell formation (1.9%). Other features included myocardial tissue necrosis (20.4%), the presence of the SARS-CoV-2 spike protein (16.7%) and microthrombosis (3.7%). Conclusions: The histopathological characteristics of SARS-CoV-2 vaccine-induced myocarditis were heterogenous, the only common characteristic was the presence of lymphocyte infiltration in more than half of the cases. Studies of unreported past cases may provide further insights into the topic.
Źródło:
European Journal of Translational and Clinical Medicine; 2023, 6, 2; 85-90
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The multidimensional nature of attitudes towards preventive vaccinations – a cross-sectional survey among Poles aged 15–39 years
Autorzy:
Raciborski, Filip
Tomaszewska, Aneta
Rakocy, Kamil
Samel-Kowalik, Piotr
Samoliński, Bolesław
Gujski, Mariusz
Pinkas, Jarosław
Jankowski, Mateusz
Powiązania:
https://bibliotekanauki.pl/articles/2203013.pdf
Data publikacji:
2023-05-23
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Polska
vaccination
factor analysis
vaccines
vaccine hesitancy
vaccine trust
Opis:
Objectives Vaccination skepticism and vaccination refusal both constitute global public health concerns. Systematic monitoring of public attitudes towards vaccination is crucial for maintaining a high vaccination coverage rate. The study aimed to identify and characterize homogenous social groups distinguished by attitudes toward preventive vaccinations. Material and Methods Between October and November of 2021, a nationwide representative cross-sectional survey was conducted on a representative sample of 1560 inhabitants of Poland aged 15–39 years. The study questionnaire included 60 questions on public attitudes towards vaccines, vaccination, and the COVID-19 pandemic. Factor analysis was applied to identify the main dimensions of vaccination attitudes. Results Factor analysis included 22 variables and yielded 3 factors or dimensions that accounted for 48.5% of the model’s variability. Young adults were assigned into 6 homogeneous groups based on these factors: 1) general trust in vaccination, 2) vaccine safety concerns, 3) trust in fake medical news regarding COVID-19 vaccination, and denying the COVID-19 pandemic. Groups I–IV differed by sociodemographic factors and vaccination coverage rates. Nearly 60% of the respondents expressed concern regarding various aspects of vaccination. Conclusions Most of Poland’s young adults lack clearly defined attitudes towards vaccination. Attitudes towards vaccination can be divided into 6 heterogeneous groups.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 2; 214-228
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How to speak nowadays of what is very important for the functioning of the society. A review of selected health security reports
Autorzy:
Sobotka, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/2170322.pdf
Data publikacji:
2020
Wydawca:
Fundacja Instytut Nauki o Polityce
Tematy:
health security
pandemic
COVID-19
vaccines
society
health situation reports
Opis:
We live in the times when we have accustomed to the security and stability of the social system. The COVID-19 pandemic reminded us, Poles, that we have to care for our security all the time, and not only military or conomic, but also health security. The first step towards improvement of the current situation is to carry out regular examinations of society’s health security. An example of good practice as regards monitoring the health situation are the reports described in this study, which are published all over the world. They present the aspects that have to be taken into account when creating such tabulations and what instruments should be used. Proper monitoring is a key to adopting adequate remedies in order to improve Poland’s health security.
Źródło:
Polish Journal of Political Science; 2020, 6, 3; 86-124
2391-3991
Pojawia się w:
Polish Journal of Political Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy evaluation of two live virus vaccines against an emerging pseudorabies virus variant
Autorzy:
Wang, M.
Wang, L.
Zhao, Q.
Powiązania:
https://bibliotekanauki.pl/articles/2087402.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pseudorabies virus (PRV)
variant TJ
live virus vaccines
cross-protection
Źródło:
Polish Journal of Veterinary Sciences; 2019, 4; 639-645
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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