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Wyświetlanie 1-15 z 52
Tytuł:
Oracle Multimaster Replication Maintance Optimization
Autorzy:
Paci, Hakik
Xhuvani, Aleksander
Powiązania:
https://bibliotekanauki.pl/articles/1035780.pdf
Data publikacji:
2011
Wydawca:
Academicus. International Scientific Journal publishing house
Tematy:
Oracle Multimaster Data Replication
Replication
Replication group
Opis:
This paper presents a new solution for adding a new database server on an existing Oracle Multimaster data replication system. In normal conditions adding a new database server on this system we cannot insert, delete and update data during this time. So during this time the system is down and we can make only queries. The time for adding the new database server depends on the number of tables on the replication group and on the network conditions. To reduce this time we propose to replace the Replication group in more than one replication group based on logic of database schema. So we will have a replication group for base data, one replication group for most populated tables and another group for non most used tables. Using this method on the Oracle database schema with 250 replication tables and communication speed 1Mbit/s, the time reduced seven times. This research is implemented on border control system (Total Information Management System at Ministry of Interior) in Albania and using this solution we can add or remove replication sites with minimal down time.
Źródło:
Academicus International Scientific Journal; 2011, 03; 145-152
2079-3715
2309-1088
Pojawia się w:
Academicus International Scientific Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Performance evaluation of different types of session guarantees version vectors
Autorzy:
Piątkowski, Ł.
Sobaniec, C.
Sobański, G.
Powiązania:
https://bibliotekanauki.pl/articles/206073.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
session guarantees
distributed
replication
Opis:
Session guarantees define consistency properties of replicas in a distributed system from the point of view of a single, migrating client. Consistency is checked by ensuring execution of required operations by servers. Consistency protocols of session gua- rantees usually use version vectors for efficient representation of sets of writes. This paper presents performance evaluation of several consistency protocols of session guarantees that use different forms of version vectors. The evaluation was carried out by means of simu- lation experiments.
Źródło:
Control and Cybernetics; 2011, 40, 3; 731-749
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Achieving high dependability of an endoscopy recommender system (ERS)
Autorzy:
Zieliński, J.
Krawczyk, H.
Powiązania:
https://bibliotekanauki.pl/articles/1965771.pdf
Data publikacji:
2004
Wydawca:
Politechnika Gdańska
Tematy:
telemedicine
security
dependability
replication
Opis:
The paper presents a strategy for achieving high dependability of a computer-based system devoted to endoscopic examination (ERS). Two levels of replication are used: hardware (3 computers) and database (redundant copies). Archivisation of documents describing patient examinations and films made during such examinations is described. The influence of the used techniques on performance and dependability of the replicated system is estimated.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2004, 8, 2; 237-242
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Creative industries and knowledge replication
Autorzy:
Łukasik, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/419668.pdf
Data publikacji:
2019
Wydawca:
Wydawnictwo Uniwersytetu Ekonomicznego we Wrocławiu
Tematy:
creative industries
management
knowledge replication
Opis:
The concept of creative industries is becoming popular in recent years. Therefore, many publications deal with this topic. Nevertheless, fewer of them are dedicated to managerial issues. Most publications concentrate on the scope of creative industries and their influence on economy and society. The first aim of this paper is to present the specificity of management of organization in creative industry and its activity. The second aim is to collect and cite different definitions of knowledge replication to explain the meaning of the notion of knowledge replication. The third aim is to show the role of knowledge replication for organization’s activity in creative industries. The article also contains an introduction concerning different approaches to definition and classification of creative industries.
Źródło:
Nauki o Zarządzaniu; 2019, 24, 3; 10-15
2080-6000
Pojawia się w:
Nauki o Zarządzaniu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypotheses and dilemmas around the origin and uniqueness of life
Autorzy:
Legocki, Andrzej B.
Powiązania:
https://bibliotekanauki.pl/articles/1916654.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
origin of replication
chemical evolution
Opis:
The emergence of life on Earth and its almost infinite diversity, reflected by a myriad of living organisms, are among the dilemmas that have forever fascinated scientists and philosophers. Today, we are still not able to determine what exactly initiated the chain of events leading to the rise of life – the mechanism of replication of initial structures or perhaps the occurrence of first metabolic reactions. Further approximations of these issues shall probably constitute an overwhelming driving force for future development of life sciences.
Źródło:
Nauka; 2020, 3
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Database Replication for Disconnected Operations with Quasi Real-Time Synchronization
Autorzy:
Mucha, Rafał
Baliś, Bartosz
Grigoras, Costin
Kitowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/27312921.pdf
Data publikacji:
2023
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
multi-primary database replication
Bucardo
EDB Replication Server
PostgreSQL
PostgresBDR
TPC
CAP theorem
continuous synchronizatio
Opis:
Database replication is a way to improve system throughput or achieve highavailability. In most cases, the use of an active-active replica architecture isefficient and easy to deploy. Such a system has CP properties (from the CAPtheorem: consistency, availability, and network-partition tolerance). Creat-ing an AP (available and partition-tolerant) system requires the use of multi-primary replication. Because of the many difficulties in its implementation, thisapproach is not widely used; however, ALICE’s deployment of CCDB (exper-iment conditions and calibration database) needs to be an AP system in twolocations. This necessity became the inspiration for examining the state-of-the-art methods in this field and testing the available solutions. The tests thatwere performed evaluated the performance of the chosen replication tools: Bu-cardo, and EDB Replication Server; these showed that the tested tools couldbe successfully used for the continuous synchronization of two independentdatabase instances.
Źródło:
Computer Science; 2023, 24 (3); 407--426
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification and properties of the Deinococcus grandis and Deinococcus proteolyticus single-stranded DNA binding proteins (SSB)
Autorzy:
Filipkowski, Paweł
Kur, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1041115.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bacteria
purification
expression
DNA replication
SSB
Opis:
To study the biochemical properties of SSB's from Deinococcus grandis (DgrSSB) and Deinococcus proteolyticus (DprSSB), we have cloned the ssb genes obtained by PCR and have developed Escherichia coli overexpression systems. The genes consist of an open reading frame of 891 (DgrSSB) and 876 (DprSSB) nucleotides encoding proteins of 296 and 291 amino acids with a calculated molecular mass of 32.29 and 31.33 kDa, respectively. The amino-acid sequence of DgrSSB exhibits 45%, 44% and 82% identity and the amino-acid sequence of DprSSB reveals 43%, 43% and 69% identity with Thermus aquaticus (TaqSSB), Thermus thermophilus (TthSSB) and Deinococcus radiodurans SSBs, respectively. We show that DgrSSB and DprSSB are similar to Thermus/Deinococcus SSBs in their biochemical properties. They are functional as homodimers, with each monomer encoding two single-stranded DNA binding domains (OB-folds). In fluorescence titrations with poly(dT), both proteins bind single-stranded DNA with a binding site size of about 33 nt per homodimer. In a complementation assay in E. coli, DgrSSB and DprSSB took over the in vivo function of EcoSSB. Thermostability with half-lives of about 1 min at 65-67.5°C make DgrSSB and DprSSB similar to the known SSB of Deinococcus radiodurans (DraSSB).
Źródło:
Acta Biochimica Polonica; 2007, 54, 1; 79-87
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Activities of human telomerase in cancer development, detection and therapeutics - A Review
Autorzy:
Pal, Partha
Ray, Spandita
De (Dutta), Koly
Powiązania:
https://bibliotekanauki.pl/articles/1190141.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chromosomes
End-replication
Telomere
Telomerase
Cancer
Therapeutic
Opis:
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, which are essential for maintaining the stability of the linear eukaryotic chromosomes. Progressive telomere shortening is an inevitable occurrence in normal somatic cells due to the end-replication problem leading to limited replication efficiency. The hallmark characteristics of human cancer cells include infinite reproductive potential, uncontrolled proliferation and immortality. These abilities of transformed cancerous cells are mainly due to the maintenance of their telomeres since degradation of chromosomal telomeric ends leads to cellular senescence or death. Thus telomere biology is important in the study of human cancer development. The mechanism by virtue the cancer cells are able to divide indefinitely is by maintaining telomeres. Activity of telomerase, a telomere-elongating ribonucleoprotein reverse transcriptase enzyme, is responsible for inducing the property of immortality to cancer cells. In humans nearly about 80% to 90% cancer cells activate telomerase and elongate their telomeres to overcome the end-replication problem. Telomere shortening suppresses cancer formation in contrast according to certain reports it sometimes promotes genomic instability which leads to enhancement of carcinogenesis and consequently the development of malignancy. Majority of cancer cells activate telomerase, but it remains mysterious as to find the reasons of the fact that certain cancer cells often show shorter telomeres in comparison to the cells in the surrounding normal tissues. This controversial role of telomerase associated with certain transformed cells leading to the cancerous state in relation to its role in normal cells is an interesting field to study which points out to the fact of development of cancer cells targeting drugs based on telomerase activities as an alternative weapon in combating against this dreaded human disease. The present review focuses on the activity of telomerase in telomere maintenance in the development of cancerous cells in humans, the use of telomerase as an assay technique for cancer detection as well as the anti-cancer therapeutic approach of targeting the telomerase in the current era of treatment of human cancer.
Źródło:
World Scientific News; 2016, 42; 87-100
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distributed web service repository
Autorzy:
Nawrocki, P.
Mamla, A.
Powiązania:
https://bibliotekanauki.pl/articles/305281.pdf
Data publikacji:
2015
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH
Tematy:
web service
repository
heterogeneity
data replication
node balancing
Opis:
The increasing availability and popularity of computer systems has resulted in a demand for new language- and platform-independent ways of data exchange. This demand has, in turn, led to significant growth in the importance of systems based on Web services. Alongside the growing number of systems accessible via Web services came the need for specialized data repositories that could offer effective means of searching the available services. The development of mobile systems and wireless data transmission technologies has allowed us to use distributed devices and computer systems on a greater scale. The accelerating growth of distributed systems might be a good reason to consider the development of distributed Web service repositories with built-in mechanisms for data migration and synchronization.
Źródło:
Computer Science; 2015, 16 (1); 55-73
1508-2806
2300-7036
Pojawia się w:
Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders
Autorzy:
Copeland, William
Ponamarev, Mikhail
Nguyen, Dinh
Kunkel, Thomas
Longley, Matthew
Powiązania:
https://bibliotekanauki.pl/articles/1043659.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
aging
DNA replication
mitochondria
DNA repair
DNA polymerase
Opis:
This paper summarizes recent advances in understanding the links between the cell's ability to maintain integrity of its mitochondrial genome and mitochondrial genetic diseases. Human mitochondrial DNA is replicated by the two-subunit DNA polymerase γ (pol γ). We investigated the fidelity of DNA replication by pol γ with and without exonucleolytic proofreading and its p55 accessory subunit. Pol γ has high base substitution fidelity due to efficient base selection and exonucleolytic proofreading, but low frameshift fidelity when copying homopolymeric sequences longer than four nucleotides. Progressive external ophthalmoplegia (PEO) is a rare disease characterized by the accumulation of large deletions in mitochondrial DNA. Recently, several mutations in the polymerase and exonuclease domains of the human pol γ have been shown to be associated with PEO. We are analyzing the effect of these mutations on the human pol γ enzyme. In particular, three autosomal dominant mutations alter amino acids located within polymerase motif B of pol γ. These residues are highly conserved among family A DNA polymerases, which include T7 DNA polymerase and E. coli pol I. These PEO mutations have been generated in pol γ to analyze their effects on overall polymerase function as well as the effects on the fidelity of DNA synthesis. One mutation in particular, Y955C, was found in several families throughout Europe, including one Belgian family and five unrelated Italian families. The Y955C mutant pol γ retains a wild-type catalytic rate but suffers a 45-fold decrease in apparent binding affinity for the incoming dNTP. The Y955C derivative is also much less accurate than is wild-type pol γ, with error rates for certain mismatches elevated by 10- to 100-fold. The error prone DNA synthesis observed for the Y955C pol γ is consistent with the accumulation of mtDNA mutations in patients with PEO. The effects of other pol γ mutations associated with PEO are discussed.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 155-167
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of coating fabrication processes on the optical efficiency of replicated Moiré diffraction gratings
Autorzy:
Ribeiro, J. E.
Powiązania:
https://bibliotekanauki.pl/articles/220824.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
diffraction gratings
Moiré interferometry
gratings replication
optical efficiency
Opis:
One of the most important parameters in the study of diffraction gratings is their optical efficiency. This paper analyzes the different manufacturing processes to cover gratings of Moiré interferometry and their influence on the quality and absolute efficiency of replicated gratings on the surfaces of specimens. The Moiré interferometry is a field measurement technique that has been used in many different fields such as applied mechanics, microelectronics, biomechanics or micromechanics, hence the importance of this study. The applied reflected coating was done by sputtering and aluminium vaporization processes. In this work different materials and thickness layers were analyzed. The obtained coatings have a high degree of reflectivity on the replicated gratings.
Źródło:
Metrology and Measurement Systems; 2013, 20, 1; 119-126
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bacterial DNA repair genes and their eukaryotic homologues: 5. The role of recombination in DNA repair and genome stability
Autorzy:
Nowosielska, Anetta
Powiązania:
https://bibliotekanauki.pl/articles/1040931.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
homologous recombination
Escherichia coli
DSB
replication forks
DNA repair
Opis:
Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Repair by homologous recombination is generally accurate as it uses undamaged homologous DNA molecule as a repair template. In Escherichia coli homologous recombination repairs both the double-strand breaks and single-strand gaps in DNA. DNA double-strand breaks (DSB) can be induced upon exposure to exogenous sources such as ionizing radiation or endogenous DNA-damaging agents including reactive oxygen species (ROS) as well as during natural biological processes like conjugation. However, the bulk of double strand breaks are formed during replication fork collapse encountering an unrepaired single strand gap in DNA. Under such circumstances DNA replication on the damaged template can be resumed only if supported by homologous recombination. This functional cooperation of homologous recombination with replication machinery enables successful completion of genome duplication and faithful transmission of genetic material to a daughter cell. In eukaryotes, homologous recombination is also involved in essential biological processes such as preservation of genome integrity, DNA damage checkpoint activation, DNA damage repair, DNA replication, mating type switching, transposition, immune system development and meiosis. When unregulated, recombination can lead to genome instability and carcinogenesis.
Źródło:
Acta Biochimica Polonica; 2007, 54, 3; 483-494
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Interactive methodology for spatial replication and research
Autorzy:
Hysenaj, M
Powiązania:
https://bibliotekanauki.pl/articles/118121.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
data circulation
replication
spatio-textual technology
law of cosine
Opis:
The paper outlines geographic search technology as the future of research methodology. Due to the importance of geographical environment in the routine issues, the close connection between spatial extension and most of the phenomena running over the world, the geographic query process turns to be key factor in overcoming hazard decision-making and evalu-ation. We describe a two step process where derived output from spatio-textual research could be largely disseminated by spatial replication techniques. Spatial research differs in that it requires a combination of text and geographical data. The mathematical formula to calculate distances derives from the assertion that the Earth is nearly spherical (ignoring ellipsoidal effects) so great-circle distance formulas give the distance between points on the surface of the Earth correct to within 0.5% or so. Based on the search range and limit, we introduce the Cosine algorithm who offers better speed performance and data retrieval accuracy. Retrieved data exploit spatial replication technique potentiality. When it comes to spatial data we deal extensive amount of information. Web Gis Albania is an informative platform initially structured for academicals purposes further enriched with modules which support the spatial data circulation.
Źródło:
Applied Computer Science; 2015, 11, 3; 76-87
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In chase of statistically significant result. Consequences of widespread use of NHST (null hypothesis significance testing) in psychology
Autorzy:
Karpe, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/703004.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
NHST
p-hacking
HARKing
selective publishing
replication crisis
false positives
Opis:
NHST (null hypothesis significance testing) is the most popular statistical paradigm in psychology. Mistakes in interpretation of its assumptions and their consequences are topic for methodological and statistical discussion for over fifty years. Article presents two problems associated with NHST that are particularly prevalent in psychology: identifying non-significant results with research failure and conducting underpowered research. They can contribute to increase in exploiting questionable research practices in order to obtain desirable, significant outcomes. Three practices: p-hacking, HARKing and selective publishing are described, along with analysis of their impact on replication crisis in psychological science.
Źródło:
Nauka; 2017, 1
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
UV- and MMS-induced mutagenesis of lO(am)8 phage under nonpermissive conditions for phage DNA replication.
Autorzy:
Krwawicz, Joanna
Czajkowska, Anna
Felczak, Magdalena
Pietrzykowska, Irena
Powiązania:
https://bibliotekanauki.pl/articles/1043364.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mutagenesis
dnaQ49
λ phage
mutL
DNA replication
UmuDC
uvrA
Opis:
Mutagenesis in Escherichia coli, a subject of many years of study is considered to be related to DNA replication. DNA lesions nonrepaired by the error-free nucleotide excision repair (NER), base excision repair (BER) and recombination repair (RR), stop replication at the fork. Reinitiation needs translesion synthesis (TLS) by DNA polymerase V (UmuC), which in the presence of accessory proteins, UmuD', RecA and ssDNA-binding protein (SSB), has an ability to bypass the lesion with high mutagenicity. This enables reinitiation and extension of DNA replication by DNA polymerase III (Pol III). We studied UV- and MMS-induced mutagenesis of λO(am)8 phage in E. coli 594 sup+ host, unable to replicate the phage DNA, as a possible model for mutagenesis induced in nondividing cells (e.g. somatic cells). We show that in E. coli 594 sup+ cells UV- and MMS-induced mutagenesis of λO(am)8 phage may occur. This mutagenic process requires both the UmuD' and C proteins, albeit a high level of UmuD' and low level of UmuC seem to be necessary and sufficient. We compared UV-induced mutagenesis of λO(am)8 in nonpermissive (594 sup+) and permissive (C600 supE) conditions for phage DNA replication. It appeared that while the mutagenesis of λO(am)8 in 594 sup+ requires the UmuD' and C proteins, which can not be replaced by other SOS-inducible protein(s), in C600 supE their functions may be replaced by other inducible protein(s), possibly DNA polymerase IV (DinB). Mutations induced under nonpermissive conditions for phage DNA replication are resistant to mismatch repair (MMR), while among those induced under permissive conditions, only about 40% are resistant.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 921-939
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 52

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