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    Wyświetlanie 1-17 z 17
    Tytuł:
    Preparation of conjugated nitroalkenes: short review
    Autorzy:
    Zawadzińska, Karolina
    Gaurav, Gajendra Kumar
    Jasiński, Radomir
    Powiązania:
    https://bibliotekanauki.pl/articles/35110314.pdf
    Data publikacji:
    2022
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    nitroalkenes
    organic synthesis
    nitrocompounds
    nitroalkeny
    synteza organiczna
    nitrozwiązki
    Opis:
    Key protocols of the preparation of conjugated nitroalkenes were reviewed and critically discussed. It was established, that optimal strategy for the obtaining of target compounds are small molecules extrusion processes from saturated nitro-compounds. Among them, the most universal methodologies based on carboxylic acids elimination have been discussed, which provide for smooth applications.
    Źródło:
    Scientiae Radices; 2022, 1, 1; 69-83
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mikrofale w syntezie organicznej: historia i perspektywy
    Autorzy:
    Lipińska, T. M
    Powiązania:
    https://bibliotekanauki.pl/articles/273516.pdf
    Data publikacji:
    2013
    Wydawca:
    Roble
    Tematy:
    mikrofale
    promieniowanie mikrofalowe
    technika mikrofalowa
    synteza organiczna
    microwaves
    microwave radiation
    microwave techniques
    organic synthesis
    Źródło:
    LAB Laboratoria, Aparatura, Badania; 2013, 18, 4; 6-10
    1427-5619
    Pojawia się w:
    LAB Laboratoria, Aparatura, Badania
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nowoczesne metody pozyskiwania substancji biologicznie aktywnych przy zastosowaniu reakcji wieloskładnikowych ze szczególnym uwzględnieniem reakcji Ugi
    New methods of receive biologically active substances in multicomponent reactions with particular focus on Ugi reaction
    Autorzy:
    Ryng, S.
    Jęśkowiak, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/172211.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    reakcja wieloskładnikowa
    reakcja Ugi
    synteza organiczna
    synteza ukierunkowana na różnorodność
    multicomponent reaction
    Ugi reaction
    diversity-oriented synthesis
    Opis:
    In the last decade a change of thought has taken place in the pharmaceutical industry which has led to a renaissance of the Multicomponent reactions (MCRs) [1]. Under the inspiration of diversity-oriented-synthesis (DOS), numerous efforts have been devoted to find powerful synthetic tools for rapidly accessing maximum molecular diversity with minimum cost. In the toolbox enabling DOS for generating molecular libraries, MCRs are now recognized as one of the most useful and powerful strategies [2], which provide the highest number of compounds for the least synthetic effort [3]. Following the rapid progress in the research area of MCRs, widespread application has been found in many different areas such as chemical biology, natural product synthesis, pharmaceuticals as well as agrochemistry [2]. The overall aim of a DOS is to generate a small-molecule collection with a high degree of structural, and thus functional, diversity that interrogates large areas of chemical space simultaneously [4]. In Targed-Oriented Synthesis (TOS) a complex target is transformed into a sequence of progressively simpler structures by formally performing chemical reactions in the reverse-synthetic direction [3]. Special subclasses are isocyanide based MCRs (IMCRs). They are particularly interesting because they are more versatile and diverse than the remaining MCRs. Today most MCRs chemistry performed with isocyanides relates to the classical reactions of Passerini and Ugi (Scheme 1)[5]. In Ugi four-component reaction (U-4CR), carboxylic acids, primary amines and oxo components (aldehydes or ketones) react with isocyanides in polar solvents to obtain -amino carboxamides (Schemes 2 and 3). Occasionally however, selective conversion of amide groups into other functional groups is desirable for an increase of diversity of the IMCR-derived compounds [6]. In this reaction two substituted amide groups are formed under release of one equivalent of water. Thus, the U-4CR is an atom-economic and environmentally friendly reaction. It was also shown that water can be used as the solvent. This reaction is typically performed by stirrling the components for approximately 1 day in small quantities of a protic solvent (e.g. methanol or trifluoroethanol) [7]. The examples of Ugi reactions are described in the Schemes 4–10. Multicomponent reactions have become attractive tools in modern synthetic organic chemistry. Among their many advantages, they allow the creation of large chemical libraries of diverse, complex molecular structures, starting from simple materials within a short time frame. Not surprisingly, these particular features have made MCRs especially appealing to medicinal chemists [8].
    Źródło:
    Wiadomości Chemiczne; 2017, 71, 1-2; 45-63
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kwas winowy i jego pochodne we współczesnej chemii organicznej
    Tartaric acid and its derivatives in current organic chemistry
    Autorzy:
    Grajewski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/171622.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    kwas winowy
    winiany
    stereochemia
    synteza organiczna
    kataliza
    tartaric acid
    tartrates
    stereochemistry
    organic synthesis
    catalysis
    Opis:
    The tartaric acid and its salts have been present in chemistry for almost 350 years, since Pierre Seignette isolated Rochelle salt in 1675. Since that time tartaric acid and its derivatives have been often used in chemistry due to their accessibility, enantiopurity, relatively low cost and presence of different functional groups which easily allow to modify the molecule. Many tartaric acid derivatives serve as catalysts in important stereoselective transformations such as Sharpless asymmetric epoxidation or asymmetric Rousch aryloboronation. In many others reactions tartaric acid have been employed as a chiral building block for natural products synthesis, highly functionalized molecules or ligand design such as well known TADDOL or its analogues. Its polar functional groups allow to form crystals with amines and aminoalcohols what is widely used for their enantiopurification and resolution. The relatively new subdiscipline is the use of tartaric acid in chiral recognition and chiral discrimination in nanochemistry and enantioselective chromatography. The other, recent applications of tartaric acid include functionalization of metal layers, antibacterial and antifungal activity among many others. The significance of tartaric acid is evident – since 2000, words “tartaric acid” or “tartrates” can be found in databases over four thousand times. Taking that into account this short review is concentrated on selected applications of tartaric acid and its derivatives in organic chemistry in recent several years.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 5-6; 495-519
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowania enzymów z tkanek zwierzęcych w syntezie organicznej i biokatalizie. Część I. Hydrolazy
    Applications of hydrolases from animal tissues in organic synthesis
    Autorzy:
    Hibner, H.
    Ostaszewski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/172016.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    enzymy zwierzęce
    biokataliza
    synteza organiczna
    zastosowania hydrolaz
    animal enzymes
    biocatalysis
    organic synthesis
    applications of hydrolases
    Opis:
    This work presents systematically enzymes which can be obtained form animal tissue and their applications in synthesis of pharmaceuticals and nonracemic organic compounds. It lays out similarities in procedures of isolation and purification of particular enzymes. Such procedures usually are so simple that they can be used in every industrial or research laboratory. Most animal enzymes are well-investigated and their structures and substrate specificity are known. They are used as biocatalysts in many chemical processes. Others were used in one or a few reactions but their natural substrates and biochemical properties are described. Trials of predicting potential applications of such enzymes and other substrates for them were done. In this part typical applications of hydrolases: lipases (porcine pancreatic lipase [8–17], lamb pregastric lipase [22]), esterases (porcine, horse liver esterase, liver acetone powders [34–43, 46]), L-aminoacylase [48, 49], pepsin [56], trypsin [58, 59], imidase [52, 53], aldohexose hydrolases [60, 62-64], nucleotide pyrophosphatase [65]; were described. Also examples of immobilized [10, 32] or recombined [49] enzymes are given in the text. These modifications enhance catalytic properties or reduce costs of using enzymes. In practical applications a biocatalytic effect of enzymes from animal sources is often compared with microbial ones. This text is focused on processes where animal enzymes gave much better results (yield and enantioselectivity) than microorganisms. They are also proper, unlike whole microorganisms, to investigate and computer analysis of mechanism of the reaction. Enzymes isolated from animal tissues usually have well-defined structure of active site which is a key to predict mechanisms.
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 7-8; 557-583
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zastosowania wybranych enzymów z tkanek zwierzęcych w syntezie organicznej i biokatalizie. Część II. Oksydoreduktazy, transferazy, liazy, izomerazy
    Applications of enzymes from animal tissues in organic synthesis, Part 2
    Autorzy:
    Hibner, H.
    Ostaszewski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/172018.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    enzymy zwierzęce
    biokataliza
    synteza organiczna
    zastosowania enzymów
    animal enzymes
    biocatalysis
    organic synthesis
    application of enzymes
    Opis:
    This work shows systematically known types of animal enzymes and their applications in synthesis of pharmaceuticals and nonracemic organic compounds. It lays out similarities in procedures of isolation and purification of particular enzymes. Such procedures usually are so simple that they can be used in every industrial or research laboratory. Most animal enzymes are well-investigated and their structures and substrate specificity are known. They are used as biocatalysts in many chemical processes. Others were used in one or a few reactions but their natural substrates and biochemical properties are described. Trials of predicting potential applications of such enzymes and other substrates for them were performed. Typical applications of: – Oxidoreductases: horse liver alcohol dehydrogenase [3–13], lactate dehydrogenase [16–18], glutamate dehydrogenase [19, 20], carbonyl reductase [24], catalase [27]; – Transferases: transaldolase [29], galactosyltransferase [30], UDP-glucuronosyltransferase [31], fucosyltransferase [34], farnesyl diphosphate synthase [35]; – Lyases: DOPA decarboxylase [38, 39], aldolase [42]; – Isomerases: N-acyl-D-glucosamine 2-epimerase [44] were described. Also examples of or recombined [24, 39, 44] enzymes are given in the text. These modifications enhance catalytic properties or reduce costs of using enzymes. In practical applications a biocatalytic effect of enzymes from animal sources is often compared with microbial ones. This text is focused on processes where animal enzymes gave much better results (yield and enantioselectivity) than microorganisms. They are also proper, unlike whole microorganisms, to investigate and computer analysis of mechanism of the reaction. Enzymes isolated from animal tissues usually have well-defined structure of active site which is a key to predict mechanisms. A quantitative analysis of applications of these enzymes was performed. Among animal enzymes hydrolases and oxidoreductases have found the most applications in synthesis. Transferases are also often used. Other classes of enzymes seldom act as biocatalysts. It is general tendency, true also in relation to microbial and plant enzymes.
    Źródło:
    Wiadomości Chemiczne; 2011, 65, 7-8; 585-607
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biokatalityczne metody otrzymywania nieracemicznych alkoholi aryloallilowych
    Biocatalytic methods for preparation of nonracemic arylallylic alcohols
    Autorzy:
    Szymkuć, S.
    Ostaszewski, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/172469.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    biokataliza
    nieracemiczne alkohole aryloallilowe
    synteza organiczna
    enzymy
    mikroorganizmy
    biocatalysis
    nonracemic arylallylic alcohols
    organic synthesis
    enzymes
    microorganisms
    Opis:
    Different methods for preparing nonracemic arylallylic alcohols are presented in this work. A key feature was an application the biocatalyst as a mean to obtain final products. These compounds play an important role in pharmaceutical industry, because they are substrates in the synthesis of various important therapeutics [1–3]. Methods presented in this work are divided into five main groups: 1. enantioselective hydroxylation, 2. microbiological deracemization, 3. enzymatic kinetic resolution, 4. enzymatic dynamic kinetic resolution, 5. enantioselective reduction. First two methods use only microorganisms like bacteria [4, 5, 10], fungi [6–8] or yeasts [11] as biocatalysts. Owing to the metabolic processes in the cells it was possible to obtain nonracemic arylallylic alcohol (results for method 2 are presented in Table 1). Unfortunately, the data were insufficient to create direct correlation between values of enantiomeric excess and types of applied microorganisms. Methods 3 and 4 used only isolated enzymes as biocatalysts. They belong to two classes: hydrolases and oxidoreductases. Oxidoreductases were used in the enzymatic kinetic resolution based on the enantioselective oxidation [28] of one enantiomer of the racemic arylallylic alcohol. Nevertheless, hydrolases [12–27], mainly lipases, isolated from microorganisms are enzymes of common use in enzymatic kinetic resolution. Owing to this method it was possible to obtain final products with excellent enantioselectivity (results are presented in Tables 2 and 3). Because kinetic resolution and dynamic kinetic resolution are related processes, in most cases similar enzymes are used. The choice of lipases as biocatalysts for method 4 was caused by the fact that they are able to catalyze enantioselective transesterification of arylallylic alcohols or their acetates. Furthermore, racemization is very important factor for efficacy of dynamic kinetic resolution processes. In most cases they are catalyzed by different types of complexes based on palladium [30, 31] and ruthenium [32, 34]. Final products prepared by this method had very high enantiomeric excesses and yields up to 93% (results are presented in Tables 4 and 5). The only method, presented in this work, that allowed to use both enzymes [39–41] and microorganisms [35–38] as biocatalysts, was enantioselective reduction. This method allows to obtain nonracemic arylallylic alcohols with excellent enantiomeric excess and yields up to 85% (results are presented in Table 6). In summary, all methods presented in this work show the advantages of biocatalysis as an alternative route to traditional chemical method
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 1-2; 93-118
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anion alkoksyallenowy w syntezie związków naturalnych i ich analogów
    Alkoxyallene anion in the synthesis of natural products and their analogues
    Autorzy:
    Busiak, B.
    Utecht, G.
    Jasiński, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/172377.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    alkoksyalleny
    addycja nukleofilowa
    synteza organiczna
    związki naturalne
    związki heterocykliczne
    alkoxyallenes
    nucleophilic addition
    organic synthesis
    natural products
    heterocycles
    Opis:
    Among diverse systems containing multiple bonds, cumulenes are recognized as the most reactive derivatives towards both nucleophilic and electrophilic agents, and for this reason, they are considered as important class of substrates for organic synthesis. Over the last three decades alkoxyallenes have been demonstrated as highly useful C3-building blocks for the construction of numerous N-, O-, and S-containing heterocycles, including enantiomerically pure compounds. Special attention has been paid to lithiated alkoxyallenes as suitable nucleophiles for the reactions with alkyl halides, strained heterocycles, carbonyl compounds and their derivatives. The presence of the allene unit in the initially formed adducts opens up several possibilities in the preparation of more complex systems. In this review, selected applications of lithiated alkoxyallenes in the synthesis of natural products and their analogues are discussed.
    Źródło:
    Wiadomości Chemiczne; 2016, 70, 1-2; 3-23
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Bezpośrednia synteza azydków i tioli organicznych pochodnych glikolu etylenowego w zmodyfikowanej reakcji Appela
    Direct synthesis of organic azides and thiols derived from ethylene glycol via modified Appel reaction 1
    Autorzy:
    Stefaniak, M.
    Jasiński, M.
    Urbaniak, K.
    Romański, J.
    Seliger, P.
    Gutowska, N
    Powiązania:
    https://bibliotekanauki.pl/articles/141899.pdf
    Data publikacji:
    2014
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
    Tematy:
    synteza organiczna
    tiole
    azydki
    reakcja „click”
    makrocykle
    kompleksy metali
    organic synthesis
    thiols
    azides
    click reaction
    macrocycles
    metal complexes
    Opis:
    Klasyczną metodę konwersji alkoholi pierwszorzędowych w odpowiednie halogenki alkilowe z użyciem trifenylofosfiny oraz tetrahalogenometanu, tzw. reakcję Appela, zaadoptowano do bezpośredniej syntezy terminalnych tioli i azydków organicznych pochodnych glikolu etylenowego oraz jego siarkowego analogu. W kluczowym etapie opisanej procedury one-pot, otrzymane in situ, w reakcji z N-bromosukcynimidem (NBS), odpowiednie dibromopochodne zostały przekształcone w związki docelowe w reakcji z nukleofilem siarkowym lub azotowym. Wybrane diazydki wykorzystano w syntezie nowych układów makrocyklicznych, które przetestowano pod kątem ich właściwości kompleksotwórczych.
    Classical method of conversion of primary alcohols into corresponding alkyl halides by usage of triphenylphosphine and tetrahalogenated methane, so-called Appel reaction, was adopted for the direct synthesis of terminal organic thiols and azides derived from ethylene glycol and its sulfurated analogue. In key step of the presented ‘one-pot’ protocol, corresponding dibromides, generated in situ via reaction with N-bromosuccinimide (NBS), were converted into desired products by treatment with appropriate sulfur or nitrogen nucleophile. A series of diazides and dithiols derived from (poly)ethylene glycols and their sulfur analogues were obtained. Selected diazides were utilized for the construction of novel macrocyclic systems, that were tested incontext of their complexing properties.
    Źródło:
    Chemik; 2014, 68, 7; 592-599
    0009-2886
    Pojawia się w:
    Chemik
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ditlenek węgla w syntezie organicznej
    Carbon dioxide in organic synthesis
    Autorzy:
    Burczyk, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/172758.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    wiązanie ditlenku węgla
    surowce odnawialne
    synteza organiczna
    kataliza
    kompleksy metali przejściowych
    carbon dioxide fixation
    renewable resources
    organic synthesis
    catalysis
    transition metal complexes
    Opis:
    Carbon dioxide is an abundant, cheap, almost nontoxic, thermodynamically stable, inert electrophile. Exploitation of CO 2 as a chemical feedstock, although will almost certainly not reduce its atmospheric concentration significantly, aims to generate high-value products and more-efficient processes. In recent years efficient transition-metal complexes have been used to perform homogeneously catalyzed transformations of CO 2 . This paper presents an overview of available catalytic routes for the synthesis of carboxylic acids, lactones, urea and carbamates, linear and cyclic carbonates as well as polycarbonates. Reduction processes of CO 2 are shortly men - tioned as well. C arboxylic acids have been synthesized via : (i) carboxylation of organolithium, organomagnesium (Scheme 2 [35]), organoboron (Scheme 3 [40 -42]), organozinc (Scheme 4 [43, 44]) and organotin (Scheme 5 [45, 46]) compounds; (ii) oxidative cycloaddition of CO 2 to olefins and alkynes (Scheme 6 -10 [47 -50, 57]) catalyzed by Ni(0)-complexes; (iii) transition-metal catalyzed reductive hydrocarboxylation of unsaturated compounds (Scheme 11, 12 [64 -67]); (iv) carboxylation of C-H bond (Scheme 13 [69 -71]). Telomerization of dienes, for instance 1,3-butadiene, and CO 2 in the presence of Ni(II) and Pd(II) complexes leads to lactones and esters of carboxylic acids (Scheme 14, 15 [73 -79]). Nucleophilic ammonia, primary and secondary amines react with CO 2 to give, respectively, urea and carbamic acid esters - carbamates and isocyanates (Scheme 16 -18 [94, 95]), thus eliminating the use of phosgene in their synthesis. CO 2 reacts with alcohols, diols and epoxides in the presence of transition-metal complexes (Fig. 2) and the reaction products are: linear carbonates (Scheme 20, 21 [110 -118]), cyclic carbonates (Scheme 22 -24 [153 -170]) and polycarbonates (Scheme 25, 26, Fig. 3, Tab. 1 [179 -186]). Finally, hydrogenation of CO 2 , leading to the formation of CO, HCOOH, CH 3 OH, CH 4 , C 2 H 6 and C 2 H 4 (Scheme 27), as well as electrochemical and photochemical reductions in the pre - sence of homogeneous and heterogeneous catalysts have been shortly reviewed.
    Źródło:
    Wiadomości Chemiczne; 2013, 67, 1-2; 1-53
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synteza policyklicznych, skondensowanych węglowodorów heteroaromatycznych zawierających w pierścieniu atomy azotu i siarki
    Synthesis of polycyclic, linearly fused heteroaromatic hydrocarbons containing nitrogen and sulfur atoms
    Autorzy:
    Bodzioch, A.
    Bałczewski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/410271.pdf
    Data publikacji:
    2010
    Wydawca:
    Uniwersytet Humanistyczno-Przyrodniczy im. Jana Długosza w Częstochowie. Wydawnictwo Uczelniane
    Tematy:
    organiczna elektronika
    liniowo skondensowane, policykliczne węglowodory heteroaromatyczne
    związki czynne biologicznie
    synteza
    organic electronics
    linearly fused, policyclic heteroaromatic hydrocarbons
    biologically active compounds
    synthesis
    Opis:
    W przeglądzie zaprezentowano metody syntezy policyklicznych, liniowo skondensowanych węglowodorów heteroaromatycznych zawierających w pierścieniu aromatycznym atomy siarki i azotu. W ostatnich latach związki te znalazły praktyczne zastosowanie w syntezie produktów czynnych biologicznie oraz w badaniach nad najnowszej generacji organicznymi elementami elektronicznymi, takimi jak diody, tranzystory, ogniwa, lasery, bramki logiczne, koncentratory słoneczne, itp.
    In this review, methods of syntheses of polycyclic, linearly fused heteroaromatic hydrocarbons containing nitrogen and sulfur atoms are presented. These compounds have recently found applications in synthesis of biologically active compounds and in research on the newest generation of organoelectronic devices, like diodes, transistors, photovoltaics, lasers, logic gates, solar concentrators, etc.
    Źródło:
    Chemistry, Environment, Biotechnology; 2010, 14; 7-33
    2083-7097
    Pojawia się w:
    Chemistry, Environment, Biotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Metal-organic frameworks for efficient drug adsorption and delivery
    Autorzy:
    Hyjek, Kornelia
    Jodłowski, Przemysław
    Powiązania:
    https://bibliotekanauki.pl/articles/35134841.pdf
    Data publikacji:
    2023
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    drug delivery systems
    metal-organic frameworks
    synthesis
    characterization
    drug loading
    biocompatibility
    systemy dostarczania leków
    sieć metalo-organiczna
    synteza
    charakterystyka
    akumulacja leku
    biokompatybilność
    Opis:
    In recent years, the number of materials used as drug delivery systems (DDS) has increased dramatically. The widespread use of DDSs has improved both the safety and efficacy of therapy. The systems currently in use pose numerous drawbacks and require proper improvements. Although many modern materials are being developed, metal-organic frameworks (MOFs) deserve special attention. Thermal and chemical stability, high specific surface area, low toxicity, high biocompatibility, and great potential for modification are the main features enabling MOFs to be used as DDS. In this review, we describe MOFs, their structure, synthesis, and characterization, as well as drug loading, drug release kinetics, and bioassays. A critical approach is to outline the disadvantages as well as the limitations of MOFs and to identify areas that need to be studied more thoroughly. Nonetheless, the prospective nature of MOFs as DDS and potential adsorbents in overdose or poisoning is presented and highlighted.
    Źródło:
    Scientiae Radices; 2023, 2, 2; 115-189
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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