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Wyszukujesz frazę "Mycobacterium fortuitum" wg kryterium: Temat


Wyświetlanie 1-2 z 2
Tytuł:
Nontuberculous mycobacterial skin disease in cat; diagnosis and treatment - case report
Autorzy:
Krajewska-Wędzina, M.
Dąbrowska, A.
Augustynowicz-Kopeć, E.
Weiner, M.
Szulowski, K.
Powiązania:
https://bibliotekanauki.pl/articles/2085034.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
mycobacteriosis
Mycobacterium fortuitum
MOTT
cats
nontuberculous mycobacteria
Opis:
Introduction. Mycobacterial diseases of humans and animals can be caused by mycobacteria other than tuberculosis (MOTT). The transmission of the infection primarily occurs via the respiratory or oral routes, but also via a damaged skin barrier. MOTT have high resistance to external factors; therefore, infected, undiagnosed animals can pose a risk for public health. Case report. The case study describes mycobacterial skin infection in a domestic cat. The correct diagnosis was reached four months after the appearance of the first clinical signs. Those were purulent, granulomatous lesions and fistulas, which could potentially act as a source of the infection for the owners and the veterinarian who cared for the animal. Conclusion. Despite using advanced diagnostic techniques, establishing the final cause of the cat’s illness was a lengthy process. The skin lesions could contribute to the transmission of the bacteria in the environment. Non-targeted treatments could also cause antimicrobial resistance.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 3; 511-513
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
INSIGHTS INTO MYCOBACTERIAL ACTIVITY AND CYTOTOXICITY OF SUBSTITUED ISOXAZOLE-4-CARBOHYDRAZIDE DERIVATIVES.
Autorzy:
Płoszaj, Paulina
Junka, Adam
Szponar, Bogumiła
Mączyński, Marcin
Ryng, Stanisław
Bartoszewicz, Marzenna
Piwowar, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/895364.pdf
Data publikacji:
2018-06-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide
Mycobacterium fortuitum
Opis:
The purpose of this study was to evaluate the antimycobacterial activity of novel derivatives of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide 1, isoniazid (INH) structural analogue. A set of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide 1 derivatives 2a-j have been obtained by condensation reactions with aldehydes and further transformed by cyclization with corresponding orthoesters to 5-amino-3-methylisoxazole[5,4-d]pyrimidin-4-one derivatives 3a-j and 4a-j. From the structural and functional point of view, all these products proved to be biologically important and could be used as substrates for further synthesis. 21 out of 31 structures were newly developed. Described compounds were screened against Mycobacterium fortuitum in MABA test. The most active compound 2e, 2g revealed minimum inhibitory concentration at 16 μg/ml. In addition, these compounds revealed low cytotoxicity against lung (A549) and fibroblasts (L929) cell lines. The results demonstrated the potential and importance of further development of 5-amino-3-methyl-4-isoxazolecarboxylic acid hydrazide derivatives as a new class of antimycobacterial compounds.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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