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    Wyświetlanie 1-4 z 4
    Tytuł:
    Japanese quince (Chaenomeles japonica L.) fruit polyphenolic extract modulates carbohydrate metabolism in HepG2 cells via AMP-activated protein kinase
    Autorzy:
    Zakłos-Szyda, Małgorzata
    Pawlik, Nina
    Powiązania:
    https://bibliotekanauki.pl/articles/1038525.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    AMPK
    diabetes
    glucose metabolism
    HepG2
    Japanese quince
    polyphenols
    Opis:
    Type 2 diabetes mellitus (T2D) is a chronic diet-related disease which due to many dangerous complications has become a prominent health problem of the world. The aim of the study was to explore the in vitro activity of Japanese quince (Chaenomeles japonica L., family Rosaceae, JQ) fruit polyphenolic extract as modulator of carbohydrates metabolism. The research was designed to investigate the effect of JQ polyphenolic extract on glucose metabolism in human hepatoma HepG2 cell line cultured under normal non-metabolically changed and hyperglycemic conditions. Pretreatment of the cells with JQ preparation caused decrease of intracellular ROS generation and influenced mitochondrial membrane polarization which seemed to lead to AMPK activation. Further effects observed in HepG2 cells were associated with activation of the enzyme: elevation of glucose uptake and glycogen content, and alleviation of gluconeogenesis through modulation of PEPCK, PTP1B, FOXO1 and GLUT2/4 expression. These findings suggest that JQ polyphenols exhibit hypoglycemic effects via modulation of AMPK signaling in hepatocytes.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 67-78
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells
    Autorzy:
    Owczarek, Katarzyna
    Hrabec, Elżbieta
    Fichna, Jakub
    Sosnowska, Dorota
    Koziołkiewicz, Maria
    Szymański, Jacek
    Lewandowska, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/1038623.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    flavanols
    Japanese quince (Chaenomeles japonica)
    colon cells
    COX-2
    MMP-9
    NF-κB
    Opis:
    Natural polyphenols and polyphenol-rich extracts have been found to possess preventive and therapeutic potential against several types of cancers, including colorectal cancer (CRC), which is an example of an inflammation-associated cancer. This study examines the chemopreventive effect of a Japanese quince (Chaenomeles japonica) fruit flavanol preparation (JQFFP) on colon cancer SW-480 cells. JQFFP, rich in procyanidin monomers and oligomers, was found to inhibit the SW-480 cell viability by 40% at 150 µM catechin equivalents (CE) after 72 h incubation when compared to control, but it was non-toxic to normal colon fibroblast CCD-18Co cells. Furthermore, 100 µM CE JQFFP suppressed COX-2 mRNA expression to 36.7% of control values and protein expression to 77%. In addition, JQFFP reduced the MMP-9 protein expression (to 24% vs. control at 100 µM CE) and caused inhibition of its enzymatic activity (to 35% vs. control at 100 µM CE). Not only did JQFFP inhibit the COX-2 and MMP-9 levels, but it also reduced the NF-κB protein expression (to 65% of control) and phosphorylation of its p65 subunit (to 51%) at 100 µM CE. These results provide the first evidence that JQFFP inhibits COX-2, MMP-9, and NF-κB expression, suggesting that it has cytotoxic, anti-inflammatory, and anti-metastatic activities towards the colon cancer SW-480 cells.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 567-576
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pigwowiec japoński (Chaenomeles japonica L.) jako surowiec o właściwościach prozdrowotnych – aktualny stan wiedzy
    Japanese quince (Chaenomeles japonica L.) as a raw material about health properties - current state of knowledge
    Autorzy:
    Byczkiewicz, Szymon
    Kobus-Cisowska, Joanna
    Szulc, Piotr
    Telichowska, Aleksandra
    Szczepaniak, Oskar
    Dziedziński, Marcin
    Powiązania:
    https://bibliotekanauki.pl/articles/883925.pdf
    Data publikacji:
    2019-12-15
    Wydawca:
    Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Maszyn Rolniczych
    Tematy:
    pigwowiec japonski
    Chaenomeles japonica
    owoce
    zwiazki bioaktywne
    wlasciwosci prozdrowotne
    Japanese quince
    bioactive compounds
    functional properties
    Opis:
    Pigwowiec japoński (Chaenomeles japonica L.) jest kolczastym, karłowatym krzewem powszechnie występującym w Polsce. Uprawiany jest ze względu na kwaśne i aromatyczne owoce, które zawierają związki bioaktywne, takie jak katechina, epikatechina, proantocyjanidyna, triterpeny, witamina C oraz pektyny. Owoce powszechnie wykorzystywane są w medycynie chińskiej oraz tradycyjnej. Skład owoców pigwowca determinuje korzystne właściwości, przez co mogą być cennym składnikiem do zastosowania w przemyśle farmaceutycznym, kosmetycznym i spożywczym.
    Japanese quince (Chaenomeles japonica L.) is a prickly, dwarf shrub found in Poland. They are cultivate for their acidic and aromatic fruit, which contain bioactive compounds such as catechin, epicatechin, proanthocyanidin, triterpenes, vit-amin C and pectin. For this reason, the fruit is widely used in Chinese and traditional medicine. The composition of quince fruit determines its beneficial properties, which makes it a valuable ingredient for use in both the pharmaceutical, cosmetics and food industries.
    Źródło:
    Technika Rolnicza Ogrodnicza Leśna; 2019, 5; 22-25
    1732-1719
    2719-4221
    Pojawia się w:
    Technika Rolnicza Ogrodnicza Leśna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pentacyclic triterpenoids and polyphenols accumulation in cell suspension culture of Chaenomeles japonica (Thunb.) Lindl. ex Spach
    Autorzy:
    Kikowska, M.
    Wlodarczyk, A.
    Stochmal, A.
    Zuchowski, J.
    Thiem, B.
    Powiązania:
    https://bibliotekanauki.pl/articles/71498.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    pentacyclic triterpenoid
    triterpenoid
    polyphenol
    accumulation
    cell suspension
    callus
    Chaenomeles japonica
    Japanese quince
    chlorogenic acid
    ursolic acid
    oleanolic acid
    Opis:
    Introduction: Callus and cell suspension cultures are widely applied in investigation of production of highvalue secondary metabolites, which may be used as cosmeceuticals, nutraceuticals and pharmaceuticals. Plant cell cultures are promising alternative to intact plant sources for the production of plant-derived drugs of industrial importance. Objective: The aim of the study was to (i) initiate the cell suspension culture of Chaenomeles japonica from homogenous and uniform callus, (ii) stabilize the selected line and (iii) verify its ability to produce the desired groups of secondary metabolites – pentacyclic triterpenoids and polyphenols. Methods: To establish a cell suspension culture, stabilized and homogeneous callus was selected. Cell cultures were systematically passaged every 2 weeks to fresh liquid medium with the same composition. Biomass from cultures at the growth phase and stationary phase was designated for phytochemical research. UHPLC-DAD-MS analyzes were performed. At the same time, their macroscopic and microscopic observations were carried out. Results: Cells of suspension culture line A2 were characterized by the intense divisions. Cell culture extracts (both from the growth phase and stationary phase) contained pentacyclic triterpenoids. In addition, phenolic compounds (chlorogenic acid and proanthocyanidins type B) and in a small amount also epicatechin are present in the extract of the cells harvested from the growth phase. In the present studies, three pentacyclic triterpenoids were detected and quantified in the extracts of cell suspensions and callus line A2. Ursolic and oleanolic acids were the main triterpenoids in the studied extracts. The cell suspension culture from the growth phase exhibited the highest content of ursolic, oleanolic, and betulinic acid (separately and together). Conclusion: The cell suspension culture of Chaenomeles japonica is a promising source of pentacyclic triterpenoids.
    Źródło:
    Herba Polonica; 2019, 65, 1
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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