- Tytuł:
- Układy liposom-polimer jako nośniki białek zakotwiczonych przez GPI
- Autorzy:
- Łukasiewicz, Magdalena
- Powiązania:
- https://bibliotekanauki.pl/articles/1034203.pdf
- Data publikacji:
- 2012
- Wydawca:
- Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
- Tematy:
-
Aktywność białka
Białka kotwiczące przez GPI
Liposomy
Liposomy a odpowiedź immunologiczna
Technologia liposomalna
Trwałość liposomów i metody ich stabilizacji
Układy liposomalne - Opis:
- This paper presents the development of novel liposomal nanocarriers which can be used in delivery of biologically-active substances, such as proteins. There is a great interest in liposomal carriers, which could be used for medical and pharmacological applications. However, because of low stability of liposomes, such applications are challenging. Certain external factors, such as pH, temperature or the presence of other substances in the environment may have a damaging effect on the lipid vesicles. Proteins are known to play an essential role in the functioning of living organisms. They have mechanical-structural functions, but they can also act as biocatalysts (enzymes), neurotransmitters, or are involved in the transport of small molecules and ions in tissue. The interest in GPI-linked proteins is related to their ability to incorporate in the lipid bilayer. They have a glycosylphosphatidylinositol anchor with two long alkyl chains. These chains can incorporate in the cell membrane, thus allowing their attachment to the outer surface of vesicles. Coating them with polyelectrolytes can increase the stability of liposomes. It was found that some polymeric films have the ability to stabilize the liposomal nanocarriers of proteins. That can be correlated with the value of the zeta potential of polymer which coats liposomes, as well as with the shape of a polymeric chain. The polymeric coating can be carefully chosen to ensure that the stabilizing effect will be associated with protein protection reflected in its high enzymatic activity.
- Źródło:
-
Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe; 2012, 5; 57-75
2082-3827
2084-977X - Pojawia się w:
- Zeszyty Naukowe Towarzystwa Doktorantów Uniwersytetu Jagiellońskiego. Nauki Ścisłe
- Dostawca treści:
- Biblioteka Nauki
Artykuł