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    Wyświetlanie 1-4 z 4
    Tytuł:
    THE EFFECTS OF SULFUR-CONTAINING COMPOUNDS ON REDOX STATUS IN HOMOCYSTEINE-TREATED RATS
    Autorzy:
    Sobot, Tanja S.
    Zivkovic, Vladimir I.
    Srejovic, Ivan M.
    Jeremic, Jovana N.
    Nikolic Turnic, Tamara R.
    Ponorac, Nenad D.
    Petkovic, Anica M.
    Jakovljevic, Vladimir L.
    Djuric, Dragan M.
    Powiązania:
    https://bibliotekanauki.pl/articles/895260.pdf
    Data publikacji:
    2019-02-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    oxidative stress
    homocysteine
    N-acetylcysteine
    L-cysteine
    L-methionine
    sulfur amino acids
    Opis:
    There is growing interest in the activity of sulfur-containing compounds on redox balance in physiological and pathological conditions, considering that some of these compounds have not only antioxidative but also pro-oxidative activities. Aim of this study was to assess possible differences in the effects of various sulfur-containing compounds on redox balance of cardiovascular system in its physiological state and in the early onset of hyperhomocysteinemia. This experimental study divided Wistar albino rats into two groups: saline-treated (control) and DL-homocysteine-treated (experimental group). Rats from experimental group were subjected to subchronic subcutaneous administration of DL-homocysteine at dose of 0.45 μmol/g body weight twice a day for 2 weeks. At the end of this period, rats were sacrificed, and blood samples were collected to be analysed for homocysteine concentration and systemic oxidative stress. Isolated rat hearts were excised and attached to the Langendorff apparatus. To assess the effects of acute administration of L-methionine, L-cysteine, N-acetylcysteine, and sodium hydrogen sulfide, the hearts were perfused individually with each of the mentioned substances at same single dose of 0.5 mmol/l for 5 min. In collected samples of coronary venous effluent oxidative stress biomarkers were determined using spectrophotometry. Total homocysteine level was significantly higher in the experimental group than in the control group, and the effects of applied sulfur-containing compounds were significantly different in experimental and control groups. DL-homocysteine induced considerable changes in functioning of cardiovascular system even before an increase in plasma homocysteine values, and action of sulfur-containing compounds varied depending on the presence of homocysteine.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 147-157
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The γ-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups.
    Autorzy:
    Włodek, Przemysław
    Sokołowska, Maria
    Smoleński, Olgierd
    Włodek, Lidia
    Powiązania:
    https://bibliotekanauki.pl/articles/1043788.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    L-cysteine
    kidney
    aging
    γ-glutamyl transferase
    reactive oxygen species
    protein-bound cysteine
    glutathione
    sulfane sulfur compounds
    Opis:
    The present work was aimed to obtain information about age-dependent changes of γ-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the oldest animals. These findings indicate that the capacity for extracellular glutathione degradation and, in consequence, the availability of cysteine for intracellular glutathione biosynthesis may be impaired. The increased PB-Cys level indicates potentiation of the thiolation reaction, i.e. development of protein-mixed disulfides. These results reveal age dependent disturbances in the thiol-disulfide equilibrium in the kidneys which leads to an imbalance between pro- and antioxidatory processes.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 2; 501-507
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of chitosan on the synthesis of l-s-nitrosocysteine that participates in the regulation of the m2 pyruvate kinase isoenzyme activity associated with ehrlich ascites cells proliferation in vitro
    Autorzy:
    Ignacak, Jan
    Zagajewski, Jacek
    Pałka, Iwona
    Wiśniewska-Wrona, Maria
    Niekraszewicz, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/1035527.pdf
    Data publikacji:
    2010
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    L-S-nitrosocysteine
    L-cysteine
    inhibition of EAT cell proliferation
    microcrystalline chitosan
    pyruvate kinase M2 isoenzyme
    Opis:
    L-S-nitrosocysteine formation in EAT tumor cells and normal CRL-1636 cells incubated with microcrystalline chitosan was confirmed by RP-HPLC. The metabolite was identified based on UV-VIS spectra. The formation of L-S-nitrosocysteine in EAT tumor cells contributes to decreasing the level of L-cysteine in these cells. L-cysteine as an effector of the bifunctional M2 isoenzyme of pyruvate kinase (PK) initiates its histone kinase activity, which is responsible for histone H1 phosphorylation. A decrease of L-cysteine level in EAT tumor cells contributes to lack of histone H1 phosphorylation by the M2 PK isoenzyme and by the same token to inhibition of EAT cell proliferation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 149-158
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Distribution of cathepsin L in human umbilical cord tissues
    Autorzy:
    Gogiel, Tomasz
    Wolańska, Małgorzata
    Galewska, Zofia
    Kinalski, Piotr
    Sobolewski, Krzysztof
    Romanowicz, Lech
    Powiązania:
    https://bibliotekanauki.pl/articles/1038609.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cathepsin L
    cysteine protease inhibitors
    umbilical cord
    umbilical cord artery
    umbilical cord vein
    Wharton's jelly
    Opis:
    The extracellular matrix components show specific distribution patterns within various structures of the umbilical cord, among which Wharton's jelly is especially collagen-rich tissue. Cathepsin L is a potent cysteine protease engaged in degradation of extracellular matrix proteins, including collagens. We evaluated the activity and expression of cathepsin L, and the inhibitory effect of cysteine protease inhibitors in the umbilical cord arteries, vein and Wharton's jelly. Cathepsin L activity and anti-papain inhibitory effect of cysteine protease inhibitors were quantified in extracts of separated umbilical cord tissues using fluorogenic substrates. The results were calculated per DNA content. The enzyme expression was assessed by Western immunoblotting. The active cathepsin L activity (without activation by pepsin digestion), its percentage in the total activity (after pepsin activation), and the expression of the mature single-chain enzyme were the lowest in the umbilical cord arteries and the highest in Wharton's jelly. The effect of cysteine protease inhibitors showed similar distribution as in the case of the active enzyme, being the highest in Wharton's jelly. Distribution of the activity and expression of mature cathepsin L within the umbilical cord probably results from distinctions in the proenzyme activation process. Differences in the action of cysteine protease inhibitors can partly restrict divergences in the enzyme activity that could reflect its expression alone. Differential enzyme action seems to contribute to tissue-specific collagen turnover within the umbilical cord cells, especially those of Wharton's jelly.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 507-512
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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