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    Wyświetlanie 1-13 z 13
    Tytuł:
    Advances in immunotherapy for osteosarcoma: a review of emerging treatment strategies
    Autorzy:
    Poboży, Kamil
    Domański, Paweł
    Domańska, Julia
    Konarski, Wojciech
    Poboży, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/22792557.pdf
    Data publikacji:
    2023-09-13
    Wydawca:
    Medical Education
    Tematy:
    osteosarcoma
    immunotherapy
    immune checkpoint inhibitors
    cancer vaccines
    autophagy
    pyroptosis
    chimeric antigen receptor T cells
    Opis:
    Advances in immunotherapy for osteosarcoma have shown promising results, with the use of monoclonal antibodies and immune checkpoint inhibitors. These strategies are aimed at targeting specific molecules and pathways involved in tumour immune evasion and promoting anti-tumour immune responses. Other emerging immunotherapeutic approaches include autophagy and pyroptosis induction, chimeric antigen receptor T-cell therapy, gadolinium-bisphosphonate nanoparticles and dendritic cell-based vaccines. Continued research into these emerging treatment strategies is essential for developing effective therapies for patients with high-grade osteosarcoma.
    Źródło:
    OncoReview; 2023, 13, 3; 75-84
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Changes in haematological parameters and serum beta-2-microglobulin levels in CD4+ T-cells-stratified Nigerian HIV patients
    Autorzy:
    Ayodele Olaniyi, John
    Joseph Emeka, Godwin
    Adekunle Onifade, Abdulfatah
    Olusoji Adeyanju, Alaruru
    Kadiri Rahamon, Sheu
    Powiązania:
    https://bibliotekanauki.pl/articles/2040249.pdf
    Data publikacji:
    2021-03-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    beta-2-microglobulin
    CD4+ T-cells count
    haemocytometry
    HIV
    lymphopaenia
    Opis:
    Introduction. Reports have shown that there is a rise in beta-2-microglobulin (β2M) concentration in patients with HIV infection and that the degree of elevation correlates well with the extent of disease burden and could be an independent prognostic marker for death. However, there is the dearth of information on the interplay between alteration in haematological profile, a common cause of morbidity and mortality in HIV, and β2M. Aim. Changes in selected haematological parameters and β2M in Nigerian HIV patients stratified based on CD4+ T-cells counts were thus assessed in this study. Material and methods. Forty-eight asymptomatic, drug naïve HIV patients were enrolled into this cross-sectional study. Haemoglobin concentration (Hb), packed cell volume (PCV), total and differential white blood cell count, platelet count and CD4+ T-cells count were determined using standard methods while serum levels of β2M were determined using ELISA. Thereafter, the patients were stratified into three groups based on the CD4+ T-cells count. Results. Hb and lymphocyte counts increased with increasing CD4+ T-cells count. In contrast, neutrophils percentage, MCV and MCH reduced with increasing CD4+ T-cells count. The mean lymphocytes percentage was significantly higher while the mean neutrophils percentage was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with the patients with CD4+ T-cells count <200 cells/μl. Similarly, the mean MCV was significantly lower in patients with CD4+ T-cells count of 500–800 cells/μl compared with patients with CD4+ T-cells count of 200–499 cells/μl and patients with CD4+ T-cells count <200 cells/μl. β2M had significant positive correlation with WBC and neutrophils percentage but had a significant negative correlation with lymphocytes percentage and MCH in patients with CD4+ T-cells count <200 cells/μl. However, β2M had sig nificant positive correlation with PCV, Hb, monocytes and morphology in patients with CD4+ T-cells count of 500–800 cells/μl. Conclusion. It could be concluded from this study that HIV infection is associated with alteration in haematological profile and the alteration is CD4+ T-cells count-dependent. Also, elevation in β2M concentration appears to be a marker of lymphopaenia in patients with low CD4+ T-cells count
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2021, 1; 33-39
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of tigecycline on the production of selected cytokines and counts of murine CD4+ and CD8+ T cells - an in vitro study
    Autorzy:
    Jasiecka-Mikołajczyk, A.
    Jaroszewski, J.J.
    Maślanka, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087626.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    tigecycline
    CD4+ T cells
    CD8+ T cells
    cytokines
    mouse
    Źródło:
    Polish Journal of Veterinary Sciences; 2018, 21, 4; 819-822
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Significant expression of Foxp3 in murine extrathymic CD4+CD8+ double positive T cells
    Autorzy:
    Gregorczyk, I.
    Maślanka, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087878.pdf
    Data publikacji:
    2017
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    CD4+CD8+ double-positive (DP) T cells
    CD25
    Foxp3
    Treg cells
    mouse
    Źródło:
    Polish Journal of Veterinary Sciences; 2017, 4; 815-817
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Układ odpornościowy ssaków w obronie integralności organizmu
    Immune system of mammals in maintenance of body integrity
    Autorzy:
    Drela, Nadzieja
    Powiązania:
    https://bibliotekanauki.pl/articles/1033997.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Tematy:
    gut-associated lymphoid tissue
    immune system in pregnancy
    maternal and fetal immune system in senescence
    protective autoimmunity
    tolerance of T and B cells
    ochronna autoimmunizacja
    tolerancja limfocytów T i B
    układ odpornościowy matki i płodu podczas ciąży
    układ odpornościowy przewodu pokarmowego
    układ odpornościowy w procesie starzenia
    Opis:
    Ważną funkcją układu odpornościowego ssaków jest obrona przed patogenami, której podstawą jest zdolność komórek odporności wrodzonej i nabytej do aktywacji wskutek wiązania antygenów przez receptory komórkowe. Jednak, układ odpornościowy ssaków narażony jest przede wszystkim na kontakt z antygenami własnymi, mikrobioty jelitowej, pokarmowymi czy antygenami płodu (w przypadku osobników płci żeńskiej), a antygeny organizmów patogennych stanowią w tej grupie mniejszość. W warunkach fizjologicznych odpowiedź odpornościowa wywołana jest przez antygeny patogenów, natomiast inne, "nieszkodliwe" antygeny (własne, mikrobioty, płodowe) wywołują tolerancję. W tej pracy opisano najważniejsze mechanizmy, które zapobiegają reakcji odpornościowej na antygeny własne i chronią organizm przed rozwojem chorób autoimmunizacyjnych. Przedstawiono podstawowe mechanizmy ochrony płodu przed atakiem układu odpornościowego matki. Scharakteryzowano rolę interakcji mikrobioty jelitowej z komórkami odpornościowymi w błonie śluzowej przewodu pokarmowego, której skutkiem jest tolerancja na antygeny mikrobioty i pokarmowe, przy jednoczesnym zachowaniu gotowości do obrony przed mikroorganizmami chorobotwórczymi. Zwrócono uwagę na pozytywne skutki działania limfocytów autoreaktywnych w rozwoju narządów i utrzymaniu homeostazy układu odpornościowego.
    An important function of the mammalian immune system is the defense against pathogens, which is based on the ability of innate and adaptive immune cells to undergo activation by binding antigens by cell receptors. However, the mammalian immune system is primarily exposed to self antigens, intestinal mibrobiota, food, or fetal antigens (in the case of females), and the antigens of pathogenic organisms constitute a minority in this group. Under normal physiological conditions, the immune response is triggered by pathogen antigens, while other "harmless" antigens (self, microbiota, fetus) induce tolerance. This work describes the most important mechanisms that prevent the immune response to self antigens and protect against autoimmune diseases. Basic mechanisms of fetal protection against the attack of the mother’s immune system are presented. The role of intestinal microbiota interactions with immune cells in the gastrointestinal mucosa is characterized, which results in tolerance to microbiota and food antigens while maintaining the ability to defend against pathogenic microorganisms. Some positive effects of the autoreactivity of lymphocytes on organ development and homeostasis maintenance are emphasized.
    Źródło:
    Kosmos; 2017, 66, 4; 575-593
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection
    Autorzy:
    Miszczyk, Eliza
    Walencka, Maria
    Rudnicka, Karolina
    Matusiak, Agnieszka
    Rudnicka, Wiesława
    Chmiela, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/1039292.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Helicobacter pylori
    T cells
    proliferation
    guinea pigs
    Opis:
    Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8 - IL-8 as well as interferon gamma - IFN-γ, and transforming growth factor beta - TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 295-303
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    T-cell proliferation on immunopathogenic mechanism of psoriasis: a control based theoretical approach
    Autorzy:
    Datta, A.
    Roy, P. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/205612.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Instytut Badań Systemowych PAN
    Tematy:
    T-cells
    dendritic cells
    keratinocytes
    dermis
    epidermis
    cytokines
    T-cell proliferation
    drug efficacy
    optimal control
    Opis:
    Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8+ T-cells and also of CD4+ T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4+ T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy.
    Źródło:
    Control and Cybernetics; 2013, 42, 2; 365-386
    0324-8569
    Pojawia się w:
    Control and Cybernetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Statistical Tests Based on Empty Cells
    Testy statystyczne oparte na pustych celach
    Autorzy:
    Domański, Czesław
    Powiązania:
    https://bibliotekanauki.pl/articles/906859.pdf
    Data publikacji:
    2012
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    nonparametric tests
    tests empty cells
    student t-tests
    Wilcoxon test
    Opis:
    In professional literature on statistics, a constantly growing interest is observed in non-parametric methods. Commonly these methods are based on counting, rank or position statistics and on a number or length of series. In this paper, the least popular tests, namely tests based on a number of empty cells, are presented. David-Hellwig test and a two-sample consistency test are considered. Empirical power of the tests is presented in comparison to classic tests: Kolmogorov and Shapio-Wilk test for testing normality of a distribution and t-Student’s and Wilcoxon tests for testing consistency of two distributions.
    Źródło:
    Acta Universitatis Lodziensis. Folia Oeconomica; 2012, 269
    0208-6018
    2353-7663
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Oeconomica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena ekspresji Foxp3 i RORgamma t w jednojądrzastych komórkach krwi obwodowej u chorych z rakiem krtani jako wskaźników zaawansowania zmian nowotworowych — badania wstępne
    Expression of Foxp3 and RORgamma t in peripheral blood mononuclear cells in patients with laryngeal carcinoma as indicators of tumor stage – preliminary study
    Autorzy:
    Papież, Paweł
    Bryś, Magdalena
    Lewy-Trenda, Iwona
    Stasikowska, Olga
    Woś, Jan
    Papierz, Wielisław
    Starska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/23352191.pdf
    Data publikacji:
    2011
    Wydawca:
    Index Copernicus International
    Tematy:
    laryngeal carcinoma
    Foxp3
    RORgamma t
    peripheral blood mononuclear cells
    Opis:
    The degree of activation of cells involved in cellular immune re-sponse against tumor antigens (cytotoxic lymphocytes Te) as well as efficiency of the mechanisms which promote immunosuppression (Treg — regulatory cells CD4±CD25±Foxp3±) may determine the course of the neoplastic disease. The aim of this study was to assess the function of autologous peripheral blood mononuclear cells (PBMCs) involved in the immunological processes on the basis of expression of Foxp3 and RORgamma t molecules as well as analysis of the relationships with clinical and morphological features of the tumor (pT and pN stage, G feature, degree of invasiveness according to the TFG classification) in laryngeal carcinoma. Materia! and methods: The analysis included a group of 59 patients with verified squamous celt carcinoma of the larynx. In the pathologic evaluation pTNM classification criteria, depth of invasion and degree of histological dif-ferentiation were used. Expression levels of mRNA for Foxp3 and RORgamma t in peripheral blood mononuclear cells by quantitative analysis of the amplified product in real time (real-time RT2-PCR) were evaluated. The level of Foxp3 and RORgamma t protein expression by Western blot analysis was determined. Results: In squamous celt carcinomas of the larynx, with the highest tumor aggressiveness the significantly highest level of mRNA and protein expres-sion for Foxp3 molecule were observed. The severity of Foxp3 expression at both gene and protein level were positively linearly correlated with the degree of local extent of the tumor (pT3-4), depth of invasion (invasion of cartilage) and the degree of histological differentiation (low-differentiated tumors G3). In the study group of laryngeal cancers significantly lower level of RORgamma t expression in carcinomas with less invasive changes (pT1-2, high-differentiated tumors G1, carcinomas with microinvasion without evi-dence of invasion beyond the lamina propria) was also noted. Conclusions: The study results indicate the important role of immune celt activity as indicators of advancement of clinical and morphological changes in squamous celt carcinoma of the larynx.
    Źródło:
    Polish Journal of Otolaryngology; 2011, 65, 5; 109-116
    0030-6657
    2300-8423
    Pojawia się w:
    Polish Journal of Otolaryngology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Identification of a novel protein encoded by third conserved gene within RAG locus
    Autorzy:
    Kasztura, Monika
    Miazek, Arkadiusz
    Cebrat, Małgorzata
    Kisielow, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/1040654.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    RAG locus
    lymphocytes
    T cells
    evolutionarily conserved proteins
    Opis:
    Recently, a third evolutionarily conserved gene, NWC, was discovered within the recombination activating gene (RAG) locus, known to contain the RAG1 and RAG2 genes. Here, we identify and characterize the murine endogenous NWC protein which has no homology to any known protein and is ubiquitously expressed. In the cell, the NWC protein which has been suggested to function as a transcriptional repressor, is found in the cytoplasm as well as in the nucleus.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 1; 177-181
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Calcium- and proton-dependent relocation of annexin A6 in Jurkat T cells stimulated for interleukin-2 secretion
    Autorzy:
    Podszywalow-Bartnicka, Paulina
    Strzelecka-Kiliszek, Agnieszka
    Bandorowicz-Pikula, Joanna
    Pikula, Slawomir
    Powiązania:
    https://bibliotekanauki.pl/articles/1041071.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    interleukin-2
    ionomycin
    calcium
    annexin A6
    Jurkat T cells
    vesicular traffic
    Opis:
    Annexin A6 (AnxA6) is a Ca2+-dependent membrane-binding protein involved in vesicular traffic. The likely participation of AnxA6 in the response of lymphocytes to Ca2+ signals has not been investigated yet. The present study focuses on intracellular relocation of AnxA6 in human Jurkat T lymphoblasts upon stimulation followed by transient increase of intracellular [Ca2+] and exocytosis of interleukin-2 (IL-2). Stimulation of the cells under different experimental conditions (by lowering pH and/or by rising extracellular [Ca2+] in the presence of ionomycin) induced time-dependent transients of intracellular [Ca2+] and concomitant changes in AnxA6 intracellular localization and in IL-2 secretion, with only minor effects on cell viability and apoptosis. In resting conditions (in the presence of EGTA or with no ionophore) AnxA6 was localized uniformly in the cytosol, whereas it translocated to vesicular structures beneath the plasma membrane within 5 min following stimulation of Jurkat T cells and rise of intracellular [Ca2+] at pH 7.4. Lowering the extracellular pH value from 7.4 to 6.0 significantly enhanced this process. AnxA6 changed its location from the cytosol to the secretory granules and early endosomes which seem to represent membranous targets for annexin. In conclusion, AnxA6 is sensitive to variations in intracellular [Ca2+] upon stimulation of Jurkat T cells, as manifested by a switch in its intracellular localization from the cytosol to vesicular structures located in close proximity to the plasma membrane, suggestive of participation of AnxA6 in calcium- and proton-dependent secretion of cytokines by lymphocytes.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 2; 261-271
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells
    Autorzy:
    Łuczyński, Włodzimierz
    Stasiak-Barmuta, Anna
    Iłendo, Elżbieta
    Krawczuk-Rybak, Maryna
    Malinowska, Iwona
    Mitura-Lesiuk, Małgorzata
    Parfieńczyk, Adam
    Szymański, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/1041252.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    immunotherapy
    T-lymphocytes
    CD40L
    acute lymphoblastic leukemia
    dendritic cells
    Opis:
    Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory molecules and are poor antigen presenting cells (APCs) for T-cell activation. CD40/40L interaction stimulates B-cells to proliferate, differentiate, upregulate costimulatory molecules and increase antigen presentation. The aim of the study was to test the hypothesis that ALL cells can be turned into professional APCs by CD40L activation. Children with B-cell precursor ALL were enrolled into the study. Mononuclear cells from bone marrow or peripheral blood were stimulated with CD40L and interleukin 4. Results: 1) after culture we noted upregulation of all assessed costimulatory, adhesion and activatory molecules i.e. CD1a, CD11c, CD40, CD54, CD80, CD83, CD86, CD123, HLA class I and II; 2) CD40L activated ALL cells induced proliferation of allogeneic T-cells (measured by [3H]thymidine incorporation). These results confirm the possibility of enhancing the immunogenicity of ALL cells with the CD40L system and indicate that this approach can be used in immunotherapeutic trials.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 2; 377-382
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Proliferation and apoptosis of human T cells during replicative senescence - a critical approach.
    Autorzy:
    Jaruga, Ewa
    Skierski, Janusz
    Radziszewska, Ewa
    Sikora, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1044352.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    senescence
    p16
    CD25
    apoptosis
    T cells
    proliferation
    CD8
    Opis:
    Normal human T lymphocytes growing in culture undergo replicative senescence. Previously, we have shown that in our conditions polyclonal T cells cease proliferation after about three weeks (Radziszewska et al., 1999, Cell Biol. Int. 23, 97-103). Now we present results of a more detailed analysis of in vitro growth as well as phenotypic changes of T cells. Cell cycle analysis showed that about 20% of cells were in the S phase untill the 17th day of culture (young cells). The highest number of mitotic cells (phase G2/M; 10%) was observed during the first week of culture. All not dividing senescent cells were stopped in the G1 phase (after the 30th day of culture). The sub-G1 fraction which represents apoptotic cells did not exceed 8% during the whole period until the 30th day of culture. During in vitro T-cell growth, a rather rapid selection to CD3+CD8+ cells occurs. In the presenescent (between the 17th and 30th day) and senescent populations the majority of cells (above 90%) were CD8 positive. We also have checked the expression of α-chain interleukin-2 (IL-2) receptor (CD25). In young and presenescent cells about one third of cells was CD25 positive, but only 15% in the pool of senescent cells. Immunoblotting analysis of p16 protein recognized previously as a marker of senescent T cells, showed its highest and transient expression in presenescent cells. A critical review of the polyclonal T cell replicative senescence model is presented.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 2; 293-300
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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