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Wyświetlanie 1-10 z 10
Tytuł:
Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer.
Autorzy:
Błasiak, Janusz
Smolarz, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1044431.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gene polymorphism
PAI-1 gene
prognostic marker
plasminogen activator inhibitor-1 (PAI-1)
breast cancer
Opis:
The antigen content of plasminogen activator inhibitor-1 (PAI-1) in primary breast cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumors predict poor prognosis for patients. The gene encoding PAI-1 is highly polymorphic and an insertion (5G)/deletion (4G) polymorphism in the PAI-1 gene promoter (the 4G/5G polymorphism), may have functional significance in PAI-1 expression. In the present work the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism in subjects with breast cancer were investigated. Tumor tissues were obtained from 100 postmenopausal women with node-negative and node-positive ductal breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The 4G/5G polymorphism was determined by PCR amplification using the allele specific primers. The distribution of the genotypes of the 4G/5G polymorphism in both control and patients did not differ significantly (P > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. The 4G/5G polymorphism may not be linked with elevated level of PAI-1 observed in breast cancer and therefore may not be associated with appearance and/or progression of breast cancer.
Źródło:
Acta Biochimica Polonica; 2000, 47, 1; 191-199
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer.
Autorzy:
Smolarz, Beata
Romanowicz-Makowska, Hanna
Kulig, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043627.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
PCR
1334G/A polymorphism
prognostic marker
colorectal cancer
plasminogen activator inhibitor 1 (PAI-1)
Opis:
Plasminogen activator inhibitor 1 (PAI-1) content in colorectal cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumours predict poor prognosis. The gene encoding PAI-1 is highly polymorphic and PAI-1 gene variability could contribute to the level of PAI-1 biosynthesis. In the present work the distribution of genotypes and frequency of alleles of the 1334G/A polymorphism in 92 subjects with colorectal cancer in samples of cancer tissue and distant mucosa samples as well as in blood were investigated. Blood samples age matched healthy individuals (n = 110) served as control. The 1334G/A polymorphism was determined by PCR amplification using allele specific primers. No differences in the genotype distributions and allele frequencies between blood, distant mucosa samples and cancer tissue were detected. However, the distribution of the genotypes of the 1334G/A polymorphism in patients differed significantly (P <0.05) from those predicted by the Hardy-Weinberg equilibrium. There were significant differences in the frequencies of alleles between the colorectal cancer subjects and controls (P <0.05). The results support the hypothesis that the 1334G/A polymorphism may be associated with the incidence of colorectal cancer.
Źródło:
Acta Biochimica Polonica; 2003, 50, 2; 489-495
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tissue distribution of a menthyl-conjugated oligodeoxyribonucleotide antisense to PAI-1 mRNA
Autorzy:
Szemraj, Janusz
Al-Nedawi, Khalid
Chabielska, Ewa
Buczko, Wlodzimierz
Pawlowska, Zofia
Powiązania:
https://bibliotekanauki.pl/articles/1041329.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
PAI-1
antisense oligonucleotides
tissue distribution
Opis:
The inhibitory effect of numerous analogues of PO-16, an hexadecadeoxyribonucleotide antisense to sequences -22 to -17 of PAI-1 mRNA coding for a fragment of the signal peptide, on the expression of PAI-1 in endothelial cells, and physiological consequences of the subsequently reduced PAI-1 activity tested in vitro and in vivo, were described in our previous studies. Of particular interest was PO-16 5'-O-conjugated with menthyl phosphorothioate (MPO-16R). In this work, tissue localisation of MPO-16R labelled with [35S] phosphorothioate at the 3'-end, was determined. [35S]MPO-16R and control [35S]MPO-16R-SENSE oligonucleotides were administered intravenously into 22 rats and organ distribution of the labelled bioconjugates was assessed after 24 and 48 h. For this purpose, tissue sections were subjected to autoradiography, and quantitated by liquid scintillation after solubilisation. Overall clearance of radioactivity was already seen after 24 h, with the radioactivity recovered mainly in the kidney and liver. A smaller fraction of radioactivity was also retained in the spleen and heart. The kidney concentration of the labelled probe was higher than that of liver by 50%. The distribution of PAI-1 mRNA in untreated rat kidney, liver, spleen and heart established by two independent techniques: Ribonuclease Protection Assay and Real-Time PCR, shows the same pattern as that observed for [35S]MPO-16R antisense.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 849-855
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ nurkowania na PAI - 1 I ALFA2-antyplazminy oraz aktywność fibrynolityczna
Decreased levels of PAI-1 and alpha2-antiplasmin contribute to enhanced fibrynolitic activity in divers
Autorzy:
Radziwon, P.
Olszański, R.
Tomaszewski, R.
Lipska, A.
Dąbrowiecki, Z.
Korzeniewski, K.
Siermontowski, P.
Boczkowska-Radziwon, B
Powiązania:
https://bibliotekanauki.pl/articles/366342.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
alfa2-antyplazmina
choroba dekompresyjna
PAI-1
PAP
t-PA
alpha2-antiplasmin
decompression sickness
Opis:
Praca mówi o nie zbadanych dotychczas dokładnie powiązaniach choroby dekompresyjnej z zagadnieniami hemostazy a szczególnie fibrynolizy. Badany był wpływ ekspozycji hiperbarycznej na główne składniki systemu fibrynolizy. Dwie grupy młodych mężczyzn poddawane były ekspozycjom hierbarycznym do ciśnienia 400 kPa - grupa I - i 700 kPa - grupa II. Stosowano dekompresję powietrzna. Po ekspozycji badano nurków na obecność objawów choroby dekompresyjnej, a także poszukiwano pęcherzyków gazu w naczyniach żylnych metoda Dopplera. 15 minut po zakończeniu dekompresji pobierano krew do badań koagulologicznych. Badano stężenie i aktywność t-PA i PAI-1, stężenie PAP i alfa2-antyplazminy. W grupach badawczych nie stwierdzono wykładników choroby dekompresyjnej ani nadmiernej ilości pęcherzyków wewnątrznaczyniowych. Stwierdzono miedzy innymi spadek poziomu alfa2-antyplazminy, spadek stężenia i aktywności PAI-1. Nie zaobserwowano zmian w zakresie czynnika XII jak i t-PA. Ekspozycja hiperbaryczna i dekompresja indukuje fibrynolize, nawet bez obecności pęcherzyków gazowych.
There are a number of reported cases of decompression sickness (DCS) with haemorrhages. These cases have not been sufficiently investigated and thus bleeding complications could not be directly correlated to the enhanced fibrinolysis. The effect of hyperbaric exposition and decompression on the main components of fibrynolitic system have been measured. Two groups of 25 male divers each, were subjected to hyperbaric exposures to the pressure of either 400 kPa - group I - or 700 kPa - group II followed by a staged decompression. The divers were monitored for clinical symptoms of DCS and checked for Doppler-detected venous gas bubbles. Venous blood was drawn from divers before exposition and 15 minutes after decompression. The concentrations and activities of t-PA and PAI-1 as well as concentrations of PAP and alpha2-antiplasmin and activity of factor XIIa were measured. In all groups of divers no cases of DCS as well as detectable gas bubbles were noted. We observed elevated concentration of PAP, decreased concentration of alpha2-AP, decreased PAI-1 concentration and activity. There were no significant changes in factor XIIa activity as well a of t- PA concentration and activity. Hyperbaric exposition and decompression induce activation of fibrynolisis, even in the absence of detectable gas bubbles. Fibrynolitic activity increases mainly due to decrease of PAI-1 concentration and activity. Further clinical trials are necessary for the estimation of the importance of activation of fibrynolisis with decreased level of PAI-1 and alpha2-AP as possible risk factor for bleeding in divers.
Źródło:
Polish Hyperbaric Research; 2007, 3(20); 33-42
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
TRADITIONAL CHINESE GENERATION NAMES
Autorzy:
KAŁUŻYŃSKA, IRENA
Powiązania:
https://bibliotekanauki.pl/articles/971622.pdf
Data publikacji:
2015-12-01
Wydawca:
Polska Akademia Nauk. Instytut Języka Polskiego PAN
Tematy:
Chinese naming system
Chinese given names
Chinese generation names
names
indicating the order of birth
Chinese p’ai-hang
Opis:
Personal names usually contain some information which falls within the broad content of culture. They are often imbued with information on history, religion, social organization, mentality, values, preferences or symbols. Chinese naming practices do not restrict the inventory of possible given names, and as based upon characteristics of the Chinese culture, Chinese language and Chinese writing system, they grant a great deal more opportunity for creativity in naming than is the case in Western cultures. The paper deals with the specific tradition and practice of Chinese generational naming, i.e. it presents various types and categories of Chinese generation given names, indicating the order of birth of children within a family or within generations of a clan. Generation names appear to be unique to China. The tradition and practice of generation naming were formed to ensure the unity of the great Chinese family and to maintain its continuity and prosperity. According to the research material, there are two main types of generation names, i.e. (I) names denoting the order of birth in a family by using special seniority terms or numerals, and (II) names indicating the order of birth within generations of a family or a clan, or the seniority in a family, created by using some special generational methods of forming Chinese names, based mainly upon the characteristics of the Chinese language and its writing system.
Źródło:
Onomastica; 2015, 59; 107-121
0078-4648
Pojawia się w:
Onomastica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Engineering polymers with high mechanical and thermal resistance for electric motors
Autorzy:
Kantor, Ł.
Michalik, K.
Laska, J.
Powiązania:
https://bibliotekanauki.pl/articles/93102.pdf
Data publikacji:
2017
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
high-performance polymer
high thermal conductivity
electric motor material
PEEK PAI PPS
polimer wysokowydajny
wysoka przewodność cieplna
silnik elektryczny
Opis:
The aim of the research was to select and evaluate polymers that could be used as rotor insulation in electric motors based on Halbach array system. Which have specific material properties, such as high mechanical strength, high thermal resistance and, especially, high thermal conductivity, also at room and at elevated temperatures. Three high performance polymers were selected for the research: polyetheretherketone (PEEK), polyamideimide (PAI) and poly(p-phenylene sulphide) (PPS). Polymers were evaluated for mechanical strength, thermal conductivity, thermal diffusivity, specific heat capacity, linear thermal expansion and also differential scanning calorimetry (DSC) and thermal gravimetry (TG) analyses were carried out. Analyses are proved that all materials have appropriate properties for advanced electric motor insulator.
Źródło:
Science, Technology and Innovation; 2017, 1, 1; 39-43
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphisms variants of the MTHFR C677T and PAI-1 5G/4G genes and their combinations in the group of children with arterial ischemic stroke
Polimorficzne warianty genów MTHFR C667T oraz PAI-1 5G/4G oraz ich kombinacje w grupie dzieci z udarem niedokrwiennym mózgu
Autorzy:
Smulska, Nataliya
Rossokha, Zoia
Fishchuk, Liliya
Gorovenko, Nataliya
Nechai, Alla
Nicolaenko, Iryna
Rysliaieva, Viktotiia
Krasilenko, Iryna
Powiązania:
https://bibliotekanauki.pl/articles/1836019.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Neurologów Dziecięcych
Tematy:
children
arterial ischemic stroke
MTHFR C677T gene polymorphism
PAI-1 gene polymorphism
dzieci
udar niedokrwienny tętnic
polimorfizm genów MTHFR C677T
polimorfizm genów PAI
Opis:
Introduction. Arterial ischemic stroke (AIS) in childhood is a disorder associated with different predisposing factors, thrombophilia is one of them. We present the study of the MTHFR C677T and PAI-1 5G/4G gene polymorphisms as a possible risk factor for the development of AIS in the group of Ukrainian children. Materials and methods. 77 children from 29 days to 15 years of age were involved in this study: study group - 44 children with AIS, and 33 in a control group. Children enrolled to both groups were at similar age. Results. In the study group there was an increase in the frequency of genotypes 677CT (OR = 2.69) and 677TT, CT + TT genotypes (OR = 3.67) of the MTHFR gene, increased frequency of the 677T allele (OR = 2.57). In the study group detection of 5G/5G + 5G/4G genotypes was higher (OR = 2.82) with statistically predominance of the 5G allele (OR = 2.26) of the gene PAI -1. Higher frequency of the combination of genotypes genes 677CT + 5G/5G was found in the main group. The model of interpreting interactions was built, it allows to predict indirectly the potential intergenic interactions. Conclusions. We conclude that risk of AIS is higher in children with polymorphic variants 677CT and 677TT for the MTHFR gene; the association of polymorphic variants 5G/4G and 5G/5G for the PAI-1 gene with a decrease in the risk of developing AIS; direct interaction with the MTHFR was found for PAI-1, but of weak strength
Wstęp: Udar niedokrwienny (AIS) jest rzadkim schorzeniem wieku dziecięcego, które wiąże się z różnymi czynnikami predysponującymi. Trombofilia jest jedną z ustalonych predyspozycji genetycznych do udaru w populacji pediatrycznej. Cel: Przedstawiamy badanie polimorfizmów genów MHFR C677T i PAI-1 5G / 4G jako potencjalnego czynnika ryzyka rozwoju AIS indywidualnie i łącznie w grupie dzieci ukraińskich. Materiał i metody Badaniem objęto 77 dzieci w wieku od 29 dni do 15 lat: grupa badana - 44 dzieci z AIS oraz grupa kontrolna - 33 dzieci zakwalifikowanych do obu grup znajdowały się w podobnym wieku. Wyniki: W badanej grupie stwierdzono większą częstość genotypów 677CT (OR = 2,69) i 677TT, genotypów CT + TT (OR = 3,67) genu MTHFR oraz większą częstość allelu 677T (OR = 2,57). W analizowanej grupie wykrywalność genotypów 5G / 5G + 5G / 4G była wyższa (OR = 2,82) przy statystycznej przewadze allelu 5G (OR = 2,26) genu PAI -1. Ponadto w analizowanej grupie pacjentów stwierdzono większą częstość kombinacji genotypów 677CT + 5G / 5G w porównaniu z grupą kontrolną. Wnioski: Uzyskane wyniki badań pozwalają na stwierdzenie, że ryzyko wystąpienia AIS u dzieci jest wyższe w przypadku obecności polimorficznych wariantów 677CT i 677TT dla genu MTHFR; z kolei skojarzenie wariantów polimorficznych 5G / 4G i 5G / 5G dla genu PAI-1 wiąże się ze zmniejszonym ryzykiem rozwoju AIS. Stwierdzono także występowanie bezpośredniej interakcji MTHFR z PAI-1, jednak o małej sile oddziaływania.
Źródło:
Neurologia Dziecięca; 2020, 29, 58; 27-32
1230-3690
2451-1897
Pojawia się w:
Neurologia Dziecięca
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bricks in the Shanghai Landscape: Revealing the City’s Shifting Identities
Autorzy:
Kanagaratnam, Tina
Powiązania:
https://bibliotekanauki.pl/articles/2040202.pdf
Data publikacji:
2021-11-08
Wydawca:
Wydawnictwo Uniwersytetu Śląskiego
Tematy:
bricks
Shanghai
lilong
material history
Hai-Pai
Opis:
This paper considers the parallels between the changes in Shanghai’s brick usage through history and the city’s shifting identities. Taking a new angle on studies of the Chinese wall, the author looks at the most basic element of the wall – the brick – in the context of Shanghai’s social and political history and postcolonial theory and proposes that it was the changes in the city’s identity, precipitated by both internal and external forces, that have ultimately driven the selection and subsequent interpretation of brick types during different periods of history. This paper also considers how brick usage is employed today to reinterpret history and define heritage.
Źródło:
Śląskie Studia Polonistyczne; 2021, 18, 2; 1-12
2084-0772
2353-0928
Pojawia się w:
Śląskie Studia Polonistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
W poszukiwaniu przeszłości: Trudne dzieje Wyspy Wielkanocnej (Rapa Nui) w dwóch współczesnych filmach dokumentalnych
Searching for the Past: The difficult History of Easter Island (Rapa Nui) Depicted in Two Contemporary Documentaries
Autorzy:
Jakubowska-Vorbrich, Zuzanna
Powiązania:
https://bibliotekanauki.pl/articles/2148067.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Warszawski. Instytut Studiów Iberyjskich i Iberoamerykańskich
Tematy:
Chile
Wyspa Wielkanocna
Rapa Nui
posągi pai
film dokumentalny
etnologia
Easter Island
documentary film
ethnology
moai statues
Opis:
Artykuł przedstawia i analizuje dwa współczesne filmy dokumentalne dotyczące Wyspy Wielkanocnej (Rapa Nui): Buscando a Isla de Pascua, la película perdida [Poszukując zaginionego filmu Isla de Pascua] (2014) oraz Te Kuhane o te Tupuna / El Espíritu de los ancestros [Duch przodków] (2015). Pierwszy film opowiada historię odnalezienia i restauracji innego filmu dokumentalnego – z lat 60. – i przywrócenia go wyspiarskiej społeczności, jest to więc film o kompozycji szkatułkowej. Drugi dokument opowiada o podróży do Europy z zamiarem (fikcyjnym) odzyskania rapanujskiego posągu moai, będącego eksponatem w Muzeum Brytyjskim. Możemy go zatem nazwać filmem drogi. Oba dokumenty poruszają tematykę historyczną. społeczną i kulturalną, nie stroniąc od trudnych motywów z przeszłości i teraźniejszości Rapa Nui.
The paper presents and analyses two contemporary documentaries about Easter Island (Rapa Nui): Buscando a „Isla de Pascua”, la película perdida [In Search for the Lost Film, Isla de Pascua] (2014) and Te Kuhane o te Tupuna / El Espíritu de los ancestros [The Spirit of the Ancestors] (2015). The first movie tells the story of the discovery and restoration of another documentary, realised in the 60., as well as of bringing it back to the Rapanui community. We can call it a nested film. The other documentary is about a travel to Europe, undertaken with a (fictitious) purpose of repatriating a Rapanui stone statue – moai – exhibited in the British Museum. It can be deemed a kind of a road movie, then. Both documentaries address historical, social and cultural issues, without omitting difficult moments from Rapa Nui’s past and present times.
Źródło:
Ameryka Łacińska. Kwartalnik analityczno-informacyjny; 2021, 29, 3-4 (113-114); 75-88
1506-8900
2081-1152
Pojawia się w:
Ameryka Łacińska. Kwartalnik analityczno-informacyjny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Numerical Simulation of Breast Cancer in the Early Diagnosis with Actual Dimension and Characteristics Using Photoacoustic Tomography
Autorzy:
Ahangar Darband, Maryam
Najafi Aghdam, Esmaeil
Gharibi, Arash
Powiązania:
https://bibliotekanauki.pl/articles/31339923.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
photoacoustic
PA
photoacoustic imaging
PAI
photoacoustic tomography
breast cancer
early diagnosis
Opis:
A numerical study and simulation of breast imaging in the early detection of tumors using the photoacoustic (PA) phenomenon are presented. There have been various reports on the simulation of the PA phenomenon in the breast, which are not in the real dimensions of the tissue. Furthermore, the different layers of the breast have not been considered. Therefore, it has not been possible to rely on the values and characteristics of the resulting data and to compare it with the actual state. Here, the real dimensions of the breast at three-dimensional and different constituent layers have been considered. After reviewing simulation methods and software for different stages of the PA phenomenon, a single suitable platform, which is commercially available finite element software (COMSOL), has been selected for simulating. The optical, thermal, elastic, and acoustic characteristics of different layers of breast and tumor at radiated laser wavelength (800 nm) were accurately calculated or obtained from a reliable source. Finally, by defining an array of 32 ultrasonic sensors on the breast cup at the defined arcs of the 2D slices, the PA waves can be collected and transmitted to MATLAB software to reconstruct the images. We can study the resulting PA wave and its changes in more detail using our scenarios.
Źródło:
Archives of Acoustics; 2023, 48, 1; 25-38
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-10 z 10

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