Temat: MAO - Katalog OPAC zbiorów

Tytuł:: Antioxidant properties of PF9601N, a novel MAO-B inhibitor: assessment of its ability to interact with reactive nitrogen species
Autorzy:: Bellik, Lydia
Dragoni, Stefania
Pessina, Federica
Sanz, Elisenda
Unzeta, Mercedes
Valoti, Massimo
Powiązania:: https://bibliotekanauki.pl/articles/1040409.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: MAO-B inhibitors
peroxynitrite
l-deprenyl
nitric oxide
Parkinson's disease
Opis:: The novel MAO-B inhibitor PF9601N, its cytochrome P450-dependent metabolite FA72 and l-deprenyl were studied as potential peroxynitrite (ONOO-) scavengers and nitric oxide synthase (NOS) inhibitors. The scavenging activity of these compounds was evaluated by measuring the oxygen consumption through peroxynitrite-mediated oxidation of both linoleic acid and brain homogenate. FA72, PF9601N and l-deprenyl caused a concentration-dependent inhibition of ONOO--induced linoleic acid oxidation with an IC50 value of 60.2 µM, 82.8 µM and 235.8 µM, respectively. FA72 was the most potent also in inhibiting ONOO--induced brain homogenate oxidation with an IC50 value of 99.4 µM, while PF9601N and l-deprenyl resulted weaker inhibitors in the same experimental model, showing an IC50 value of 164.8 and 112.0 µM, respectively. Furthermore, both the novel MAO-B inhibitor as well as its metabolite were able to strongly inhibit rat brain neuronal NOS (IC50 of 183 µM and 192 µM, respectively), while l-deprenyl at the highest concentration used (3 mM), caused only a slight decrease of the enzyme activity. Moreover, inducible NOS was strongly inhibited by FA72 only. All these results suggest that PF9601N could be a promising therapeutic agent in neurodegenerative disorders such as Parkinson's disease.
Źródło:: Acta Biochimica Polonica; 2010, 57, 2; 235-239
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Strategia i taktyka nawiązywania stosunków dyplomatycznych przez Chińską Republikę Ludową z innymi państwami w latach 1949-1961
Strategy and tactics of the Peoples Republic of China concerning establishing diplomatic relations with other countries in the years 1949-1969
Autorzy:: Podlewska, Sylwia
Powiązania:: https://bibliotekanauki.pl/articles/567212.pdf
Data publikacji:: 2010
Wydawca:: Uniwersytet Warmińsko-Mazurski w Olsztynie. Instytut Nauk Politycznych
Tematy:: China
Diplomatic relations
"Lean-to-one-side"
Mao Zedong
Opis:: Due to changes in internal and international situation PRC's politics and tactics in the field of international relations was also changing in order to make the country a global power. To achieve this aim, establishing diplomatic relations with other countries was a key assumption of international politics. The author of the article has attempted to analyze the strategy and tactics of normalizingPRC's relations with other countries during the years 1949—1969 and has tried to present how they developed. Another aim of the article has been to present the process of PRC's coming out of the isolation which occurred as a result of the new government's decisions as well as other countries' 'shock' at the establishment of the communist China. The first thirty years of PRC that have been analyzed have been divided into four periods that differed from one another in the aims of home and international politics. The first period is the years 1949-1956. These years were marked by the rebuilding of the country and the growing power of the Communist Party of China (CPC) at home whereas abroad the characteristic of this period was the 'lean-to-one-side' strategy, i.e. alliance with the USSR and new relations with socialist countries, mainly with the countries of Asia. The second period is the years 1957—1960 during which the power of Mao Zedong grew as he got rid of his political opponents. Home and internal politics became more radical. The Republic of China was aiming at becoming a strong international player with powers equal to those of other socialist countries. Another aim was becoming the leader of the countries of the Third World. In the third period (1961—1965) Mao's position became less conspicuous and the country's economic situation improved. Inter-nationally, this period was characterized by the attempts to build a third direction of international politics. PRC was trying to lead in the establishment of the Third World countries' block and become the centre of the world revolution. The most radical and destructive was the fourth period of 1966-1969, i.e. the cultural revolution in¬itiated by Mao. The revolution brought about a disaster in the economic situation. Its other effect was the country's isolation. In order to stop that impasse, PRC finally turned 'right' i.e. towards the capitalist countries. Intensive actions were taken that normalized the relations with those countries. Owing to that flexibility, already in 1970 PRC initiated the process by establishing diplomatic relations with Canada.
Źródło:: Forum Politologiczne; 2010, 11 - Chiny i państwa azjatyckie - karty z historii i wyzwania współczesności; 111-146
1734-1698
Pojawia się w:: Forum Politologiczne
Dostawca treści:: Biblioteka Nauki

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