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Tytuł:
17 beta-estradiol affects proliferation and apoptosis of canine bone marrow mesenchymal stem cells in vitro
Autorzy:
Zhou, Z.-H.
Gu, C.-W.
Li, J.
Huang, X.-Y.
Deng, J.-Q.
Shen, L.-H.
Cao, S.-Z.
Deng, J.-L.
Zuo, Z.-C.
Wang, Y.
Ma, X.-P.
Ren, Z.-H.
Yu, S.-M.
Powiązania:
https://bibliotekanauki.pl/articles/2087308.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
apoptosis
bone marrow mesenchymal stem cells (BMSCs)
canine
proliferation
17 beta-estradiol (E2)
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 235-245
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line
Autorzy:
Guan, Shu-Wen
Duan, Leng-Xin
Li, Yuan-Yuan
Wang, Ben-Xiang
Zhou, Qiu-Li
Powiązania:
https://bibliotekanauki.pl/articles/1041255.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polypeptide
velvet antler
promoting cell proliferation
Opis:
A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg·L-1 and 5-80 mg·L-1, respectively).
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 395-397
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection
Autorzy:
Miszczyk, Eliza
Walencka, Maria
Rudnicka, Karolina
Matusiak, Agnieszka
Rudnicka, Wiesława
Chmiela, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1039292.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Helicobacter pylori
T cells
proliferation
guinea pigs
Opis:
Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8 - IL-8 as well as interferon gamma - IFN-γ, and transforming growth factor beta - TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.
Źródło:
Acta Biochimica Polonica; 2014, 61, 2; 295-303
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
Autorzy:
Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.
Powiązania:
https://bibliotekanauki.pl/articles/284321.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin
Opis:
Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 132-134
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between clinical stage of oral cancer and expression of immunohistochemical markers
Autorzy:
Świątkowski, Wojciech
Rahnama, Mansur
Tomaszewski, Tomasz
Bigas, Mariola
Świątkowska, Agnieszka
Łobacz, Michał
Wallner, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1393147.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
oral cancer
neoplasm markers
squamous cell carcinoma
proliferation markers
Opis:
Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease. Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. The methods: Immunohistochemical analysis using the detection system DAKO K5007 Cat - Dako REAL ™ Detection System, Peroxidase DAB +, Rabbit / Mouse. Results: Based upon the statistical results, significant correlation between p53 protein and tumor staging; however, a correlation between the level of expression of EGFR, p44/42, PCNA and staging was not likewise revealed. Conclusions: Looking for oral squamous cell carcinoma markers remains an actual issue. Identification of specific markers of oral cancer could be used in screening the population, determining prognosis and response to treatment.
Źródło:
Polish Journal of Surgery; 2017, 89, 6; 17-22
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Atom od Bosforu po Zatokę Perską – perspektywy energetyki jądrowej na Bliskim Wschodzie
The atom from the Bosphorus to the Persian Gulf – the perspective of nuclear power in the Middle East
Autorzy:
Tolak, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/527007.pdf
Data publikacji:
2014
Wydawca:
Collegium Civitas
Tematy:
Nuclear Energy
Industry
Proliferation
Nuclear Power Plant
Opis:
The article is an attempt to analyze the current situation and plans for the development of the nuclear industry in the Middle East after the failure in Fukushima. Next to the southern and eastern Asian countries nuclear power becomes a choice of countries of the Middle East region. Taking into account the significant gaps in economic and scientific potential, and the unstable political situation in the countries of the region – projects to build nuclear power stations seem to be a particularly complex challenge. The article analyzes the entered and planned investments and risks, which may arise in connection with the implementation of adopted plans.
Źródło:
Securitologia; 2014, 2(20); 101-114
1898-4509
Pojawia się w:
Securitologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Białko cacybp/sip i jego rola w organizacji cytoszkieletu
Cacybp/sip protein and its role in cytoskeleton organization
Autorzy:
Filipek, Anna
Góral, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1033942.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Tematy:
CacyBP/SIP
cancers
cytoskeleton
differentiation
proliferation
neurodegeneration
target proteins
białka efektorowe
cytoszkielet
neurodegeneracja
nowotwory
proliferacja
różnicowanie
Opis:
Białko CacyBP/SIP występuje w różnych komórkach i tkankach ssaków, a jego wysoki poziom notowany jest w mózgu, śledzionie, grasicy oraz w wielu nowotworach. CacyBP/SIP oddziałuje z wieloma białkami efektorowymi, w tym z białkami cytoszkieletu: aktyną, tubuliną, tropomiozyną. Wskazuje to, iż CacyBP/SIP bierze udział w procesach komórkowych, którym towarzyszą zmiany w organizacji cytoszkieletu zarówno w warunkach fizjologicznych jak też w różnych stanach chorobowych. W niniejszej pracy przedstawiono charakterystykę oddziaływania CacyBP/SIP z białkami cytoszkieletu oraz rolę tych interakcji w różnych procesach komórkowych.
The CacyBP/SIP protein is present in different mammalian cells and tissues. Its particularly high level is observed in brain, spleen, thymus and in many cancers. CacyBP/SIP interacts with different targets including cytoskeletal proteins such as tubulin, actin, tropomyosin. This indicates that CacyBP/SIP is involved in cellular processes associated with changes in cytoskeleton organization under physiology and pathology. In the present work the characteristics of complexes formed between CacyBP/SIP and cytoskeletal proteins and the role of those interactions are presented.
Źródło:
Kosmos; 2018, 67, 1; 131-137
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
BRAZIL´S NUCLEAR POLICY AND ITS RISE ON INTERNATIONAL STAGE
POLITYKA NUKLEARNA BRAZYLI I JEJ ZNACZENIE NA ARENIE MIĘDZYNARODOWEJ
Autorzy:
Šubrtová, Natália
Terem, Peter
Powiązania:
https://bibliotekanauki.pl/articles/550526.pdf
Data publikacji:
2018
Wydawca:
Wyższa Szkoła Biznesu i Przedsiębiorczości w Ostrowcu Świętokrzyskim
Tematy:
nuclear program
nuclear energy
nuclear reactor
non-proliferation
program jądrowy
energia jądrowa
reaktor jądrowy
nieproliferacja
Opis:
From global point of view, there is certainly no shortage of academic contributions, professional scientific analyses or journalistic articles focused on Brazil and its nuclear program. However, such an assertion cannot be used when discussing Central European knowledge of Brazil’s nuclear program and security ambitions. Considered all above, this article aims to bring closer the current South-American leader to readers in our region and briefly introduce them to its nuclear program, influence it has on forming Brazil’s foreign security policy and projection of the country internationally.
Z globalnego punktu widzenia z pewnością nie brakuje prac naukowych, profe-sjonalnych analiz naukowych czy artykułów dziennikarskich poświęconych Brazylii i jej programowi jądrowemu. Twierdzenia takiego nie można jednak wykorzystać przy omawianiu środkowoeuropejskiej wiedzy o programie nuklearnym Brazylii i ambicjach w zakresie bezpieczeństwa. Rozważając powyższe, niniejszy artykuł ma na celu przybliżenie aktualnego przywódcy Ameryki Południowej dla czytelników w naszym regionie i krótko przedstawić je programowi jądrowemu, wpłynąć na kształtowanie zagranicznej polityki bezpieczeństwa. Brazylii i projekcję kraju na arenie międzynarodowej.
Źródło:
Acta Scientifica Academiae Ostroviensis. Sectio A, Nauki Humanistyczne, Społeczne i Techniczne; 2018, 12(2)/2018; 224-243
2300-1739
Pojawia się w:
Acta Scientifica Academiae Ostroviensis. Sectio A, Nauki Humanistyczne, Społeczne i Techniczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION
Autorzy:
Liu, Zhenzhong
Wu, Song
Li, Xiaoqian
Powiązania:
https://bibliotekanauki.pl/articles/895460.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA
Opis:
Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 295-304
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can transforming growth factor-β1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?
Autorzy:
Czeczuga-Semeniuk, Ewa
Anchim, Tomasz
Dzięcioł, Janusz
Dąbrowska, Milena
Wołczyński, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1041552.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
estradiol
apoptotic index
tamoxifen
TGF-β1
proliferation
MCF-7
retinoids
Opis:
Retinoic acid and transforming growth factor-β (TGF-β) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [3H]thymidine incorporation and the proliferative activity of PCNA- and Ki 67-positive cells. The apoptotic index and expression of the Bcl-2 and p53 antigens in MCF-7 cells were also determined. Exogenous TGF-β1 added to the cell culture showed antiproliferative activity within the concentration range of 0.003-30 ng/ml. Irrespective of TGF-β1 concentrations, a marked reduction in the stimulatory action of estradiol (10-9 and 10-8 M) was observed whereas in combination with tamoxifen (10-7 and 10-6 M) only 30 ng/ml TGF-β1 caused a statistically significant reduction to aproximately 30% of the proliferative cells. In further experiments we examined the effect of exposure of breast cancer cells to retinoids in combination with TGF-β1. The incorporation of [3H]thymidine into MCF-7 cells was inhibited to 52 ± 19% (control =100%) by 3 ng/ml TGF-β1, and this dose was used throughout. It was found that addition of TGF-β1 and isotretinoin to the culture did not decrease proliferation, while TGF-β1 and tretinoin at low concentrations (3 × 10-8 and 3 × 10-7 M) reduced the percentage of proliferating cells by aproximately 30% (67±8% and 67±5%, P <0.05 compared to values in the tretinoin group). Both retinoids also led to a statistically significant decrease in the stimulatory effect of 10-9 M estradiol, attenuated by TGF-β1. In addition, the retinoids in combination with TGF-β1 and tamoxifen (10-6 M) caused a further reduction in the percentage of proliferating cells. Immunocytochemical analysis showed that all the examined compounds gave a statistically significant reduction in the percentage of cells with a positive reaction to PCNA and Ki 67 antigen. TGF-β1, isotretinoin and tretinoin added to the culture resulted in the lowest percentage of PCNA positive cells. However, the lowest fraction of Ki 67 positive cells was observed after addition of isotretinoin. The obtained results also confirm the fact that the well-known regulatory proteins Bcl-2 and p53 play an important role in the regulation of apoptosis in the MCF-7 cell line, with lowered Bcl-2 expression accompanying easier apoptotic induction. The majority of the examined compounds act via the p53 pathway although some bypass this important proapoptotic factor.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 733-745
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes accompanying proliferative capacity and morphology of Nicotiana tabacum L. callus in response to 2,4-D
Zmiany związane ze zdolnością do proliferacji i morfologią kalusa Nicotiana tabacum L. w odpowiedzi na różne stężenia 2,4-D
Autorzy:
Gatz, Andrzej
Tomaszewska-Sowa, Agnieszka
Figas, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1628038.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
Nicotiana tabacum
2
4-dichlorophenoxyacetic acid
proliferation
cell divisions
callus morphology
Opis:
The common trait of all auxins is a stimulation of cell elongation and also cell division in the presence of cytokinin; both are essential for callus induction and its multiplication. The response of plant tissues to various compounds with auxin activity may be quite different. In this study, the effectiveness of a synthetic auxin, 2,4-dichlorofenoxyacetic acid (2,4-D), instead of the generally applied natural auxin, indole-3-acetic acid (IAA), was tested for the proliferation of Nicotiana tabacum callus. The following concentrations of 2,4-D were tested: 0.1, 0.5, 1.0, 1.5, and 2.0 mg dm−3. Callus was derived from stem pith and its proliferation allowed on MS medium through five subcultures at 25°C and in darkness. After each passage, the fresh weight and morphological features of the callus were determined. The 0.5 mg dm−3 2,4-D treatment was the most favorable for producing the greatest increase in fresh weight in each of five subsequent subcultures as well as maintaining normal morphological features for proliferation. However, the 1.0 mg dm−3 2,4-D treatment in comparison with the lowest, 0.1 mg dm−3, was more beneficial when considering regular increases of fresh weight and a better cell cohesion for callus growth.
Do indukcji i namnażania kalusa niezbędne jest zastosowanie odpowiedniej auksyny, podanej samodzielnie lub z cytokininą. Spośród naturalnych auksyn IAA jest często wykorzystywana do stymulowania proliferacji kalusa Nicotiana tabacum. Zastosowanie IAA wymaga wyższych stężeń ze względu na nietrwałość, wynikającą z wrażliwości na światło i wysoką temperaturę. Takich ograniczeń nie posiada syntetyczna auksyna 2,4-D. Celem tej pracy była ocena przydatności 2,4-D do proliferacji kalusa Nicotiana tabacum z następującymi wariantami stężeń 0.1, 0.5, 1.0, 1.5 i 2 mg dm−3. Proliferację kalusa z rdzenia łodygi przeprowadzono na pożywce MS przez 5 pasaży bez dostępu światła i w temperaturze 25°C. Po każdym pasażu określono świeżą masę i cechy morfologiczne kalusa takie jak barwa, struktura powierzchni i stopień spójności komórek. Spośród badanych stężeń 2,4-D, najefektywniej stymulującym było 0.5 mg dm−3 ze względu na najwyższy przyrost świeżej masy w każdym z pięciu kolejnych pasaży oraz sprzyjające proliferacji cechy morfologiczne kalusa. Wariant stężenia 1.0 mg dm−3 2,4-D w porównaniu z 0.1 mg dm−3 okazał się korzystniejszy, ponieważ charakteryzował się regularnymi przyrostami i lepszą dla namnażania spójnością komórek kalusa.
Źródło:
Acta Agrobotanica; 2017, 70, 4
0065-0951
2300-357X
Pojawia się w:
Acta Agrobotanica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in the pathomorphological diagnosis of gastrointestinal neuroendocrine neoplasms in 2017
Autorzy:
Nasierowska-Guttmejer, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1062924.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
G3 NET
Ki-67 proliferation index
NEC
neuroendocrine carcinoma
neuroendocrine tumors
Opis:
The following changes were introduced in 2017 WHO and TnM classifications: 1. a new group of well-differentiated neuroendocrine tumors with the proliferation index of more than 20% and mitotic count of 20 per 10 hpf (NET G3), formerly classified under neuroendocrine carcinomas (NEC G3) 2. the division of poorly differentiated neuroendocrine tumors (PD NET) with the Ki-67 index of more than 20% into two groups in terms of the degree of differentiation and prognosis: NET G3 and NEC. 3. the replacement of MANEC with MINEN within the mixed group 4. the verification of histological grading (G) criteria 5. new TNM staging criteria, based on ENETS guidelines.
Źródło:
OncoReview; 2017, 7, 3; 109-115
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Chemical modification of poly ε-caprolactone with wollastonite and its influence on biological properties of osteoblast like-cells MG-63
Autorzy:
Ścisłowska-Czarnecka, A.
Menaszek, E.
Kołaczkowska, E.
Błażewicz, M.
Podporska, J.
Powiązania:
https://bibliotekanauki.pl/articles/284898.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polycaprolactone
wollastonite
osteoblast-like MG-63 cells
cell adhesion
viability
proliferation
alkaline phosphatase
Opis:
PCL (poly-ε-caprolactone) is a biocompatible and biodegradable polymer of aliphatic polyester group. However, PCL does not effectively bind to the bone in contrast to bioactive inorganic compounds such as wollastonite. For this wollastonite (WS) is regarded as a potential bioactive material for bone tissue engeenering although its main drawback is brittlennes. Therefore we synthesized polymer nanocomposite materials composed of poly-ε-caprolactone and wollastonite (PCL/wollastonite) containing either 0.5% or 5% of the latter modifying filler. And we aimed to verify biological properties of the nanocomposite PCL/WS materials, in comparison to the pure PCL, on cultures of osteoblast-like cells MG-63. The study revealed that the adherence of the osteoblast-like cells to the tested materials was enhanced by the PCL modification (PCL/5WS > PCL/0.5WS > PCL) while cell viability/proliferation was not altered. Furthermore, the activity of alkaline phosphatase indicative of osteoblast differentiation (maturation) was enhanced when the cells were cultured with either PCL/5WS or PCL/0.5WS. Overall, our results indicate that PCL-modified wollastonite improves biological properties of the basic biomaterial suggesting its potential usefulness/application for the bone tissue regeneration.
Źródło:
Engineering of Biomaterials; 2011, 14, 102; 11-14
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clastogenic and toxicological assessment of cashew (Anacardium occidentale) nut bark extracts in Wistar rats
Autorzy:
Owumi, Solomon
Fatoki, John
Gbadegesin, Michael
Odunola, Oyeronke
Powiązania:
https://bibliotekanauki.pl/articles/1039006.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Cashew bark oil
tattooing
toxicity
micronuclei
cell proliferation
skin cancer
Opis:
Occupational exposures to environmental toxicants have been associated with the onset of skin lesions-including cancers. Identification and reduction of exposure to such compounds is an important public health goal. We examined the effect of cashew shell oil (CSO), used in skin tattooing for its potential to induce skin transformation in rats. Corn oil and CSO (25, 50, and 100%) were topically applied to depilated sections of Wistar' rat skin (groups: I-IV) for six weeks. Effect of treatments on serum transaminases activity, histological changes in hepatocytes and induction of micronuclei in the bone marrow were examined. In addition, CSO-induced hepatocyte proliferation was also quantified. All animals survived the course of the study. Reduced percentage change in body weight and physical trauma were observed in CSO-treated rat. The effects were more prominent in Group IV (100% CSO). Relative liver weights and number of hepatocytes (cells/mm2) increased significantly in groups II-IV relative to control (p < 0.05). Serum transaminases activities were not significantly (p > 0.05) affected in treated groups. Hepatic histopathology revealed moderate sinusoidal congestion (group II), in addition to portal congestion in (group III), with mononuclear cellular infiltration (group IV) animals. In addition, CSO induced significant micronuclei formation of polychromatic erythrocyte (mPCEs) in the rat bone marrow (p < 0.05) when compared with control. Topical application of CSO disrupted skin cells integrity resulting in physical trauma. In addition, CSO appears to be clastogenic and induces hepatocyte proliferation. Occupational exposure to CSO especially for engraving tattoos in humans should be discouraged and further studies need to be conducted.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 563-567
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 106

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