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Tytuł:
Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4plus and CD8plus T cells in calves
Autorzy:
Maslanka, T
Jaroszewski, J.J.
Markiewicz, W.
Jabubowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/31556.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
peripheral blood
T cell
calf
CD4plus T cell
CD8plus T cell
apoptosis
meloxicam
flunixin meglumine
lymphocyte
antiinflammatory drug
Opis:
The aim of the study was to determine whether treatment with recommended doses of meloxicam or flunixin had an effect on the apoptosis of peripheral blood T lymphocytes in calves. The study was carried out on 4-5 months old calves (n = 24, 8 per group). Experimental animals were injected subcutaneously with a single dose of 0.5 mg . kg-1 of meloxicam or intravenously with 3 doses of 2.2 mg . kg-1 day-1 of flunixin. The non-treatment animals served as control. Blood samples were taken at day 0 and at days 1, 2, 3, 5, 7 and 14 after the first NSAIDs injection. Apoptosis was determined by flow cytometry using Annexin V-PE/7-AAD staining. The kinetic analysis of apoptosis in the total lymphocyte population, as well as in the CD4+ and CD8+ subsets did not reveal significant differences in the frequency of early apoptotic cells between control and experimental groups throughout the period studied. Although, 24 h after administration of the first dose of NSAIDs, late-stage apoptosis/necrosis was significantly increased in the total lymphocyte population (the meloxicam group), as well as in the CD4+ (the meloxicam group and the flunixin group) and CD8+ (the flunixin group) subsets of T cells. However, this disturbance was transient, relatively poorly expressed and, thus, unlikely to be of clinical significance. Our results indicate that the use of meloxicam or flunixin in accordance with the recommended dosage regimen in cattle do not have a clinically significant influence on apoptosis of peripheral blood T cells.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 3-12
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CD30-positive T-cell lymphoproliferation of the bulbar conjuntival mucosa showing spontaneous remission
Autorzy:
Paula, Marticorena Álvarez
Garrido Ceca, Guadalupe
Guijarro Rojas, Mercedes
Powiązania:
https://bibliotekanauki.pl/articles/1927972.pdf
Data publikacji:
2021
Wydawca:
Medical Education
Tematy:
CD30
T-cell
conjunctival
lymphoproliferative
Opis:
Introduction: CD30-positive T-cell lymphoproliferative lesions represent a spectrum of heterogeneous disorders. Clinical case: An incision biopsy was performed in a 25-year-old man with a lump in the bulbar conjunctiva. Immunohistochemistry indicated membrane positivity for CD3 and CD30 in over 75%. PCR identified the monoclonal nature of the T-cells. The hematological study was normal. Following biopsy, the conjunctival tumor diminished until disappear. Conclusions: Mucosal CD30-positive T-cell lymphoproliferation could be ascribed to a reactive process but it is necessary to rule out a primary conjunctival tumor or the first manifestation of an anaplastic large cell lymphoma.
Źródło:
OphthaTherapy; 2021, 8, 1; 45-48
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children
Autorzy:
Kotłowska-Kmieć, Aldona
Bąkowska, Alicja
Szarszewski, Adam
Kamińska, Barbara
Łuczak, Grażyna
Radys, Wojciech
Landowski, Piotr
Brodzicki, Jacek
Korzon, Maria
Liberek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1040535.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
T cell
H. pylori
FasL
Fas
apoptosis
lymphocyte
Opis:
The pathomechanism of Helicobacter pylori action upon gastric mucosa and its role in the pathogenesis of gastritis have not been fully elucidated. The aim of this study was to evaluate the most prevalent lymphocyte subpopulations of the gastric mucosa in gastritis in children, as well as to evaluate the expression of Fas and Fas ligand receptors (FasL), periapoptotic markers of gastric mucosa lymphocytes before and after H. pylori eradication. Forty nine patients aged 6 to 17 years, investigated due to chronic abdominal pain, were studied. The obtained tissue samples were analysed by immunohistochemistry. Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNγ) and Fas and FasL proteins in the gastric mucosa. B and T helper lymphocytes were found to play a major role in the inflammatory infiltration in the gastric mucosa in children during H. pylori infection. Their expression was found to decrease after eradication. The enhanced expression of Fas receptor on lymphocytes before treatment and a decrease of this expression after eradication of H. pylori were shown. It was demonstrated that there is a correlation between CD4 and Fas receptor expression that may induce apoptosis of the helper lymphocytes in infected children.
Źródło:
Acta Biochimica Polonica; 2009, 56, 3; 433-438
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution of CD4 and CD8 T cells in the small intestine of mice after probiotic treatment and Trichinella spiralis infection
Autorzy:
Dvoroznakova, E.
Buckova, B.
Hurnikova, Z.
Revajova, V.
Laukova, A.
Powiązania:
https://bibliotekanauki.pl/articles/5886.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
distribution
CD4 T cell
CD8 T cell
small intestine
mouse
mice
probiotic
treatment
Trichinella spiralis
animal infection
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
IgG antibody and eosinophil responses during heterologous infection of BALB-c mice with Trichinella spiralis and Heligmosomoides polygyrus
Autorzy:
Doligalska, M.
Mijal, J.
Laskowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/840273.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
T helper cell
parasite
mouse
mice
host response
heterologous infection
eosinophil
Heligmosomoides polygyrus
Trichinella spiralis
T cell
antibody
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Experimental inflammatory bowel disease - role of T cells
Autorzy:
Szczepanik, M.
Gryglewski, A.
Bryniarski, K.
Stachura, J.
Ptak, W.
Powiązania:
https://bibliotekanauki.pl/articles/70282.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
myeloperoxidase
B lymphocyte
inflammatory bowel disease
chronic colitis
colitis
T cell
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
T-cell proliferation on immunopathogenic mechanism of psoriasis: a control based theoretical approach
Autorzy:
Datta, A.
Roy, P. K.
Powiązania:
https://bibliotekanauki.pl/articles/205612.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
T-cells
dendritic cells
keratinocytes
dermis
epidermis
cytokines
T-cell proliferation
drug efficacy
optimal control
Opis:
Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8+ T-cells and also of CD4+ T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4+ T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy.
Źródło:
Control and Cybernetics; 2013, 42, 2; 365-386
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lethal acute liver failure in a 60 y/o female patient with AILD III (Ann Arbor) T-cell lymphoma in remission state - case report
Autorzy:
Kuczynska, M.
Dziaduch, E.
Grzywa-Celinska, A.
Lachowska-Kotowska, P.
Mosiewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/3662.pdf
Data publikacji:
2014
Wydawca:
Instytut Medycyny Wsi
Tematy:
acute liver failure
liver function
female patient
hepatic cirrhosis
T cell
lymphoma cell
remission state
Źródło:
Journal of Pre-Clinical and Clinical Research; 2014, 08, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
B cells and CD4plus T cells play a key role in resistance to Babesia microti infection in mice
Autorzy:
Szymczak, J.
Donskow-Lysoniewska, K.
Doligalska, M.
Powiązania:
https://bibliotekanauki.pl/articles/5563.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Babesia microti
parasitic infection
babesiosis
mice
B cell
CD4plus T cell
resistance
mouse
Źródło:
Annals of Parasitology; 2016, 62, Suppl.
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lymphocyte subpopulations and apoptosis of immune cells in rabbits experimentally infected with a strain of the RHD virus having a variable haemagglutination capacity
Autorzy:
Niedzwiedzka-Rystwej, P.
Deptula, W.
Powiązania:
https://bibliotekanauki.pl/articles/31022.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
lymphocyte subpopulation
apoptosis
immune cell
rabbit
experimental infection
RHD virus
hemagglutination capacity
granulocyte
T cell
B cell
Opis:
The paper describes the immunological response in the matter of percentage of T cells (receptor CD5+) and subpopulations (Th with receptor CD4+, Tc/Ts with receptor CD8+, T with receptor CD25+) and B cells with receptor CD19+, as well as the percentage of apoptotic granulocytes and lymphocytes, in rabbits experimentally infected with the Hagenow strain of the RHD virus. The material chosen for the experiment is special, as among all strains of RHD virus, there are only two strains which carry the variable haemagglutination capacity of red cells. The results of the study show that the Hagenow strain gives an untypical picture of T and B lymphocytes, whereas the results in inducing apoptosis seems to corespond with previous data, confirming the inclusion of apoptosis from 4 h p.i. and the intensity of the phenomenon being higher in granulocytes.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: Insights from a mathematical model
Autorzy:
Bodnar, Marek
Foryś, Urszula
Piotrowska, Monika J.
Bodzioch, Mariusz
Romero-Rosales, Jose A.
Belmonte-Beitia, Juan
Powiązania:
https://bibliotekanauki.pl/articles/24200684.pdf
Data publikacji:
2023
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
glioblastoma
CAR-T cell therapy
mathematical modelling
periodic treatment
glejak wielopostaciowy
terapia CAR-T
modelowanie matematyczne
Opis:
Chimeric antigen receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. Its success has led, in recent years, to its use being tested for different solid tumours, including glioblastoma, a type of primary brain tumour, characterised by aggressiveness and recurrence. This paper presents an analytical study of a mathematical model describing the competition of CAR-T and glioblastoma tumour cells, taking into account their immunosuppressive capacity. The model is formulated in a general way, and its basic properties are investigated. However, most of the analysis considers the model with exponential tumour growth, assuming this growth type for simplicity. The existence and stability of steady states are studied, and the subsequent focus is on two different types of treatment: constant and periodic. Finally, protocols for CAR-T cell therapy of glioblastoma are numerically derived; these are aimed at preventing the tumour from reaching a critical size and at prolonging the patients’ survival time as much as possible. The analytical and numerical results provide theoretical support for the treatment of glioblastoma using CAR-T cells.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2023, 33, 3; 379--394
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification of CD4plus T cell epitopes from Staphylococcus aureus secretome using immunoinformatic prediction and molecular docking
Autorzy:
Francis, D.
Kumar, A.
Chittalakkottu, S.
Powiązania:
https://bibliotekanauki.pl/articles/2096359.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
CD4+
T cell
epitope prediction
secretory proteins
Staphylococcus aureus
peptide vaccine
molecular docking
Opis:
One major reason for the lack of clinical success of Staphylococcus aureus vaccine candidates is the inability of the antigens to develop a CD4+ T cell-mediated immune response. Hence, it is important to identify CD4+ T cell antigens from S. aureus. CD4+ T cells are activated following the presentation of epitopes derived from exogenous proteins on HLA class II molecules. Fifty-nine secretory proteins of S. aureus were analyzed computationally for the presence of HLA class II binding peptides. Fifteen-mer peptides were generated, and their binding to 26 HLA class II alleles was predicted. The structural feasibility of the peptides binding to HLA-II was studied using molecular docking. Of the 16,724 peptides generated, 6991 (41.8%) were predicted to bind to any one of the alleles with an IC50 value below 50 nM. Comparative sequence analysis revealed that only 545 of the strong binding peptides are non-self in the human system. Approximately 50% of the binding peptides were monoallele-specific. Moreover, approximately 95% of the predicted strong binding non-self peptides interacted with the binding groove of at least one HLA class II molecule with a glide score better than !10 kcal/mol. On the basis of the analysis of the strength of binding, non-self presentation in the human host, propensity to bind to a higher number of alleles, and energetically favorable interactions with HLA molecules, a set of 11 CD4+ T cell epitopes that can be used as vaccine candidates was identified.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 43-54
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytopathology of canine lymphomas (100 cases)
Autorzy:
Sapierzynski, R.
Micun, J.
Jagielski, D.
Jurka, P.
Powiązania:
https://bibliotekanauki.pl/articles/31296.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cytopathology
canine lymphoma
lymphoma
dog
malignant lymphoma
tumour
animal disease
occurrence
T cell
biopsy
Opis:
Malignant lymphoma is one of the most common malignant tumours occurring in dogs. Fine needle aspiration biopsy (FNAB) is an excellent, specific diagnostic procedure used to assess pathological processes in lymph nodes. The aim of the present study was to conduct a cytopathological analysis of lymphoma in dogs and to analyse some epidemic aspects of occurrence of lymphoma in 100 dogs using Giemsa stained slides. Samples were obtained by fine needle aspiration biopsy, fine needle non-aspiration biopsy, lymph node impression smears and by examination of body cavity effusions. The determination of the type and subtype of tumour was made on the basis of the updated Kiel classification adopted for dogs. Based on cytopathological analysis, the lymphoma was diagnosed in 100 dogs: 44 were female and 56 male. The animals’ age ranged from 1.5 year to 15 years (median: 7.5 years), the animals were of different breeds (72% of all dogs belonged to 28 different breeds) and crossbreeds (28%). In 29% of dogs the regional or general lymphadenomegaly was the only clinical sign observed, in remaining cases (71%) at least one abnormality connected to lymphoma was found. Among all diagnosed lymphomas, high-grade lymphomas were more prevalent (86% of all cases) than low-grade lymphomas (14% of all cases). The possibility of boxers having a predisposition to T cell lymphoma development could be also suspected.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnosis of Pneumocystis carinii infection by a serum polymerase chain reaction
Autorzy:
Golab, E.
Sobolewska, A.
Dzbenski, T.
Bitkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/836353.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
Pneumocystis carinii
infection
serum
diagnosis
laboratory diagnosis
pneumonia
polymerase chain reaction
rRNA gene
T cell
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The presence of CD25 on bovine WC1 plus gamma delta T cells is positively correlated with their production of IL-10 and TGF-beta, but not IFN-gamma
Autorzy:
Maslanka, T.
Jaroszewski, J.J.
Markiewicz, W.
Ziolkowski, H.
Barski, D.
Powiązania:
https://bibliotekanauki.pl/articles/32183.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cattle
WC1 cell
T cell
T lymphocyte
transforming growth factor-beta
interleukin 10
interferon-gamma
CD25 antigen
CD25 molecule
Opis:
WC1+ cells in cattle exhibit both regulatory and effector activities. However, it has not been elucidated whether they are so plastic that both activities co-exist in one cell or there are separate subpopulations of effector and regulatory cells. Since the production of IFN-γ and IL-10 seems to be related to WC1+ cells’ effector and regulatory function, respectively, the main aim of this study was to determine whether those cytokines are produced by separate subpopulations of WC1+, or are co-produced by the same cells. Due to increasingly frequent emphasised role of consumption of IL-2 in the mechanism of suppressor action of mouse CD25+CD4+ T regulatory cells, expression of the receptor’s α chain for interleukin 2 (CD25) on WC1+ lymphocytes has been evaluated. An average of 5.21% of WC1+ cells obtained from PBMCs of 12-month-old heifers show constitutive expression of the CD25 molecule, with CD25highWC1+ and CD25lowWC1+ cells accounting for 1.05% and 4.10% of WC1+ lymphocytes, respectively. For detection of intracellular cytokine production, PBMCs were stimulated with concanavalin A. Both IFN-γ- and IL-10-producing cells within the CD25-WC1+ and CD25+WC1+ subpopulations were mainly separate subpopulations. The average percentage of IFN-γ+IL-10-, IFN-γ-IL-10+ and IFN-γ+IL-10+ cells among CD25-WC1+ lymphocytes was 4.03%, 2.67% and 0.51%, respectively. A positive correlation was observed between the presence of the CD25 molecule on WC1+ lymphocytes and production of IL-10 and TGF-β, because the average percentage of IFN-γ-IL-10+ and IFN-γ+IL-10+ among CD25+WC1+ lymphocytes was 3 and 4.5 times higher as compared to the corresponding cells in the CD25-WC1+ subpopulation, whereas the percentage of IFN-γ+IL-10- cells in both the subpopulations was not significantly different. The percentage of TGF-β+ cells within the CD25+WC1+ subpopulation was 2.72 times as high as that of CD25-WC1+ lymphocytes. Therefore, with respect to the production of IFN-γ, IL-10 and TGF-β, CD25+WC1+ lymphocytes turn out to have a more suppressor profile than CD25-WC1+.
Źródło:
Polish Journal of Veterinary Sciences; 2012, 15, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model
Autorzy:
Noworyta-Glowacka, J.
Beresinska, M.
Bankowski, R.
Wiadrowska, B.
Siennicka, J.
Ludwicki, J.K.
Powiązania:
https://bibliotekanauki.pl/articles/875152.pdf
Data publikacji:
2014
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
chlorpyrifos
pesticide
human exposure
immunomodulation
B cell
T cell
natural killer cell
in vivo model
immune system
lymphocyte
organophosphorus pesticide
Opis:
Background. Current studies have indicated many environmental factors, such as pesticides, that cause immune system disorders through inducing changes in humoral and cellular responses thereby increasing the risk of contracting infectious diseases and cancer. The literature suggests that low exposures to certain organophosphorus pesticides stimulate the immune system, whilst high exposures result in decreased function. Precise mechanisms for the fall in immunocompetence are often unclear, however it can be predicted that the intimate interaction between the nervous and immune systems can potentially lead to toxicity. Objectives. To determine the effects of organophosphorus pesticide, chlorpyrifos that is often used in Poland, on selected immunological responses, such as immune-competent cell proportions formed experimentally in-vivo by cells of Wistar rats during subchronic exposures after 45 and 90 days. Materials and Methods. The test was carried out on ten male and ten female Wistar rats in each of three test groups, who received 3 chlorpyrifos doses for 90 days intragastrically, according to OECD guidelines (No. 401). Two control groups were given olive oil. After completion, the animals were deeply anaesthetised by a mixture of ketamine (Vetaketam) and xylazine (Vetaxym). Immuno-competent cells were profiled by a commercial monoclonal antibody method. In order to measure the dynamics of any changes, the aforementioned immunological responses were investigated after 45 days using the same procedures for obtaining the relevant biological test material. Results. Test animals exposed to chlorpyrifos had altered number of white bood cells which were either increased or decreased relative to controls after 45 and 90 days for all exposure levels used. Conclusions. The study demonstrated changes in white-blood cell (lymphocyte) response profiles, reflecting an immunomodulation although such changes were equivocal, where both suppression and stimulation were observed.
Wprowadzenie. Współczesne badania naukowe wskazują, iż wiele czynników środowiskowych, wliczając w to pestycydy, powoduje zaburzenia układu odpornościowego poprzez indukowanie zmian w odpowiedzi humoralnej i komórkowej, co w efekcie może prowadzić do zwiększonej zapadalności na choroby zakaźne i nowotworowe. Doniesienia literaturowe sugerują, że niskie poziomy narażenia na niektóre pestycydy fosforoorganiczne powodują stymulację układu odpornościowego, zaś wyższe, obniżenie funkcji immunologicznych. W wielu przypadkach nie jest poznany dokładny mechanizm spadku odporności, jednak poprzez związek funkcji neurologicznych i immunologicznych można przewidzieć potencjalne skutki działania toksycznego. Cel. Celem badań było określenie wpływu chloropiryfosu na wybrane parametry odpowiedzi immunologicznej, takie jak skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo szczurów laboratoryjnych szczepu Wistar, w trakcie ekspozycji subchronicznej 45 i 90 dniowej. Materiał i metody. Badanie wykonano na samcach (10 szt.) i samicach (10 szt.) szczurów rasy Wistar. Zwierzętom z grupy badanej podawano dożołądkowo chloropiryfos przez 90 dni, zgodnie z zaleceniami OECD (Guideline No 401). Grupa kontrolna otrzymywała oliwę z oliwek. Po zakończeniu eksperymentu zwierzęta poddawano głębokiej narkozie przy użyciu mieszaniny: ketaminy (Vetaketam) i ksylazyny (Vetaxym). W celu określenia dynamiki ewentualnych zmian zbadano wyżej wymienione parametry immunologiczne po 45 dniach doświadczenia przy zachowaniu tych samych procedur uzyskania materiału badawczego. Wyniki. Uzyskane wyniki wskazują, że narażanie zwierząt doświadczalnych na chloropiryfos zmieniało skład odsetkowy komórek immunokompetentnych w modelu doświadczalnym in vivo zwiększając albo zmniejszając ich wartość w stosunku do poziomów oznaczonych u grupy zwierząt kontrolnych po 45 i 90 dniowej ekspozycji i na wszystkich poziomach narażania. Wnioski. Odnotowane w wyniku przeprowadzonych badań zmiany w profilu białokrwinkowym świadczące o działaniu immunomodulującym były niejednoznaczne przyjmując formę zarówno immunosupresji jak i immunostymulacji.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2014, 65, 4
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Limited pattern of TCR delta chain gene rearrangement on the RNA level in multiple sclerosis
Autorzy:
Nowak, J
Januszkiewicz, D.
Pernak, M.
Hertmanowska, H.
Nowicka-Kujawska, K.
Rembowska, J.
Lewandowski, K.
Nowak, T.
Wender, M.
Powiązania:
https://bibliotekanauki.pl/articles/2041829.pdf
Data publikacji:
2001
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
patient
human genetics
brain
multiple sclerosis
autoagression
T cell receptor rearrangement
gene rearrangement
RNA level
chain gene
Źródło:
Journal of Applied Genetics; 2001, 42, 4; 531-540
1234-1983
Pojawia się w:
Journal of Applied Genetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of global dynamics for HIV-infection of CD4+T cells and its treatment
Autorzy:
Bodzioch, Mariusz
Choiński, Marcin
Foryś, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/747663.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Matematyczne
Tematy:
HIV, CD4+T cell, IL-2, HAART therapy, global stability
HIV, limfocyty CD4$^+$T, interleukina IL-2, terapia HAART, globalna stabilność
Opis:
Przeciwwirusowe terapie dla pacjentów z wirusem HIV są stale ulepszane. Podawanie kombinacji dwóch lub więcej leków powoduje spadek liczby wirusów poniżej poziomu detekcji u wielu pacjentów. W szczególności połączenie wysoce efektywnej terapii antyretrowirusowej (HAART) z aktywatorem immunologicznym (interleukiną 2, IL-2) wydaje się stanowić skuteczną metodę długookresowej kontroli replikacji wirusa  HIV in vivo.W naszym artykule zaproponowaliśmy matematyczny model odpowiedzi odpornościowej dla pacjentów z wirusem HIV przy zastosowaniu połączonej terapii  HAART i IL-2. Zbadaliśmy dynamikę modelu w poszukiwaniu warunków, przy których układ odpornościowy odnawia się dzięki takiej terapii. Z~analitycznego punltu widzenia oznacza to globalną stabilność stanu stacjonarnego odpowiadającego zdrowemu organizmowi. Analiza matematyczna została uzupełniona symulacjami komputerowymi.
Antiviral therapy for HIV-infected patients has greatly improved in recent years. Administration of drug combinations consisting of two or more different drugs can reduce and maintain virus load below detection level in many patients. Cyclic administration of the immune activator interleukin-2 (IL-2) in combination with highly active antiretroviral therapy (HAART) has been suggested as an effective strategy to realize long-term control of HIV replication in vivo. In this article, we formulate a mathematical model of immune response for HIV-infected individual in the presence of HAART and IL-2. We look  for the conditions under which the immune system recovers by applying IL-2 as an immune activator along with HAART. From analytical point of view this means global stability of the disease-free equilibrium. Comprehensive numerical simulations are presented to illustrate the analytical results.
Źródło:
Mathematica Applicanda; 2018, 46, 1
1730-2668
2299-4009
Pojawia się w:
Mathematica Applicanda
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Low Leakage and Robust Sub-threshold SRAM Cell Using Memristor
Autorzy:
Mustaqueem, Zeba
Ansari, Abdul Quaiyum
Akram, Md Waseem
Powiązania:
https://bibliotekanauki.pl/articles/2200681.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
6T SRAM cell
memristor
power dissipation
read and write operation
leakage current
stability
non-volatile circuit
Opis:
This work aims to improve the total power dissipation, leakage currents and stability without disturbing the logic state of SRAM cell with concept called sub-threshold operation. Though, sub-threshold SRAM proves to be advantageous but fails with basic 6T SRAM cell during readability and writability. In this paper we have investigated a non-volatile 6T2M (6 Transistors & 2 Memristors) sub-threshold SRAM cell working at lower supply voltage of VDD=0.3V, where Memristor is used to store the information even at power failures and restores previous data with successful read and write operation overcomes the challenge faced. This paper also proposes a new configuration of non-volatile 6T2M (6 Transistors & 2 Memristors) subthreshold SRAM cell resulting in improved behaviour in terms of power, stability and leakage current where read and write power has improved by 40% and 90% respectively when compared to 6T2M (conventional) SRAM cell. The proposed 6T2M SRAM cell offers good stability of RSNM=65mV and WSNM=93mV which is much improved at low voltage when compared to conventional basic 6T SRAM cell, and improved leakage current of 4.92nA is achieved as compared.
Źródło:
International Journal of Electronics and Telecommunications; 2022, 68, 4; 667--676
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3)
Autorzy:
Jerzak, Malgorzata
Nowakowski, Andrzej
Górski, Andrzej
Baranowski, Włodzimierz
Kniotek, Monika
Powiązania:
https://bibliotekanauki.pl/articles/989476.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
vulvar cancer
nk cell
pregnancy
t reg
Opis:
Introduction and objective. The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3). Material and methods. NK cell and T reg activity in the study patient were analysed using flow cytometry. Results. Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome. Conclusions. Although vulvar cancer may influence immune cell activity, this issue merits further study.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell-mediated response in nodular and ocular forms of human toxoplasmosis
Autorzy:
Dziubek, Z.
Zarnowska, H.
Gorski, A.
Basiak, W.
Kajfasz, P.
Bielawska, M.
Powiązania:
https://bibliotekanauki.pl/articles/838536.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
toxoplasmosis
cell-mediated response
T lymphocyte
man
humoral response
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mycotoxin – induced apoptosis in swine kidney epithelial cells
Autorzy:
Chrustek, Agnieszka
Twarużek, Magdalena
Zastempowska, Ewa
Grajewski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/2182166.pdf
Data publikacji:
2016-12-31
Wydawca:
Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Tematy:
aflatoxins
apoptosis
mycotoxins
ochratoxin A
swine kidney cell line
T2 toxin
Opis:
Apoptosis, as the programmed cell death, plays a significant role in proper functioning of an organism, both in the postnatal period and during embryogenesis. Disturbances in this process can lead to the occurrence of several dysfunctions, e.g. cancer, stroke, Alzheimer’s disease and others. Apoptosis can be triggered by factors such as oxidative stress, free radicals, UV radiation and cytotoxic drugs, but also mycotoxins, e.g. aflatoxins, ochratoxin A and trichothecenes. These toxins are produced primarily by fungi of Aspergillus, Penicillium, Fusarium and Stachybotrys genera. The aim of the study was to investigate the effect of mycotoxins on the occurrence of apoptosis in the swine kidney (SK) epithelial cells. For this purpose, trichothecene T2 toxin was used at a concentration of 2.5 µM and 25 µM, aflatoxin B1 at a dose of 10 µM and 30 µM, and ochratoxin A concentrations of 50 µM and 80 µM. The results were assessed using flow cytometer Muse Cell Analyzer (Merck). Studies have shown high sensitivity of the cell line SK on mycotoxins. Apoptosis was caused by all kinds of toxins and depended on the dose of examined substance. T2 toxin at a concentration of 2.5 µM caused apoptosis in 6.9% of the cells, whereas at a concentration of 25 µM in 26.35% of the cells. Aflatoxin B1 used at concentrations of 10 µM and 30 µM caused apoptosis in 13.5% and 40.6% of the cells, respectively. The use of ochratoxin A in concentrations of 50 µM and 80 µM caused the occurrence of apoptosis respectively in 68.51% and 60.41% of the cells.
Źródło:
Annales Universitatis Paedagogicae Cracoviensis Studia Naturae; 2016, 1; 105-114
2543-8832
2545-0999
Pojawia się w:
Annales Universitatis Paedagogicae Cracoviensis Studia Naturae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seeding cell number required for optimal lipid accumulation during adipocyte differentiation using 3T3-L1 cell line
Autorzy:
Ariyanto, Eko Fuji
Odaiyappan, Naren A/L S.
Lidyana, Lynna
Wikayani, Tenny Putri
Qomarilla, Nurul
Wira, Dwi Wahyudha
Triatin, Rima Destya
Powiązania:
https://bibliotekanauki.pl/articles/1076694.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
3T3-L1 preadipocytes
differentiation
lipid accumulation
seeding cell number
Opis:
Obesity is one of the major causes of metabolic diseases such as diabetes and heart attack, and, hence, can lead to low quality of life. Elaborating adipocyte differentiation is very crucial for formulating the treatment and prevention of obesity. The objective of this study is to investigate the seeding cell number required to obtain optimum lipid accumulation during adipocyte differentiation using the 3T3-L1 cell line. Two sets of 5.48×104 (for Day 0 and Day 8 of differentiation), of 10.96×104 (for Day 8) and of 21.92×104 (for Day 8) of 3T3-L1 cells were seeded in each wells of a 12-well plate. Isobuthylmethylxanthine (IBMX), Dexamethasone, and Insulin-containing differentiation cocktails was added into the medium at Day 0 for 48 hours. The medium was changed every two days. Day 0 and Day 8 samples were then stained using Oil Red O and were examined under the microscope to observe the lipid droplets (red-coloured). The lipid droplets were quantified by measuring the absorbance at wavelength of 550 nm. In the study, seeding the number of 10.96×104 cells produced very significantly higher lipid accumulation, as compared with seeding the number of 5.48×104 cells. However, doubling the seeding number into 21.92×104 cells did not increase the lipid droplets significantly. This study found that the optimum seeding number to obtain the maximum lipid droplets during 3T3-L1 adipocyte differentiation was 10.96×104 cells.
Źródło:
World News of Natural Sciences; 2019, 25; 220-226
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and characterization of rat gastric microvascular endothelial cells as a model for studying gastric angiogenesis in vitro
Autorzy:
Jones, M.K.
Wang, H.
Tomikawa, M.
Szabo, I.L.
Kawanaka, H.
Sarfeh, I.J.
Tarnawski, A.S.
Powiązania:
https://bibliotekanauki.pl/articles/71014.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
capillary microvessel
gastric endothelial cell
T lymphocyte
endothelial cell
monoclonal antibody
monocyte
angiogenesis
microvasculature
stomach
in vitro
rat
platelet
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CD4 and CD8 cells in mice infected with Trichinella spiralis and treated with cyclosporine A
Autorzy:
Karmanska, K
Houszka, M.
Mista, D.
Stefaniak, E.
Powiązania:
https://bibliotekanauki.pl/articles/836501.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
immunoenzymatic method
mouse
infection
mice
cell
T lymphocyte
immunofluorescent method
cyclosporin A
larva
Trichinella spiralis
Opis:
Studies were undertaken to evaluate by parasitological techniques the course of intestinal and muscular invasions in mice infected with Trichinella spiralis and treated with TFX-Thymomodulin (TFX-Th). Studies were conducted on 120 mice of BALB/c and SWISS strains, infected each with a mean invasive dose of 300 T. spiralis larvae. TFX-Th (Thymoorgan GmbH Pharmazie Co. KG, Vienenburg, Germany) was administered subcutaneously at 30 mg/kg body weight. Depending upon duration of TFX-Th administration and stages of intestinal and muscular invasions, three experiments were distinguished in the study. The results indicated that TFX-Th promoted eradication of larvae from muscles, whether administered at the early of the late stage of T. spiralis invasion.
Źródło:
Annals of Parasitology; 1994, 40, 4
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 27

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