- Tytuł:
- Cytomegalovirus immediate early gene UL37 encodes a novel MHC-like protein
- Autorzy:
-
Wyrwicz, Lucjan
Rychlewski, Leszek - Powiązania:
- https://bibliotekanauki.pl/articles/1040815.pdf
- Data publikacji:
- 2008
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
Betaherpesvirinae
CMV
protein structure prediction
MHC I class
bioinformatics
apoptosis - Opis:
- The cytomegalovirus (CMV) genome encodes four clusters of genes expressed immediately after infection - i.e.: UL36-38, UL122-123, TRS1-IRS1, and US3. The general function of these genes is associated with inhibition of cellular mechanisms of antiviral response. Although several biological processes have been mapped onto specific gene products, the knowledge of the molecular mechanism of their activity remains fragmentary. Here, we report the application of protein structure prediction methods in assigning the function to a glycosylated domain encoded by UL37 of CMV (gpUL37, UL37x3). The discerned similarity clearly points out that this domain represents a novel type of a major histocompatibility complex (MHC)-like protein, and consequently may play a central role in an additional mechanism of escape from antiviral response.
- Źródło:
-
Acta Biochimica Polonica; 2008, 55, 1; 67-74
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł