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    Wyświetlanie 1-13 z 13
    Tytuł:
    Antiparasitic drug-design strategy as an interdisciplinary process
    Autorzy:
    Boczon, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/836476.pdf
    Data publikacji:
    1994
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Trichinella
    Leishmania
    drug
    Trypanosoma
    Protozoa
    antiprotozoon drug
    phosphoglicerate kinase
    antiparasitic drug
    Źródło:
    Annals of Parasitology; 1994, 40, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antiparasitic drug-design strategy as an interdisciplinary process
    Autorzy:
    Boczoń, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/2151472.pdf
    Data publikacji:
    1994
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Trichinella
    Leishmania
    drug
    Trypanosoma
    Protozoa
    antiprotozoon drug
    phosphoglicerate kinase
    antiparasitic drug
    Źródło:
    Wiadomości Parazytologiczne; 1994, 40, 3; 313-314
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunosuppression during Leishmania donovani infection: a potential target for the development of therapy
    Autorzy:
    Flora, R.
    Aghazadeh-Dibavar, S.
    Bandyopadhyay, M.
    Dasgupta, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/5556.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    immunosuppression
    Leishmania donovani
    parasite
    infection
    therapy
    leishmanial infection
    leishmaniasis
    Opis:
    Dysfunction of T-helper 1 mediated immune responses is a hallmark of the progression of visceral leishmaniosis (VL). Several factors such as altered antigen presentation, and abnormalities in MHC/HLA, antigen processing, and T cell receptor recognition regulate the onset of immunosuppression. Recent investigations on VL patients suggest that susceptibility to visceral leishmaniosis is genetically determined and varies between populations in different geographical locations. Emerging evidence also indicates the importance of the role played by myeloid derived suppressor cells in progressive VL. This study provides a mechanistic view of means to target the signaling mechanisms of immunosuppression to determine potential therapeutic interventions.
    Źródło:
    Annals of Parasitology; 2014, 60, 4
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In vitro Antileishmanial Activity of Hydroalcoholic Extract, Fractions, and Compounds Isolated from Leaves of Piper ovatum Vahl against Leishmania amazonensis
    Autorzy:
    RODRIGUES-SILVA, Daniel
    NAKAMURA, Celso Vataru
    DIAS FILHO, Benedito Prado
    UEDA-NAKAMURA, Tânia
    CORTEZ, Diógenes Aparício Garcia
    Powiązania:
    https://bibliotekanauki.pl/articles/763714.pdf
    Data publikacji:
    2009
    Wydawca:
    Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
    Tematy:
    Antiprotozoan activity
    ultrastructure alterations
    Leishmania amazonensis
    Piper ovatum
    Opis:
    We assessed the biological activity of a crude extract, a mixture of several fractions, and a pure compound obtained from Piper ovatum Vahl against promastigote and amastigote forms of Leishmania amazonensis. The medicinal plant P. ovatum is used popularly as an anesthetic and anti-inflammatory. This study included the extraction process and bioassay-guided fractionation by the adsorption chromatography and Sephadex LH-20 method. A progressive increase in the antileishmanial effect was observed in the course of fractionation. The 50% inhibitory concentration (IC50) for dichloromethane-ethyl acetate (1:1 v/v) fraction was 2.1 μg/ml and 24 μg/ml; mixture of piperovatine: piperlongumune (2:3) 0.9 μg/ml and 24 μg/ml; piperovatine (1) 9.5 μg/ml and 10 μg/ml; and piperlonguminine (2) 2.5 μg/ml and 9.0 μg/ml, for promastigote and amastigote forms, respectively. Cytotoxicity analysis indicated that these toxic concentrations were much higher for J774G8 macrophages and Vero cells than for the protozoans. The mixture of piperovatine: piperlongumune (2:3) showed important antiprotozoal activity against the amastigote and promastigote forms of L. amazonensis, and it produced morphological changes in promastigotes and amastigotes at 0.9 μg/ml and 24 μg/ml (50% growth inhibition concentration), respectively, including intense cytoplasmic vacuolization, mitochondrial swelling, and mitochondrial damage, as revealed by transmission electron microscopy.
    Źródło:
    Acta Protozoologica; 2009, 48, 1
    0065-1583
    1689-0027
    Pojawia się w:
    Acta Protozoologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rola dopełniacza w odporności na zakażenia pierwotniakami
    Autorzy:
    Jankowski, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148914.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Naegleria fowleri
    dopelniacze
    odpornosc organizmow
    bialko C
    swidrowce
    Toxoplasma gondii
    mechanizmy obronne
    Leishmania
    opornosc na pasozyty
    parazytologia
    pierwotniaki
    inwazja pasozytnicza
    Trypanosoma cruzi
    Entamoeba histolytica
    Opis:
    The scope of this work is the presentation of new theories concerning the role of complement (C) in the resistance of high organism to the infection caused by protozoa. The mechanisms protecting of Entamoeba histolytica, Leishmania spp., Trypanosoma cruzi, Toxoplasma gondii and Naegleria fowleri from the action of C are also described.
    Źródło:
    Wiadomości Parazytologiczne; 1997, 43, 4; 369-383
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rola dopelniacza w odpornosci na zakazenia pierwotniakami
    Autorzy:
    Jankowski, S
    Powiązania:
    https://bibliotekanauki.pl/articles/837137.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    Naegleria fowleri
    dopelniacze
    odpornosc organizmow
    bialko C
    swidrowce
    Toxoplasma gondii
    mechanizmy obronne
    Leishmania
    opornosc na pasozyty
    parazytologia
    pierwotniaki
    inwazja pasozytnicza
    Trypanosoma cruzi
    Entamoeba histolytica
    Opis:
    The scope of this work is the presentation of new theories concerning the role of complement (C) in the resistance of high organism to the infection caused by protozoa. The mechanisms protecting of Entamoeba histolytica, Leishmania spp., Trypanosoma cruzi, Toxoplasma gondii and Naegleria fowleri from the action of C are also described.
    Źródło:
    Annals of Parasitology; 1997, 43, 4; 369-383
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rownoczesne zarazenie makrofagow przez Leishmania donovani i wirus HIV-1
    Autorzy:
    Branska, B
    Lucinska, A.
    Galary, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/839203.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    czynniki chorobotworcze
    makrofagi
    wirusy
    pierwotniaki
    parazytologia
    wirus HIV-1
    Leishmania donovani
    Opis:
    The observation that hypophosphoglycan (LPG) from Leishmania donovani can lead to TNF-alfa mediated induction ofHIV-1 expression supports the idea that these protozoan parasites can be envisaged as putative cofactors in the pathogenesis of HIV-1 infection.
    Źródło:
    Annals of Parasitology; 1998, 44, 4; 647-651
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Równoczesne zarażenie makrofagów przez Leishmania donovani i wirus HIV-1
    CO-INFECTION OF MACROPHAGES WITH LEISHMANIA DONOVANI AND VIRUS HIV-1
    Autorzy:
    Brańska, B.
    Lucińska, A.
    Galary, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148876.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    czynniki chorobotworcze
    makrofagi
    wirusy
    pierwotniaki
    parazytologia
    wirus HIV-1
    Leishmania donovani
    Opis:
    The observation that hypophosphoglycan (LPG) from Leishmania donovani can lead to TNF-alfa mediated induction ofHIV-1 expression supports the idea that these protozoan parasites can be envisaged as putative cofactors in the pathogenesis of HIV-1 infection.
    Źródło:
    Wiadomości Parazytologiczne; 1998, 44, 4; 647-651
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Seroepidemiological study of canine Leishmania infantum and Toxoplasma gondii infections in Shanghai, China, and analysis of risk factors
    Autorzy:
    Jiang, Wei
    Wang, Yan
    Liu, Yingchun
    Li, Tao
    Chen, Yongjun
    Wang, Shaohui
    Han, Xiangan
    Wang, Quan
    Powiązania:
    https://bibliotekanauki.pl/articles/990968.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    seroprevalence
    leishmania infantum
    toxoplasma gondii
    household dogs
    risk factors
    Opis:
    The aim of this study was to determine the seroprevalence of Leishmania infantum and Toxoplasma gondii among household dogs in Shanghai (the most important industrial and commercial city in China), and to assess the possible risk factors associated with the infection. During 2014–2015, a total of 408 sera were collected from healthy household dogs and tested for L. infantum and T. gondii infection using commercial ELISA kits. The endemic characteristics according to gender, age group and breed were revealed by statistical descriptions and inference. The positive rates of L. infantum infection (24/408, 5.9%) were lower than those of T. gondii infection (37/408, 9.1%), and co-infection with both parasites was detected in seven dogs (7/408, 1.7%). Seropositivity for either parasite was more likely associated with age: the seroprevalence of T. gondii infection ranged from 1.3% (dogs≤1 year) – 18.7% (dogs>6 years), whereas that of L. infantum ranged from 1.3% (dogs≤1 year) – 9.9 % (dogs>6 years). Interestingly, the rates of exposure to both L. infantum and T. gondii were higher in males than in females. Relatively higher exposure rates for L. infantum and T. gondii were also observed in crossbred dogs compared with purebred dogs. However, neither gender nor breed is likely a determining factor for infection with these two parasites (P > 0.05). Identification of the risk factors that underlie these differences may help in the prevention of L. infantum and T. gondii infection in household dogs. To the best of our knowledge, this is the first report of L. infantum and T. gondii infection in household dogs in Shanghai, which shows that these two important parasites are still prevalent in this region. Therefore, it is necessary to take integrated strategies for prevention and control of infection in animals, which could help to reduce human infection in the region.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2016, 23, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The case of visceral leishmaniasis complicated by disseminated intravascular coagulation syndrome
    Autorzy:
    Goljan, J.
    Nahorski, W.
    Gorski, J.
    Kryger, T.
    Felczak-Korzybska, I.
    Powiązania:
    https://bibliotekanauki.pl/articles/841191.pdf
    Data publikacji:
    1998
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    parasite
    leishmaniasis
    Polska
    Leishmania infantum
    visceral leishmaniasis
    Źródło:
    Annals of Parasitology; 1998, 44, 3
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of toll-like receptor agonists in the immunotherapy of leishmaniosis. An update and proposal for a new form of anti-leishmanial therapy
    Autorzy:
    Dasgupta, S.
    Aghazadeh-Dibavar, S.
    Bandyopadyay, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/6077.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    toll-like receptor
    immune response
    immunotherapy
    leishmaniasis
    new form
    therapy
    parasitic infection
    Leishmania
    Opis:
    The use of toll-like receptor agonists in immunotherapy is a new approach in the prevention of immunosuppression during fatal Leishmania parasite infection. The objective of such immunotherapy is to activate specific cell-mediated immune responses, macrophage activation and antigen-responsive inflammation, to kill intracellular amastigotes. Toll-like receptor agonist-based treatment in immunocompetent hosts can be effective either by selective use of the agonists alone or in combination with the anti-leishmanial drug stibanate. Recent investigations suggest that toll-like receptor signal pathways constitute a possible new mode of anti-leishmanial treatment. This article describes the prospect of toll-like receptor – mediated signal pathways in the immunotherapy of cutaneous and visceral leishmaniosis, as well as post kala-azar dermal leishmaniosis (PKADL), a skin-sequel of visceral infection. Suitable synthetic agonists need to be developed for toll-like receptors to overcome immunosuppression.
    Źródło:
    Annals of Parasitology; 2014, 60, 2
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zrodlo i znaczenie genetycznego zroznicowania populacji pasozytniczych pierwotniakow
    Autorzy:
    Majewska, A C
    Sulima, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/837049.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zroznicowanie genetyczne
    Leishmania
    Giardia
    struktura populacji
    pierwotniaki
    parazytologia
    zroznicowanie gatunkowe
    Toxoplasma
    populacje zwierzat
    pasozyty
    Trypanosoma
    Cryptosporidium
    Opis:
    The application of biochemical and molecular techniques in parasitological studies has provided increasing evidences of genetic polymorphism among parasite populations. This review presents possible origins of genetic variation within populations of various protozoan species. Since the mode of reproduction has an important influence on genetic polymorphism within parasite populations these considerations refer mainly to some protozoan parasites which have various life cycles, e.g. Giardia, Trypanosoma, Cryptosporidium, Toxoplasma. Also other factors associated with parasites (such as: transmission and passage history in laboratory conditions; occurrence in different hosts or geographic regions; selective pressure of drugs; competitive interactions between populations) that affect parasite genetic diversity are discussed. However, the number of examined isolates of parasites and genetic markers, assortment of methods, probes, primers and reagents used is also of significance. The significance of genetic variability in parasite populations is still the subject of much interest and controversy. A simple interpretation of such variation is impossible because of the complexity of host-parasite interactions. The knowledge of parasite diversity at the nucleic acids level has continually increased, but a corect interpretation of this phenomenon requires at least the same knowledge of genetic variability in host populations. Nevertheless, genetic variability in protozoan parasites has many important implications, e.g. for taxonomy, epidemiology, control and evolution. Genetic differences within parasite populations might also be associated with phenotypic variability, e.g. virulence, antigenicity, infectivity, drug sensitivity, hostpreference etc.
    Źródło:
    Annals of Parasitology; 1999, 45, 3; 293-307
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Źródło i znaczenie genetycznego zróżnicowania populacji pasożytniczych pierwotniaków
    SOURCE AND SIGNIFICANCE OF GENETIC POLYMORPHISM OF SELECTED PARASITIC PROTOZOA
    Autorzy:
    Majewska, A. C.
    Sulima, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148795.pdf
    Data publikacji:
    1999
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zroznicowanie genetyczne
    Leishmania
    Giardia
    struktura populacji
    pierwotniaki
    parazytologia
    zroznicowanie gatunkowe
    Toxoplasma
    populacje zwierzat
    pasozyty
    Trypanosoma
    Cryptosporidium
    Opis:
    The application of biochemical and molecular techniques in parasitological studies has provided increasing evidences of genetic polymorphism among parasite populations. This review presents possible origins of genetic variation within populations of various protozoan species. Since the mode of reproduction has an important influence on genetic polymorphism within parasite populations these considerations refer mainly to some protozoan parasites which have various life cycles, e.g. Giardia, Trypanosoma, Cryptosporidium, Toxoplasma. Also other factors associated with parasites (such as: transmission and passage history in laboratory conditions; occurrence in different hosts or geographic regions; selective pressure of drugs; competitive interactions between populations) that affect parasite genetic diversity are discussed. However, the number of examined isolates of parasites and genetic markers, assortment of methods, probes, primers and reagents used is also of significance. The significance of genetic variability in parasite populations is still the subject of much interest and controversy. A simple interpretation of such variation is impossible because of the complexity of host-parasite interactions. The knowledge of parasite diversity at the nucleic acids level has continually increased, but a corect interpretation of this phenomenon requires at least the same knowledge of genetic variability in host populations. Nevertheless, genetic variability in protozoan parasites has many important implications, e.g. for taxonomy, epidemiology, control and evolution. Genetic differences within parasite populations might also be associated with phenotypic variability, e.g. virulence, antigenicity, infectivity, drug sensitivity, hostpreference etc.
    Źródło:
    Wiadomości Parazytologiczne; 1999, 45, 3; 293-307
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-13 z 13

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