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Tytuł:
A case of bovine tuberculosis in pigs in Poland - a country free from the disease
Autorzy:
Lipiec, M.
Radulski, L.
Szulowski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2082990.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
pigs
bovine tuberculosis
eradication
Opis:
Introduction. Bovine tuberculosis is a chronic contagious disease caused by Mycobacterium bovis or Mycobacterium caprae. Before widespread action conducted in Poland between 1959–1975 to combat bovine tuberculosis (BTB), about 40% of all tuberculosis cases in pigs was caused by the bovine bacillus. At the present time, correctly carried out, long-term control of cattle has resulted in cases of bovine tuberculosis in pigs and humans being extremely rare and sporadic. In pigs, tuberculosis is most often caught in a slaughterhouse during slaughter. Materials and method. Samples came from pigs kept on the farm. Traditional bacteriological methods on solid media (Stonebrink, LJ with pyruvate) supported by the semi-automatic, liquid indicative culture method (MGIT) and PCR test were applied in targeted studies. The GenoType Mycobacterium MTBC and CM tests (Hain Lifescience, Germany) were used to additionally confirm that isolated strains classification was used. Results. Strains of mycobacteria were isolated from all examined pigs. Mycobacterium bovis was determined by real time PCR and Hain Genotype methods. Conclusions. In order to effectively fight against BTB, all animals on farms should be tested, regardless of species, while the milk of suspected cows should be utilized without being used for feed. It is important to adapt the current legal regulations to the current epidemiological situation.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 29-32
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comprehensive review of primary gall bladder tuberculosis
Autorzy:
Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj
Powiązania:
https://bibliotekanauki.pl/articles/1392422.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
Gall bladder
Tuberculosis
Antitubercular drugs
Opis:
Tuberculosis (TB) is an infectious disease that can involve any organ system of the body. Abdominal TB can be gastrointestinal, lymph-nodal, visceral or peritoneal. Gall bladder (GB) is rarely involved as a primary organ in abdominal TB. On extensive research, the literature on gall bladder TB is limited to case reports. There has been no review on this rare abdominal pathology. The GB tuberculosis is difficult to diagnose preoperatively. It is a rare differential among the more common gall bladder pathologies like cholelithiasis, or a gall bladder malignancy. Standard histopathology of a resected specimen helps in this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers a chance to cure. Through this review the authors have tried to provide an insight into this entity.
Źródło:
Polish Journal of Surgery; 2018, 90, 4; 52-54
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comprehensive review on Primary gallbladder tuberculosis
Autorzy:
Gupta, Ashish
Gupta, Amit
Anjum, Rohik
Agrawal, Saumya
Mallik, Dhiraj
Powiązania:
https://bibliotekanauki.pl/articles/1392736.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
gallbladder
Tuberculosis
Antitubercular drugs
Opis:
Tuberculosis (TB) is an infectious disease that can affect any organ system of the body. Abdominal TB can be gastrointestinal, lymph nodal, visceral or peritoneal. The gallbladder (GB) is rarely involved in abdominal TB as a primary organ. Extensive research literature on gallbladder TB is limited to case reports. There has been no review on this rare abdominal pathology. GB tuberculosis is a difficult diagnosis preoperatively. It is a rare differential among the more common gallbladder pathologies such as cholelithiasis, or a gallbladder malignancy. Typical histopathology of the resected specimen helps to establish this rare diagnosis. Subjecting every specimen to histopathological examination followed by medical treatment offers the chance of cure. Through this review, the authors attempt to provide an insight into this disease entity.
Źródło:
Polish Journal of Surgery; 2018, 90, 2; 10-12
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A novel method of Mycobacterium tuberculosis complex strain differentiation using polymorphic GC-rich gene sequences
Autorzy:
Kotłowski, Roman
Powiązania:
https://bibliotekanauki.pl/articles/1039112.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Mycobacterium tuberculosis complex
PGRS
genotyping
Opis:
Tuberculosis is one of the leading infectious diseases. In this work, a new genotyping method of Mycobacterium tuberculosis (Mtb) complex strain is presented. 27 Mtb genomes were analyzed for the presence of length polymorphism within polymorphic GC-rich gene sequences. Four genes, Rv3345c, Rv3507, Rv0747 and Rv3511, showing variation in length depending on the Mtb strain were selected for designing primer sequences flanking variable regions for the PCR method. Identification of 16 genotypes among 27 analyzed genomes demonstrated usefulness of our genotyping method in differentiation of Mtb genomes based on sequence polymorphism in the four PGRS genes.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 317-322
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A rare case of isolated pancreatic tuberculosis in a 70-year-old patient - a case report
Autorzy:
Słupski, Maciej
Wiciński, Michał
Khuat, Dawid
Pawlak-Osińska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1392244.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
pancreas
tuberculosis
tumor
Opis:
We report a case of rare solitary pancreatic tuberculoma. 70 years old woman admitted to hospital in order to conduct diagnostics of a tumor located in the head of the pancreas. All symptoms pointed at pancreatic cancer, but histopathological examinations were inconclusive. Additionally, there were no clinical signs or symptoms of tuberculosis in the lungs. X-ray of the chest showed no abnormalities. The patient denied tuberculosis in the medical interview. There were no bacilli in the sputum. During exploratory laparotomy, the samples of tissue have been taken for pathomorphological examination. The microscopic image caused suspicion of Mycobacterium tuberculosis etiology, which was confirmed by Ziehl-Neelsen staining. In recent years, tuberculosis has become more and more common in Europe, which is why the described case can be a guide for doctors to help to avoid diagnostic errors and speed up the treatment process.
Źródło:
Polish Journal of Surgery; 2019, 91, 2; 48-50
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A review of tuberculosis and parasitic disease co-infection in ungulates, with regard to the potential threat to European bison (Bison bonasus)
Autorzy:
Gałązka, M.
Didkowska, A.
Anusz, K.
Pyziel-Serafin, A.
Powiązania:
https://bibliotekanauki.pl/articles/16647526.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
bovine tuberculosis
co-infection
Fasciola hepatica
helminths
Mycobacterium bovis
Mycobacterium caprae
parasites
Opis:
Bovine tuberculosis (BTB) is a dangerous zoonosis which presents a serious problem for endangered species such as European bison (Bison bonasus). Little is known about the influence of parasitic co-infections on the course and diagnosis of tuberculosis in animals. The best known co-infection in cattle is Fasciola hepatica and Mycobacterium bovis. The aim of this study was to review the most recent literature regarding tuberculosis and parasite co-infection in ungulates and relate the results to European bison. Our findings indicate that any comprehensive diagnosis of BTB should include parasitological monitoring, and the possible impact of such invasions on cellular response-based tuberculosis tests should be taken into account. The diagnosis of BTB is complex, as is its pathogenesis, and parasitic infestations can have a significant impact on both. This should be taken into account during further research and monitoring of tuberculosis in European bison.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 155-161
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A study on the mycobacterial burden and phenotypic drug resistance pattern with reference to the GeneXpert Cycle Threshold values in pulmonary tuberculosis
Autorzy:
Kashyap, Bineeta
Sarkar, Krishna
Singh, Kapil
Hyanki, Puneeta
Powiązania:
https://bibliotekanauki.pl/articles/29520459.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
CBNAAT
cycle threshold values
rifampicin resistance
smear microscopy
tuberculosis
Opis:
Introduction and aim. Tuberculosis (TB) remains a significant global health challenge. Early and accurate diagnosis is crucial to prevent further transmission. The present study aimed to correlate cycle threshold values with smear microscopy and culture positivity, and determine cut-off cycle threshold values for levels of smear grade and culture positivity. Material and methods. Forty presumptive cases of pulmonary TB were included and subjected to Ziehl-Neelsen stain, culture on Lowenstein Jensen media, CBNAAT and drug susceptibility testing for first line anti-tubercular drugs. Results. Our study predicts 3+, 2+, and 1+ sputum smear grade at a cut-off of Ct value ≤ 16.74, ≤19.68, and ≤ 22.32 respectively. A strong positive correlation was found between time to culture positivity and Ct value. A cut-off of Ct value ≤22.32 predicts culture positivity with a sensitivity of 92%, and a specificity of 67%. None of the isolates showed rifampicin resistance by 1% proportion method. Conclusion. Understanding the appropriate utilization of CBNAAT Ct values and their correlation with smear microscopy grade, culture, and drug susceptibility testing can assist clinicians in early identification and prompt initiation of appropriate treatment. This knowledge can contribute to the prevention of drug resistance, reduced transmission, and a decreased disease burden associated with TB.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 730-735
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adenozyno-5’-o-(n-acylosulfamoilowe) pochodne jako potencjalne leki przeciwgruźlicze
5’-o-[n-(acyl)sulfamoyl]adenosine derivatives as potential antituberculosis drugs
Autorzy:
Kulik, K.
Baraniak, J.
Powiązania:
https://bibliotekanauki.pl/articles/172072.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
leki przeciwgruźlicze
prątek gruźlicy
acyloadenylany
antituberculosis drugs
Mycobacterium tuberculosis
acyladenylates
Opis:
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is the leading bacterial cause of infectious disease mortality. The current WHOapproved treatment for TB involves a three- or four-drug regimen comprising isoniazid, rifampin, pyrazinamide, and/or ethambutol for a minimum of 6 months. While these first-line agents remain useful in treating susceptible Mycobacterium tuberculosis strains, the emergence of multidrug resistant tuberculosis demands the development of new drugs [1]. Iron acquisition is an essential process for M. tuberculosis as well as almost all other microorganisms. However, this essential micronutrient is highly sequestered in a mammalian host. In response to iron starvation, Mtb produces small-molecule iron chelators, a pair of related peptidic siderophores known as mycobactin and carboxymycobactins that vary by the appended lipid residue termed siderophores [4, 5, 7, 8]. Because mycobactins are critical for growth and virulence of M. tuberculosis, they have emerged as attractive targets for the development of anti-TB agents [4]. Biosynthesis of mycobactin is initiated by the aryl acid adenylation enzyme MbtA which activates salicylic acid forming an acyladenylate intermediate (Sal- AMP). MbtA is also responsible for loading the acyladenylate intermediate onto the thiolation domain of MbtB-SH – the enzyme taking part in the next step of biosynthesis process [10]. Given the documented importance of many siderophores for virulence and lack of human aryl acid adenylation enzymes homologues, several analogues possessing stable linkers as bioisosteres of the labile acyl phosphate function have been synthesized as the potent enzyme inhibitors [13]. The initial lead compound 5’-O-[N- (salicyl)sulfamoyl]adenosine (Sal-AMS) has emerged as a promising inhibitor of MbtA and was shown to possess promising whole-cell activity toward M. tuberculosis.
Źródło:
Wiadomości Chemiczne; 2016, 70, 7-8; 455-472
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Air transport and the spread of infectious diseases
Autorzy:
Kulczyński, Marcin
Tomaszewski, Mateusz
Łuniewski, Michał
Olender, Alina
Powiązania:
https://bibliotekanauki.pl/articles/1179535.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
MERS
West Nile Virus
air transport
aircraft
airport
aviation
infectious diseases
influenza
pandemic
tuberculosis
Opis:
Dynamically growing number of airline passengers and flights, especially intercontinental ones, is a key factor conducive to the spread of infectious diseases. The threat to public health may be even more noticeable if it is taken into account, that the developing countries record larger increase in air traffic than most European high developed states with good sanitary conditions. The aim of the study is to make a review of the literature concerning risk assessment and ways to prevent transmission of infectious diseases aboard civil aircrafts. Airline-associated spread of infectious diseases can refer to airborne and vector-borne diseases, as well as these transmitted by fecal-oral route. The particular danger of rapid spread of a disease through airline passengers is caused by influenza virus strains with the potential for causing pandemics or coronaviruses that are infectious agents of MERS and SARS. Passengers suffering from active tuberculosis are also a reason of a serious epidemiological concern. Also other airborne diseases like measles can be easily transmitted by air transport when travelling from endemic countries. On the other hand, flight-related food poisonings are less and less frequent – the most common cause are still bacteria of the Salmonella genus. Among vector-borne diseases, particular attention is paid to the problem of possible transfer of mosquitoes infected with West Nile Virus. In the prevention of the spread of communicable diseases via air transport, there are important factors such as: efficient identifying of sick travellers and crew members, use of personal protective equipment (such as masks with HEPA filter) by passengers travelling alongside sick person, efficient ventilation inside the passenger cabin, proper disinfection of aircrafts' interiors, vaccination of cabin crews against influenza and proper preparation and handling of catering provided to aircrafts.
Źródło:
World Scientific News; 2017, 76; 123-135
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
All that fistulises is not Crohn’s disease: Multiple entero-enteric fistulae in intestinal tuberculosis
Autorzy:
Singh, Harjeet
Mandavdhare, Harshal
Sharma, Vishal
Powiązania:
https://bibliotekanauki.pl/articles/1392382.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
intestinal tuberculosis
crohn’s disease
fistula
intestinal obstruction
surgery
Opis:
Abdominal tuberculosis is a common problem for clinicians in the tropical world and may manifest with varying clinical scenarios. Intestinal tuberculosis could have intestinal ulcers, strictures, hypertrophic lesions like polyps and may be complicated by perforation, bleeding, and intestinal obstruction. Crohn’s disease is an important differential of intestinal tuberculosis which is closely mimics intestinal tuberculosis in clinical, endoscopic, radiological and histological presentation. Crohn’s disease is known to have a fistulising variant. We report the case of 23 year old lady who had disseminated tuberculosis with intestinal involvement and seemed to improve on anti-tubercular therapy (ATT) but present with intestinal obstruction in the third month of ATT. Surgical exploration revealed clumping of bowel loops with multiple ileo-ileal fistulae. The case is presented because of the presence of entero-enteric fistulae and also because it demonstrated that intestinal tuberculosis may need surgical intervention even after initial improvement because of complications like intestinal obstruction.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 35-37
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis and modelling of territorial vulnerability to epidemiological diseases in the Wilaya of Batna (Algeria) – case of tuberculosis
Autorzy:
Asma, Douha
Mahdi, Kalla
Powiązania:
https://bibliotekanauki.pl/articles/2029709.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie
Tematy:
GIS
AHP
tuberculosis
Batna
vulnerability
environment
gruźlica
środowisko
podatność na zagrożenia
Opis:
Some epidemiological situations, because of their magnitude and their propagation dynamics, can escape local or national control. For example, the world is currently experiencing an uncontrollable cross-border spread of the corona virus (Covid-19). The Wilaya of Batna is among the most affected in Algeria by many epidemiological diseases, including tuberculosis, which raises questions about possible causal links between this contagious and often fatal disease and the environmental and socio-economic reality of this territory. We based our study on a number of factors, covering economic, societal and health aspects, which constitute indicators of the standard of living in each of the 61 communes of the Wilaya of Batna. The relationship between the epidemiological status of tuberculosis in these communes and these indicators showed significant correlations and thus confirmed the reliability of the choice of parameters of vulnerability to tuberculosis. To understand their interaction and impact on the disease and its spatial distribution, we used the hierarchical multicriteria analysis (AHP) method, the results of which were implemented in a GIS database. The aim was to provide health and territorial decision makers with a decision support tool. The results show that the spatial distribution of tuberculosis cases which reappeared in the Wilaya of Batna after its eradication since years is in good correlation with the socio-economic situation of each commune of the territory and confirm that this scourge of tuberculosis is closely linked to the degradation of the living conditions of the inhabitants.
Źródło:
Geomatics, Landmanagement and Landscape; 2021, 4; 31-45
2300-1496
Pojawia się w:
Geomatics, Landmanagement and Landscape
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of resistance to antimycobacterial drugs among MTBC strains isolated from cattle in Poland as a threat to human health
Analiza oporności na leki przeciwprątkowe wśród szczepów MTBC izolowanych od bydła w Polsce jako zagrożenie dla zdrowia ludzi
Autorzy:
Weiner, M.
Krajewska, M.
Zabost, A.
Augustynowicz-Kopeć, E.
Szulowski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2048912.pdf
Data publikacji:
2020
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
drug resistance
Mycobacterium tuberculosis
bovine tuberculosis
public health
antimicrobial
lekooporność
Mycobacterium tuberculosis complex
gruźlica bydlęca
zdrowie publiczne
leki przeciwprątkowe
Opis:
Background. Tuberculosis is a highly contagious disease affecting humans and animals. It is caused by mycobacteria that are part of the Mycobacterium tuberculosis complex (MTBC). The etiological agent causing bovine tuberculosis is mycobacteria bovis: Mycobacterium bovis and Mycobacterium caprae. According to the World Health Organization bovine tuberculosis is classified as direct zoonosis. Material and methods. The study material consisted of 129 MTBC strains isolated from Polish cattle, which were microbiologically analyzed. The resistance phenotype was tested for first-line anti-tuberculosis drugs used in the treatment of tuberculosis in humans. The drugs included streptomycin, isoniazid, rifampicin, ethambutol, and pyrazinamide. The MTBC strains tested in this study were isolated from cattle tissue post mortem so that the determination of drug resistance could meet only the epidemiological criterion. Results. Polish strains of mycobacteria bovis have not acquired environmental resistance despite the huge dynamics of changes in the phenotype of mycobacterial tuberculosis resistance. Strains classified as M. bovis are characterized by natural resistance to PZA, which is typical of this species. Conclusions. Drug resistance imposes the use of additional drugs. Drugs that are less effective than the basic drugs, drugs causing side effects more frequently and drugs that are much more expensive.
Wprowadzenie. Gruźlica jest wysoce zakaźną chorobą ludzi i zwierząt, którą powodują prątki wchodzące w skład kompleksu Mycobacterium tuberculosis (MTBC). Czynnikiem etiologicznym gruźlicy bydlęcej są prątki bydlęce: Mycobacterium bovis i Mycobacterium caprae. Zgodnie z klasyfikacją Światowej Organizacji Zdrowia, gruźlica typu bydlęcego zaliczana jest do zoonoz bezpośrednich. Materiał i metody. W pracy poddano analizie mikrobiologicznej 129 szczepów MTBC wyizolowanych od bydła w Polsce. Fenotyp oporności zbadano pod kątem leków przeciwprątkowych pierwszej linii stosowanych w leczeniu gruźlicy u ludzi: streptomycyny, izoniazydu, rifampicyny, etambutolu i pyrazynamidu. Szczepy MTBC badane w niniejszej pracy wyizolowano z tkanek bydła pobranych post mortem, tak że oznaczenie lekooporności w tym zadaniu spełniło jedynie kryterium epidemiologiczne. Wyniki. Polskie szczepy prątka bydlęcego nie nabyły oporności środowiskowej. Szczepy sklasyfikowane jako M. bovis cechują się charakterystyczną dla tego gatunku naturalną opornością na PZA. Wnioski. Wystąpienie lekooporności zmusza do stosowania leków dodatkowych, mniej skutecznych niż leki podstawowe i powodujących częściej objawy uboczne, a jednocześnie znacznie droższych.
Źródło:
Health Problems of Civilization; 2020, 14, 1; 24-28
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Animal tuberculosis as a potential danger to men
Gruźlica zwierząt jako potencjalne zagrożenie dla człowieka
Autorzy:
Krajewska, M.
Weiner, M.
Augustynowicz-Kopeć, E.
Powiązania:
https://bibliotekanauki.pl/articles/2052645.pdf
Data publikacji:
2017
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
Mycobacterium tuberculosis complex
bovine tuberculosis
public health
zoonosis
transmission
gruźlica bydlęca
zdrowie publiczne
zoonoza
transmisja
Opis:
Tuberculosis (latin: tuberculosis) is an infectious disease which affects man and many species of animals. The aetiological factor of tuberculosis are bacillus which belong to the Mycobacterium tuberculosis complex (MTBC) while their host preferences, gene sequence and the level of drug resistance can differ. MTBC constitute a morphologically and biochemically homogeneous group of bacteria which mainly spreads through the aerogenic channel on small, dry particles of phlegm called droplet nuclei which are discharged while infected people or animals cough. Infection occurs after predisposed individual inhales into his or her lungs the bacilli, where they easily multiply in the soft lungs tissue and cause infection. The World Health Organization (WHO) classified bovine tuberculosis (bTB) as direct zoonosis, in which case the transmission of disease is possible without the indirect host’s involvement. Moreover, bTB is the best example of anthroponosis, when the disease is transferred from animal to men. The possibility of dividing the strains of animal bacillus into the two genres: M. bovis and M. caprae raises some significant legal concerns in Europe since in many of its countries, including among others Poland, caprae is not considered to be an etiological factor of bTB.
Gruźlica (łac. tuberculosis) jest zakaźną chorobą ludzi i wielu gatunków zwierząt. Czynnikiem etiologicznym gruźlicy są prątki należące do Mycobacterium tuberculosis complex (MTBC), różniące się między sobą różnym powinowactwem do rodzaju gospodarza, sekwencjami w genach oraz cechami lekooporności. Stanowią niejednorodną grupę pod względem morfologicznym i biochemicznym. Prątki należące do kompleksu tuberculosis przenoszone są głównie drogą aerogenną na małych, wyschniętych cząstkach śluzu zwanych jądrami kropelek (droplet nuclei), które są wydzielane w czasie kaszlu chorych ludzi i zwierząt. Zakażenie następuje, gdy wrażliwy na zakażenie osobnik zaaspiruje prątki do płuc, gdzie w delikatnej tkance mogą się one rozmnażać dając początek infekcji. Zgodnie z klasyfikacją Światowej Organizacji Zdrowia (WHO) gruźlica bydlęca zaliczana jest do zoonoz bezpośrednich, gdzie przeniesienie czynnika infekcyjnego odbywa się bez pomocy żywicieli pośrednich. Ponadto gruźlica zwierząt jest najlepszym przykładem antropozoonozy, gdzie transmisja choroby możliwa jest ze zwierzęcia na człowieka. Możliwość różnicowania szczepów prątka bydlęcego na gatunki M. bovis i M. caprae rodzi w Europie istotne wątpliwości prawne, ponieważ w wielu krajach caprae nie widnieje jako czynnik etiologiczny gruźlicy bydlęcej, w tym m. in. w Polsce.
Źródło:
Health Problems of Civilization; 2017, 11, 1; 10-14
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-tubercular substances produced by plants
Autorzy:
Polak, Żaneta
Kapka-Skrzypczak, Lucyna
Powiązania:
https://bibliotekanauki.pl/articles/972532.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
tuberculosis
endophytes
plant medicines
natural drugs
natural compounds
Opis:
Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 2; 147-152
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antimycobacterial activity of ethanolic extract of Artemisia absinthium L.
Autorzy:
Hojageldiyev, T.
Bolmammedov, Y.
Gurbanaliyev, S.
Powiązania:
https://bibliotekanauki.pl/articles/1075710.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Artemisia absinthium
Mycobacteria tuberculosis
Mycobacterium tuberculosis
antimycobacterial
ethanolic extract
Opis:
It is known that, drugs used in the treatment of tuberculosis show toxic effect to organism especially to liver beside its therapeutic effect. Because of ineffectiveness of drugs used in the treatment regimen of tuberculosis against multidrug resistance (MDR) and extensively drug-resistance (XDR) tuberculosis requires the development of new treatment methods and new novel drugs. Considering the usage of Artemisia absinthium in traditional medicine in treatment of wounds which suggests its antibacterial activity it seems that, also it may have significant antimycobacterial activity. The objective of present study was to evaluate antibacterial activity of ethanolic extract of A. absinthium against M. tuberculosis. In this study, the effect of ethanolic extract of A. absinthium was tested against tuberculosis and pharmaco-toxicological properties evaluated on laboratory animals. The 20%, 40%, 70% and 96% ethanolic extracts of A. absinthium prepared then its bacteriostatic and bactericidal activities were evaluated by validated methods. Data were analyzed by GraphPad Prism 7.0 at the level P<0.05. Results showed that ethanolic extracts of A. absinthium show no toxicological properties with having high LD50. All concentrations of extract show high bacteriostatic activity on M. tuberculosis. 96% ethanolic extract has highest bactericidal effect among other concentrations. By conducting further studies, as a results of our study, antimycobacterial drug can be prepared from A. absinthium.
Źródło:
World Scientific News; 2019, 119; 224-230
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 98

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