Temat: NF-κB transcription factors - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: NF-κB signaling pathway and free radical impact
Autorzy:: Siomek, Agnieszka
Powiązania:: https://bibliotekanauki.pl/articles/1039704.pdf
Data publikacji:: 2012
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: nitrogen oxygen species
NF-κB transcription factors
reactive oxygen species
Opis:: The activation of NF-κB transcription factor is critical for a wide range of processes such as immunity, inflammation, cell development, growth and survival. It is activated by a variety of stimuli including cytokines, ionizing radiation and oxidative stress. Redox modulations of NF-κB pathway have been widely demonstrated. Studies carried out during last years have advanced our knowledge about possible connections between NF-κB pathway and the impact of free radicals. This review is an endeavor to gather recent results focused on this issue, although an important question, whether oxidative stress plays a physiological role in NF-κB activation, seems to be still unanswered.
Źródło:: Acta Biochimica Polonica; 2012, 59, 3; 323-331
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The nuclear factor-kappaB (NF-κB): from a versatile transcription factor to a ubiquitous therapeutic target
Autorzy:: Yates, Laura
Górecki, Dariusz
Powiązania:: https://bibliotekanauki.pl/articles/1041153.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: nuclear factor-kappaB (NF-κB)
IκB kinase complex (IKK)
transcription factors
inhibitory-kappaB (IκB)
Opis:: The nuclear factor-kappaB (NF-κB) transcription factors regulate a plethora of cellular pathways and processes including the immune response, inflammation, proliferation, apoptosis and calcium homeostasis. In addition to the complexity of its physiological roles, the composition and function of this family of proteins is very complicated. While the basic understanding of NF-κB signalling is extensive, relatively little is know of the in vivo dynamics of this pathway or what controls the balance between various outcomes. Although we know a large number of NF-κB-responsive genes, the contribution of these genes to a specific response is not always clear. Finally, the involvement of NF-κB in pathological processes is only now beginning to be unravelled. In addition to cancer and immunodeficiency disorders, altered regulation of NF-κB has been associated with several inherited diseases. These findings indicate that modulation of the NF-κB pathways may be beneficial. However, our limited knowledge of NF-κB signalling hinders therapeutic approaches: in many situations it is not clear whether the enhancement or inhibition of NF-κB activity would be beneficial or which pathways to interfere with and what the required level of activation is. Further studies of the role of NF-κB are needed as these may result in novel therapeutic strategies for a wide variety of diseases.
Źródło:: Acta Biochimica Polonica; 2006, 53, 4; 651-662
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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