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    Wyświetlanie 1-4 z 4
    Tytuł:
    USE OF GLUTARIC ACID TO IMPROVE THE SOLUBILITY AND DISSOLUTION PROFILE OF GLIPIZIDE THROUGH PHARMACEUTICAL COCRYSTALLIZATION
    Autorzy:
    Batool, Fakhra
    Ahmad, Mahmood
    Minhas, Muhammad U.
    Khalid, Qandeel
    Idrees, Hafiz A.
    Khan, Fahad M.
    Powiązania:
    https://bibliotekanauki.pl/articles/895470.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    FTIR
    SEM
    PXRD
    thermal analysis
    glipizide
    glutaric acid
    Opis:
    The purpose of current study was to improve the solubility and dissolution profile of BCS class-II drug Glipizide using glutaric acid as a coformer via various cocrystalization techniques i.e., dry grinding, liquid assisted grinding, slurry and solvent evaporation. Fourier Transform Infrared Spectroscopy (FTIR) was performed to determine the interaction between components of glipizide-glutaric acid (GPZ-GLU) cocrystals. Powder X-ray Diffraction (PXRD) studies confirmed the crystalline nature of formulated cocrystals. Scanning Electron Microscopy (SEM) revealed cylindrical to rectangular shape of cocrystals. Flow properties of GPZ-GLU cocrystals were evaluated by micromeritics analysis. Size and surface morphology was determined by zeta sizer analysis and optical microscopy. Differential scanning calorimetry (DSC) and Thermogravimetric (TGA) analysis were performed to determine the melting points as well as thermal stability of pure components and formulated GPZ-GLU cocrystals. In-vitro drug release studies were carried out using dissolution apparatus-II. GPZ-GLU cocrystals showed higher drug release at pH 6.8 as compared to pH 1.2. However, percent drug release of optimum formulations at pH 6.8 was determined as; 24%-92.2% (F3) and 12.0%-93.5% (F7). Solubility studies revealed improved solubility as compared to pure drug in water i.e., 53 folds and 54.27 folds from F3 and F7 cocrystals, respectively. Finally it was concluded that glutaric acid has improved the solubility and dissolution profile of glipizide. However, many cocrystal formers have been reported in literature that can be used to enhance the physicochemical properties as well as bioavailability of poorly soluble drugs via cocrystalization technique.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 103-114
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis of citrates of selected lanthanides (Er, Ho and Lu)
    Autorzy:
    Janusz, Władysław
    Pikus, Stanisław
    Skwarek, Ewa
    Olszewska, Elżbieta
    Powiązania:
    https://bibliotekanauki.pl/articles/1450220.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    PXRD diffraction
    Powder X-Ray Diffraction
    FTIR
    Fourier Transform Infrared
    Er
    Erbium
    Ho
    Holmium
    Lu
    Lutetium
    citrates of Er
    citrates of Ho
    citrates of Lu
    Opis:
    Holmium, erbium and lutetium citrates can be synthesized by transforming freshly precipitated holmium, erbium and lutetium hydroxides in the citric acid solution under the hydrothermal conditions (above 100 ℃) after 3 days of reaction. In this paper in order to determine the synthesis conditions, the hydroxide and citrate stability areas of selected lanthanides were compared. The studies of the structure of the obtained holmium citrate, erbium and lutetium samples showed that these compounds crystallize in a monoclinic system. The crystallite sizes determined by the HalderWagner method were 67.8 ± 8.0nm, 103.7 ± 4.5nm and 68.1 ± 4.2nm, respectively for the holmium citrate, erbium citrate and lutetium citrate samples. The shifts of the hydroxyl and carboxyl groups of citric acid in the FTIR spectrum indicate the interactions of both groups with holmium, erbium and lutetium cations. Then the obtained samples were subjected to the analysis of composition, and their particle size distribution was determined.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2020, 56, 6; 225-234
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Iron-bearing phases affecting the colour of upper Neogene clayey sediments from Dymaczewo Stare, west-central Poland
    Autorzy:
    Klęsk, Jakub
    Błachowski, Artur
    Diduszko, Ryszard
    Kruszewski, Łukasz
    Widera, Marek
    Powiązania:
    https://bibliotekanauki.pl/articles/2204349.pdf
    Data publikacji:
    2022
    Wydawca:
    Uniwersytet im. Adama Mickiewicza w Poznaniu
    Tematy:
    mineral composition
    powder X-ray diffraction
    PXRD
    iron minerals
    57Fe Mössbauer spectroscopy
    57Fe- MS
    Poznań clays
    Mio-Pliocene
    skład mineralny
    proszkowa dyfrakcja rentgenowska
    minerały żelaza
    spektroskopia Mössbauera
    iły poznańskie
    Opis:
    The present paper investigates the colour dependence of mineral compositions in clay-rich sedimentary strata, mainly clayey silts, the emphasis being on iron-bearing minerals (rather than clay minerals) by using powder X-ray diffraction (PXRD) and 57Fe Mössbauer spectroscopy (57Fe-MS). The PXRD-based phase analysis has demonstrated the variable compositions of samples, consisting of, inter alia, quartz, calcite or gypsum, and admixtures of potassium feldspars and plagioclase. Hematite + goethite (sample D1, dark red), goethite (sample D2, pinkish brown), poorly crystalline goethite (sample D3, orange) and jarosite (sample D4, yellow) have been distinguished. A very low jarosite content was detected in sample D5 (light grey); this did not affect its colour. The potential yellow/brown shades in sample D6 (dark grey), coming from trace amounts of jarosite, are masked by macroscopically visible organic matter. In the case of the two last-named samples (D5 and D6), with trace amounts of Fe-bearing minerals, it is most likely that the organic matter was effective in influencing the light and dark grey colour of the sediment, respectively.
    Źródło:
    Geologos; 2022, 28, 2; 129--139
    1426-8981
    2080-6574
    Pojawia się w:
    Geologos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    THE POSSIBILITY OF USING X-RAY POWDER DIFFRACTION, INFRARED AND RAMAN SPECTROSCOPY IN THE STUDY OF THE IDENTIFICATION OF STRUCTURAL POLYMORPHS OF ACETAMINOPHEN
    Autorzy:
    Stasiłowicz, Anna
    Mizera, Mikołaj
    Tykarska, Ewa
    Lewandowska, Kornelia
    Miklaszewski, Andrzej
    Cielecka-Piontek, Judyta
    Powiązania:
    https://bibliotekanauki.pl/articles/895486.pdf
    Data publikacji:
    2019-12-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    acetaminophen
    PXRD
    Raman
    FT-IR
    structural polymorphism
    Opis:
    Paracetamol (acetaminophen), a pain-killer with antipyretic properties, shows structural polymorphism. It occurs in three polymorphic forms: monoclinic, orthorhombic, and unstable form III. In the study, the commercially available samples of paracetamol (P1 and P2) were examined using X-ray powder diffraction, infrared, and Raman spectroscopy. Results demonstrated that all of the methods defined polymorphic forms of paracetamol in the samples. However, only Raman spectroscopy and PXRD methods detected impurities in the sample P1. These methods transpired to be more sensitive than the FT-IR method, which identified samples of paracetamol as one structural form (monoclinic polymorph). Moreover, the Raman spectroscopy identified impurities in the form P1 as changes in the crystalline form.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 997-1004
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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